| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Fon Chen, Chien-Hsiang Chang, Zih-Ning Huang, Yu-Chu Su, Sue-Joan Chang, Jeng-Shiung Ja. The JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma. Leukemia & lymphoma. vol 60. issue 5. 2020-07-13. PMID:30277103. |
here, we report that the bioactivity of antcin h, an analog of the jak2 inhibitor zhankuic acid a (zaa), inhibits lmp1-induced jak/stat related signaling and induces lymphoma cell line apoptosis. |
2020-07-13 |
2023-08-13 |
mouse |
| Fang Gan, Xuan Zhou, Yajiao Zhou, Lili Hou, Xingxiang Chen, Cuiling Pan, Kehe Huan. Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3. Archives of toxicology. vol 93. issue 4. 2020-05-22. PMID:30923867. |
dnmt inhibitor (5-aza-2-dc), promoted socs3 expression, inhibited jak2 and stat3 expression, alleviated cytotoxicity, apoptosis and dna damage induced by ota at 4.0 µg/ml in pk15 cells. |
2020-05-22 |
2023-08-13 |
Not clear |
| Fang Gan, Xuan Zhou, Yajiao Zhou, Lili Hou, Xingxiang Chen, Cuiling Pan, Kehe Huan. Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3. Archives of toxicology. vol 93. issue 4. 2020-05-22. PMID:30923867. |
while, in pams, 5-aza-2-dc had no effects on socs3 expression induced by ota at 4.0 µg/ml, but inhibited jak2 and stat3 expression, and alleviated cytotoxicity, apoptosis and dna damage induced by ota. |
2020-05-22 |
2023-08-13 |
Not clear |
| Ya-Ru Yan, Yang Luo, Ming Zhong, Li Sha. MiR-216a inhibits proliferation and promotes apoptosis of human airway smooth muscle cells by targeting JAK2. The Journal of asthma : official journal of the Association for the Care of Asthma. vol 56. issue 9. 2020-05-08. PMID:30299194. |
mir-216a inhibits proliferation and promotes apoptosis of human airway smooth muscle cells by targeting jak2. |
2020-05-08 |
2023-08-13 |
human |
| Hui Shan, Sheng Yao, Yang Ye, Qiang Y. 3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells. Acta pharmacologica Sinica. vol 40. issue 12. 2020-04-21. PMID:31201357. |
3-deoxy-2β,16-dihydroxynagilactone e, a natural compound from podocarpus nagi, preferentially inhibits jak2/stat3 signaling by allosterically interacting with the regulatory domain of jak2 and induces apoptosis of cancer cells. |
2020-04-21 |
2023-08-13 |
Not clear |
| Ning Li, Dong Mao, Yansha Cao, Hua Li, Fu Ren, Keyan L. Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway. International journal of oncology. vol 52. issue 5. 2020-03-06. PMID:29512698. |
the proliferation and apoptotic assays demonstrated that sirt6 was able to suppress colon cancer cell proliferation and induce apoptosis via the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2020-03-06 |
2023-08-13 |
Not clear |
| Shuang Cao, Guohua Wang, Jia Wang, Cheng Li, Le Zhan. Hsa_circ_101280 promotes hepatocellular carcinoma by regulating miR-375/JAK2. Immunology and cell biology. vol 97. issue 2. 2020-01-14. PMID:30302825. |
overall, both the in vitro and in vivo studies revealed that hsa_circ_101280 largely facilitated the tumorigenesis of hcc, characterized by the promoted proliferation and suppressed apoptosis of hcc cells, by sponging mir-375 and upregulating jak2. |
2020-01-14 |
2023-08-13 |
mouse |
| Donglai Zhou, Tingting Ding, Bin Ni, Yunyan Jing, Shanxin Li. Hydroxysafflor Yellow A mitigated myocardial ischemia/reperfusion injury by inhibiting the activation of the JAK2/STAT1 pathway. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173173. |
in vivo, animals treated with hsya presented less severe myocardial injury and decreased janus kinase 2 (jak2)/signal transducer and activator of transcription 1 (stat1) activity, improved antioxidant capacity and decreased apoptosis. |
2019-12-23 |
2023-08-13 |
Not clear |
| Ji-Hye Seo, Hyun Woo Choi, Ha-Na Oh, Mee-Hyun Lee, Eunae Kim, Goo Yoon, Seung-Sik Cho, Seon-Min Park, Young Sik Cho, Jung-Il Chae, Jung-Hyun Shi. Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30070696. |
licochalcone d directly targets jak2 to induced apoptosis in human oral squamous cell carcinoma. |
2019-12-10 |
2023-08-13 |
human |
| Zhao Cheng, Yifang Yi, Sisi Xie, Haizhi Yu, Hongling Peng, Guangsen Zhan. The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling. Oncotarget. vol 8. issue 63. 2019-11-20. PMID:29290986. |
the effect of the jak2 inhibitor tg101209 against t cell acute lymphoblastic leukemia (t-all) is mediated by inhibition of jak-stat signaling and activation of the crosstalk between apoptosis and autophagy signaling. |
2019-11-20 |
2023-08-13 |
Not clear |
| Zhao Cheng, Yifang Yi, Sisi Xie, Haizhi Yu, Hongling Peng, Guangsen Zhan. The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling. Oncotarget. vol 8. issue 63. 2019-11-20. PMID:29290986. |
tg101209 initiated apoptosis and autophagy in t-all cells; therefore, this jak2 inhibitor may be a potential drug or alternative therapy for t-all. |
2019-11-20 |
2023-08-13 |
Not clear |
| PeiPei Wang, Jian Sun, SuJun Lv, Tao Xie, XueDan Wan. Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30983593. |
rat myocardial h9c2 cells were cultured in vitro and divided into 5 treatment groups in vitro; expressions of mir-15b, jak2, p-jak2, stat3, and p-stat3 in h9c2 cells were detected, and the apoptosis and ros content were detected by flow cytometry. |
2019-09-10 |
2023-08-13 |
rat |
| PeiPei Wang, Jian Sun, SuJun Lv, Tao Xie, XueDan Wan. Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30983593. |
results we found that the increased mir-15b expression during myocardial i-r injury in rats downregulated the expression of jak2 and activity of the jak2-stat3 pathway, promoted myocardial apoptosis and ros production, and aggravated myocardial i-r injury. |
2019-09-10 |
2023-08-13 |
rat |
| PeiPei Wang, Jian Sun, SuJun Lv, Tao Xie, XueDan Wan. Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30983593. |
apigenin treatment can downregulate mir-15b expression, increase the expression of jak2 and the activity of jak2-stat3 pathway, reduce myocardial apoptosis and ros production, and alleviate myocardial i-r injury. |
2019-09-10 |
2023-08-13 |
rat |
| PeiPei Wang, Jian Sun, SuJun Lv, Tao Xie, XueDan Wan. Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30983593. |
conclusions api treatment downregulated the expression of mir-15b and upregulated the expression of jak2 and the activity of the jak2-stat3 pathway, thereby alleviating myocardial i-r injury, cardiomyocyte apoptosis, and ros production in vitro. |
2019-09-10 |
2023-08-13 |
rat |
| Lintuo Huang, Zhengxiang Huang, Wenjun Lin, Lu Wang, Xiongbai Zhu, Xin Chen, Shengwu Yang, Chen L. Salidroside suppresses the growth and invasion of human osteosarcoma cell lines MG63 and U2OS in vitro by inhibiting the JAK2/STAT3 signaling pathway. International journal of oncology. vol 54. issue 6. 2019-08-30. PMID:31081055. |
furthermore, our findings demonstrated that salidroside induced the apoptosis, g0/g1 phase arrest and suppressed the invasion of osteosarcoma cells by inhibiting the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway, as determined by western blot analysis. |
2019-08-30 |
2023-08-13 |
human |
| Jing Wang, Moussa Ide Nasser, Salah Adlat, Ming Ming Jiang, Nan Jiang, Li Ga. Atractylenolide II Induces Apoptosis of Prostate Cancer Cells through Regulation of AR and JAK2/STAT3 Signaling Pathways. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-08-15. PMID:30545141. |
the cell apoptosis process induced by atr ii in both du145 and lncap cells was associated with its ability to inhibit androgen receptor (ar) with overexpression of protein inhibitor of activated stat-1 (pias1) and the repression of janus kinase (jak2) signaling pathways. |
2019-08-15 |
2023-08-13 |
human |
| Yang Wang, Hua-Jun Sun, Rong-Gui Li, Xiao-Mei Wang, Zhi-Qiang Cheng, Nan Lo. Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes. Molecular medicine reports. vol 19. issue 2. 2019-05-24. PMID:30569122. |
taken together, the results suggested that upregulated jak2 and cyclin‑b1 may be responsible for the enhanced proliferation of melanoma cells, and that bcl‑2 upregulation and bax downregulation may account for the suppressed apoptosis of these cells. |
2019-05-24 |
2023-08-13 |
mouse |
| Kendra Sweet, Lori Hazlehurst, Eva Sahakian, John Powers, Lisa Nodzon, Fadi Kayali, Kelly Hyland, Ashley Nelson, Javier Pinilla-Ibar. A phase I clinical trial of ruxolitinib in combination with nilotinib in chronic myeloid leukemia patients with molecular evidence of disease. Leukemia research. vol 74. 2019-05-14. PMID:30340199. |
preclinical evidence indicates that the bone marrow microenvironment provides a protective niche for leukemic stem cells, allowing them to evade the effects of bcr-abl tyrosine kinase inhibitors (tkis), but that targeting of the jak-stat pathway with the jak2 inhibitor ruxolitinib increases tki-induced apoptosis. |
2019-05-14 |
2023-08-13 |
Not clear |
| A N Johnston, W Bu, S Hein, S Garcia, L Camacho, L Xue, L Qin, C Nagi, S G Hilsenbeck, J Kapali, K Podsypanina, J Nangia, Y L. Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions. Breast cancer research : BCR. vol 20. issue 1. 2019-05-08. PMID:29778097. |
many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-janus kinase 2 (jak2)-signal transducer and activator of transcription 5 (stat5) signaling both induces cell differentiation and suppresses apoptosis. |
2019-05-08 |
2023-08-13 |
Not clear |