| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Liu, C B Liu, M G Mohi, K Arai, S Watanab. Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF. Oncogene. vol 19. issue 4. 2000-03-16. PMID:10698527. |
although jak2 is essential for hgm-csf dependent anti gamma irradiation-induced apoptosis, it appeared that jak2 does not seem sufficient for the activity. |
2000-03-16 |
2023-08-12 |
mouse |
| S L Gaffen, S Y Lai, G D Longmore, K D Liu, M A Goldsmit. Genetic evidence for an additional factor required for erythropoietin-induced signal transduction. Blood. vol 94. issue 1. 1999-07-23. PMID:10381500. |
in the present study, we have identified a cellular context (the interleukin-2 [il-2]-dependent ht-2 line) in which the epo stimulation of the epor fails to support cellular proliferation, stat-5 induction, or mapk activation, despite efficient phosphorylation of the epor and jak2 and inhibition of apoptosis after withdrawal of il-2. |
1999-07-23 |
2023-08-12 |
Not clear |
| H Bao, S M Jacobs-Helber, A E Lawson, K Penta, A Wickrema, S T Sawye. Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells). Blood. vol 93. issue 11. 1999-06-24. PMID:10339482. |
constitutive stat5 activity, activated through an unknown pathway not including jak2 or epor, may act in concert with the constitutive pi3-kinase/pkb/akt pathway to protect the epo-independent hcd57-srei cells from apoptosis and promote limited proliferation. |
1999-06-24 |
2023-08-12 |
Not clear |
| M G Mohi, K i Arai, S Watanab. Activation and functional analysis of Janus kinase 2 in BA/F3 cells using the coumermycin/gyrase B system. Molecular biology of the cell. vol 9. issue 12. 1999-02-04. PMID:9843570. |
janus kinase 2 (jak2) protein tyrosine kinase plays an important role in interleukin-3- or granulocyte-macrophage colony-stimulating factor-mediated signal transduction pathways leading to cell proliferation, activation of early response genes, and inhibition of apoptosis. |
1999-02-04 |
2023-08-12 |
Not clear |
| H U Simon, S Yousefi, B Dibbert, F Levi-Schaffer, K Blase. Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. European journal of immunology. vol 27. issue 12. 1998-02-20. PMID:9464845. |
to test whether tyrosine phosphorylation of jak2 is linked to gm-csf-mediated prolonged eosinophil survival, we determined the effect of tyrphostin b42 on eosinophil viability and apoptosis. |
1998-02-20 |
2023-08-12 |
human |
| H U Simon, S Yousefi, B Dibbert, F Levi-Schaffer, K Blase. Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. European journal of immunology. vol 27. issue 12. 1998-02-20. PMID:9464845. |
prevention of jak2 activation by tyrphostin b42 was associated with the inability of gm-csf to prevent eosinophil apoptosis. |
1998-02-20 |
2023-08-12 |
human |
| H Zhuang, Z Niu, T C He, S V Patel, D M Wojchowsk. Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2. The Journal of biological chemistry. vol 270. issue 24. 1995-07-17. PMID:7782312. |
erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of jak2. |
1995-07-17 |
2023-08-12 |
human |