| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marianna Kulka, Dean D Metcalf. High-resolution tracking of cell division demonstrates differential effects of TH1 and TH2 cytokines on SCF-dependent human mast cell production in vitro: correlation with apoptosis and Kit expression. Blood. vol 105. issue 2. 2005-02-15. PMID:15367434. |
high-resolution tracking of cell division demonstrates differential effects of th1 and th2 cytokines on scf-dependent human mast cell production in vitro: correlation with apoptosis and kit expression. |
2005-02-15 |
2023-08-12 |
human |
| Marianna Kulka, Dean D Metcalf. High-resolution tracking of cell division demonstrates differential effects of TH1 and TH2 cytokines on SCF-dependent human mast cell production in vitro: correlation with apoptosis and Kit expression. Blood. vol 105. issue 2. 2005-02-15. PMID:15367434. |
to determine the effect of these cytokines on stem cell factor (scf)-dependent human mast cell production, we used high-resolution tracking of cell division and correlated the results with cell apoptosis, expression of kit, and mast cell degranulation. |
2005-02-15 |
2023-08-12 |
human |
| Jia Fei, Huan Zhan. [Effect and mechanism of VEGF antisense phosphorothioate deoxynucleotides on HL-60 leukemic cells]. Zhongguo shi yan xue ye xue za zhi. vol 12. issue 5. 2005-01-26. PMID:15498126. |
after culture for 72 hours, inhibitive rate of cell growth was detected with mtt methods, viable cells were counted with trypan blue exclusion each 24 hour, cell configuration and apoptosis were observed with geimsa staining and flow cytometry respectively, level of vegf protein was detected with vegf elisa kit. |
2005-01-26 |
2023-08-12 |
Not clear |
| S Wong, J McLaughlin, D Cheng, C Zhang, K M Shokat, O N Witt. Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 50. 2005-01-14. PMID:15505216. |
in the cellular context of mature myeloid cells and pro/pre b cells that do not express kit, monospecific bcr-abl inhibition was quantitatively as effective as imatinib mesylate in suppressing cell growth and inducing apoptosis. |
2005-01-14 |
2023-08-12 |
Not clear |
| Zs Pirger, K Elekes, T Kis. Functional morphology of the salivary gland of the snail, Helix pomatia: a histochemical and immunocytochemical study. Acta biologica Hungarica. vol 55. issue 1-4. 2005-01-13. PMID:15270238. |
using an apoptosis kit, we could also establish that this process was due to rather an apoptotic than a necrotic mechanism. |
2005-01-13 |
2023-08-12 |
mouse |
| G Sakuntala Warshamana-Greene, Julie Litz, Elisabeth Buchdunger, Francesco Hofmann, Carlos García-Echeverría, Geoffrey W Krysta. The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Molecular cancer therapeutics. vol 3. issue 5. 2005-01-11. PMID:15141010. |
previous data suggested that igf-i protects cells from apoptosis induced by sti571, an efficient inhibitor of kit signal transduction, by activating the critical phosphatidylinositol 3-kinase-akt pathway. |
2005-01-11 |
2023-08-12 |
Not clear |
| Amie S Corbin, Ian J Griswold, Paul La Rosée, Kevin W H Yee, Michael C Heinrich, Corinne L Reimer, Brian J Druker, Michael W N Deininge. Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970. Blood. vol 104. issue 12. 2004-12-30. PMID:15304388. |
mln518 additionally targets active site mutant cell lines, inhibiting cell proliferation, kit, and signal transducer and activator of transcription-3 (stat3) phosphorylation and inducing apoptosis at concentrations that may be clinically achievable. |
2004-12-30 |
2023-08-12 |
Not clear |
| Wings T Y Loo, Mary N B Cheung, Louis W C Cho. The inhibitory effect of a herbal formula comprising ginseng and carthamus tinctorius on breast cancer. Life sciences. vol 76. issue 2. 2004-12-16. PMID:15519364. |
the apoptotic effect was studied by flow cytometry analysis of dna strand breaks and apoptag peroxidase in situ apoptosis kit by the tunel assay. |
2004-12-16 |
2023-08-12 |
human |
| Min Zhang, Fang Liu, Wei He, Yong You, Ping Zou, Ling-Bo Li. Inhibition of Fas-mediated apoptosis in Yac-1 cell via Anti-Fas ribozyme. Acta biochimica et biophysica Sinica. vol 36. issue 3. 2004-10-19. PMID:15202504. |
after treated with anti-fas antibody (jo2), yac-1 cell viability was measured with mtt assay, caspase-3 proteolytic activity was detected, and cell apoptosis was measured according to annexin v apoptosis detecting kit. |
2004-10-19 |
2023-08-12 |
mouse |
| Martin Sattler, Ravi Salgi. Targeting c-Kit mutations: basic science to novel therapies. Leukemia research. vol 28 Suppl 1. 2004-07-22. PMID:15036937. |
sporadic mutations of kit as well as autocrine/paracrine activation mechanisms of the scf/kit pathway have been implicated in a variety of malignancies, where its primary contribution to metastases is in enhancing tumor growth and reducing apoptosis. |
2004-07-22 |
2023-08-12 |
Not clear |
| Kwang Sik Suh, Yeon Ho Nam, Young Min Ahn, Nam Jae Kim, Cheol Young Park, Gwanpyo Koh, Seungjoon Oh, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Ki. Effect of Scutellariae radix extract on the high glucose-induced apoptosis in cultured vascular endothelial cells. Biological & pharmaceutical bulletin. vol 26. issue 11. 2004-06-28. PMID:14600417. |
determination of endothelial cell apoptosis was performed using dna gel electrophoresis, terminal deoxynuclotidyl transferase-mediated dutp nick end-labeling (tunel) assay, and an elisa kit. |
2004-06-28 |
2023-08-12 |
Not clear |
| Jin-Song Jia, Shi-Rong Xu, Cong-Rong Jia, Jie Ma, Sen Ha, Yin-Rong Yao, Yi Wang, Cui-Ying Sh. [Proliferation regulation effect of cyclin G1 antisense oligodeoxy-nucleotides with liposomal transfection on HL-60 cell]. Zhongguo shi yan xue ye xue za zhi. vol 12. issue 1. 2004-06-15. PMID:14989768. |
the cell apoptosis was detected by electron microscopy, in situ cell apoptosis detection kit (pod), dna gel electrophoresis and flow cytometry (fcm). |
2004-06-15 |
2023-08-12 |
Not clear |
| Osamu Suzuki, Yoshihiro Nozawa, Masafumi Ab. Sialic acids linked to glycoconjugates of Fas regulate the caspase-9-dependent and mitochondria-mediated pathway of Fas-induced apoptosis in Jurkat T cell lymphoma. International journal of oncology. vol 23. issue 3. 2004-05-04. PMID:12888916. |
mitochondrial membrane potentials (deltapsim) measured with a mitocapture assay kit demonstrated that the loss of deltapsim involved in fas-induced apoptosis was enhanced by pre-treatment with neuraminidase. |
2004-05-04 |
2023-08-12 |
human |
| Anette Duensing, Michael C Heinrich, Christopher D Fletcher, Jonathan A Fletche. Biology of gastrointestinal stromal tumors: KIT mutations and beyond. Cancer investigation. vol 22. issue 1. 2004-04-21. PMID:15069768. |
oncogenic kit activation leads to phosphorylation of various substrate proteins and, in turn, to activation of signal transduction cascades regulating cell proliferation, apoptosis, chemotaxis, and adhesion. |
2004-04-21 |
2023-08-12 |
Not clear |
| Tong-Chun Wen, Marta Rogido, Tom Genetta, Augusto Sol. Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brain. Neuroscience letters. vol 355. issue 3. 2004-03-17. PMID:14732457. |
additionally, double staining with a red in situ apoptosis detection kit and the epor antibody indicated that epor-positive cells were in apoptotic cell death in the ischemic area. |
2004-03-17 |
2023-08-12 |
rat |
| S Sakata, K Sakamaki, K Watanabe, N Nakamura, S Toyokuni, Y Nishimune, C Mori, S Yonehar. Involvement of death receptor Fas in germ cell degeneration in gonads of Kit-deficient Wv/Wv mutant mice. Cell death and differentiation. vol 10. issue 6. 2004-02-19. PMID:12761576. |
all the results clearly indicate that fas-mediated apoptosis is involved in germ cell degeneration accompanied by defects in kit-mediated signals, and kit signaling negatively regulates fas-mediated apoptosis in vivo. |
2004-02-19 |
2023-08-12 |
mouse |
| J R Farley, B Stilt-Coffin. Apoptosis may determine the release of skeletal alkaline phosphatase activity from human osteoblast-line cells. Calcified tissue international. vol 68. issue 1. 2004-01-29. PMID:12037623. |
apoptosis was determined by the presence of nucleosomes (histone-associated dna) in the cytoplasm of the cells by using a commercial kit. |
2004-01-29 |
2023-08-12 |
human |
| Elspeth J Gold, Richard J B Francis, Arthur Zimmermann, Sally L Mellor, Mark Cranfield, Gail P Risbridger, Nigel P Groome, Antony M Wheatley, Jean S Flemin. Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis. Molecular and cellular endocrinology. vol 201. issue 1-2. 2004-01-29. PMID:12706302. |
apoptosis was assessed histologically and with an in situ cell death detection kit (tunel). |
2004-01-29 |
2023-08-12 |
rat |
| Floris A de Jong, Jaap Verwei. Role of imatinib mesylate (Gleevec/Glivec) in gastrointestinal stromal tumors. Expert review of anticancer therapy. vol 3. issue 6. 2004-01-21. PMID:14686698. |
inhibiting the downstream signaling of kit switches the cell balance into apoptosis. |
2004-01-21 |
2023-08-12 |
Not clear |
| E M Connolly, E Gaffney, J V Reynold. Gastrointestinal stromal tumours. The British journal of surgery. vol 90. issue 10. 2003-11-17. PMID:14515284. |
mutations of kit are common in malignant gists and lead to constitutional activation of tyrosine kinase function, which causes cellular proliferation and resistance to apoptosis. |
2003-11-17 |
2023-08-12 |
Not clear |