| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin-Ming Yang, Yao-Yu Cheng, Zhen-Liang Zhang, Cong Kan. Role of Methylprednisolone in Treatment of Spinal Cord Injured with Bone Marrow Mesenchymal Stem Cells Transplantation in Rats and Its Effect on the Expressions of Tumor Necrosis Factor-α and Interleukin-1β. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 39. issue 5. 2019-02-12. PMID:29125102. |
objective to investigate the role of methylprednisolone (mp) in treatment of spinal cord injured (sci) with bone marrow mesenchymal stem cells (bmscs) transplantation in rats and its effect on the expressions of tumor necrosis factor-α(tnf-α) and interleukin-1β(il-1β) at the local tissues.methods forty male sprague-dawley(sd) rats were used to establish the models of sci according to the modified allen's contusion method and then divided into four groups (n=10 in each group) by using random numbers table:mp group,bmscs group,bmscs+mp group,and control group.mp was intravenously administrated immediately after sci.bmscs labeled by 5-bromo-2-deoxyuridine(brdu)were transplanted into the injured sites of spinal cord after two hours of sci.on the 1 st,7 th,and 14th days after sci,when functional outcome measurements were evaluated by the basso-beattie-bresnahan (bbb) score.on the 14th day after treatment,the spine cord tissues were harvested for the tnf-α/il-1β immunohistochemistry,and tunel staining method was used to detect cell apoptosis rate.brdu-positive bmscs were examined in bmscs group and bmscs+mp group.results functional recovery of hind limb in mp+bmscs group was the best among the four group.on the 1 st day after injury,the bbb scores showed no significant difference among four group(χ |
2019-02-12 |
2023-08-13 |
rat |
| Ming-Ju Hsieh, Chiao-Wen Lin, Mu-Kuan Chen, Su-Yu Chien, Yu-Sheng Lo, Yi-Ching Chuang, Yi-Ting Hsi, Chia-Chieh Lin, Jui-Chieh Chen, Shun-Fa Yan. Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways. Scientific reports. vol 7. 2018-11-14. PMID:28327651. |
moreover, mp leading to cell cycle arrest at g2/m phase, which subsequently activates caspase-3, -8, -9 and parp to induce cell apoptosis. |
2018-11-14 |
2023-08-13 |
Not clear |
| Sajad Hassanzadeh, Seyed Behnamedin Jameie, Mehdi Mehdizadeh, Mansooreh Soleimani, Zeinab Namjoo, Maryam Soleiman. FNDC5 expression in Purkinje neurons of adult male rats with acute spinal cord injury following treatment with methylprednisolone. Neuropeptides. vol 70. 2018-10-25. PMID:29907375. |
therapy with mp inhibits apoptosis in irfndc5 purkinje cells and restores them. |
2018-10-25 |
2023-08-13 |
rat |
| Chen Shuona, Yin Hua, Chang Jingjing, Peng Hui, Dang Zh. Physiology and bioprocess of single cell of Stenotrophomonas maltophilia in bioremediation of co-existed benzo[a]pyrene and copper. Journal of hazardous materials. vol 321. 2018-08-30. PMID:27607928. |
in this study, we applied flow cytometry to obtain a better understanding of membrane potential (mp), apoptosis and cell cycle of stenotrophomonas maltophilia affected by combined pollutants of benzo[a]pyrene(bap) and cu(ii). |
2018-08-30 |
2023-08-13 |
Not clear |
| Perihan Seda Ateş, İsmail Ünal, Ünsal Veli Üstündağ, Ahmet Ata Alturfan, Türkan Yiğitbaşı, Ebru Emekli-Alturfa. Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos. Journal of biochemical and molecular toxicology. vol 32. issue 3. 2018-07-10. PMID:29360218. |
our aim was to evaluate the effects of mp on the development of zebrafish embryos focusing on development, locomotor activity, oxidant-antioxidant status, apoptosis, and ccnd1 and myca expressions. |
2018-07-10 |
2023-08-13 |
zebrafish |
| Perihan Seda Ateş, İsmail Ünal, Ünsal Veli Üstündağ, Ahmet Ata Alturfan, Türkan Yiğitbaşı, Ebru Emekli-Alturfa. Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos. Journal of biochemical and molecular toxicology. vol 32. issue 3. 2018-07-10. PMID:29360218. |
mp exposure increased malformations, lpo, apoptosis, ccnd1 and myca expressions, and decreased gst activities and no levels compared with the control group. |
2018-07-10 |
2023-08-13 |
zebrafish |
| Xie Su, Peng Cheng, Dong-Hong Den. [Research Advance of Microparticles in Hypercoagulation of Hemolytic Anemia-Review]. Zhongguo shi yan xue ye xue za zhi. vol 25. issue 2. 2018-07-06. PMID:28446324. |
microparticles (mp) are small membrane vesicles released from many different cell types in response to cellular activation or apoptosis, which have the procoagulant effect. |
2018-07-06 |
2023-08-13 |
Not clear |
| Somedeb Ball, Kenneth Nugen. Microparticles in Hematological Malignancies: Role in Coagulopathy and Tumor Pathogenesis. The American journal of the medical sciences. vol 355. issue 3. 2018-07-02. PMID:29549921. |
microparticles (mp) are submicron vesicles released from various cells in response to activation, injury or apoptosis. |
2018-07-02 |
2023-08-13 |
Not clear |
| Gonzalo J Martínez, Jennifer Y Barraclough, Shirley Nakhla, Vivian Kienzle, Stacy Robertson, Ziad Mallat, David S Celermajer, Sanjay Pate. Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients. Bioscience reports. vol 37. issue 1. 2017-12-21. PMID:27913753. |
mp are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. |
2017-12-21 |
2023-08-13 |
Not clear |
| Mohammad Faujul Kabir, Johari Mohd Ali, Mitra Abolmaesoomi, Onn Haji Hashi. Melicope ptelefolia leaf extracts exhibit antioxidant activity and exert anti-proliferative effect with apoptosis induction on four different cancer cell lines. BMC complementary and alternative medicine. vol 17. issue 1. 2017-08-21. PMID:28476158. |
the present study reports antioxidant, anti-proliferative, and apoptosis induction activities of mp leaf extracts. |
2017-08-21 |
2023-08-13 |
Not clear |
| B Tokarz-Deptuła, B Hukowska-Szematowicz, P Niedźwiedzka-Rystwej, A Trzeciak-Ryczek, W Deptuł. Values of apoptosis of lymphocytes and granulocytes in peripheral blood of Polish mixed-breed rabbits in the annual cycle. Polish journal of veterinary sciences. vol 20. issue 1. 2017-06-29. PMID:28525323. |
assessment of apoptosis of lymphocytes and granulocytes was performed using as facscan cytometer by becton dickinson with facsdiva software (usa), using as apofluor® green caspase reagent kit (mp biomedicals, usa) to detect the activity of the total caspase pool 1, 3, 4, 5, 6, 7, 8, 9 in granulocytes and lymphocytes of rabbit peripheral blood. |
2017-06-29 |
2023-08-13 |
rabbit |
| Hong-Liang Weng, Ming-Jing Wan. Effects of microRNA‑338‑3p on morphine‑induced apoptosis and its underlying mechanisms. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27432229. |
the aim of the present study was to investigate the effects of microrna-338-3p (mir-338-3p) on morphine (mp)-induced apoptosis, and its underlying mechanisms. |
2017-04-06 |
2023-08-13 |
mouse |
| Xiaorong Qi, Licheng Du, Xiancheng Chen, Lijuan Chen, Tao Yi, Xiang Chen, Yanjun Wen, Yuquan Wei, Xia Zha. VEGF-D-enhanced lymph node metastasis of ovarian cancer is reversed by vesicular stomatitis virus matrix protein. International journal of oncology. vol 49. issue 1. 2017-03-30. PMID:27211072. |
matrix protein (mp) of vesicular stomatitis virus (vsv) exhibits potent antitumor and antiangiogenic activities through inducing apoptosis and inhibiting angiogenesis. |
2017-03-30 |
2023-08-13 |
mouse |
| Xiaorong Qi, Licheng Du, Xiancheng Chen, Lijuan Chen, Tao Yi, Xiang Chen, Yanjun Wen, Yuquan Wei, Xia Zha. VEGF-D-enhanced lymph node metastasis of ovarian cancer is reversed by vesicular stomatitis virus matrix protein. International journal of oncology. vol 49. issue 1. 2017-03-30. PMID:27211072. |
mp significantly reduced the invasion of vegfd-sk cells, tumor volume, lymphatic metastasis rates and lymphatic vessel density compared with control groups (p<0.05), accompanied with down-expression of vegf-d and mmp-2 and increased apoptosis. |
2017-03-30 |
2023-08-13 |
mouse |
| Zhi-Yao He, Feng Deng, Xia-Wei Wei, Cui-Cui Ma, Min Luo, Ping Zhang, Ya-Xiong Sang, Xiao Liang, Li Liu, Han-Xiao Qin, Ya-Li Shen, Ting Liu, Yan-Tong Liu, Wei Wang, Yan-Jun Wen, Xia Zhao, Xiao-Ning Zhang, Zhi-Yong Qian, Yu-Quan We. Ovarian cancer treatment with a tumor-targeting and gene expression-controllable lipoplex. Scientific reports. vol 6. 2017-02-17. PMID:27026065. |
such an anti-tumor effect was due to the increased expression of mp in tumor tissue, which led to the induction of tumor cell apoptosis, inhibition of tumor cell proliferation and suppression of tumor angiogenesis. |
2017-02-17 |
2023-08-13 |
mouse |
| Zibiao Zhong, Qianchao Hu, Zhen Fu, Ren Wang, Yan Xiong, Yang Zhang, Zhongzhong Liu, Yanfeng Wang, Qifa Y. Increased Expression of Aldehyde Dehydrogenase 2 Reduces Renal Cell Apoptosis During Ischemia/Reperfusion Injury After Hypothermic Machine Perfusion. Artificial organs. vol 40. issue 6. 2017-01-17. PMID:26582147. |
renal apoptosis was detected by tunel staining, and the expression of aldh2, cleaved-caspase 3, bcl-2/ bax, mapk in renal tissue was detected by immunohistochemistry or western blot; 24 h after surgery, the concentration of cr in mp group was 355 ± 71μmol/l, in cs group was 511 ± 44 μmol/l (p < 0.05), while the bun was 15.02 ± 2.34 mmol/l in mp group, 22.64 ± 3.58 mmol/l in cs group (p < 0.05). |
2017-01-17 |
2023-08-13 |
Not clear |
| Zibiao Zhong, Qianchao Hu, Zhen Fu, Ren Wang, Yan Xiong, Yang Zhang, Zhongzhong Liu, Yanfeng Wang, Qifa Y. Increased Expression of Aldehyde Dehydrogenase 2 Reduces Renal Cell Apoptosis During Ischemia/Reperfusion Injury After Hypothermic Machine Perfusion. Artificial organs. vol 40. issue 6. 2017-01-17. PMID:26582147. |
the rate of apoptosis and expression of cleaved caspase-3, p-p38, p-erk, and p-jnk in mp group was significantly lower than that in cs group (p < 0.05), while expression of aldh2 and bcl-2/bax in mp group was significantly higher than that in cs group (p < 0.05); expression of cleaved caspase-3 in both mp and cs group significantly increased as compared with that in normal group (p < 0.05). |
2017-01-17 |
2023-08-13 |
Not clear |
| Zibiao Zhong, Qianchao Hu, Zhen Fu, Ren Wang, Yan Xiong, Yang Zhang, Zhongzhong Liu, Yanfeng Wang, Qifa Y. Increased Expression of Aldehyde Dehydrogenase 2 Reduces Renal Cell Apoptosis During Ischemia/Reperfusion Injury After Hypothermic Machine Perfusion. Artificial organs. vol 40. issue 6. 2017-01-17. PMID:26582147. |
in conclusion, increased expression of aldh2 can reduce the renal cell apoptosis through inhibiting mapk pathway during ischemia/reperfusion injury (iri) after hypothermic mp. |
2017-01-17 |
2023-08-13 |
Not clear |
| Kaitlyn M Dykstra, Cheryl Allen, Ella J Born, Huaxiang Tong, Sarah A Holstei. Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. Oncotarget. vol 6. issue 39. 2016-09-26. PMID:26595805. |
we have shown previously that disruption of the isoprenoid biosynthetic pathway (ibp) causes a block in mp secretion through a disruption of rab gtpase activity, leading to an enhanced unfolded protein response and subsequent apoptosis in mm cells. |
2016-09-26 |
2023-08-13 |
Not clear |
| Mikael Evander, Olof Gidlöf, Björn Olde, David Erlinge, Thomas Laurel. Non-contact acoustic capture of microparticles from small plasma volumes. Lab on a chip. vol 15. issue 12. 2016-02-16. PMID:25943791. |
microparticles (mp) are small (100-1000 nm) membrane vesicles shed by cells as a response to activation, stress or apoptosis. |
2016-02-16 |
2023-08-13 |
Not clear |