| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emira Bousoik, Hamidreza Montazeri Aliabad. "Do We Know Jack" About JAK? A Closer Look at JAK/STAT Signaling Pathway. Frontiers in oncology. vol 8. 2020-10-01. PMID:30109213. |
among the proteins in this family jak2 has been associated with important downstream proteins, including signal transducers and activators of transcription (stats), which in turn regulate the expression of a variety of proteins involved in induction or prevention of apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Feng-Tao Yi, Qi-Ping L. Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344203. |
mechanistically, muc1 inhibited irradiation-induced apoptosis through activation of janus kinase 2 (jak2) and stat3, and induction of anti-apoptotic proteins induced myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and bcl2 like 1 (bcl-xl). |
2020-09-30 |
2023-08-13 |
human |
| Zan Liu, Licheng Ren, Xu Cui, Le Guo, Bimei Jiang, Jie Zhou, Pengfei Liang, Jizhang Zeng, Zhiyou He, Pihong Zhan. Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662596. |
ex vivo, we transfected c2c12 myoblasts with lentivirus carrying the jak2 plasmid and found that jak2-overexpressed myoblasts exhibited a decrease in autophagy and apoptosis after ogd/r treatment, as well as less cell death. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zan Liu, Licheng Ren, Xu Cui, Le Guo, Bimei Jiang, Jie Zhou, Pengfei Liang, Jizhang Zeng, Zhiyou He, Pihong Zhan. Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662596. |
finally, western blot analysis determined that p-jak2, p-akt, p-mtor and p-erk1/2 levels were significantly elevated, accompanied by jak2 overexpression but without p-stat3, and inhibition of the akt and erk1/2 pathway resulted in elevated apoptosis and/or autophagy. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zan Liu, Licheng Ren, Xu Cui, Le Guo, Bimei Jiang, Jie Zhou, Pengfei Liang, Jizhang Zeng, Zhiyou He, Pihong Zhan. Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662596. |
these results demonstrated that jak2 may play an important protective role in muscular ischemia and reperfusion injury during dti development by inhibition of autophagy and apoptosis through the akt and erk1/2 pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dianhui Xiu, Dawei Wang, Jing Wang, Fujian Ji, Wenlei Zhan. MicroRNA-543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway. Oncology letters. vol 17. issue 2. 2020-09-30. PMID:30675310. |
the aim of the present study was to investigate the function of microrna-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway was a direct target of microrna-543. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mi-Ae Kang, Jongsung Lee, Sang Hoon Ha, Chang Min Lee, Kyoung Min Kim, Kyu Yun Jang, See-Hyoung Par. Interleukin4Rα (IL4Rα) and IL13Rα1 Are Associated with the Progress of Renal Cell Carcinoma through Janus Kinase 2 (JAK2)/Forkhead Box O3 (FOXO3) Pathways. Cancers. vol 11. issue 9. 2020-09-30. PMID:31540495. |
moreover, pharmacological inhibition of jak2 induced the nuclear localization of foxo3, leading to increase apoptosis and decrease cell proliferation rate in a498 and achn cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Brianna M Craver, Thanh Kim Nguyen, Jenny Nguyen, Hellen Nguyen, Christy Huynh, Sarah J Morse, Angela G Fleischma. The SMAC mimetic LCL-161 selectively targets JAK2 Experimental hematology & oncology. vol 9. 2020-09-30. PMID:31908904. |
the smac mimetic lcl-161 selectively targets jak2 evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (iaps). |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Zhang, Yan Wang, Junjie Ma, Xingqiang Lai, Jiali Fang, Guanghui Li, Lu Xu, Guanghui Pan, Zheng Che. Exogenous MSCs ameliorate hypoxia/reoxygenation injury in renal tubular epithelial cells through JAK/STAT signaling pathway-mediated regulation of HMGB1. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559991. |
when the cells were transfected with sirna stat3, the expression of stat3 at protein and mrna levels and jak2 and hmgb1 at mrna level was down-regulated; the cell viability was reduced and apoptosis increased. |
2020-09-29 |
2023-08-13 |
Not clear |
| Keyan Chen, Yingjie Sun, Yugang Diao, Tiezheng Zhang, Wanwei Don. Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncology letters. vol 16. issue 1. 2020-09-29. PMID:29928398. |
in jak2 knockdown experiments using sirna, hrs treatment following hypoxia/reoxygenation also significantly increased the viability of myocardial cells, decreased the rate of myocardial cell apoptosis, elevated the levels of sod and suppressed the release of mda and lactate dehydrogenase in the control sirna and cpb groups (p<0.05). |
2020-09-29 |
2023-08-13 |
rat |
| H Wei, W-R He, K-M Chen, X-W Wang, C-J Y. MiR-101 affects proliferation and apoptosis of cervical cancer cells by inhibition of JAK2. European review for medical and pharmacological sciences. vol 23. issue 13. 2020-09-29. PMID:31298355. |
mir-101 affects proliferation and apoptosis of cervical cancer cells by inhibition of jak2. |
2020-09-29 |
2023-08-13 |
Not clear |
| H Wei, W-R He, K-M Chen, X-W Wang, C-J Y. MiR-101 affects proliferation and apoptosis of cervical cancer cells by inhibition of JAK2. European review for medical and pharmacological sciences. vol 23. issue 13. 2020-09-29. PMID:31298355. |
this study investigated the role of mir-101 in regulating jak2 expression and affecting the proliferation and apoptosis of cervical cancer cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Hiroki Akiyama, Yoshihiro Umezawa, Daisuke Watanabe, Keigo Okada, Shinya Ishida, Ayako Nogami, Osamu Miur. Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Cancers. vol 12. issue 2. 2020-09-28. PMID:32050632. |
we here demonstrate that the usp9x inhibitor wp1130 or eoai3402143 (g9) inhibited proliferation and induced apoptosis more efficiently in cells dependent on jak2-v617f than on cytokine-activated jak2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xiaorui Hu, Lili Yuan, Teng M. Mechanisms of JAK-STAT signaling pathway mediated by CXCL8 gene silencing on epithelial-mesenchymal transition of human cutaneous melanoma cells. Oncology letters. vol 20. issue 2. 2020-09-28. PMID:32724443. |
compared with the blank group, the expression levels of jak2, stat3, vimentin and n-cadherin in cxcl8 sirna group, ag490 group and cxcl8 sirna + ag490 group were decreased, the expression of e-cadherin was increased, the cell proliferation ability was decreased and apoptosis was increased (p<0.05). |
2020-09-28 |
2023-08-13 |
human |
| Xiaorui Hu, Lili Yuan, Teng M. Mechanisms of JAK-STAT signaling pathway mediated by CXCL8 gene silencing on epithelial-mesenchymal transition of human cutaneous melanoma cells. Oncology letters. vol 20. issue 2. 2020-09-28. PMID:32724443. |
compared with cxcl8 sirna group, the expression of jak2, stat3, vimentin and n-cadherin in cxcl8 sirna + ag490 group were significantly decreased, the expression of e-cadherin was significantly increased, cell proliferation ability was decreased and apoptosis was increased (p<0.05). |
2020-09-28 |
2023-08-13 |
human |
| Jiangqiang Chen, Zuhui Che. Downregulation of miR-19a inhibits the proliferation and promotes the apoptosis of osteosarcoma cells by regulating the JAK2/STAT3 pathway. Oncology letters. vol 20. issue 5. 2020-09-28. PMID:32934740. |
the present study was designed to explore the regulatory effects of microrna (mir)-19a on the proliferation and apoptosis of osteosarcoma cells, and its influence on the activation of the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Robyn A Wong, Xujun Luo, Mimi Lu, Zhenyi An, Daphne A Haas-Kogan, Joanna J Phillips, Kevan M Shokat, William A Weiss, Qi Wen Fa. Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma. Cancer research. vol 80. issue 4. 2020-08-21. PMID:31806641. |
cooperative blockade of pkcα and jak2 drives apoptosis in glioblastoma. |
2020-08-21 |
2023-08-13 |
human |
| Robyn A Wong, Xujun Luo, Mimi Lu, Zhenyi An, Daphne A Haas-Kogan, Joanna J Phillips, Kevan M Shokat, William A Weiss, Qi Wen Fa. Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma. Cancer research. vol 80. issue 4. 2020-08-21. PMID:31806641. |
apoptosis induced by pp242 resulted from off-target cooperative inhibition of jak2 and protein kinase c alpha (pkcα). |
2020-08-21 |
2023-08-13 |
human |
| Robyn A Wong, Xujun Luo, Mimi Lu, Zhenyi An, Daphne A Haas-Kogan, Joanna J Phillips, Kevan M Shokat, William A Weiss, Qi Wen Fa. Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma. Cancer research. vol 80. issue 4. 2020-08-21. PMID:31806641. |
significance: these findings identify pkcα and jak2 as targets that drive apoptosis in glioblastoma, potentially representing a clinically translatable approach for glioblastoma. |
2020-08-21 |
2023-08-13 |
human |
| Jessica Petiti, Valentina Rosso, Marco Lo Iacono, Cristina Panuzzo, Chiara Calabrese, Elisabetta Signorino, Lucrezia Pironi, Antonio Cartellà, Enrico Bracco, Barbara Pergolizzi, Tiziana Beltramo, Carmen Fava, Daniela Cillon. Curcumin induces apoptosis in JAK2-mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways. Journal of cellular and molecular medicine. vol 23. issue 6. 2020-07-29. PMID:31033209. |
the jak2 v617f is the most common mutation in philadelphia negative patients and results in a constitutive activation of the jak/stat pathway, conferring a proliferative advantage and apoptosis inhibition. |
2020-07-29 |
2023-08-13 |
Not clear |