| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cuijuan Qian, Jun Yao, Jiji Wang, Lan Wang, Meng Xue, Tianhua Zhou, Weili Liu, Jianmin S. ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells. Molecular and cellular biochemistry. vol 387. issue 1-2. 2014-09-26. PMID:24178240. |
specific down-regulation of jak2 suppressed cell proliferation and colony-forming units, induced g2/m arrest in sgc7901 cells, but had no significant effect on cell apoptosis in vitro or tumor growth inhibition in vivo. |
2014-09-26 |
2023-08-12 |
mouse |
| Cuijuan Qian, Jun Yao, Jiji Wang, Lan Wang, Meng Xue, Tianhua Zhou, Weili Liu, Jianmin S. ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells. Molecular and cellular biochemistry. vol 387. issue 1-2. 2014-09-26. PMID:24178240. |
interestingly, jak2 silencing-induced activation of erk1/2, and inactivation of erk1/2 using the specific erk inhibitor pd98059 markedly enhanced jak2 shrna-induced cell proliferation inhibition, cell cycle arrest and apoptosis. |
2014-09-26 |
2023-08-12 |
mouse |
| Cuijuan Qian, Jun Yao, Jiji Wang, Lan Wang, Meng Xue, Tianhua Zhou, Weili Liu, Jianmin S. ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells. Molecular and cellular biochemistry. vol 387. issue 1-2. 2014-09-26. PMID:24178240. |
our results implicate jak2 silencing-induced cell proliferation inhibition, cell cycle arrest, and erk1/2 inhibition could enhance apoptosis induced by jak2 silencing in sgc7901 cells. |
2014-09-26 |
2023-08-12 |
mouse |
| Yun-Yi Liu, Qian Zheng, Bin Fang, Wei Wang, Feng-Yun Ma, Sadia Roshan, Amal Banafa, Ming-Jie Chen, Jun-Li Chang, Xiao-Min Deng, Ke-Xiu Li, Guang-Xiao Yang, Guang-Yuan H. Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 33. issue 3. 2014-09-11. PMID:23771657. |
suppression of jak2/stat3 signalling pathway by ag490, an inhibitor of jak2, resulted in apoptosis and an increase in ros in response to germacrone exposure. |
2014-09-11 |
2023-08-12 |
human |
| Cuijuan Qian, Jiji Wang, Jun Yao, Lan Wang, Meng Xue, Weili Liu, Jianmin S. Involvement of nuclear JAK2 signaling in AG490-induced apoptosis of gastric cancer cells. Anatomical record (Hoboken, N.J. : 2007). vol 296. issue 12. 2014-07-23. PMID:24151255. |
involvement of nuclear jak2 signaling in ag490-induced apoptosis of gastric cancer cells. |
2014-07-23 |
2023-08-12 |
human |
| Cuijuan Qian, Jiji Wang, Jun Yao, Lan Wang, Meng Xue, Weili Liu, Jianmin S. Involvement of nuclear JAK2 signaling in AG490-induced apoptosis of gastric cancer cells. Anatomical record (Hoboken, N.J. : 2007). vol 296. issue 12. 2014-07-23. PMID:24151255. |
moreover, silencing of human homolog of drosophila hairy and enhancer of split (hes) 1 with sirna partly blocked ag490-induced nuclear translocation of jak2, and enhanced ag490-induced apoptosis in sgc7901 cells. |
2014-07-23 |
2023-08-12 |
human |
| H M Mehta, M Futami, T Glaubach, D W Lee, J R Andolina, Q Yang, Z Whichard, M Quinn, H F Lu, W M Kao, B Przychodzen, C A Sarkar, A Minella, J P Maciejewski, S J Core. Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition. Leukemia. vol 28. issue 5. 2014-07-10. PMID:24170028. |
alterations in the c-terminal domain of the gcsfr result in leukemic properties of enhanced growth, impaired differentiation and resistance to apoptosis, suggesting that they can behave as oncogenic drivers, sensitive to jak2 inhibition. |
2014-07-10 |
2023-08-12 |
Not clear |
| Q Liao, Z Zeng, X Guo, X Li, F Wei, W Zhang, X Li, P Chen, F Liang, B Xiang, J Ma, M Wu, H Tang, M Deng, X Zeng, K Tang, W Xiong, G L. LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation. Oncogene. vol 33. issue 16. 2014-06-23. PMID:23708661. |
induction of lplunc1 overexpression inhibited npc cell proliferation, induced npc cell arrest, promoted npc cell apoptosis even after il-6 stimulation and inhibited the growth of implanted npc tumors in vivo, which were associated with decreasing cyclin d1 and bcl-2 expression and the janus kinase 2 (jak2)/stat3 activation, but enhancing bax and p21 expression. |
2014-06-23 |
2023-08-12 |
Not clear |
| Braden C McFarland, G Kenneth Gray, Susan E Nozell, Suk W Hong, Etty N Benvenist. Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells. Molecular cancer research : MCR. vol 11. issue 5. 2014-05-02. PMID:23386688. |
in this study, we confirmed that jsi-124 inhibits both constitutive and stimulus-induced janus kinase 2 (jak2) and stat3 phosphorylation, and decreases cell proliferation while inducing apoptosis in cultured gbm cells. |
2014-05-02 |
2023-08-12 |
human |
| Cui-Juan Qian, Jun Yao, Jian-Min S. Nuclear JAK2: form and function in cancer. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 9. 2014-03-11. PMID:21809458. |
nuclear jak2 is linked to a variety of cellular functions, such as cell cycle progression, apoptosis and genetic instability. |
2014-03-11 |
2023-08-12 |
Not clear |
| Salma Hasan, Catherine Lacout, Caroline Marty, Marie Cuingnet, Eric Solary, William Vainchenker, Jean-Luc Villeva. JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα. Blood. vol 122. issue 8. 2013-11-05. PMID:23863895. |
this study shows that jak2(v617f) in mice amplifies not only late but also early hematopoietic cells, giving them a proliferative advantage through high cell cycling and low apoptosis that may sustain mpn emergence but is lost upon ifnα treatment. |
2013-11-05 |
2023-08-12 |
mouse |
| Ariel Amaru Calzada, Olga Pedrini, Guido Finazzi, Flavio Leoni, Paolo Mascagni, Martino Introna, Alessandro Rambaldi, Josée Gola. Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients. Experimental hematology. vol 41. issue 3. 2013-05-20. PMID:23111067. |
givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from jak2(v617f) myeloproliferative neoplasm patients. |
2013-05-20 |
2023-08-12 |
Not clear |
| Megumi Funakoshi-Tago, Tatsuaki Nagata, Kenji Tago, Masaki Tsukada, Kazuyuki Tanaka, Shigeo Nakamura, Tadahiko Mashino, Tadashi Kasahar. Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway. Cellular signalling. vol 24. issue 11. 2013-01-09. PMID:22750290. |
here we found that a water-soluble pyrrolidinium fullerene derivative, c(60)-bis (n, n-dimethylpyrrolidinium iodide), markedly induced apoptosis of jak2 v617f mutant-induced transformed cells through a novel mechanism, inhibiting c-jun n-terminal kinase (jnk) activation pathway but not generation of reactive oxygen species (ros). |
2013-01-09 |
2023-08-12 |
mouse |
| Megumi Funakoshi-Tago, Tatsuaki Nagata, Kenji Tago, Masaki Tsukada, Kazuyuki Tanaka, Shigeo Nakamura, Tadahiko Mashino, Tadashi Kasahar. Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway. Cellular signalling. vol 24. issue 11. 2013-01-09. PMID:22750290. |
strikingly, the knockdown of ask1 enhanced the sensitivity to pyrrolidinium fullerene derivative-induced apoptosis, and the treatment with a jnk inhibitor, sp600125, also induced apoptosis of the transformed cells by jak2 v617f mutant. |
2013-01-09 |
2023-08-12 |
mouse |
| Christopher J Ott, Nadja Kopp, Liat Bird, Ronald M Paranal, Jun Qi, Teresa Bowman, Scott J Rodig, Andrew L Kung, James E Bradner, David M Weinstoc. BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. vol 120. issue 14. 2012-12-18. PMID:22904298. |
crlf2 heterodimerizes with the il7 receptor (il7r) and signals through jak2, jak1, and stat5 to drive proliferation and suppress apoptosis. |
2012-12-18 |
2023-08-12 |
mouse |
| Yan-Ling Ren, Hong-Yan Ton. [Effect of homoharringtonine combined with AG490 on JAK2-STAT5 associated signal pathway in HEL cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 5. 2012-12-06. PMID:22040954. |
the cell survival rates were tested by mtt, apoptosis was tested by flow cytometry after hel cells were treated by 20 ng/ml hht, 100 µmol/l ag490 and 20 ng/ml hht in combination with 100 µmol/l ag490, while the signal proteins such as p-jak2, p-stat5 and bcl-xl activated by abnormal activated jak2 were tested by western blot. |
2012-12-06 |
2023-08-12 |
Not clear |
| Yan-Ling Ren, Hong-Yan Ton. [Effect of homoharringtonine combined with AG490 on JAK2-STAT5 associated signal pathway in HEL cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 5. 2012-12-06. PMID:22040954. |
the results showed that both hht and ag490 could inhabit the hel cell proliferation after being treated for 24 hours, and annexin v-pi double staining confirmed early apoptosis while hht effect was more obvious, western blot showed that the expressions of p-jak2 and p-stat5 were down-regulated, while the total protein levels of jak2 and stat5 were stable. |
2012-12-06 |
2023-08-12 |
Not clear |
| Wan Du, Jie Hong, Ying-Chao Wang, Yan-Jie Zhang, Ping Wang, Wen-Yu Su, Yan-Wei Lin, Rong Lu, Wei-Ping Zou, Hua Xiong, Jing-Yuan Fan. Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. Journal of cellular and molecular medicine. vol 16. issue 8. 2012-12-03. PMID:22050790. |
to investigate the role of both jak2 and stat3 in the mechanism underlying crc apoptosis, we inhibited jak2 with ag490 and depleted stat3 with a small interfering rna. |
2012-12-03 |
2023-08-12 |
Not clear |
| Ariel Amaru Calzada, Katia Todoerti, Luca Donadoni, Anna Pellicioli, Giacomo Tuana, Raffaella Gatta, Antonino Neri, Guido Finazzi, Roberto Mantovani, Alessandro Rambaldi, Martino Introna, Luigia Lombardi, Josée Gola. The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2(V617F) myeloproliferative neoplasm cells. Experimental hematology. vol 40. issue 8. 2012-10-01. PMID:22579713. |
gvs inhibited colony formation and proliferation and induced apoptosis at doses two- to threefold lower in a panel of jak2(v617f) mpn compared to jak2 wild-type myeloid leukemia cell lines. |
2012-10-01 |
2023-08-12 |
Not clear |
| Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz, Eric Bachman, Alexander A Szewczak, Deborah Walker, Lin Xu, Melaney Bouthillette, Kaleen M Childers, Brian Dolinski, Andrew M Haidle, Johnny Kopinja, Linda Lee, Jongwon Lim, Kevin D Little, Yanhong Ma, Anjili Mathur, Jan-Rung Mo, Erin O'Hare, Ryan D Otte, Brandon M Taoka, Wenxian Wang, Hong Yin, Anna A Zabierek, Weisheng Zhang, Shuxia Zhao, Joe Zhu, Jonathan R Young, C Gary Marshal. Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera. PloS one. vol 7. issue 5. 2012-09-19. PMID:22623993. |
in cultured cells, mrlb-11055 blocked proliferation and induced apoptosis in a manner consistent with jak2 pathway inhibition. |
2012-09-19 |
2023-08-12 |
mouse |