| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Liu, Xin Wang, Chunhong Hu, Tiehui H. Inhibition of proliferation and induction of apoptosis by trimethoxyl stilbene (TMS) in a lung cancer cell line. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 9. 2012-09-18. PMID:22296367. |
tms inhibited proliferation (ic50 8.6 μmol/l) and induced apoptosis of the cells in a concentration-dependent manner., also inducing apoptosis accompanied by up-regulated expression and cleavage activation of caspase-3, up-regulation of iκb and down-regulation of nfκb, stat3, stat5b, and jak2 signal transduction. |
2012-09-18 |
2023-08-12 |
Not clear |
| Álvaro Cuesta-Domínguez, Mara Ortega, Cristina Ormazábal, Matilde Santos-Roncero, Marta Galán-Díez, Juan Luis Steegmann, Ángela Figuera, Eva Arranz, José Luis Vizmanos, Juan A Bueren, Paula Río, Elena Fernández-Rui. Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384256. |
treatment with the jak2 inhibitor tg101209 abrogated bcr-jak2 and stat5 phosphorylation, decreased bcl-xl expression and triggered apoptosis of transformed ba/f3 cells. |
2012-08-27 |
2023-08-12 |
mouse |
| Bin Li, Guangsen Zhang, Cui Li, Dan He, Xinying Li, Chunfang Zhang, Faqing Tang, Xiyun Deng, Jingchen Lu, Youhong Tang, Ruijuan Li, Zhuchu Chen, Chaojun Dua. Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL. PloS one. vol 7. issue 4. 2012-08-03. PMID:22523564. |
in vitro inhibition of jak2 in eol-1, primary f/p(+) cel cells (pc) and t674i f/p imatinib resistant cells(ir) by either jak2-specific short interfering rna (sirna) or the tryphostin derivative ag490(ag490), significantly reduced cellular proliferation and induced cellular apoptosis. |
2012-08-03 |
2023-08-12 |
Not clear |
| Toshikage Nagao, Gaku Oshikawa, Nan Wu, Tetsuya Kurosu, Osamu Miur. DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087308. |
here we examine the effects of dna damage stress on jak2 or jak2-v617f and on induction of apoptosis in hematopoietic cells. |
2012-05-18 |
2023-08-12 |
Not clear |
| Toshikage Nagao, Gaku Oshikawa, Nan Wu, Tetsuya Kurosu, Osamu Miur. DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087308. |
studies with pharmacological inhibitors and genetic manipulations further showed that downregulation of the pi3k/akt pathway leading to the activation of gsk3β may be involved in downregulation of jak2 or jak2-v617f as well as in synergistic induction of bax activation and apoptosis. |
2012-05-18 |
2023-08-12 |
Not clear |
| Toshikage Nagao, Gaku Oshikawa, Nan Wu, Tetsuya Kurosu, Osamu Miur. DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β. PloS one. vol 6. issue 11. 2012-05-18. PMID:22087308. |
together, these data suggest that dna damage stress with simultaneous inhibition of the kinase activity causes degradation of jak2 or jak2-v617f by caspase cleavage and proteasomal degradation through gsk3β activation, which is closely involved in synergistic induction of apoptosis in hematopoietic cells. |
2012-05-18 |
2023-08-12 |
Not clear |
| Chao-Hung Chen, Tusty-Jiuan Hsieh, Kun-Der Lin, Hsing-Yi Lin, Mei-Yueh Lee, Wei-Wen Hung, Pi-Jung Hsiao, Shyi-Jang Shi. Increased unbound retinol-binding protein 4 concentration induces apoptosis through receptor-mediated signaling. The Journal of biological chemistry. vol 287. issue 13. 2012-05-16. PMID:22308028. |
we found that increase of apo-/holo-rbp4 concentration ratio delayed the displacement of rbp4 with "stimulated by retinoic acid 6" (stra6), enhanced janus kinase 2 (jak2)/stat5 cascade, up-regulated adenylate cyclase 6 (ac6), increased camp, enhanced jnk1/p38 cascade, suppressed crbp-i/rarα (cellular retinol-binding protein/retinoic acid receptor α) expression, and led to apoptosis in hk-2 and human umbilical vein endothelial cells. |
2012-05-16 |
2023-08-12 |
human |
| Chao-Hung Chen, Tusty-Jiuan Hsieh, Kun-Der Lin, Hsing-Yi Lin, Mei-Yueh Lee, Wei-Wen Hung, Pi-Jung Hsiao, Shyi-Jang Shi. Increased unbound retinol-binding protein 4 concentration induces apoptosis through receptor-mediated signaling. The Journal of biological chemistry. vol 287. issue 13. 2012-05-16. PMID:22308028. |
furthermore, stra6, jak2, stat5, jnk1, or p38 sirna and camp-pka inhibitor reversed the repression of crbp-i/rarα and apoptosis in apo-rbp4 stimulation. |
2012-05-16 |
2023-08-12 |
human |
| Oliver Hantschel, Wolfgang Warsch, Eva Eckelhart, Ines Kaupe, Florian Grebien, Kay-Uwe Wagner, Giulio Superti-Furga, Veronika Sex. BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nature chemical biology. vol 8. issue 3. 2012-05-15. PMID:22286129. |
nevertheless, several jak2 tkis induced apoptosis in bcr-abl(+) cells irrespective of the presence of jak2. |
2012-05-15 |
2023-08-12 |
Not clear |
| Braden C McFarland, Jing-Yuan Ma, Catherine P Langford, G Yancey Gillespie, Hao Yu, Ying Zheng, Susan E Nozell, Dennis Huszar, Etty N Benvenist. Therapeutic potential of AZD1480 for the treatment of human glioblastoma. Molecular cancer therapeutics. vol 10. issue 12. 2012-05-11. PMID:22027691. |
azd1480 treatment effectively blocks constitutive and stimulus-induced jak1, jak2, and stat-3 phosphorylation in both human and murine glioma cells, and leads to a decrease in cell proliferation and induction of apoptosis. |
2012-05-11 |
2023-08-12 |
mouse |
| Mamta Gupta, Jing Jing Han, Mary Stenson, Matthew Maurer, Linda Wellik, Guangzhen Hu, Steve Ziesmer, Ahmet Dogan, Thomas E Witzi. Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation. Blood. vol 119. issue 12. 2012-05-07. PMID:22323454. |
apoptosis induced by jak2 inhibition was dependent on inhibition of autocrine il-10 and c-myc expression and independent of bcl-2 family expression. |
2012-05-07 |
2023-08-12 |
Not clear |
| Jinbing Zhao, Guangzhao Li, Yang Zhang, Xingfen Su, Chunhua Han. The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats. Cytokine. vol 56. issue 2. 2012-01-30. PMID:21843949. |
as a result, we found that tbi could activate jak2 and stat3, and increase cell apoptosis in pericontusional cortex. |
2012-01-30 |
2023-08-12 |
human |
| Alfonso Quintás-Cardama, Taghi Manshouri, Zeev Estrov, David Harris, Ying Zhang, Amos Gaikwad, Hagop M Kantarjian, Srdan Verstovse. Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Investigational new drugs. vol 29. issue 5. 2012-01-24. PMID:20372971. |
atiprimod-induced cell growth inhibition of jak2 (v617f)-positive cells was coupled with induction of apoptosis, as evidenced by heightened mitochondrial membrane potential and caspase-3 activity, as well as parp cleavage, increased turnover of the anti-apoptotic x-linked mammalian inhibitor of apoptosis (xiap) protein, and inhibition of the pro-apoptotic protein bcl-2 in a time- and dose-dependent manner. |
2012-01-24 |
2023-08-12 |
mouse |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
in the current study, we found that in glioma cells u251, ad-bfgf-sirna impedes the activation of erk1/2 and jak2, but not src, decreases il-6 secretion, reduces stat3 phosphorylation, decreases the levels of downstream molecules cyclind1 and bcl-xl, and ultimately results in the collapse of mitochondrial membrane potentials as well as the induction of mitochondrial-related apoptosis. |
2012-01-17 |
2023-08-12 |
human |
| Yan Liu, Aiguo Liu, Huameng Li, Chenglong Li, Jiayuh Li. Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 8. 2012-01-05. PMID:21490132. |
our results showed that celecoxib decreased stat3 phosphorylation by reducing janus-activated kinase (jak2) phosphorylation and caused apoptosis in hcc cells. |
2012-01-05 |
2023-08-12 |
human |
| S Hart, K C Goh, V Novotny-Diermayr, C Y Hu, H Hentze, Y C Tan, B Madan, C Amalini, Y K Loh, L C Ong, A D William, A Lee, A Poulsen, R Jayaraman, K H Ong, K Ethirajulu, B W Dymock, J W Woo. SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies. Leukemia. vol 25. issue 11. 2011-12-22. PMID:21691275. |
as a consequence sb1518 has potent anti-proliferative effects on myeloid and lymphoid cell lines driven by mutant or wild-type jak2 or flt3, resulting from cell cycle arrest and induction of apoptosis. |
2011-12-22 |
2023-08-12 |
mouse |
| Ajoy K Samanta, Sandip N Chakraborty, Yan Wang, Ellen Schlette, E Premkumar Reddy, Ralph B Arlinghau. Destabilization of Bcr-Abl/Jak2 Network by a Jak2/Abl Kinase Inhibitor ON044580 Overcomes Drug Resistance in Blast Crisis Chronic Myelogenous Leukemia (CML). Genes & cancer. vol 1. issue 4. 2011-11-10. PMID:20798787. |
therefore, targeting jak2 and bcr-abl kinases is an effective way to destabilize bcr-abl and its network complex, which leads to the onset of apoptosis in im-sensitive and im-resistant bcr-abl+ cells. |
2011-11-10 |
2023-08-12 |
Not clear |
| Takayuki Ikezoe, Shinsuke Kojima, Mutsuo Furihata, Jing Yang, Chie Nishioka, Asako Takeuchi, Mayuka Isaka, H Phillip Koeffler, Akihito Yokoyam. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. International journal of cancer. vol 129. issue 10. 2011-11-04. PMID:21207414. |
moreover, we found that az960, a novel and specific inhibitor of the jak2 kinase, potently inhibited the clonogenic growth and induced apoptosis of freshly isolated aml cells from patients in association with cleavage of caspase 3 and downregulation of anti-apoptotic bcl-xl proteins. |
2011-11-04 |
2023-08-12 |
Not clear |
| H Jäkel, C Weinl, L Hengs. Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. Oncogene. vol 30. issue 32. 2011-10-25. PMID:21423214. |
janus kinase 2 (jak2) couples ligand activation of cell surface cytokine receptors to the regulation of cellular functions including cell cycle progression, differentiation and apoptosis. |
2011-10-25 |
2023-08-12 |
Not clear |
| Annet Kirabo, S Paul Oh, Hideko Kasahara, Kay-Uwe Wagner, Peter P Sayesk. Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice. Journal of molecular and cellular cardiology. vol 50. issue 6. 2011-09-26. PMID:21420414. |
finally, when compared to controls, the vsmc jak2 null mice exhibited significantly less ang ii-induced vsmc proliferation and migration in vitro and in vivo and more apoptosis. |
2011-09-26 |
2023-08-12 |
mouse |