| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaorong Qi, Licheng Du, Xiancheng Chen, Lijuan Chen, Tao Yi, Xiang Chen, Yanjun Wen, Yuquan Wei, Xia Zha. VEGF-D-enhanced lymph node metastasis of ovarian cancer is reversed by vesicular stomatitis virus matrix protein. International journal of oncology. vol 49. issue 1. 2017-03-30. PMID:27211072. |
mp significantly reduced the invasion of vegfd-sk cells, tumor volume, lymphatic metastasis rates and lymphatic vessel density compared with control groups (p<0.05), accompanied with down-expression of vegf-d and mmp-2 and increased apoptosis. |
2017-03-30 |
2023-08-13 |
mouse |
| Zhi-Yao He, Feng Deng, Xia-Wei Wei, Cui-Cui Ma, Min Luo, Ping Zhang, Ya-Xiong Sang, Xiao Liang, Li Liu, Han-Xiao Qin, Ya-Li Shen, Ting Liu, Yan-Tong Liu, Wei Wang, Yan-Jun Wen, Xia Zhao, Xiao-Ning Zhang, Zhi-Yong Qian, Yu-Quan We. Ovarian cancer treatment with a tumor-targeting and gene expression-controllable lipoplex. Scientific reports. vol 6. 2017-02-17. PMID:27026065. |
such an anti-tumor effect was due to the increased expression of mp in tumor tissue, which led to the induction of tumor cell apoptosis, inhibition of tumor cell proliferation and suppression of tumor angiogenesis. |
2017-02-17 |
2023-08-13 |
mouse |
| Zibiao Zhong, Qianchao Hu, Zhen Fu, Ren Wang, Yan Xiong, Yang Zhang, Zhongzhong Liu, Yanfeng Wang, Qifa Y. Increased Expression of Aldehyde Dehydrogenase 2 Reduces Renal Cell Apoptosis During Ischemia/Reperfusion Injury After Hypothermic Machine Perfusion. Artificial organs. vol 40. issue 6. 2017-01-17. PMID:26582147. |
renal apoptosis was detected by tunel staining, and the expression of aldh2, cleaved-caspase 3, bcl-2/ bax, mapk in renal tissue was detected by immunohistochemistry or western blot; 24 h after surgery, the concentration of cr in mp group was 355 ± 71μmol/l, in cs group was 511 ± 44 μmol/l (p < 0.05), while the bun was 15.02 ± 2.34 mmol/l in mp group, 22.64 ± 3.58 mmol/l in cs group (p < 0.05). |
2017-01-17 |
2023-08-13 |
Not clear |
| Zibiao Zhong, Qianchao Hu, Zhen Fu, Ren Wang, Yan Xiong, Yang Zhang, Zhongzhong Liu, Yanfeng Wang, Qifa Y. Increased Expression of Aldehyde Dehydrogenase 2 Reduces Renal Cell Apoptosis During Ischemia/Reperfusion Injury After Hypothermic Machine Perfusion. Artificial organs. vol 40. issue 6. 2017-01-17. PMID:26582147. |
the rate of apoptosis and expression of cleaved caspase-3, p-p38, p-erk, and p-jnk in mp group was significantly lower than that in cs group (p < 0.05), while expression of aldh2 and bcl-2/bax in mp group was significantly higher than that in cs group (p < 0.05); expression of cleaved caspase-3 in both mp and cs group significantly increased as compared with that in normal group (p < 0.05). |
2017-01-17 |
2023-08-13 |
Not clear |
| Zibiao Zhong, Qianchao Hu, Zhen Fu, Ren Wang, Yan Xiong, Yang Zhang, Zhongzhong Liu, Yanfeng Wang, Qifa Y. Increased Expression of Aldehyde Dehydrogenase 2 Reduces Renal Cell Apoptosis During Ischemia/Reperfusion Injury After Hypothermic Machine Perfusion. Artificial organs. vol 40. issue 6. 2017-01-17. PMID:26582147. |
in conclusion, increased expression of aldh2 can reduce the renal cell apoptosis through inhibiting mapk pathway during ischemia/reperfusion injury (iri) after hypothermic mp. |
2017-01-17 |
2023-08-13 |
Not clear |
| Kaitlyn M Dykstra, Cheryl Allen, Ella J Born, Huaxiang Tong, Sarah A Holstei. Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. Oncotarget. vol 6. issue 39. 2016-09-26. PMID:26595805. |
we have shown previously that disruption of the isoprenoid biosynthetic pathway (ibp) causes a block in mp secretion through a disruption of rab gtpase activity, leading to an enhanced unfolded protein response and subsequent apoptosis in mm cells. |
2016-09-26 |
2023-08-13 |
Not clear |
| Mikael Evander, Olof Gidlöf, Björn Olde, David Erlinge, Thomas Laurel. Non-contact acoustic capture of microparticles from small plasma volumes. Lab on a chip. vol 15. issue 12. 2016-02-16. PMID:25943791. |
microparticles (mp) are small (100-1000 nm) membrane vesicles shed by cells as a response to activation, stress or apoptosis. |
2016-02-16 |
2023-08-13 |
Not clear |
| Shan Gao, Jie Ding, Hai-Jun Xiao, Zhi-Qiang Li, Yan Chen, Xing-Sheng Zhou, Jing-E Wang, Jiang Wu, Wei-Ze Sh. Anti-inflammatory and anti-apoptotic effect of combined treatment with methylprednisolone and amniotic membrane mesenchymal stem cells after spinal cord injury in rats. Neurochemical research. vol 39. issue 8. 2015-10-26. PMID:24890008. |
the combination treatment with mp (50 mg/kg) and delayed transplantation of am-mscs after rat spinal cord injury, significantly reduced (1) myeloperoxidase activity, (2) the proinflammatory cytokines: tumor necrosis factor-α, interleukin (il)-1β, il-6, il-17, interferon-γ and (3) the cell apoptosis [terminal deoxynucleotidyl transferase, dutp nick end labeling (tunel) staining, and caspase-3, bax and bcl-2 expressions]; increased: (1) the levels of the anti-inflammatory cytokines (il-10 and transforming growth factor-β1) and (2) the survival rate of am-mscs in the injury site. |
2015-10-26 |
2023-08-13 |
rat |
| Rui-Rui Zheng, Wei Hu, Cheng-Guang Sui, Nan Ma, You-Hong Jian. Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells. Oncology reports. vol 32. issue 6. 2015-06-29. PMID:25269557. |
the results showed that doxorubicin and gemcitabine decreasede proliferation, and increased apoptosis in the mcf7 mp and sp cells in vitro. |
2015-06-29 |
2023-08-13 |
mouse |
| Leonardo A Calderon, Juliana C Sobrinho, Kayena D Zaqueo, Andrea A de Moura, Amy N Grabner, Maurício V Mazzi, Silvana Marcussi, Auro Nomizo, Carla F C Fernandes, Juliana P Zuliani, Bruna M A Carvalho, Saulo L da Silva, Rodrigo G Stábeli, Andreimar M Soare. Antitumoral activity of snake venom proteins: new trends in cancer therapy. BioMed research international. vol 2014. 2015-05-13. PMID:24683541. |
their mechanisms of action include direct toxic action (pla2s), free radical generation (laaos), apoptosis induction (pla2s, mp, and laaos), and antiangiogenesis (disintegrins and lectins). |
2015-05-13 |
2023-08-12 |
mouse |
| Céline Gleizes, Andrei Constantinescu, Malak Abbas, Houda Bouhadja, Fatiha Zobairi, Laurence Kessler, Florence Tot. Liraglutide protects Rin-m5f β cells by reducing procoagulant tissue factor activity and apoptosis prompted by microparticles under conditions mimicking Instant Blood-Mediated Inflammatory Reaction. Transplant international : official journal of the European Society for Organ Transplantation. vol 27. issue 7. 2015-02-02. PMID:24612163. |
cell-derived mps were applied to naive rin-m5f for 24 h. apoptosis, mp release, tf activity, p-iκb expression, and mp-mediated apoptosis were measured in target cells. |
2015-02-02 |
2023-08-12 |
rat |
| Céline Gleizes, Andrei Constantinescu, Malak Abbas, Houda Bouhadja, Fatiha Zobairi, Laurence Kessler, Florence Tot. Liraglutide protects Rin-m5f β cells by reducing procoagulant tissue factor activity and apoptosis prompted by microparticles under conditions mimicking Instant Blood-Mediated Inflammatory Reaction. Transplant international : official journal of the European Society for Organ Transplantation. vol 27. issue 7. 2015-02-02. PMID:24612163. |
indirect cytoprotection led to 20% reduction in mp generation, thereby lowering mp-mediated apoptosis (6.3% vs. 3.7%, p = 0.022) and nf-κb activation (-50%) in target cells. |
2015-02-02 |
2023-08-12 |
rat |
| Kamlesh K Bhopale, Miriam Falzon, G A S Ansari, Bhupendra S Kaphali. Alcohol oxidizing enzymes and ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells. In vitro cellular & developmental biology. Animal. vol 50. issue 4. 2014-12-12. PMID:24281792. |
confluent ar42j cells were pre-treated with inhibitors of adh class i and ii [4-methylpyrazole (mp)] or class i, ii, and iii [1,10-phenanthroline (pt)], cytochrome p450 2e1 (trans-1,2-dichloroethylene) or catalase (sodium azide) followed by incubation with 800 mg% ethanol at 37°c for 6 h. ethanol metabolism, cell viability, cytotoxicity (apoptosis and necrosis), cell proliferation status, and formation of faees in ar42j cells were measured. |
2014-12-12 |
2023-08-12 |
rat |
| Diane M Spencer, Julie Gauley, David S Pisetsk. The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis. Innate immunity. vol 20. issue 3. 2014-11-25. PMID:23839527. |
taken together, these studies indicate that the nucleic acid content of mps from activated and apoptotic cells have important similarities, suggesting that events during tlr activation may lead to apoptosis and subsequent mp release. |
2014-11-25 |
2023-08-12 |
Not clear |
| C Chen, R L Yan. A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 46. issue 8. 2014-10-03. PMID:23903687. |
flow cytometry showed that mp induced g1 cell cycle arrest and apoptosis in a dose-dependent manner. |
2014-10-03 |
2023-08-12 |
human |
| Armen V Gyulkhandanyan, Asuman Mutlu, David J Allen, John Freedman, Valery Leyti. BH3-mimetic ABT-737 induces strong mitochondrial membrane depolarization in platelets but only weakly stimulates apoptotic morphological changes, platelet shrinkage and microparticle formation. Thrombosis research. vol 133. issue 1. 2014-10-01. PMID:24268298. |
little is known, however, about the relationship between ΔΨm depolarization and downstream morphological manifestations of platelet apoptosis, cell shrinkage and microparticle (mp) formation. |
2014-10-01 |
2023-08-12 |
Not clear |
| Wei Wang, Cheng-Hai Zhao, Ning Zhang, Jian Wan. Vitamin D analog EB1089 induces apoptosis in a subpopulation of SGC-7901 gastric cancer cells through a mitochondrial-dependent apoptotic pathway. Nutrition and cancer. vol 65. issue 7. 2014-06-26. PMID:24099173. |
eb1089 decreased the proliferation, increased apoptosis, and induced mitochondrial damage in the sp cells isolated from 1 cell type (sgc-7901), but not mp cells, through increased bax and decreased bcl-2 and bcl-xl protein expression. |
2014-06-26 |
2023-08-12 |
Not clear |
| Pu Xia, Wen-Feng Gou, Shuang Zhao, Hua-Chuan Zhen. Crizotinib may be used in Lewis lung carcinoma: a novel use for crizotinib. Oncology reports. vol 30. issue 1. 2014-01-17. PMID:23615728. |
our results indicate that crizotinib can induce apoptosis and g1 phase arrest in llc mp cells. |
2014-01-17 |
2023-08-12 |
Not clear |
| Friedrich Felix Hoyer, Meike Kristin Giesen, Carolina Nunes França, Dieter Lütjohann, Georg Nickenig, Nikos Werne. Monocytic microparticles promote atherogenesis by modulating inflammatory cells in mice. Journal of cellular and molecular medicine. vol 16. issue 11. 2014-01-06. PMID:22697268. |
microparticles (mp) are generated during a vast number of biological processes such as inflammation, cell activation and apoptosis. |
2014-01-06 |
2023-08-12 |
mouse |
| Yu hong Jing, Yi ping Hou, Yan feng Song, Jie Yi. Methylprednisolone improves the survival of new neurons following transient cerebral ischemia in rats. Acta neurobiologiae experimentalis. vol 72. issue 3. 2013-11-19. PMID:23093011. |
mp was found to decrease apoptosis and tnf-alpha and il-6 expression at 3 days after mcao in the ipsilateral striatum. |
2013-11-19 |
2023-08-12 |
rat |