| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung-Chul Li. Fas-related apoptosis in gastric adenocarcinoma. Oncology reports. vol 10. issue 1. 2003-06-06. PMID:12469145. |
immunohistochemical staining for fas, fasl and cd45, tacs trade mark in situ apoptosis detection kit, and double staining with the observation under a confocal scanning laser microscope were employed. |
2003-06-06 |
2023-08-12 |
human |
| Christopher P Shelburne, Roland P Piekorz, L Andrew Bouton, Hey Jin Chong, John J Rya. Mast cell-restricted p70 Stat6 isoform is a product of selective proteolysis. Cytokine. vol 19. issue 5. 2003-05-09. PMID:12393168. |
we defined a role for il-4 in mast cell homeostasis through inhibiting expression of kit and f(c)epsilonri, and by inducing mast cell apoptosis. |
2003-05-09 |
2023-08-12 |
Not clear |
| Fabrice Guerif, Veronique Cadoret, Valerie Rahal-Perola, Jacques Lansac, Florence Bernex, Jean Jacques Panthier, Marie Thérèse Hochereau-de Reviers, Dominique Royer. Apoptosis, onset and maintenance of spermatogenesis: evidence for the involvement of Kit in Kit-haplodeficient mice. Biology of reproduction. vol 67. issue 1. 2003-01-17. PMID:12080001. |
apoptosis, onset and maintenance of spermatogenesis: evidence for the involvement of kit in kit-haplodeficient mice. |
2003-01-17 |
2023-08-12 |
mouse |
| E Sasso-Cerri, S M Miragli. In situ demonstration of both TUNEL-labeled germ cell and Sertoli cell in the cimetidine-treated rats. Histology and histopathology. vol 17. issue 2. 2002-10-22. PMID:11962745. |
for detection of dna breaks (apoptosis) in the cells of the seminiferous epithelium, the testicular sections were treated by the tunel method (apop-tag plus peroxidase kit). |
2002-10-22 |
2023-08-12 |
rat |
| Reuben Kapur, Saurabh Chandra, Ryan Cooper, Jennifer McCarthy, David A William. Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor. Blood. vol 100. issue 4. 2002-09-12. PMID:12149209. |
activation of kit by mr-scf was associated with a significantly lower incidence of apoptosis and cell death in erythroid cells compared to either other isoform. |
2002-09-12 |
2023-08-12 |
Not clear |
| Stéphane Maddens, Alexandra Charruyer, Isabelle Plo, Patrice Dubreuil, Stuart Berger, Bernard Salles, Guy Laurent, Jean-Pierre Jaffrézo. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect. Blood. vol 100. issue 4. 2002-09-12. PMID:12149210. |
based on the role of the sphingomyelin (sm) cycle apoptotic pathway in ir-induced apoptosis, we hypothesized that one of the kit signaling components might inhibit ir-induced ceramide production or ceramide-induced apoptosis. |
2002-09-12 |
2023-08-12 |
human |
| Michael C Heinrich, Brian P Rubin, B Jack Longley, Jonathan A Fletche. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Human pathology. vol 33. issue 5. 2002-07-24. PMID:12094373. |
oncogenic mutations enable the kit receptor to phosphorylate various substrate proteins, leading to activation of signal transduction cascades which regulate cell proliferation, apoptosis, chemotaxis, and adhesion. |
2002-07-24 |
2023-08-12 |
Not clear |
| T Ito, S Fujieda, H Tsuzuki, H Sunaga, M Fukuda, H Sait. Appearance of bax protein after preoperative chemoradiotherapy is a prognostic factor in maxillary cancer. Acta oto-laryngologica. vol 121. issue 8. 2002-07-17. PMID:11813905. |
furthermore, apoptotic cells were visualized using an in situ apoptosis detection kit and the apoptosis index (ai) was defined as the number of positive cancer cells per 1,000 cancer cells. |
2002-07-17 |
2023-08-12 |
Not clear |
| Sang Kook Lee, Yoen Hoi Heo, Vernon E Steele, John M Pezzut. Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells. Anticancer research. vol 22. issue 1A. 2002-06-25. PMID:12017340. |
enrichment of mono- and oligonucleosomes in the cytoplasm was monitored as an indication of apoptosis using an elisa kit. |
2002-06-25 |
2023-08-12 |
mouse |
| Yongsheng Ma, Shan Zeng, Dean D Metcalfe, Cem Akin, Sasa Dimitrijevic, Joseph H Butterfield, Gerald McMahon, B Jack Longle. The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood. vol 99. issue 5. 2002-05-16. PMID:11861291. |
using 2 subclones of the hmc1 mast cell line, which both express kit with an identical rt mutation but which differ in that one also expresses the asp816val est mutation, both compounds inhibited the rt mutant kit, thereby suppressing proliferation and producing apoptosis in the rt mutant-only cell line. |
2002-05-16 |
2023-08-12 |
human |
| Yongsheng Ma, Shan Zeng, Dean D Metcalfe, Cem Akin, Sasa Dimitrijevic, Joseph H Butterfield, Gerald McMahon, B Jack Longle. The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood. vol 99. issue 5. 2002-05-16. PMID:11861291. |
neither compound suppressed activation of asp816val est mutant kit, and neither produced apoptosis or significantly suppressed proliferation of the cell line expressing the asp816val mutation. |
2002-05-16 |
2023-08-12 |
human |
| K Liu, J Husler, J Ye, S S Leonard, D Cutler, F Chen, S Wang, Z Zhang, M Ding, L Wang, X Sh. On the mechanism of Cr (VI)-induced carcinogenesis: dose dependence of uptake and cellular responses. Molecular and cellular biochemistry. vol 222. issue 1-2. 2002-02-27. PMID:11678606. |
the activation of transcription factors was assessed by electrophoretic mobility shift assay and western blot analysis, dna damage by single cell gel electrophoresis assay, cell apoptosis by dna fragmentation assay, and cell proliferation by a non-radioactive elisa kit. |
2002-02-27 |
2023-08-12 |
human |
| G D Demetr. Targeting c-kit mutations in solid tumors: scientific rationale and novel therapeutic options. Seminars in oncology. vol 28. issue 5 Suppl 17. 2002-01-10. PMID:11740803. |
preclinical experiments showed rapid inhibition of ligand-independent kit phosphorylation, decreased cellular proliferation, and induction of apoptosis after exposure of gist cells to imatinib mesylate in vitro. |
2002-01-10 |
2023-08-12 |
Not clear |
| A L Mikkelsen, E Høst, S Lindenber. Incidence of apoptosis in granulosa cells from immature human follicles. Reproduction (Cambridge, England). vol 122. issue 3. 2001-12-10. PMID:11597313. |
an apoptag detection kit was used to stain the granulosa cells and to detect apoptosis. |
2001-12-10 |
2023-08-12 |
human |
| I Plo, D Lautier, N Casteran, P Dubreuil, M Arock, G Lauren. Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma. Oncogene. vol 20. issue 46. 2001-12-07. PMID:11709710. |
kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase cgamma. |
2001-12-07 |
2023-08-12 |
Not clear |
| I Plo, D Lautier, N Casteran, P Dubreuil, M Arock, G Lauren. Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma. Oncogene. vol 20. issue 46. 2001-12-07. PMID:11709710. |
previous studies have demonstrated that activation of kit by stem cell factor (scf), its natural ligand, or by gain-of-function point mutation in its intracellular domain, confers significant protection against apoptosis induced by growth factor deprivation or radiation. |
2001-12-07 |
2023-08-12 |
Not clear |
| I Plo, D Lautier, N Casteran, P Dubreuil, M Arock, G Lauren. Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma. Oncogene. vol 20. issue 46. 2001-12-07. PMID:11709710. |
this study shows that daunorubicin-induced apoptosis and cytotoxicity were reduced in the murine ba/f3 cells transfected with kit (ba/f3-kit) in the presence of scf and in ba/f3 cells transfected with a constitutively active kit variant (ba/f3-kitdelta27), compared to either parental ba/f3 (ba/f3-wt) or unstimulated ba/f3-kit cells. |
2001-12-07 |
2023-08-12 |
Not clear |
| R J Herbert, B Vilhar, C Evett, C B Orchard, H J Rogers, M S Davies, D Franci. Ethylene induces cell death at particular phases of the cell cycle in the tobacco TBY-2 cell line. Journal of experimental botany. vol 52. issue 361. 2001-10-04. PMID:11479326. |
using apoptag, an in situ apoptosis detection kit, nuclear dna fragmentation was observed in the tby-2 cells which were often isolated on the end of a filament of normal cells. |
2001-10-04 |
2023-08-12 |
Not clear |
| T Matysiak-Budnik, A Thomas-Collignon, F Mégraud, M Heyma. Alterations of epithelial permeability by Helicobacter and IL-1beta in vitro: protective effect of rebamipide. Digestive diseases and sciences. vol 46. issue 7. 2001-08-09. PMID:11478510. |
after incubation, the monolayers were submitted to evaluation of apoptosis by using the apoptotic cell death detection elisa kit and to assessment of epithelial permeability in ussing chamber where the ionic conductance (g), fluxes of mannitol (j(man)) and of horseradish peroxidase in both intact (j(hrpi))- and degraded (j(d)) form, were measured. |
2001-08-09 |
2023-08-12 |
Not clear |
| C P Shelburne, J J Rya. The role of Th2 cytokines in mast cell homeostasis. Immunological reviews. vol 179. 2001-07-19. PMID:11292031. |
our laboratory has characterized an in vitro model of mast cell homeostasis, by which long-term exposure of murine bone-marrow-derived mast cells to the th2-derived cytokines il-3, il-4, and il-10, will induce downregulation of critical mast cell effector proteins such as kit and fcepsilon-ri, followed by mast cell apoptosis. |
2001-07-19 |
2023-08-12 |
Not clear |