| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taghi Manshouri, Zeev Estrov, Alfonso Quintás-Cardama, Jan Burger, Ying Zhang, Ana Livun, Liza Knez, David Harris, Chad J Creighton, Hagop M Kantarjian, Srdan Verstovse. Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer research. vol 71. issue 11. 2011-09-20. PMID:21512135. |
treatment with atiprimod, a potent jak2 inhibitor, caused marked growth inhibition and apoptosis of human (set-2) and mouse (fdcp-epor) jak2(v617f)-positive cells as well as primary blood or bone marrow mononuclear cells from patients with polycythemia vera; however, these effects were attenuated when any of these cell types were cocultured (cell-on-cell) with human marrow stromal cell lines (e.g., hs5, nk.tert, tm-r1). |
2011-09-20 |
2023-08-12 |
mouse |
| Taghi Manshouri, Zeev Estrov, Alfonso Quintás-Cardama, Jan Burger, Ying Zhang, Ana Livun, Liza Knez, David Harris, Chad J Creighton, Hagop M Kantarjian, Srdan Verstovse. Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer research. vol 71. issue 11. 2011-09-20. PMID:21512135. |
anti-il-6, -fgf, or -cxcl-10/ip-10 neutralizing antibodies ablated the protective effect of stromal cells and restored atiprimod-induced apoptosis of jak2(v617f)-positive cells. |
2011-09-20 |
2023-08-12 |
mouse |
| Kazuya Sumi, Kenji Tago, Tadashi Kasahara, Megumi Funakoshi-Tag. Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells. FEBS letters. vol 585. issue 12. 2011-09-05. PMID:21557940. |
interestingly, mutant jak2 enhanced resistance to cisplatin (cddp)-induced dna damage, and effectively suppressed apoptosis. |
2011-09-05 |
2023-08-12 |
Not clear |
| Hyun Jin Yun, Sun Young Kim, Young Yon Kwon, Chun-Ho Kim, Chang-Mo Kang, Eun Ju Ki. Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells. Cancer biology & therapy. vol 10. issue 4. 2011-05-05. PMID:20534983. |
our findings suggest that jak2 is necessary for induction of apoptosis following cpt treatment. |
2011-05-05 |
2023-08-12 |
human |
| Su Hui Yang, Daulat Bikram Khadka, Suk Hee Cho, Hye-Kyung Ju, Kwang Youl Lee, Ho Jae Han, Kyung-Tae Lee, Won-Jea Ch. Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors. Bioorganic & medicinal chemistry. vol 19. issue 2. 2011-05-03. PMID:21185195. |
moreover, 5p showed a positive correlation between jak2 inhibition and cytotoxicity; 5p treatment in ht-29 cells strongly inhibited jak2 activation and subsequent stat3 phosphorylation, reduced anti-apoptotic protein levels, and finally induced apoptosis. |
2011-05-03 |
2023-08-12 |
mouse |
| Jing Yang, Takayuki Ikezoe, Chie Nishioka, Mutsuo Furihata, Akihito Yokoyam. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159615. |
az960, a novel jak2 inhibitor, induces growth arrest and apoptosis in adult t-cell leukemia cells. |
2011-03-28 |
2023-08-12 |
human |
| Jing Yang, Takayuki Ikezoe, Chie Nishioka, Mutsuo Furihata, Akihito Yokoyam. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Molecular cancer therapeutics. vol 9. issue 12. 2011-03-28. PMID:21159615. |
this study found that az960, a novel inhibitor of jak2 kinase, effectively induced growth arrest and apoptosis of human t-cell lymphotropic virus type 1, htlv-1-infected t cells (mt-1 and mt-2) in parallel with downregulation of the phosphorylated forms of jak2 and bcl-2 family proteins including bcl-2 and mcl-1. |
2011-03-28 |
2023-08-12 |
human |
| Fabienne Baffert, Catherine H Régnier, Alain De Pover, Carole Pissot-Soldermann, Gisele A Tavares, Francesca Blasco, Josef Brueggen, Patrick Chène, Peter Drueckes, Dirk Erdmann, Pascal Furet, Marc Gerspacher, Marc Lang, David Ledieu, Lynda Nolan, Stephan Ruetz, Joerg Trappe, Eric Vangrevelinghe, Markus Wartmann, Lorenza Wyder, Francesco Hofmann, Thomas Radimersk. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Molecular cancer therapeutics. vol 9. issue 7. 2010-11-04. PMID:20587663. |
the compound blunts constitutive stat5 phosphorylation in jak2(v617f)-bearing cells, with concomitant suppression of cell proliferation and induction of apoptosis. |
2010-11-04 |
2023-08-12 |
mouse |
| Anurima Majumder, Lakshmanan Govindasamy, Andrew Magis, Róbert Kiss, Tímea Polgár, Rebekah Baskin, Robert W Allan, Mavis Agbandje-McKenna, Gary W Reuther, György M Keseru, Kirpal S Bisht, Peter P Sayesk. Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core. The Journal of biological chemistry. vol 285. issue 41. 2010-11-04. PMID:20667821. |
they also inhibited phosphorylation of jak2, stat3, and stat5 proteins within cells, resulting in higher levels of apoptosis via the intrinsic apoptotic pathway. |
2010-11-04 |
2023-08-12 |
human |
| Juan Li, Dominik Spensberger, Jong Sook Ahn, Shubha Anand, Philip A Beer, Cedric Ghevaert, Edwin Chen, Ariel Forrai, Linda M Scott, Rita Ferreira, Peter J Campbell, Steve P Watson, Pentao Liu, Wendy N Erber, Brian J P Huntly, Katrin Ottersbach, Anthony R Gree. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood. vol 116. issue 9. 2010-10-07. PMID:20489053. |
unexpectedly, jak2(v617f) mice develop reduced numbers of lineage(-)sca-1(+)c-kit(+) cells, which exhibit increased dna damage, reduced apoptosis, and reduced cell cycling. |
2010-10-07 |
2023-08-12 |
mouse |
| Jung-Suk Choi, Sang-Wook Kang, Jing Li, Jung Lye Kim, Ji-Young Bae, Dong Shoo Kim, Seung-Yong Shin, Jong-Gab Jun, Myeong-Hyeon Wang, Young-Hee Kan. Blockade of oxidized LDL-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving JAK2. Journal of agricultural and food chemistry. vol 57. issue 5. 2010-08-17. PMID:19196000. |
blockade of oxidized ldl-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving jak2. |
2010-08-17 |
2023-08-12 |
Not clear |
| Jung-Suk Choi, Sang-Wook Kang, Jing Li, Jung Lye Kim, Ji-Young Bae, Dong Shoo Kim, Seung-Yong Shin, Jong-Gab Jun, Myeong-Hyeon Wang, Young-Hee Kan. Blockade of oxidized LDL-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving JAK2. Journal of agricultural and food chemistry. vol 57. issue 5. 2010-08-17. PMID:19196000. |
these results suggest that quercetin and rutin inhibit cu(2+)-oxidized ldl-induced endothelial apoptosis through modulating jak2-stat3 pathways and that rutin may modulate a signaling crosstalk between jak2 and mapk. |
2010-08-17 |
2023-08-12 |
Not clear |
| Maria Cecilia S Freitas, Yoichiro Uchida, Danyun Zhao, Bibo Ke, Ronald W Busuttil, Jerzy W Kupiec-Weglinsk. Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 16. issue 5. 2010-07-23. PMID:20440769. |
jak2 blockade resulted in a significant reduction of hepatocyte apoptosis and liver injury. |
2010-07-23 |
2023-08-12 |
mouse |
| Maria Cecilia S Freitas, Yoichiro Uchida, Danyun Zhao, Bibo Ke, Ronald W Busuttil, Jerzy W Kupiec-Weglinsk. Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 16. issue 5. 2010-07-23. PMID:20440769. |
this is the first report documenting that jak2 signaling is essential in the pathophysiology of liver iri, as its selective blockage ameliorated the disease process and protected livers from inflammation and apoptosis. |
2010-07-23 |
2023-08-12 |
mouse |
| Kuei-Li Lin, Jung-Chen Su, Ching-Ming Chien, Pei-Wen Chuang, Long-Sen Chang, Shinne-Ren Li. Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells. Toxicon : official journal of the International Society on Toxinology. vol 55. issue 7. 2010-07-19. PMID:20144642. |
taken together, these results indicate that ctx iii induces apoptosis in mda-mb-231 cells via concomitant inactivation of the jak2, stat3, pi3k, and akt signaling pathways. |
2010-07-19 |
2023-08-12 |
human |
| Kuei-Li Lin, Jung-Chen Su, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 4. 2010-06-17. PMID:20197088. |
taken together, these results indicate that nfd disrupts jak2 pathway and induces apoptosis in mda-mb-231 cells. |
2010-06-17 |
2023-08-12 |
Not clear |
| Young-Kwang Yoon, Hwang-Phill Kim, Sae-Won Han, Do Youn Oh, Seock-Ah Im, Yung-Jue Bang, Tae-You Ki. KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach. Molecular carcinogenesis. vol 49. issue 4. 2010-05-12. PMID:20358631. |
combined stat3 inhibition by a jak2 inhibitor or gene knockdown with mek inhibition blocked stat3 activation, synergistically suppressed cell growth, and induced apoptosis in comutant cells. |
2010-05-12 |
2023-08-12 |
Not clear |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
apoptosis induced by jak2 inhibition is mediated by bim and enhanced by the bh3 mimetic abt-737 in jak2 mutant human erythroid cells. |
2010-04-27 |
2023-08-12 |
human |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
inhibition of jak2 activity leads to growth inhibition and apoptosis in cells with mutated jak2. |
2010-04-27 |
2023-08-12 |
human |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
however, the proapoptotic proteins involved in jak2 inhibition-induced apoptosis remain unclear. |
2010-04-27 |
2023-08-12 |
human |