| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ariel Amaru Calzada, Katia Todoerti, Luca Donadoni, Anna Pellicioli, Giacomo Tuana, Raffaella Gatta, Antonino Neri, Guido Finazzi, Roberto Mantovani, Alessandro Rambaldi, Martino Introna, Luigia Lombardi, Josée Gola. The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2(V617F) myeloproliferative neoplasm cells. Experimental hematology. vol 40. issue 8. 2012-10-01. PMID:22579713. |
gvs inhibited colony formation and proliferation and induced apoptosis at doses two- to threefold lower in a panel of jak2(v617f) mpn compared to jak2 wild-type myeloid leukemia cell lines. |
2012-10-01 |
2023-08-12 |
Not clear |
| Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz, Eric Bachman, Alexander A Szewczak, Deborah Walker, Lin Xu, Melaney Bouthillette, Kaleen M Childers, Brian Dolinski, Andrew M Haidle, Johnny Kopinja, Linda Lee, Jongwon Lim, Kevin D Little, Yanhong Ma, Anjili Mathur, Jan-Rung Mo, Erin O'Hare, Ryan D Otte, Brandon M Taoka, Wenxian Wang, Hong Yin, Anna A Zabierek, Weisheng Zhang, Shuxia Zhao, Joe Zhu, Jonathan R Young, C Gary Marshal. Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera. PloS one. vol 7. issue 5. 2012-09-19. PMID:22623993. |
in cultured cells, mrlb-11055 blocked proliferation and induced apoptosis in a manner consistent with jak2 pathway inhibition. |
2012-09-19 |
2023-08-12 |
mouse |
| Ping Liu, Xin Wang, Chunhong Hu, Tiehui H. Inhibition of proliferation and induction of apoptosis by trimethoxyl stilbene (TMS) in a lung cancer cell line. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 9. 2012-09-18. PMID:22296367. |
tms inhibited proliferation (ic50 8.6 μmol/l) and induced apoptosis of the cells in a concentration-dependent manner., also inducing apoptosis accompanied by up-regulated expression and cleavage activation of caspase-3, up-regulation of iκb and down-regulation of nfκb, stat3, stat5b, and jak2 signal transduction. |
2012-09-18 |
2023-08-12 |
Not clear |
| Álvaro Cuesta-Domínguez, Mara Ortega, Cristina Ormazábal, Matilde Santos-Roncero, Marta Galán-Díez, Juan Luis Steegmann, Ángela Figuera, Eva Arranz, José Luis Vizmanos, Juan A Bueren, Paula Río, Elena Fernández-Rui. Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384256. |
treatment with the jak2 inhibitor tg101209 abrogated bcr-jak2 and stat5 phosphorylation, decreased bcl-xl expression and triggered apoptosis of transformed ba/f3 cells. |
2012-08-27 |
2023-08-12 |
mouse |
| Bin Li, Guangsen Zhang, Cui Li, Dan He, Xinying Li, Chunfang Zhang, Faqing Tang, Xiyun Deng, Jingchen Lu, Youhong Tang, Ruijuan Li, Zhuchu Chen, Chaojun Dua. Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL. PloS one. vol 7. issue 4. 2012-08-03. PMID:22523564. |
in vitro inhibition of jak2 in eol-1, primary f/p(+) cel cells (pc) and t674i f/p imatinib resistant cells(ir) by either jak2-specific short interfering rna (sirna) or the tryphostin derivative ag490(ag490), significantly reduced cellular proliferation and induced cellular apoptosis. |
2012-08-03 |
2023-08-12 |
Not clear |
| Toshikage Nagao, Gaku Oshikawa, Nan Wu, Tetsuya Kurosu, Osamu Miur. DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087308. |
here we examine the effects of dna damage stress on jak2 or jak2-v617f and on induction of apoptosis in hematopoietic cells. |
2012-05-18 |
2023-08-12 |
Not clear |
| Toshikage Nagao, Gaku Oshikawa, Nan Wu, Tetsuya Kurosu, Osamu Miur. DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087308. |
studies with pharmacological inhibitors and genetic manipulations further showed that downregulation of the pi3k/akt pathway leading to the activation of gsk3β may be involved in downregulation of jak2 or jak2-v617f as well as in synergistic induction of bax activation and apoptosis. |
2012-05-18 |
2023-08-12 |
Not clear |
| Toshikage Nagao, Gaku Oshikawa, Nan Wu, Tetsuya Kurosu, Osamu Miur. DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087308. |
together, these data suggest that dna damage stress with simultaneous inhibition of the kinase activity causes degradation of jak2 or jak2-v617f by caspase cleavage and proteasomal degradation through gsk3β activation, which is closely involved in synergistic induction of apoptosis in hematopoietic cells. |
2012-05-18 |
2023-08-12 |
Not clear |
| Chao-Hung Chen, Tusty-Jiuan Hsieh, Kun-Der Lin, Hsing-Yi Lin, Mei-Yueh Lee, Wei-Wen Hung, Pi-Jung Hsiao, Shyi-Jang Shi. Increased unbound retinol-binding protein 4 concentration induces apoptosis through receptor-mediated signaling. The Journal of biological chemistry. vol 287. issue 13. 2012-05-16. PMID:22308028. |
we found that increase of apo-/holo-rbp4 concentration ratio delayed the displacement of rbp4 with "stimulated by retinoic acid 6" (stra6), enhanced janus kinase 2 (jak2)/stat5 cascade, up-regulated adenylate cyclase 6 (ac6), increased camp, enhanced jnk1/p38 cascade, suppressed crbp-i/rarα (cellular retinol-binding protein/retinoic acid receptor α) expression, and led to apoptosis in hk-2 and human umbilical vein endothelial cells. |
2012-05-16 |
2023-08-12 |
human |
| Chao-Hung Chen, Tusty-Jiuan Hsieh, Kun-Der Lin, Hsing-Yi Lin, Mei-Yueh Lee, Wei-Wen Hung, Pi-Jung Hsiao, Shyi-Jang Shi. Increased unbound retinol-binding protein 4 concentration induces apoptosis through receptor-mediated signaling. The Journal of biological chemistry. vol 287. issue 13. 2012-05-16. PMID:22308028. |
furthermore, stra6, jak2, stat5, jnk1, or p38 sirna and camp-pka inhibitor reversed the repression of crbp-i/rarα and apoptosis in apo-rbp4 stimulation. |
2012-05-16 |
2023-08-12 |
human |
| Oliver Hantschel, Wolfgang Warsch, Eva Eckelhart, Ines Kaupe, Florian Grebien, Kay-Uwe Wagner, Giulio Superti-Furga, Veronika Sex. BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nature chemical biology. vol 8. issue 3. 2012-05-15. PMID:22286129. |
nevertheless, several jak2 tkis induced apoptosis in bcr-abl(+) cells irrespective of the presence of jak2. |
2012-05-15 |
2023-08-12 |
Not clear |
| Braden C McFarland, Jing-Yuan Ma, Catherine P Langford, G Yancey Gillespie, Hao Yu, Ying Zheng, Susan E Nozell, Dennis Huszar, Etty N Benvenist. Therapeutic potential of AZD1480 for the treatment of human glioblastoma. Molecular cancer therapeutics. vol 10. issue 12. 2012-05-11. PMID:22027691. |
azd1480 treatment effectively blocks constitutive and stimulus-induced jak1, jak2, and stat-3 phosphorylation in both human and murine glioma cells, and leads to a decrease in cell proliferation and induction of apoptosis. |
2012-05-11 |
2023-08-12 |
mouse |
| Mamta Gupta, Jing Jing Han, Mary Stenson, Matthew Maurer, Linda Wellik, Guangzhen Hu, Steve Ziesmer, Ahmet Dogan, Thomas E Witzi. Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation. Blood. vol 119. issue 12. 2012-05-07. PMID:22323454. |
apoptosis induced by jak2 inhibition was dependent on inhibition of autocrine il-10 and c-myc expression and independent of bcl-2 family expression. |
2012-05-07 |
2023-08-12 |
Not clear |
| Jinbing Zhao, Guangzhao Li, Yang Zhang, Xingfen Su, Chunhua Han. The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats. Cytokine. vol 56. issue 2. 2012-01-30. PMID:21843949. |
as a result, we found that tbi could activate jak2 and stat3, and increase cell apoptosis in pericontusional cortex. |
2012-01-30 |
2023-08-12 |
human |
| Alfonso Quintás-Cardama, Taghi Manshouri, Zeev Estrov, David Harris, Ying Zhang, Amos Gaikwad, Hagop M Kantarjian, Srdan Verstovse. Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Investigational new drugs. vol 29. issue 5. 2012-01-24. PMID:20372971. |
atiprimod-induced cell growth inhibition of jak2 (v617f)-positive cells was coupled with induction of apoptosis, as evidenced by heightened mitochondrial membrane potential and caspase-3 activity, as well as parp cleavage, increased turnover of the anti-apoptotic x-linked mammalian inhibitor of apoptosis (xiap) protein, and inhibition of the pro-apoptotic protein bcl-2 in a time- and dose-dependent manner. |
2012-01-24 |
2023-08-12 |
mouse |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
in the current study, we found that in glioma cells u251, ad-bfgf-sirna impedes the activation of erk1/2 and jak2, but not src, decreases il-6 secretion, reduces stat3 phosphorylation, decreases the levels of downstream molecules cyclind1 and bcl-xl, and ultimately results in the collapse of mitochondrial membrane potentials as well as the induction of mitochondrial-related apoptosis. |
2012-01-17 |
2023-08-12 |
human |
| Yan Liu, Aiguo Liu, Huameng Li, Chenglong Li, Jiayuh Li. Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 8. 2012-01-05. PMID:21490132. |
our results showed that celecoxib decreased stat3 phosphorylation by reducing janus-activated kinase (jak2) phosphorylation and caused apoptosis in hcc cells. |
2012-01-05 |
2023-08-12 |
human |
| S Hart, K C Goh, V Novotny-Diermayr, C Y Hu, H Hentze, Y C Tan, B Madan, C Amalini, Y K Loh, L C Ong, A D William, A Lee, A Poulsen, R Jayaraman, K H Ong, K Ethirajulu, B W Dymock, J W Woo. SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies. Leukemia. vol 25. issue 11. 2011-12-22. PMID:21691275. |
as a consequence sb1518 has potent anti-proliferative effects on myeloid and lymphoid cell lines driven by mutant or wild-type jak2 or flt3, resulting from cell cycle arrest and induction of apoptosis. |
2011-12-22 |
2023-08-12 |
mouse |
| Ajoy K Samanta, Sandip N Chakraborty, Yan Wang, Ellen Schlette, E Premkumar Reddy, Ralph B Arlinghau. Destabilization of Bcr-Abl/Jak2 Network by a Jak2/Abl Kinase Inhibitor ON044580 Overcomes Drug Resistance in Blast Crisis Chronic Myelogenous Leukemia (CML). Genes & cancer. vol 1. issue 4. 2011-11-10. PMID:20798787. |
therefore, targeting jak2 and bcr-abl kinases is an effective way to destabilize bcr-abl and its network complex, which leads to the onset of apoptosis in im-sensitive and im-resistant bcr-abl+ cells. |
2011-11-10 |
2023-08-12 |
Not clear |
| Takayuki Ikezoe, Shinsuke Kojima, Mutsuo Furihata, Jing Yang, Chie Nishioka, Asako Takeuchi, Mayuka Isaka, H Phillip Koeffler, Akihito Yokoyam. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. International journal of cancer. vol 129. issue 10. 2011-11-04. PMID:21207414. |
moreover, we found that az960, a novel and specific inhibitor of the jak2 kinase, potently inhibited the clonogenic growth and induced apoptosis of freshly isolated aml cells from patients in association with cleavage of caspase 3 and downregulation of anti-apoptotic bcl-xl proteins. |
2011-11-04 |
2023-08-12 |
Not clear |