| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Yan Zhang, Xiao-Wen Zha. [Research advances in the role of JAK2 mutations in acute leukemia]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 17. issue 6. 2015-09-30. PMID:26108332. |
jak2 mutations might lead to jak-stat overactivation, resulting in the excessive proliferation, apoptosis resistance and differentiation blocking of blood cells. |
2015-09-30 |
2023-08-13 |
Not clear |
| Min-Beom Kim, Chulwon Kim, Won-Seok Chung, Jae-Heung Cho, Dongwoo Nam, Sung-Hoon Kim, Kwang Seok Ah. The hydrolysed products of iridoid glycosides can enhance imatinib mesylate-induced apoptosis in human myeloid leukaemia cells. Phytotherapy research : PTR. vol 29. issue 3. 2015-09-29. PMID:25583173. |
indeed, h-catalpol and h-aucubin down-regulated bcr-abl phosphorylation and inhibited constitutive stat3 activation through abrogating upstream jak2 and c-src and constitutive stat5 activation leading to apoptosis through caspase-3 activation. |
2015-09-29 |
2023-08-13 |
human |
| Hao-hao Zhang, Shan Kuang, Ying Wang, Xiao-xiao Sun, Yuan Gu, Li-hong Hu, Qiang Y. Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells. Acta pharmacologica Sinica. vol 36. issue 4. 2015-09-21. PMID:25619393. |
bigelovin inhibits stat3 signaling by inactivating jak2 and induces apoptosis in human cancer cells. |
2015-09-21 |
2023-08-13 |
human |
| Yuan Hu, Yin Hong, YuanJie Xu, Ping Liu, Dai-Hong Guo, Yibang Che. Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25213670. |
we treated five non-small-cell lung cancer cell lines with cisplatin alone or with cisplatin and jak2 inhibitor (ruxolitinib) and assessed cell viability, expression of jak2 and stat3 and cell apoptosis. |
2015-09-04 |
2023-08-13 |
human |
| Yuan-Fei Liu, Yun-Min Lu, Guo-Qiang Qu, Yuan Liu, Wei-Xiong Chen, Xiao-Hong Liao, Wu-Ming Kon. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. International journal of molecular sciences. vol 16. issue 1. 2015-09-04. PMID:25588213. |
ponicidin induces apoptosis via jak2 and stat3 signaling pathways in gastric carcinoma. |
2015-09-04 |
2023-08-13 |
Not clear |
| Yuan-Fei Liu, Yun-Min Lu, Guo-Qiang Qu, Yuan Liu, Wei-Xiong Chen, Xiao-Hong Liao, Wu-Ming Kon. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. International journal of molecular sciences. vol 16. issue 1. 2015-09-04. PMID:25588213. |
we therefore conclude that ponicidin exhibited significant growth inhibition of gastric carcinoma cell line mkn28 and induced apoptosis of mkn28 cells via the signaling pathway regulated by janus kinase 2 (jak2) and signal transducers and activators of transcription 3 (stat3). |
2015-09-04 |
2023-08-13 |
Not clear |
| Anthony D Pomicter, Anna M Eiring, Anna V Senina, Matthew S Zabriskie, James E Marvin, Josef T Prchal, Thomas O'Hare, Michael W Deininge. Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm. Experimental hematology. vol 43. issue 7. 2015-08-31. PMID:25912019. |
bms-911543 is a jak2-selective inhibitor that induces apoptosis in jak2-dependent cell lines and inhibits the growth of cd34(+) progenitor cells from patients with jak2(v617f)-positive mpn. |
2015-08-31 |
2023-08-13 |
mouse |
| Dae-Hee Lee, Ki Sa Sung, David L Bartlett, Yong Tae Kwon, Yong J Le. HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. Cellular signalling. vol 27. issue 2. 2015-08-25. PMID:25446253. |
knock down of mcl-1, stat3 inhibitor or jak2 inhibitor synergistically enhanced trail-induced apoptosis. |
2015-08-25 |
2023-08-13 |
Not clear |
| Joanna Szymańska, Piotr Smolewski, Agata Majchrzak, Barbara Cebula-Obrzut, Krzysztof Chojnowski, Jacek Trelińsk. Pro-Apoptotic Activity of Ruxolitinib Alone and in Combination with Hydroxyurea, Busulphan, and PI3K/mTOR Inhibitors in JAK2-Positive Human Cell Lines. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 24. issue 2. 2015-08-12. PMID:25931349. |
inhibition of jak2 activity by ruxolitinib (rx) results in growth inhibition and apoptosis of cells carrying the jak2v617f mutation however the exact mechanisms regulating apoptosis have not been fully elucidated. |
2015-08-12 |
2023-08-13 |
human |
| Abel Sánchez-Aguilera, Lorena Arranz, Daniel Martín-Pérez, Andrés García-García, Vaia Stavropoulou, Lucia Kubovcakova, Joan Isern, Sandra Martín-Salamanca, Xavier Langa, Radek C Skoda, Jürg Schwaller, Simón Méndez-Ferre. Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis. Cell stem cell. vol 15. issue 6. 2015-07-30. PMID:25479752. |
in mice, tamoxifen treatment blocked development of jak2(v617f)-induced myeloproliferative neoplasm in vivo, induced apoptosis of human jak2(v617f+) hspcs in a xenograft model, and sensitized mll-af9(+) leukemias to chemotherapy. |
2015-07-30 |
2023-08-13 |
mouse |
| Xiang Li, Shu-Juan Zhao, Hai-Lian Shi, Shui-Ping Qiu, Jian-Qun Xie, Hui Wu, Bei-Bei Zhang, Zheng-Tao Wang, Jian-Ye Yuan, Xiao-Jun W. Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells. Oncology reports. vol 32. issue 6. 2015-06-29. PMID:25335112. |
ber modulated multiple signaling pathway molecules involved in the regulation of cell apoptosis, including activation of p38 mapk and jnk and deactivation of jak2, p85 pi3k, akt and nf-κb. |
2015-06-29 |
2023-08-13 |
Not clear |
| Hajime Akada, Saeko Akada, Robert E Hutchison, Kazuhito Sakamoto, Kay-Uwe Wagner, Golam Moh. Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells. Stem cells (Dayton, Ohio). vol 32. issue 7. 2015-02-09. PMID:24677703. |
jak2 deficiency also causes significant apoptosis and loss of quiescence in hsc-enriched lsk (lin(-)sca-1(+)c-kit(+)) cells. |
2015-02-09 |
2023-08-12 |
mouse |
| Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Girau. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PloS one. vol 9. issue 5. 2015-01-23. PMID:24804649. |
here we show that treatment of human ags gastric cancer cells with the janus kinase (jak) inhibitor wp1066 dose-, and time-dependently inhibits stat3 phosphorylation, in conjunction with reduced jak2 phosphorylation, reduced proliferation and increased apoptosis. |
2015-01-23 |
2023-08-13 |
mouse |
| Shih-Min A Huang, Anlai Wang, Rita Greco, Zhifang Li, Claude Barberis, Michel Tabart, Vinod Patel, Laurent Schio, Raelene Hurley, Bo Chen, Hong Cheng, Christoph Lengauer, Jack Pollard, James Watters, Carlos Garcia-Echeverria, Dmitri Wiederschain, Francisco Adrian, JingXin Zhan. Combination of PIM and JAK2 inhibitors synergistically suppresses MPN cell proliferation and overcomes drug resistance. Oncotarget. vol 5. issue 10. 2015-01-23. PMID:24830942. |
combination of various pim inhibitors with a jak2 inhibitor results in significant synergistic growth inhibition of multiple mpn cancer cell lines and induction of apoptosis. |
2015-01-23 |
2023-08-13 |
Not clear |
| Hua Yang, Harshani R Lawrence, Aslamuzzaman Kazi, Harsukh Gevariya, Ronil Patel, Yunting Luo, Uwe Rix, Ernst Schonbrunn, Nicholas J Lawrence, Said M Sebt. Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation. Oncotarget. vol 5. issue 10. 2015-01-23. PMID:24930769. |
furthermore, sirna silencing or pharmacological inhibition of aurora a and jak2 with alisertib and ruxolitinib, respectively, is more effective than blocking each kinase alone at suppressing anchorage-dependent and -independent growth and invasion as well as at inducing apoptosis. |
2015-01-23 |
2023-08-13 |
mouse |
| Lin-jie Li, Neng-wen Xu, Rui-lan Gao, Xiao-jie Lin, Hong-ying Qiu, Wei-hong Liu, Yang-jin Jin, Min-lei Zha. Effects of Danshen Injection () on inhibiting proliferation and inducing apoptosis through down-regulation of mutant JAK2 gene and its protein phosphorylation in human erythroid leukemic cells. Chinese journal of integrative medicine. vol 20. issue 5. 2015-01-02. PMID:24610414. |
effects of danshen injection () on inhibiting proliferation and inducing apoptosis through down-regulation of mutant jak2 gene and its protein phosphorylation in human erythroid leukemic cells. |
2015-01-02 |
2023-08-12 |
human |
| Megumi Funakoshi-Tago, Masaki Tsukada, Toshiro Watanabe, Yuka Mameda, Kenji Tago, Tomoyuki Ohe, Shigeo Nakamura, Tadahiko Mashino, Tadashi Kasahar. Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant. International immunopharmacology. vol 20. issue 1. 2014-12-28. PMID:24631513. |
effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by jak2 v617f mutant. |
2014-12-28 |
2023-08-12 |
human |
| Megumi Funakoshi-Tago, Masaki Tsukada, Toshiro Watanabe, Yuka Mameda, Kenji Tago, Tomoyuki Ohe, Shigeo Nakamura, Tadahiko Mashino, Tadashi Kasahar. Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant. International immunopharmacology. vol 20. issue 1. 2014-12-28. PMID:24631513. |
we previously reported that pyrrolidinium fullerene markedly induced the apoptosis of jak2 v617f mutant-induced transformed cells through the reduction of apoptosis signal-regulating kinase 1 (ask1), following inhibition of the c-jun n-terminal kinase (jnk) pathway. |
2014-12-28 |
2023-08-12 |
human |
| Wenjing Tao, Xiaohong Leng, Sandip N Chakraborty, Helen Ma, Ralph B Arlinghau. c-Abl activates janus kinase 2 in normal hematopoietic cells. The Journal of biological chemistry. vol 289. issue 31. 2014-12-15. PMID:24923444. |
il-3 efficiently inhibited apoptosis of 32dp210k/r+abl cells induced by imatinib mysylate but not jak2 kinase inhibitor tg101209. |
2014-12-15 |
2023-08-13 |
mouse |
| Cuijuan Qian, Jun Yao, Jiji Wang, Lan Wang, Meng Xue, Tianhua Zhou, Weili Liu, Jianmin S. ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells. Molecular and cellular biochemistry. vol 387. issue 1-2. 2014-09-26. PMID:24178240. |
erk1/2 inhibition enhances apoptosis induced by jak2 silencing in human gastric cancer sgc7901 cells. |
2014-09-26 |
2023-08-12 |
mouse |