| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
inhibition of jak2 activity leads to growth inhibition and apoptosis in cells with mutated jak2. |
2010-04-27 |
2023-08-12 |
human |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
however, the proapoptotic proteins involved in jak2 inhibition-induced apoptosis remain unclear. |
2010-04-27 |
2023-08-12 |
human |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
in this study, we show that jak2 inhibition-induced apoptosis correlated with up-regulation of the nonphosphorylated form of the bh3-only protein bim in hematopoietic cell lines bearing jak2 mutations. |
2010-04-27 |
2023-08-12 |
human |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
knockdown of bim dramatically inhibited apoptosis induced by jak2 inhibition, which was reversed by the bh3 mimetic agent abt-737. |
2010-04-27 |
2023-08-12 |
human |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
in addition, abt-737 enhanced the apoptosis induced by jak2 inhibition in jak2 v617f(+) hel and set-2 cells. |
2010-04-27 |
2023-08-12 |
human |
| Britta Will, Tanya Siddiqi, Meritxell Alberich Jordà, Takeshi Shimamura, Katarina Luptakova, Philipp B Staber, Daniel B Costa, Ulrich Steidl, Daniel G Tenen, Susumu Kobayash. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood. vol 115. issue 14. 2010-04-27. PMID:20160166. |
these data suggest that bim is a key effector molecule in jak2 inhibition-induced apoptosis and that targeting this apoptotic pathway could be a novel therapeutic strategy for patients with activating jak2 mutations. |
2010-04-27 |
2023-08-12 |
human |
| Qi Chen, Zhongzheng Lu, Yanli Jin, Yongbin Wu, Jingxuan Pa. Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1. Cancer letters. vol 291. issue 2. 2010-04-23. PMID:19942343. |
triptolide inhibits jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing jak2v617f through caspase-3-mediated cleavage of mcl-1. |
2010-04-23 |
2023-08-12 |
human |
| Chia-Wen Chang, Wan-Hua Tsai, Woei-Jer Chuang, Yee-Shin Lin, Jiunn-Jong Wu, Ching-Chuan Liu, Pei-Jane Tsai, Ming T Li. Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis. The Journal of biological chemistry. vol 284. issue 48. 2010-01-21. PMID:19801665. |
furthermore, jak2 inhibition and p38 inhibition reduced spe b-induced apoptosis, but only p38 inhibition blocked g308s-induced apoptosis. |
2010-01-21 |
2023-08-12 |
Not clear |
| Yongchao Wang, Warren Fiskus, Daniel G Chong, Kathleen M Buckley, Kavita Natarajan, Rekha Rao, Atul Joshi, Ramesh Balusu, Sanjay Koul, Jianguang Chen, Andrew Savoie, Celalettin Ustun, Anand P Jillella, Peter Atadja, Ross L Levine, Kapil N Bhall. Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells. Blood. vol 114. issue 24. 2010-01-05. PMID:19828702. |
treatment with the jak2 tk inhibitor tg101209 attenuated jak2v617f autophosphorylation and induced apoptosis of hel92.1.7 and ba/f3-jak2v617f cells. |
2010-01-05 |
2023-08-12 |
human |
| Alfons Navarro, Tania Diaz, Antonio Martinez, Anna Gaya, Aina Pons, Bernat Gel, Carles Codony, Gerardo Ferrer, Carmen Martinez, Emili Montserrat, Mariano Monz. Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma. Blood. vol 114. issue 14. 2009-12-02. PMID:19666866. |
mir-135a-mediated jak2 down-regulation led to decreased mrna and protein levels of the antiapoptotic gene bcl-xl, suggesting a role for bcl-xl in mir-135a/jak2-mediated apoptosis. |
2009-12-02 |
2023-08-12 |
Not clear |
| Megumi Funakoshi-Tago, Kenji Tago, Kazuya Sumi, Miyuki Abe, Eriko Aizu-Yokota, Tomoyuki Oshio, Yoshiko Sonoda, Tadashi Kasahar. The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice. The Journal of biological chemistry. vol 284. issue 19. 2009-07-21. PMID:19289461. |
jak2 plays important roles in the regulation of a variety of cellular processes including cell migration, proliferation, and protection from apoptosis. |
2009-07-21 |
2023-08-12 |
mouse |
| Ian L P Beales, Olorunseun O Ogunwob. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. Journal of molecular endocrinology. vol 42. issue 4. 2009-06-22. PMID:19153190. |
we conclude that g-gly inhibits apoptosis in bo and oac via mechanisms distinct from those activated by g-17 and involving jak2 and stat3 activation. |
2009-06-22 |
2023-08-12 |
Not clear |
| Gang Chen, Shiming Zhang, Jixin Shi, Jinglu Ai, Chunhua Han. Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine. vol 45. issue 3. 2009-05-14. PMID:19144539. |
another aim of the current study was to investigate the modulation of rhepo on the activity of janus kinase 2 (jak2) and signal transducer and activator of transcription 3 (stat3), which played an important role in the signaling of apoptosis. |
2009-05-14 |
2023-08-12 |
human |
| Gang Chen, Shiming Zhang, Jixin Shi, Jinglu Ai, Chunhua Han. Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine. vol 45. issue 3. 2009-05-14. PMID:19144539. |
as a result, we found that administration of rhepo could activate jak2 and stat3 in the basilar artery and decrease the apoptosis index of endothelial cells following sah. |
2009-05-14 |
2023-08-12 |
human |
| A K Samanta, S N Chakraborty, Y Wang, H Kantarjian, X Sun, J Hood, D Perrotti, R B Arlinghau. Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Oncogene. vol 28. issue 14. 2009-04-22. PMID:19234487. |
jak2 inhibition deactivates lyn kinase through the set-pp2a-shp1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. |
2009-04-22 |
2023-08-12 |
Not clear |
| A K Samanta, S N Chakraborty, Y Wang, H Kantarjian, X Sun, J Hood, D Perrotti, R B Arlinghau. Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Oncogene. vol 28. issue 14. 2009-04-22. PMID:19234487. |
inhibition of jak2 induced apoptosis and reduced colony formation in im-sensitive and -resistant bcr-abl mutant cell lines. |
2009-04-22 |
2023-08-12 |
Not clear |
| A K Samanta, S N Chakraborty, Y Wang, H Kantarjian, X Sun, J Hood, D Perrotti, R B Arlinghau. Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Oncogene. vol 28. issue 14. 2009-04-22. PMID:19234487. |
jak2 inhibition also induced apoptosis in cml cells from blast crisis patients but not in normal hematopoietic cells. |
2009-04-22 |
2023-08-12 |
Not clear |
| Sheng-Huei Yang, Ching-Ming Chien, Jung-Chen Su, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells. Journal of biochemical and molecular toxicology. vol 22. issue 6. 2009-04-08. PMID:19111001. |
taken together, these results indicate that iqdma causes significant induction of apoptosis in k562 cells via downregulation of egfr, src, bcr-abl, jak2, and stat5 signaling and modulation of p21, p27, cyclin d1, mcl-1, bcl-x(l), and vegf proteins. |
2009-04-08 |
2023-08-12 |
human |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery. Journal of nephrology. vol 21. issue 6. 2009-03-24. PMID:19034877. |
effect of jak2 kinase inhibition on stat1 and stat3 activation and apoptosis of tubular epithelial cells induced by atp depletion/recovery. |
2009-03-24 |
2023-08-12 |
human |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery. Journal of nephrology. vol 21. issue 6. 2009-03-24. PMID:19034877. |
in an in vitro model of renal ischemia/reperfusion injury (iri), we investigated the role of jak2 kinase inhibition on signal transducer and activator of transcription 1 (stat1) and stat3 activations as well as apoptosis of human proximal tubular epithelial cells (hkcs) induced by adenosine triphosphate (atp) depletion/recovery. |
2009-03-24 |
2023-08-12 |
human |