| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Burçin Tezcanli Kaymaz, Nur Selvi, Güray Saydam, Fahri Sahin, Buket Kosov. Methylprednisolone induces apoptosis by interacting with the JAK/STAT pathway in HL-60 and K-562 leukemic cells. Hematology (Amsterdam, Netherlands). vol 17. issue 2. 2012-12-14. PMID:22664047. |
to determine the gene expression profiles of the jak/stat pathway members stat3, stat5a, stat5b at both mrna and protein levels in hl-60 and k-562 leukemia cells that were undergoing apoptosis following high-dose methylprednisolone (mp) treatment. |
2012-12-14 |
2023-08-12 |
Not clear |
| Jean-Michel Pontier, Emmanuel Gempp, Mihaela Ignatesc. Blood platelet-derived microparticles release and bubble formation after an open-sea air dive. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 37. issue 5. 2012-10-16. PMID:22735037. |
endothelial cells, blood platelets, or leukocytes shed microparticles (mp) upon activation and during cell apoptosis. |
2012-10-16 |
2023-08-12 |
rat |
| X-M Jing, Y-J Wen, W Shi, Q-Q Tang, J Li, X-C Che. VSV-MP gene therapy strategy inhibits tumor growth in nude mice model of human lung adenocarcinoma. Cancer gene therapy. vol 19. issue 2. 2012-08-16. PMID:22052213. |
vesicular stomatitis virus (vsv) matrix protein (mp) can induce in vitro apoptosis of tumor cells in the absence of other viral components. |
2012-08-16 |
2023-08-12 |
mouse |
| C M de Carvalho, P F C Menezes, G C Letenski, C E O Praes, I H S Feferman, M Lorencin. In vitro induction of apoptosis, necrosis and genotoxicity by cosmetic preservatives: application of flow cytometry as a complementary analysis by NRU. International journal of cosmetic science. vol 34. issue 2. 2012-07-09. PMID:22118339. |
the purpose of this study was to investigate and compare the in vitro apoptosis, necrosis and genotoxicity-inducing potential of five different types of preservatives: phenoxyethanol (pe), propylparaben (pp), methylparaben (mp), benzyl alcohol (ba) and ethylhexyl glycerine (eg). |
2012-07-09 |
2023-08-12 |
human |
| C M de Carvalho, P F C Menezes, G C Letenski, C E O Praes, I H S Feferman, M Lorencin. In vitro induction of apoptosis, necrosis and genotoxicity by cosmetic preservatives: application of flow cytometry as a complementary analysis by NRU. International journal of cosmetic science. vol 34. issue 2. 2012-07-09. PMID:22118339. |
our results showed that pe, pp, mp and ba have similar cytotoxic mechanisms (high apoptosis and necrosis levels only at the test concentration of 1%), whereas eg showed only an apoptosis pathway. |
2012-07-09 |
2023-08-12 |
human |
| William H Goodson, Maria Gloria Luciani, S Aejaz Sayeed, Ian M Jaffee, Dan H Moore, Shanaz H Dairke. Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women. Carcinogenesis. vol 32. issue 11. 2011-12-22. PMID:21890461. |
moreover, hrbecs pretreated with bpa, or the xe, methylparaben (mp), surmounted antiestrogenic effects of tamoxifen showing dose-dependent apoptosis evasion and induction of cell cycling. |
2011-12-22 |
2023-08-12 |
human |
| Awadh B Yadav, Pavan Muttil, Amit K Singh, Rahul K Verma, Mradul Mohan, Atul K Agrawal, Ajay S Verma, Sudhir K Sinha, Amit Misr. Microparticles induce variable levels of activation in macrophages infected with Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). vol 90. issue 3. 2011-11-21. PMID:20382085. |
about 19% of infected cells exposed to mp underwent apoptosis compared to approximately 11% cells treated otherwise. |
2011-11-21 |
2023-08-12 |
mouse |
| Xin Chen, Bin Zhang, Yan Chai, Bo Dong, Ping Lei, Rongcai Jiang, Jianning Zhan. Methylprednisolone exacerbates acute critical illness-related corticosteroid insufficiency associated with traumatic brain injury in rats. Brain research. vol 1382. 2011-11-15. PMID:21262204. |
the purpose of this study was to test the hypothesis that methylprednisolone (mp), a synthetic glucocorticoid, promotes post-traumatic apoptosis in both the hypothalamus and pituitary, resulting in acute circi and increased mortality in the acute phase of traumatic brain injury (tbi). |
2011-11-15 |
2023-08-12 |
rat |
| Xin Chen, Bin Zhang, Yan Chai, Bo Dong, Ping Lei, Rongcai Jiang, Jianning Zhan. Methylprednisolone exacerbates acute critical illness-related corticosteroid insufficiency associated with traumatic brain injury in rats. Brain research. vol 1382. 2011-11-15. PMID:21262204. |
moreover, tem revealed morphological changes characteristic of apoptosis in both the pvn and adenohypophysis of high-dose mp treated rats. |
2011-11-15 |
2023-08-12 |
rat |
| Xin Chen, Bin Zhang, Yan Chai, Bo Dong, Ping Lei, Rongcai Jiang, Jianning Zhan. Methylprednisolone exacerbates acute critical illness-related corticosteroid insufficiency associated with traumatic brain injury in rats. Brain research. vol 1382. 2011-11-15. PMID:21262204. |
these data suggest that mp therapy for tbi could increase neuronal apoptosis in both the hypothalamus and pituitary and consequently exacerbate acute circi and mortality induced by tbi. |
2011-11-15 |
2023-08-12 |
rat |
| T Neri, C Armani, A Pegoli, C Cordazzo, Y Carmazzi, S Brunelleschi, C Bardelli, M C Breschi, P Paggiaro, A Cel. Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles. The European respiratory journal. vol 37. issue 6. 2011-10-07. PMID:21148223. |
microparticles (mp) are phospholipid vesicles shed by cells upon activation or apoptosis. |
2011-10-07 |
2023-08-12 |
human |
| Thang Q Hoang, Christine Rampon, Jean-Marie Freyssinet, Sophie Vriz, Danièle Kerbiriou-Nabia. A method to assess the migration properties of cell-derived microparticles within a living tissue. Biochimica et biophysica acta. vol 1810. issue 9. 2011-09-19. PMID:21609754. |
cells undergoing activation or apoptosis exhibit plasma membrane changes, leading to the formation of shed vesicles (microparticles, mp). |
2011-09-19 |
2023-08-12 |
Not clear |
| Yun Mi Kang, Gyeong Hae Kim, Jae Il Kim, Da Yeon Kim, Bit Na Lee, So Mi Yoon, Jae Ho Kim, Moon Suk Ki. In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer. Biomaterials. vol 32. issue 20. 2011-08-22. PMID:21440935. |
consistent with the observed suppression of tumor growth, intratumorally injected free dox or dox released from dox-loaded mp gels caused apoptosis of tumor cells. |
2011-08-22 |
2023-08-12 |
mouse |
| Nicolas Amabile, Pierre-Emmanuel Rautou, Alain Tedgui, Chantal M Boulange. Microparticles: key protagonists in cardiovascular disorders. Seminars in thrombosis and hemostasis. vol 36. issue 8. 2011-03-08. PMID:21069633. |
microparticles (mp) are shed membrane vesicles released by various cell types following apoptosis or activation. |
2011-03-08 |
2023-08-12 |
human |
| Friedrich Felix Hoyer, Georg Nickenig, Nikos Werne. Microparticles--messengers of biological information. Journal of cellular and molecular medicine. vol 14. issue 9. 2011-02-17. PMID:20597998. |
apoptosis is associated with the release of microparticles (mp). |
2011-02-17 |
2023-08-12 |
Not clear |
| Mathieu Cambos, Tatiana Scorz. Robust erythrophagocytosis leads to macrophage apoptosis via a hemin-mediated redox imbalance: role in hemolytic disorders. Journal of leukocyte biology. vol 89. issue 1. 2011-02-08. PMID:20884648. |
as erythrophagocytosis has been involved in mp dysfunction and as certain hemolytic disorders associate to mp apoptosis, a possible link between erythrophagocytosis and the viability of phagocytes was investigated herein. |
2011-02-08 |
2023-08-12 |
Not clear |
| Mathieu Cambos, Tatiana Scorz. Robust erythrophagocytosis leads to macrophage apoptosis via a hemin-mediated redox imbalance: role in hemolytic disorders. Journal of leukocyte biology. vol 89. issue 1. 2011-02-08. PMID:20884648. |
although crbc were weakly phagocytosed and did not affect mp viability significantly, erythrophagocytosis of oxidized rbc and dsrbc was robust and resulted in a sharp decrease of mp viability via apoptosis. |
2011-02-08 |
2023-08-12 |
Not clear |
| Mathieu Cambos, Tatiana Scorz. Robust erythrophagocytosis leads to macrophage apoptosis via a hemin-mediated redox imbalance: role in hemolytic disorders. Journal of leukocyte biology. vol 89. issue 1. 2011-02-08. PMID:20884648. |
moreover, oxidized rbc, dsrbc, and he generated ros species, which were responsible for the apoptosis of mp. |
2011-02-08 |
2023-08-12 |
Not clear |
| Mathieu Cambos, Tatiana Scorz. Robust erythrophagocytosis leads to macrophage apoptosis via a hemin-mediated redox imbalance: role in hemolytic disorders. Journal of leukocyte biology. vol 89. issue 1. 2011-02-08. PMID:20884648. |
furthermore, ho-1, strongly induced in response to treatment with oxidized rbc, dsrbc, or he, was shown to protect mp partially against apoptosis, suggesting that robust erythro-phagocytosis may exceed the detoxification capabilities of mp. |
2011-02-08 |
2023-08-12 |
Not clear |
| Mathieu Cambos, Tatiana Scorz. Robust erythrophagocytosis leads to macrophage apoptosis via a hemin-mediated redox imbalance: role in hemolytic disorders. Journal of leukocyte biology. vol 89. issue 1. 2011-02-08. PMID:20884648. |
taken together, these results suggest that enhanced erythrophagocytosis associated to hemolytic disorders leads to mp apoptosis in vitro and may have critical implications for the control of malaria infection and for the exacerbated susceptibility to bacterial infections during hemolytic disorders. |
2011-02-08 |
2023-08-12 |
Not clear |