| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiunan Yu, Xiaohong L. microRNA-1906 protects cerebral ischemic injury through activating Janus kinase 2/signal transducer and activator of transcription 3 pathway in rats. Neuroreport. vol 31. issue 12. 2021-08-13. PMID:32427806. |
after treating with jak2/stat3 pathway inhibitor ag490, the phosphorylation of jak2 and stat3 was inhibited and the effects of mir-1906 on neurological score, infarct volume, brain water content, neuronal apoptosis and inflammatory factors were reversed. |
2021-08-13 |
2023-08-13 |
rat |
| Yumei Ren, Yuling Liu, Shouchuan Wang, Zhen Lei, Yongbin Yan, Xutao Guan, Jianghong Hou, Shan Zhu, Haijun Shan, Xinlei Tian, Quan Wang, Caihong Cao, Yingying Zhang, Yunfeng M. Zhike pingchuan granules improve bronchial asthma by regulating the IL-6/JAK2/STAT3 pathway. Experimental and therapeutic medicine. vol 22. issue 2. 2021-07-15. PMID:34257712. |
the expression of proteins related to apoptosis and the il-6/janus kinase 2 (jak2)/stat3 pathway was detected by western blot analysis. |
2021-07-15 |
2023-08-13 |
mouse |
| Xiang-Tao Zhang, Min Sun, Li Zhang, Yi-Ke Dai, Fei Wan. The potential function of miR-135b-mediated JAK2/STAT3 signaling pathway during osteoblast differentiation. The Kaohsiung journal of medical sciences. vol 36. issue 9. 2021-07-02. PMID:32319222. |
mc3t3-e1 cells in both mir-135b mimics and ag490 groups manifested decrease in cell viability, alp activity, and mineralized nodes, as well as reductions in osteoblast-specific genes and proteins of jak2, p-jak2, and p-stat3, but increase in cell apoptosis. |
2021-07-02 |
2023-08-13 |
Not clear |
| Jijun Xiong, Jie Quan, Chaosheng Qin, Xiaogang Wang, Qinghua Dong, Bingdong Zhan. Dexmedetomidine Exerts Brain-Protective Effects Under Cardiopulmonary Bypass Through Inhibiting the Janus Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 2. 2021-07-01. PMID:31834821. |
dex suppressed janus kinase 2 (jak2)/signal transducers and activators of transcription 3 (stat3) pathway activated by cpb, ameliorated cpb-induced brain injury in rats by reducing inflammatory response, and inhibited neuronal apoptosis. |
2021-07-01 |
2023-08-13 |
rat |
| Xuan-Qi Zheng, Jin-Feng Huang, Jia-Liang Lin, Ya-Xin Zhu, Min-Qi Wang, Mei-Liang Guo, Xing-Jie Zan, Ai-Min W. Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury. Colloids and surfaces. B, Biointerfaces. vol 199. 2021-06-17. PMID:33385822. |
baricitinib can effectively inhibit the jak2/stat3 pathway of microglia in vitro; while in vivo experiments show that bari-p hydrogel treatment can inhibit the phosphorylation of jak2, stat3 and suppress the production of inflammatory cytokines, and reduces neuronal apoptosis. |
2021-06-17 |
2023-08-13 |
rat |
| João Agostinho Machado-Neto, Juan Luiz Coelho-Silva, Fábio Pires de Souza Santos, Priscila Santos Scheucher, Paulo Vidal Campregher, Nelson Hamerschlak, Eduardo Magalhães Rego, Fabiola Train. Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2 Investigational new drugs. vol 38. issue 3. 2021-06-01. PMID:31286322. |
autophagy inhibition potentiates ruxolitinib-induced apoptosis in jak2 jak2 |
2021-06-01 |
2023-08-13 |
Not clear |
| Yifeng Ni, Hao Zhang, Jing Zhang, Zhi Li, Zubing L. Inhibition of JAK2 by AG490 promotes TNF-α-induced apoptosis by inhibiting autophagy in MC3T3-E1 cells. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539921. |
inhibition of jak2 by ag490 promotes tnf-α-induced apoptosis by inhibiting autophagy in mc3t3-e1 cells. |
2021-05-20 |
2023-08-13 |
Not clear |
| Yifeng Ni, Hao Zhang, Jing Zhang, Zhi Li, Zubing L. Inhibition of JAK2 by AG490 promotes TNF-α-induced apoptosis by inhibiting autophagy in MC3T3-E1 cells. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539921. |
ag490 was used to inhibit jak2 signaling, which promoted apoptosis and attenuated autophagy induced by tnf-α. |
2021-05-20 |
2023-08-13 |
Not clear |
| Yifeng Ni, Hao Zhang, Jing Zhang, Zhi Li, Zubing L. Inhibition of JAK2 by AG490 promotes TNF-α-induced apoptosis by inhibiting autophagy in MC3T3-E1 cells. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539921. |
this study demonstrated for the first time that jak2 inhibition by ag490 may play a crucial role in tnf-α-induced apoptosis by inhibiting autophagy and inhibiting the stat3, akt, and erk signaling pathways. |
2021-05-20 |
2023-08-13 |
Not clear |
| Xiaowen Bao, Jianwei Zhu, Chaoxing Ren, Ang Zhao, Mingya Zhang, Zhiming Zhu, Xuanzhao Lu, Yuning Zhang, Xiaotian Li, Xinyu Sima, Jiaqi Li, Qi Zhang, Bo M. β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways. Chemico-biological interactions. vol 342. 2021-05-19. PMID:33878321. |
the silencing of nf-κb/p65, jak2 and stat3, respectively, increased the sensitivity of the pca cells to β-ea induced apoptosis. |
2021-05-19 |
2023-08-13 |
human |
| Huiyu Yao, Yue Ma, Lily Jun-Shen Huan. Deletion of miR-451 curbs JAK2(V617F)-induced erythrocytosis in polycythemia vera by oxidative stress-mediated erythroblast apoptosis and hemolysis. Haematologica. vol 105. issue 4. 2021-04-27. PMID:31399524. |
deletion of mir-451 curbs jak2(v617f)-induced erythrocytosis in polycythemia vera by oxidative stress-mediated erythroblast apoptosis and hemolysis. |
2021-04-27 |
2023-08-13 |
Not clear |
| Ethan L Morgan, Andrew Macdonal. JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death. Cancers. vol 11. issue 12. 2021-03-10. PMID:31817106. |
here, we demonstrate that inhibiting jak2 reduces cell proliferation and induces apoptosis in hpv transformed cervical cancer cells. |
2021-03-10 |
2023-08-13 |
human |
| Ethan L Morgan, Andrew Macdonal. JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death. Cancers. vol 11. issue 12. 2021-03-10. PMID:31817106. |
finally, we demonstrate that the clinically available jak2 inhibitor ruxolitinib synergises with cisplatin in inducing apoptosis, highlighting jak2 as a promising therapeutic target in hpv-driven cancers. |
2021-03-10 |
2023-08-13 |
human |
| Sha Yang, Xiaoning Wang, Cancan Duan, Jianyong Zhan. A novel approach combining metabolomics and molecular pharmacology to study the effect of Gei Herba on mouse hematopoietic function. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-02-26. PMID:32768939. |
lbz activates pi3k/akt signaling pathways and granulocyte-colony-stimulating-factor (g-csf)-mediated janus kinase 2 (jak2)/transcription 3 (stat3), resulting in inhibiting the release of cytochrome c. further, lbz inhibits caspase-mediated mitochondrial-dependent apoptosis mediated by caspase-9 and caspase-3. |
2021-02-26 |
2023-08-13 |
mouse |
| Hua Fang, Fang-Xiang Zhang, Hua-Feng Li, Miao Yang, Ren Liao, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Jian-Ping Zhan. PRR34-AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1-dependent JAK-STAT signaling pathway. Journal of cellular physiology. vol 235. issue 3. 2020-12-17. PMID:31556112. |
upregulated prr34-as1 diminished expression of jak1, stat1, jak2, and stat3 as well as cell apoptosis, while enhancing cell proliferation in vitro. |
2020-12-17 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
reducing prlr expression and jak2 activity results in an increase in bdnf expression and inhibits the apoptosis of ca3 hippocampal neurons in a chronic mild stress model of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Yongzhi Xia, Haijian Xia, Dan Chen, Zhengbu Liao, Yi Ya. Mechanisms of autophagy and apoptosis mediated by JAK2 signaling pathway after spinal cord injury of rats. Experimental and therapeutic medicine. vol 14. issue 2. 2020-10-01. PMID:28781630. |
mechanisms of autophagy and apoptosis mediated by jak2 signaling pathway after spinal cord injury of rats. |
2020-10-01 |
2023-08-13 |
rat |
| Emira Bousoik, Hamidreza Montazeri Aliabad. "Do We Know Jack" About JAK? A Closer Look at JAK/STAT Signaling Pathway. Frontiers in oncology. vol 8. 2020-10-01. PMID:30109213. |
among the proteins in this family jak2 has been associated with important downstream proteins, including signal transducers and activators of transcription (stats), which in turn regulate the expression of a variety of proteins involved in induction or prevention of apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Feng-Tao Yi, Qi-Ping L. Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344203. |
mechanistically, muc1 inhibited irradiation-induced apoptosis through activation of janus kinase 2 (jak2) and stat3, and induction of anti-apoptotic proteins induced myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and bcl2 like 1 (bcl-xl). |
2020-09-30 |
2023-08-13 |
human |
| Zan Liu, Licheng Ren, Xu Cui, Le Guo, Bimei Jiang, Jie Zhou, Pengfei Liang, Jizhang Zeng, Zhiyou He, Pihong Zhan. Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662596. |
ex vivo, we transfected c2c12 myoblasts with lentivirus carrying the jak2 plasmid and found that jak2-overexpressed myoblasts exhibited a decrease in autophagy and apoptosis after ogd/r treatment, as well as less cell death. |
2020-09-30 |
2023-08-13 |
Not clear |