| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Chappell, P A Tilbrook, T Bittorf, S M Colley, G T Meyer, S P Klinke. Prevention of apoptosis in J2E erythroid cells by erythropoietin: involvement of JAK2 but not MAP kinases. Cell death and differentiation. vol 4. issue 2. 2006-03-02. PMID:16465216. |
it was concluded that erythropoietin-induced protection from apoptosis involved jak2, but not map kinases or c-jun. |
2006-03-02 |
2023-08-12 |
Not clear |
| Amany Tawfik, Liming Jin, Amy K L Banes-Berceli, Ruth B Caldwell, Safia Ogbi, Amanda Shirley, Dwayne Barber, John D Catravas, David M Stern, David Fulton, R William Caldwell, Mario B Marrer. Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2. Vascular pharmacology. vol 43. issue 5. 2006-01-31. PMID:16257269. |
finally, immunoblot analysis of caspase-3 and parp cleavage confirmed a role for activation of jak2 in both hg- or ros-induced apoptosis, based on inhibition by either ag-490 or adenoviral transfection with a dominant-negative jak2 mutant. |
2006-01-31 |
2023-08-12 |
Not clear |
| Amany Tawfik, Liming Jin, Amy K L Banes-Berceli, Ruth B Caldwell, Safia Ogbi, Amanda Shirley, Dwayne Barber, John D Catravas, David M Stern, David Fulton, R William Caldwell, Mario B Marrer. Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2. Vascular pharmacology. vol 43. issue 5. 2006-01-31. PMID:16257269. |
in conclusion the activation of jak2 plays a pivotal role in oxidant stress-induced commitment of ecs to apoptosis, based on studies with hg and h(2)o(2). |
2006-01-31 |
2023-08-12 |
Not clear |
| Eduardo Mascareno, Daniel L Beckles, M A Q Siddiqu. Janus kinase-2 signaling mediates apoptosis in rat cardiomyocytes. Vascular pharmacology. vol 43. issue 5. 2006-01-31. PMID:16269269. |
likewise, the oxidative stress, via the hypoxia/reoxygenation treatment of rat adult cardiomyocytes, produced apoptosis that was dependent upon activation of jak2. |
2006-01-31 |
2023-08-12 |
rat |
| Erina Sakamoto, Fumihiko Hato, Takayuki Kato, Chikahiko Sakamoto, Mika Akahori, Masayuki Hino, Seiichi Kitagaw. Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845643. |
we have recently demonstrated that granulocyte-colony stimulating factor (g-csf) delays human neutrophil apoptosis via up-regulation of cellular inhibitor of apoptosis 2 (ciap2), which is dependent on activation of janus kinase 2 (jak2) and signal transducer and activator of transcription 3 (stat3). |
2005-09-08 |
2023-08-12 |
human |
| E Puxeddu, J A Knauf, M A Sartor, N Mitsutake, E P Smith, M Medvedovic, C R Tomlinson, S Moretti, J A Fagi. RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response. Endocrine-related cancer. vol 12. issue 2. 2005-08-22. PMID:15947106. |
functional clustering of genes with greater than or less than 1.75-fold expression change (86 genes) revealed ret/ptc3-induced regulation of genes with key functions in apoptosis (ripk3, tdga), cell-cell signaling (cdh6, fn1), cell cycle (il24), immune and inflammation response (cxcl10, scya2, il6, gbp2, oas1, tap1, rt1aw2, c2ta, irf1, lmp2, psme2, prkr), metabolism (aldob, ptges, nd2, gss, gstt1), signal transduction (socs3, nf1, jak2, cpg21, dusp6, socs1, stat1, stat3, cish) and transcription (nr4a1, junb, hfh1, runx1, foxe1). |
2005-08-22 |
2023-08-12 |
Not clear |
| Elena Bulanova, Vadim Budagian, Zane Orinska, Martina Hein, Frank Petersen, Lutz Thon, Dieter Adam, Silvia Bulfone-Pau. Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 7. 2005-06-07. PMID:15778342. |
however, in the time period between commitment to apoptosis and actual cell death, atp triggered rapid but transient phosphorylation of multiple signaling molecules in bmmcs and mc/9 cells, including erk, jak2, and stat6. |
2005-06-07 |
2023-08-12 |
mouse |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
cuc q inhibits selectively the activation of stat3 and induces apoptosis without inhibition of jak2, src, akt, erk, or jnk activation. |
2005-05-31 |
2023-08-12 |
mouse |
| Beverly E Barton, Thomas F Murphy, Ping Shu, Hosea F Huang, Markus Meyenhofer, Arnold Barto. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Molecular cancer therapeutics. vol 3. issue 10. 2005-04-21. PMID:15486184. |
previously, we reported that antisense oligonucleotides specific for stat3 were better at inducing apoptosis than inhibitors of jak1 or jak2, the upstream activating kinases of stat3. |
2005-04-21 |
2023-08-12 |
Not clear |
| Beverly E Barton, James G Karras, Thomas F Murphy, Arnold Barton, Hosea F-S Huan. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines. Molecular cancer therapeutics. vol 3. issue 1. 2004-11-04. PMID:14749471. |
ag490 (jak2 specific) induced apoptosis in du145 but not in nrp-154 prostate cancer lines, whereas piceatannol (jak1 specific) induced apoptosis in nrp-154 but not in du145 cells. |
2004-11-04 |
2023-08-12 |
Not clear |
| M Marchisio, P M Grimley, A Di Baldassarre, E Santavenere, S Misci. Novel shift of Jak/Stat signalling characterizes the protective effect of aurintricarboxylic acid (ATA) from tumor necrosis factor-alpha toxicity in human B lymphocytes. International journal of immunopathology and pharmacology. vol 17. issue 1. 2004-10-22. PMID:15000861. |
apoptosis effected by tnf-alpha alone was suppressed by ata and this event was paralleled by phosphorylation and nuclear translocation of jak2, stat2, stat4 and nf-kb, along with inhibition of caspase activation. |
2004-10-22 |
2023-08-12 |
human |
| Eric M Sandberg, Peter P Sayesk. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15159394. |
jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. |
2004-09-24 |
2023-08-12 |
rat |
| Eric M Sandberg, Peter P Sayesk. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15159394. |
we therefore examined the role that jak2 plays in vascular smooth muscle cell apoptosis following hydrogen peroxide treatment. |
2004-09-24 |
2023-08-12 |
rat |
| Eric M Sandberg, Peter P Sayesk. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15159394. |
here, we report that jak2 tyrosine kinase activation by hydrogen peroxide is required for apoptosis of vascular smooth muscle cells. |
2004-09-24 |
2023-08-12 |
rat |
| Eric M Sandberg, Peter P Sayesk. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15159394. |
however, apoptosis was prevented by either the expression of a dominant negative jak2 protein or by the jak2 pharmacological inhibitor ag490. |
2004-09-24 |
2023-08-12 |
rat |
| Eric M Sandberg, Peter P Sayesk. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15159394. |
these data demonstrate that the activation of jak2 tyrosine kinase by hydrogen peroxide is essential for apoptosis of vascular smooth muscle cells. |
2004-09-24 |
2023-08-12 |
rat |
| Eric M Sandberg, Peter P Sayesk. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15159394. |
furthermore, this report identifies jak2 as a potential therapeutic target in vascular diseases in which vascular smooth muscle cell apoptosis contributes to pathological progression. |
2004-09-24 |
2023-08-12 |
rat |
| Christoph J Auernhammer, Franziska Dorn, George Vlotides, Sabine Hengge, Florian B Kopp, Gerald Spoettl, Neziha Cengic, Dieter Engelhardt, Matthias M Webe. The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. The Journal of endocrinology. vol 180. issue 3. 2004-05-27. PMID:15012602. |
rescue of y-1 cells from mosm-induced apoptosis by the jak2 inhibitor, ag490, and the general caspase inhibitor, z-vad-fmk, demonstrates jak activation and subsequent caspase activation to be essential for mosm-induced apoptosis in adrenocortical y-1 tumor cells. |
2004-05-27 |
2023-08-12 |
human |
| Mario B Marrero, Roger L Papke, Balwinder S Bhatti, Seán Shaw, Merouane Bencheri. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. The Journal of pharmacology and experimental therapeutics. vol 309. issue 1. 2004-05-04. PMID:14722323. |
nicotine interaction with the alpha7 nachr inhibits abeta (1-42) interaction with the same receptor, and the abeta (1-42)-induced apoptosis is prevented through nicotine-induced activation of jak2. |
2004-05-04 |
2023-08-12 |
Not clear |
| Mario B Marrero, Roger L Papke, Balwinder S Bhatti, Seán Shaw, Merouane Bencheri. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. The Journal of pharmacology and experimental therapeutics. vol 309. issue 1. 2004-05-04. PMID:14722323. |
this study supports central and opposite roles for jak2 and shp-1 in the control of apoptosis and alpha7-mediated neuroprotection in pc12 cells. |
2004-05-04 |
2023-08-12 |
Not clear |