| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gladell P Paner, Simone Silberman, Grace Hartman, Kenneth C Micetich, Gerard V Aranha, Serhan Alka. Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors. Anticancer research. vol 23. issue 3B. 2003-08-28. PMID:12894500. |
this study demonstrates that stat3 is constitutively activated in gist and jak2 blockade leads to tumor growth inhibition and apoptosis indicating the involvement of the jak/stat signaling pathway in gist cellular survival. |
2003-08-28 |
2023-08-12 |
Not clear |
| Bernhard Saile, Christoph Eisenbach, Hammoudeh El-Armouche, Katrin Neubauer, Giuliano Ramador. Antiapoptotic effect of interferon-alpha on hepatic stellate cells (HSC): a novel pathway of IFN-alpha signal transduction via Janus kinase 2 (JAK2) and caspase-8. European journal of cell biology. vol 82. issue 1. 2003-08-13. PMID:12602946. |
taken together ifn-alpha inhibits apoptosis of activated hsc by activation of jak2 which inhibits the caspase-8 apoptosis pathway. |
2003-08-13 |
2023-08-12 |
rat |
| Holger Ruchatz, Addolorata Maria Luce Coluccia, Paola Stano, Edoardo Marchesi, Carlo Gambacorti-Passerin. Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells. Experimental hematology. vol 31. issue 4. 2003-05-20. PMID:12691918. |
constitutive activation of jak2 contributes to proliferation and resistance to apoptosis in npm/alk-transformed cells. |
2003-05-20 |
2023-08-12 |
human |
| Mauricio Rojas, Martin Olivier, Luis F Garcí. Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis. Cellular immunology. vol 217. issue 1-2. 2002-12-24. PMID:12426001. |
inhibitors of ptk (ag-126), or jak2 (ag-490) inhibited tnf-alpha and no production, caspase 1 activation and apoptosis, suggesting that m. tuberculosis-induction of these events depends on jak2/stat1-alpha activation. |
2002-12-24 |
2023-08-12 |
Not clear |
| Pedro J Real, Angels Sierra, Ana De Juan, Jose C Segovia, Jose M Lopez-Vega, Jose L Fernandez-Lun. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene. vol 21. issue 50. 2002-11-19. PMID:12400004. |
in addition, blockade of stat3 activation by treatment with epidermal growth factor receptor and jak2 kinase inhibitors or transfection with a dominant negative stat3, sensitizes 435b cells to chemotherapy-induced apoptosis. |
2002-11-19 |
2023-08-12 |
Not clear |
| Shanhai Xie, Hui Lin, Tong Sun, Ralph B Arlinghau. Jak2 is involved in c-Myc induction by Bcr-Abl. Oncogene. vol 21. issue 47. 2002-11-04. PMID:12370803. |
of interest, il-3 containing medium reversed the sti-571 induced apoptosis of 32dp210 cells but did not reverse the induction of apoptosis by ag490, which strongly supports the specificity of the inhibitory effects of ag490 on the jak2 tyrosine kinase. |
2002-11-04 |
2023-08-12 |
mouse |
| Hanne Olsen, Malin A Hedengran Faulds, Pipsa Saharinen, Olli Silvennoinen, Lars Arne Haldosé. Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells. Biochemical and biophysical research communications. vol 296. issue 1. 2002-09-06. PMID:12147240. |
in the present study we have investigated the role for jak2 in proliferation, differentiation, and apoptosis of the mammary epithelial cell line hc11 by stably overexpressing two hyperactive jak2 mutants. |
2002-09-06 |
2023-08-12 |
Not clear |
| Hanne Olsen, Malin A Hedengran Faulds, Pipsa Saharinen, Olli Silvennoinen, Lars Arne Haldosé. Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells. Biochemical and biophysical research communications. vol 296. issue 1. 2002-09-06. PMID:12147240. |
proliferation was not affected by any of the mutants whereas the ability to undergo apoptosis was decreased implicating a transforming potential of the jak2 mutants. |
2002-09-06 |
2023-08-12 |
Not clear |
| Jianwu Xie, Matthew J LeBaron, Marja T Nevalainen, Hallgeir Ru. Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11821424. |
furthermore, suppression of jak2 in hc11 cells was associated with constitutive activation of oncoprotein stat3 and a hyperproliferative phenotype characterized by increased mitotic rate, reduced apoptosis, and reduced contact inhibition. |
2002-06-07 |
2023-08-12 |
mouse |
| Y Gu, Y Zou, R Aikawa, D Hayashi, S Kudoh, T Yamauchi, H Uozumi, W Zhu, T Kadowaki, Y Yazaki, I Komur. Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes. Molecular and cellular biochemistry. vol 223. issue 1-2. 2002-04-25. PMID:11681720. |
these findings suggest that gh has a direct protective effect on cardiac myocytes against apoptosis and that the effect of gh is attributed at least in part to the activation of erks through ras and ptks including jak2, src, and egf receptor tyrosine kinase. |
2002-04-25 |
2023-08-12 |
rat |
| M Digicaylioglu, S A Lipto. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature. vol 412. issue 6847. 2001-08-30. PMID:11493922. |
activation of neuronal epo receptors (epors) prevents apoptosis induced by nmda (n-methyl-d-aspartate) or no by triggering cross-talk between the signalling pathways of janus kinase-2 (jak2) and nuclear factor-kappab (nf-kappab). |
2001-08-30 |
2023-08-12 |
Not clear |
| M Digicaylioglu, S A Lipto. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature. vol 412. issue 6847. 2001-08-30. PMID:11493922. |
transfection of cerebrocortical neurons with a dominant interfering form of jak2 or an ikappabalpha super-repressor blocks epo-mediated prevention of neuronal apoptosis. |
2001-08-30 |
2023-08-12 |
Not clear |
| A Muto, M Kizaki, C Kawamura, H Matsushita, Y Fukuchi, A Umezawa, T Yamada, J Hata, N Hozumi, K Yamato, M Ito, Y Ueyama, Y Iked. A novel differentiation-inducing therapy for acute promyelocytic leukemia with a combination of arsenic trioxide and GM-CSF. Leukemia. vol 15. issue 8. 2001-08-16. PMID:11480559. |
gm-csf was found to be associated with increased tyrosine phosphorylation of jak2 kinase in both nb4 and uf-1 cells, and a specific inhibitor of jak2, ag490, completely blocked the ability of gm-csf to prevent apoptosis and induce differentiation of as2o3-treated uf-1 cells. |
2001-08-16 |
2023-08-12 |
mouse |
| H Yoshikawa, K Matsubara, G S Qian, P Jackson, J D Groopman, J E Manning, C C Harris, J G Herma. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nature genetics. vol 28. issue 1. 2001-05-31. PMID:11326271. |
this growth suppression was caused by apoptosis and was reproduced by ag490, a specific, chemical jak2 inhibitor that reversed constitutive phosphorylation of stat3 in socs-1 inactivated cells. |
2001-05-31 |
2023-08-12 |
human |
| H M Huang, C J Huang, J J Ye. Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways. Blood. vol 96. issue 5. 2000-10-18. PMID:10961875. |
in tf-1 cells, the defect of il-5 in apoptosis suppression and mcl-1 induction was associated with the incapability to highly phosphorylate janus kinases (jak1, jak2), signal transducer and activator of transcription-5 (stat5), mitogen-activated protein kinase (mapk), and akt/pkb, whereas scf costimulation restored the potent phosphorylation of mapk and akt/pkb, but not stat5. |
2000-10-18 |
2023-08-12 |
Not clear |
| J De Vos, M Jourdan, K Tarte, C Jasmin, B Klei. JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. British journal of haematology. vol 109. issue 4. 2000-08-31. PMID:10929036. |
jak2 tyrosine kinase inhibitor tyrphostin ag490 downregulates the mitogen-activated protein kinase (mapk) and signal transducer and activator of transcription (stat) pathways and induces apoptosis in myeloma cells. |
2000-08-31 |
2023-08-12 |
human |
| P E Kovanen, I Junttila, K Takaluoma, P Saharinen, L Valmu, W Li, O Silvennoine. Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells. Blood. vol 95. issue 5. 2000-03-29. PMID:10688817. |
reversal of pkc-delta-mediated inhibition by the overexpression of jak2 promoted apoptosis in differentiating 32d cells. |
2000-03-29 |
2023-08-12 |
Not clear |
| R Liu, C B Liu, M G Mohi, K Arai, S Watanab. Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF. Oncogene. vol 19. issue 4. 2000-03-16. PMID:10698527. |
it is well documented that the boxl region is essential for gm-csf dependent activation of jak2 and jak2 specific inhibitor ag490 suppressed anti gamma, irradiation-induced apoptosis by hgm-csf. |
2000-03-16 |
2023-08-12 |
mouse |
| R Liu, C B Liu, M G Mohi, K Arai, S Watanab. Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF. Oncogene. vol 19. issue 4. 2000-03-16. PMID:10698527. |
although jak2 is essential for hgm-csf dependent anti gamma irradiation-induced apoptosis, it appeared that jak2 does not seem sufficient for the activity. |
2000-03-16 |
2023-08-12 |
mouse |
| S L Gaffen, S Y Lai, G D Longmore, K D Liu, M A Goldsmit. Genetic evidence for an additional factor required for erythropoietin-induced signal transduction. Blood. vol 94. issue 1. 1999-07-23. PMID:10381500. |
in the present study, we have identified a cellular context (the interleukin-2 [il-2]-dependent ht-2 line) in which the epo stimulation of the epor fails to support cellular proliferation, stat-5 induction, or mapk activation, despite efficient phosphorylation of the epor and jak2 and inhibition of apoptosis after withdrawal of il-2. |
1999-07-23 |
2023-08-12 |
Not clear |