| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G D Demetr. Targeting c-kit mutations in solid tumors: scientific rationale and novel therapeutic options. Seminars in oncology. vol 28. issue 5 Suppl 17. 2002-01-10. PMID:11740803. |
preclinical experiments showed rapid inhibition of ligand-independent kit phosphorylation, decreased cellular proliferation, and induction of apoptosis after exposure of gist cells to imatinib mesylate in vitro. |
2002-01-10 |
2023-08-12 |
Not clear |
| A L Mikkelsen, E Høst, S Lindenber. Incidence of apoptosis in granulosa cells from immature human follicles. Reproduction (Cambridge, England). vol 122. issue 3. 2001-12-10. PMID:11597313. |
an apoptag detection kit was used to stain the granulosa cells and to detect apoptosis. |
2001-12-10 |
2023-08-12 |
human |
| I Plo, D Lautier, N Casteran, P Dubreuil, M Arock, G Lauren. Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma. Oncogene. vol 20. issue 46. 2001-12-07. PMID:11709710. |
kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase cgamma. |
2001-12-07 |
2023-08-12 |
Not clear |
| I Plo, D Lautier, N Casteran, P Dubreuil, M Arock, G Lauren. Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma. Oncogene. vol 20. issue 46. 2001-12-07. PMID:11709710. |
previous studies have demonstrated that activation of kit by stem cell factor (scf), its natural ligand, or by gain-of-function point mutation in its intracellular domain, confers significant protection against apoptosis induced by growth factor deprivation or radiation. |
2001-12-07 |
2023-08-12 |
Not clear |
| I Plo, D Lautier, N Casteran, P Dubreuil, M Arock, G Lauren. Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma. Oncogene. vol 20. issue 46. 2001-12-07. PMID:11709710. |
this study shows that daunorubicin-induced apoptosis and cytotoxicity were reduced in the murine ba/f3 cells transfected with kit (ba/f3-kit) in the presence of scf and in ba/f3 cells transfected with a constitutively active kit variant (ba/f3-kitdelta27), compared to either parental ba/f3 (ba/f3-wt) or unstimulated ba/f3-kit cells. |
2001-12-07 |
2023-08-12 |
Not clear |
| R J Herbert, B Vilhar, C Evett, C B Orchard, H J Rogers, M S Davies, D Franci. Ethylene induces cell death at particular phases of the cell cycle in the tobacco TBY-2 cell line. Journal of experimental botany. vol 52. issue 361. 2001-10-04. PMID:11479326. |
using apoptag, an in situ apoptosis detection kit, nuclear dna fragmentation was observed in the tby-2 cells which were often isolated on the end of a filament of normal cells. |
2001-10-04 |
2023-08-12 |
Not clear |
| T Matysiak-Budnik, A Thomas-Collignon, F Mégraud, M Heyma. Alterations of epithelial permeability by Helicobacter and IL-1beta in vitro: protective effect of rebamipide. Digestive diseases and sciences. vol 46. issue 7. 2001-08-09. PMID:11478510. |
after incubation, the monolayers were submitted to evaluation of apoptosis by using the apoptotic cell death detection elisa kit and to assessment of epithelial permeability in ussing chamber where the ionic conductance (g), fluxes of mannitol (j(man)) and of horseradish peroxidase in both intact (j(hrpi))- and degraded (j(d)) form, were measured. |
2001-08-09 |
2023-08-12 |
Not clear |
| C P Shelburne, J J Rya. The role of Th2 cytokines in mast cell homeostasis. Immunological reviews. vol 179. 2001-07-19. PMID:11292031. |
our laboratory has characterized an in vitro model of mast cell homeostasis, by which long-term exposure of murine bone-marrow-derived mast cells to the th2-derived cytokines il-3, il-4, and il-10, will induce downregulation of critical mast cell effector proteins such as kit and fcepsilon-ri, followed by mast cell apoptosis. |
2001-07-19 |
2023-08-12 |
Not clear |
| K Gałazka, J Stachur. Factors associated with progression of primary gastric marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT type). Polish journal of pathology : official journal of the Polish Society of Pathologists. vol 51. issue 3. 2001-04-19. PMID:11247394. |
the mib-1 antibody was used for the ki-67 proliferative antigen epitope, as well as the apoptag in situ apoptosis detection kit (oncor). |
2001-04-19 |
2023-08-12 |
Not clear |
| K Itoh, K Suzuki, K Bise, H Itoh, P Mehraein, S Wei. Apoptosis in the basal ganglia of the developing human nervous system. Acta neuropathologica. vol 101. issue 2. 2001-04-12. PMID:11271378. |
to examine how apoptosis occurs in the developing human brain, we performed a morphometric tunel study, using a commercially available kit (apoptag kit, oncor inc.). |
2001-04-12 |
2023-08-12 |
human |
| Y Yoshida, T Kurokawa, N Fukuno, Y Nishikawa, N Kamitani, F Kotsuj. Markers of apoptosis and angiogenesis indicate that carcinomatous components play an important role in the malignant behavior of uterine carcinosarcoma. Human pathology. vol 31. issue 12. 2001-01-25. PMID:11150369. |
dna nick was labeled immunostained by using an apop tag in situ apoptosis detection kit for exploring apoptosis. |
2001-01-25 |
2023-08-12 |
Not clear |
| J Domen, I L Weissma. Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other. The Journal of experimental medicine. vol 192. issue 12. 2001-01-18. PMID:11120768. |
these studies show that two separate signals are necessary to prevent apoptosis in hscs, and that kit ligand by itself provides a strong proliferative stimulus to hscs. |
2001-01-18 |
2023-08-12 |
mouse |
| K Reynaud, M A Driancour. Oocyte attrition. Molecular and cellular endocrinology. vol 163. issue 1-2. 2000-11-28. PMID:10963881. |
the control of oocyte apoptosis is not fully understood, although survival factors (lif, kit ligand and fgf), as well as death inducing factors (fas ligand, tgfbeta), have been identified. |
2000-11-28 |
2023-08-12 |
Not clear |
| I Flores, D R Jones, I Mérid. Changes in the balance between mitogenic and antimitogenic lipid second messengers during proliferation, cell arrest, and apoptosis in T-lymphocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 13. 2000-11-08. PMID:11023971. |
we have examined the relationship between diacylglycerol and ceramide and the levels of the lipids phosphatidylcholine and sphingomyelin, their potential precursors, in the human t-cell line kit 225 cultured in three distinct conditions to favor apoptosis, cell arrest, and proliferation. |
2000-11-08 |
2023-08-12 |
human |
| J Kumi-Diaka, A Butle. Caspase-3 protease activation during the process of genistein-induced apoptosis in TM4 testicular cells. Biology of the cell. vol 92. issue 2. 2000-10-19. PMID:10879632. |
caspase-3 enzymatic activity was determined using caspase apoptosis assay kit. |
2000-10-19 |
2023-08-12 |
Not clear |
| M A Driancourt, K Reynaud, R Cortvrindt, J Smit. Roles of KIT and KIT LIGAND in ovarian function. Reviews of reproduction. vol 5. issue 3. 2000-10-19. PMID:11006164. |
during early folliculogenesis, kit together with kit ligand controls oocyte growth and theca cell differentiation, and protects preantral follicles from apoptosis. |
2000-10-19 |
2023-08-12 |
mouse |
| S Takano, K Tsuboi, A Matsumura, Y Tomono, Y Mitsui, T Nos. Expression of the angiogenic factor thymidine phosphorylase in human astrocytic tumors. Journal of cancer research and clinical oncology. vol 126. issue 3. 2000-04-11. PMID:10741908. |
they were also evaluated for the degree of apoptosis by a apoptag kit. |
2000-04-11 |
2023-08-12 |
human |
| Y Ma, E Carter, X Wang, C Shu, G McMahon, B J Longle. Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. The Journal of investigative dermatology. vol 114. issue 2. 2000-03-15. PMID:10652004. |
kit stimulates mast cell proliferation and prevents apoptosis of neoplastic mast cells. |
2000-03-15 |
2023-08-12 |
Not clear |
| T Tenjo, M Toyoda, J Okuda, I Watanabe, T Yamamoto, K Tanaka, M Ohtani, T Nohara, H Kawasaki, N Tanigaw. Prognostic significance of p27(kip1) protein expression and spontaneous apoptosis in patients with colorectal adenocarcinomas. Oncology. vol 58. issue 1. 2000-03-01. PMID:10644940. |
tumor cell apoptosis, proliferation and p27 expression using an in situ apoptosis detection kit, anti-ki67 antibody and anti-p27 antibody were investigated in 171 colorectal adenocarcinoma specimens, together with the assessment of mutated p53 expression. |
2000-03-01 |
2023-08-12 |
Not clear |
| M L Lamoreu. Strain-specific white-spotting patterns in laboratory mice. Pigment cell research. vol 12. issue 6. 2000-01-27. PMID:10614578. |
at least in the case of the w (kit) locus, white spotting has been attributed to apoptosis. |
2000-01-27 |
2023-08-12 |
mouse |