| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuzhen Liu, Dongmei Yu, Peng Wei, Jiansheng Cai, Min Xu, Haoyu He, Xu Tang, Chuntao Nong, Yi Wei, Xia Xu, Xiaoting Mo, Zhiyong Zhang, Jian Qi. JAK2/STAT3 Signaling Pathway and Klotho Gene in Cadmium-induced Neurotoxicity In Vitro and In Vivo. Biological trace element research. 2022-09-27. PMID:36166115. |
in comparison with the high-dose cd exposure group, after adding tyrphostin ag490 (ag490), the apoptosis rate of pc12 cells increased, whereas the phosphorylation levels of jak2 and stat3 in the cells decreased significantly (p < 0.05). |
2022-09-27 |
2023-08-14 |
rat |
| Yue Xie, Zhao-Wei Zheng, Hao-Ting He, Zhi-Bo Chan. LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer. The Kaohsiung journal of medical sciences. 2022-09-02. PMID:36054559. |
furthermore, adam28 overexpression attenuated mir-128-3p overexpression-induced apoptosis and autophagy inhibition in nsclc by increasing the phosphorylation of jak2 and stat3. |
2022-09-02 |
2023-08-14 |
mouse |
| Yu Zhang, Kun Zhuang, Shanshan Yuan, Wangli Si, Yijun Li, Jun Zhang, Jiaming Li. Effects of mir-195 Targeted Regulation of JAK2 on Proliferation, Invasion, and Apoptosis of Gastric Cancer Cells. Computational and mathematical methods in medicine. vol 2022. 2022-08-05. PMID:35928970. |
effects of mir-195 targeted regulation of jak2 on proliferation, invasion, and apoptosis of gastric cancer cells. |
2022-08-05 |
2023-08-14 |
Not clear |
| Yi-Hong Wu, Hsing-Yu Chen, Wei-Chin Hong, Chen-Ying Wei, Jong-Hwei Su Pan. Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682967. |
carboplatin-induced thrombocytopenia through jak2 downregulation, s-phase cell cycle arrest and apoptosis in megakaryocytes. |
2022-06-10 |
2023-08-14 |
mouse |
| Yunmoon Oh, Jin-Sol Lee, Ji Sun Lee, Jae Hyeon Park, Hyung Sik Kim, Sungpil Yoo. JAK2 Inhibitor, Fedratinib, Inhibits P-gp Activity and Co-Treatment Induces Cytotoxicity in Antimitotic Drug-Treated P-gp Overexpressing Resistant KBV20C Cancer Cells. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35562984. |
furthermore, vic-fedratinib had similar cytotoxic effects to co-treatment with other jak2 inhibitors (i.e., vic-cep-33779 or vic-nvp-bsk805) at the same dose; similar cytotoxic mechanisms (i.e., early apoptosis) were observed between treatments, suggesting that co-treatment with jak2 inhibitors is generally cytotoxic to p-gp-overexpressing resistant cancer cells. |
2022-05-14 |
2023-08-13 |
Not clear |
| Ashish Kumar, Ambika Sharma, Shailendra Handu, Jagjit Singh, Manisha Naithan. Molecular docking analysis of piperlongumine with different apoptotic proteins involved in Hepatocellular Carcinoma. Bioinformation. vol 17. issue 9. 2022-05-11. PMID:35539886. |
piperlongumine was docked with the hcc targets such as vascular endothelial growth factor (vegf), epidermal growth factor receptor, aurora-2, nuclear factor kappa-b (nf-kb), jak2 kinase, fibroblast growth factor receptor 4, bcl-2-like protein 1,apopain, and apoptosis regulator bcl-2 using |
2022-05-11 |
2023-08-13 |
Not clear |
| Yunmoon Oh, Jin-Sol Lee, Ji Sun Lee, Jae Hyeon Park, Hyung Sik Kim, Sungpil Yoo. Co-treatment of Low Dose Pacritinib, a Phase III Jak2 Inhibitor, Greatly Increases Apoptosis of P-gp Over-expressing Cancer Cells With Multidrug Resistance. Anticancer research. vol 42. issue 5. 2022-04-30. PMID:35489775. |
co-treatment of low dose pacritinib, a phase iii jak2 inhibitor, greatly increases apoptosis of p-gp over-expressing cancer cells with multidrug resistance. |
2022-04-30 |
2023-08-13 |
Not clear |
| Yanqiu Gao, Shuangfeng Li, Rui Dong, Xiaoyan L. Long noncoding RNA MIR3142HG accelerates lipopolysaccharide-induced acute lung injury via miR-95-5p/JAK2 axis. Human cell. 2022-03-12. PMID:35277830. |
overexpression of mir-95-5p promoted cell viability but suppressed apoptosis and inflammatory response via targeting jak2 in lps-induced ali cells. |
2022-03-12 |
2023-08-13 |
Not clear |
| Futoon Abedrabbu Al-Rawashde, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Hamid Ali Nagi Al-Jama. Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 12. 2021-12-30. PMID:34967577. |
the present study aimed to evaluate the effect of tq on the expression of bcr abl, jak2, stat3, stat5a and stat5b genes and their consequences on the cell proliferation and apoptosis in k562 cml cells. |
2021-12-30 |
2023-08-13 |
Not clear |
| Ankith Sherapura, Vikas H Malojirao, Prabhu Thirusangu, B S Sharath, Shivananda Kandagalla, V Vigneshwaran, Jurica Novak, Lakshmi Ranganatha, Y L Ramachandra, Shrinath M Baliga, Shaukath Ara Khanum, B T Prabhaka. Anti-neoplastic pharmacophore benzophenone-1 coumarin (BP-1C) targets JAK2 to induce apoptosis in lung cancer. Apoptosis : an international journal on programmed cell death. 2021-12-08. PMID:34837562. |
anti-neoplastic pharmacophore benzophenone-1 coumarin (bp-1c) targets jak2 to induce apoptosis in lung cancer. |
2021-12-08 |
2023-08-13 |
Not clear |
| Masumeh Sanaei, Fraidoon Kavoosi, Mohammad Pourahmad. Effect of Decitabine (5-aza-2'-deoxycytidine, 5-aza-CdR) in Comparison with Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) on DNMT1, DNMT3a and DNMT3b, HDAC 1-3, SOCS 1, SOCS 3, JAK2, and STAT3 Gene Expression in Hepatocellular Carcinoma HLE and LCL-PI 11 Cell Lines. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 7. 2021-11-27. PMID:34319031. |
the current study aimed to investigate the effect of decitabine (5-aza-2'-deoxycytidine, 5-aza-cdr) in comparison to vorinostat (suberoylanilide hydroxamic acid, saha) on dnmt1, dnmt3a and dnmt3b, hdac 1-3, socs 1, socs 3, jak2, and stat3 gene expression, cell growth inhibition, and apoptosis induction of hcc hle and lcl-pi 11 cell lines. |
2021-11-27 |
2023-08-13 |
Not clear |
| Yumei Ren, Yongbin Yan, Lei Zhen, Caihong Cao, Quan Wang, Yingying Zhang, Shan Zh. Zhike Pingchuan Granule suppresses interleukin (IL)-6 or the medium of M2 macrophages induced apoptosis in human bronchial epithelial cells. Bioengineered. vol 12. issue 1. 2021-11-23. PMID:34608825. |
as shown in results, zkpc perturbed the expression of il-6 inducible genes important for apoptosis, oxidative and inflammatory response, which was enhanced by jak2 inhibitor. |
2021-11-23 |
2023-08-13 |
human |
| Loukik Arora, Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Amudha Deivasigamani, Alan Prem Kumar, Ajaikumar B Kunnumakkara, Manoj Garg, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Kanchugarakoppal S Rangappa, Kam Man Hui, Gautam Sethi, Kwang Seok Ah. Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway. Cancers. vol 13. issue 21. 2021-11-18. PMID:34771643. |
tris dba decreased cell viability, increased apoptosis, and inhibited il-6 induced/constitutive activation of stat3, jak1, jak2, and src in hcc and mm cells. |
2021-11-18 |
2023-08-13 |
mouse |
| Hao Li, Wenchao Xu, Xiaming Liu, Tao Wang, Shaogang Wang, Jihong Liu, Hongyang Jian. JAK2 deficiency improves erectile function in diabetic mice through attenuation of oxidative stress, apoptosis, and fibrosis. Andrology. vol 9. issue 5. 2021-11-10. PMID:34085398. |
jak2 deficiency improves erectile function in diabetic mice through attenuation of oxidative stress, apoptosis, and fibrosis. |
2021-11-10 |
2023-08-13 |
mouse |
| Hao Li, Wenchao Xu, Xiaming Liu, Tao Wang, Shaogang Wang, Jihong Liu, Hongyang Jian. JAK2 deficiency improves erectile function in diabetic mice through attenuation of oxidative stress, apoptosis, and fibrosis. Andrology. vol 9. issue 5. 2021-11-10. PMID:34085398. |
janus kinase 2 (jak2) is activated in diabetic mellitus (dm) conditions and may enhance oxidative stress, apoptosis and fibrosis in many tissues. |
2021-11-10 |
2023-08-13 |
mouse |
| Yong Luo, Xiaobing Yang, Spyridon P Basourakos, Xuemei Zuo, Dechao Wei, Jiahui Zhao, Mingchuan Li, Qiankun Li, Tao Feng, Pengju Guo, Yongguang Jian. Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway. Frontiers in molecular biosciences. vol 8. 2021-11-10. PMID:34746227. |
then, we verified that targeting the inhibition of jak2 or stat1 could remarkably increase apoptosis and dna damage and decrease the migration of crpc cells. |
2021-11-10 |
2023-08-13 |
Not clear |
| Shujun Yang, Yaodong Song, Qiaofang Wang, Yanna Liu, Zhongwei Wu, Xiaojia Duan, Yan Zhang, Xiuqian Bi, Yuanzhang Geng, Sanyang Chen, Changju Zh. Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34075160. |
immunostaining of inflammatory and apoptotic cells was used to demonstrate lung tissue inflammation and apoptosis; elisa analysis of serum and tissue cytokine levels; and western blotting and immunohistochemical staining for the activated janus kinase 2 (jak2)-signal transducer and activator of transcription protein 3 (stat3) signalling pathway in lung tissues. |
2021-11-03 |
2023-08-13 |
mouse |
| H Wei, W-R He, K-M Chen, X-W Wang, C-J Y. MiR-101 affects proliferation and apoptosis of cervical cancer cells by inhibition of JAK2. European review for medical and pharmacological sciences. vol 25. issue 8. 2021-11-02. PMID:33928594. |
mir-101 affects proliferation and apoptosis of cervical cancer cells by inhibition of jak2. |
2021-11-02 |
2023-08-13 |
Not clear |
| H Wei, W-R He, K-M Chen, X-W Wang, C-J Y. MiR-101 affects proliferation and apoptosis of cervical cancer cells by inhibition of JAK2. European review for medical and pharmacological sciences. vol 25. issue 8. 2021-11-02. PMID:33928594. |
since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "mir-101 affects proliferation and apoptosis of cervical cancer cells by inhibition of jak2, by h. wei, w.-r. |
2021-11-02 |
2023-08-13 |
Not clear |
| Jingjie Sun, Yuping Du, Xinxin Zhang, Zhuoya Wang, Yuxi Lin, Qiaoling Song, Xiao Wang, Jihui Guo, Shanshan Li, Jing Nan, Jinbo Yan. Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3. Investigational new drugs. vol 38. issue 4. 2021-09-09. PMID:31612426. |
discovery and evaluation of atopaxar hydrobromide, a novel jak1 and jak2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated stat3. |
2021-09-09 |
2023-08-13 |
Not clear |