| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Wang, Dong Chen, Peihua Wang, Zhou Xu, Ying L. miR-375 prevents nasal mucosa cells from apoptosis and ameliorates allergic rhinitis via inhibiting JAK2/STAT3 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-09. PMID:29677549. |
additionally, overexpression of mir-375 reversed tnf-α-mediated nasal mucosa cells apoptosis, which was attenuated by jak2 overexpression. |
2018-10-09 |
2023-08-13 |
mouse |
| Seung Taek Lim, Ye Won Jeon, Hongki Gwak, Se Young Kim, Young Jin Su. Synergistic anticancer effects of ruxolitinib and calcitriol in estrogen receptor‑positive, human epidermal growth factor receptor 2‑positive breast cancer cells. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29436642. |
western blot analysis revealed that these synergistic effects of ruxolitinib and calcitriol were associated with reduced protein levels of jak2, phosphorylated jak2, c‑myc proto oncogene protein, cyclin‑d1, apoptosis regulator bcl‑2 and bcl‑2‑like protein 1, and with increased levels of caspase‑3 and bcl‑2‑associated agonist of cell death proteins. |
2018-08-27 |
2023-08-13 |
human |
| Mingze Chang, Lin Qiao, Bin Li, Juanhong Wang, Gejuan Zhang, Wenzhen Shi, Zhiqin Liu, Naibing Gu, Zhengli Di, Xinlai Wang, Ye Tia. Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance. Oncology reports. vol 38. issue 2. 2018-07-23. PMID:28677777. |
in addition, sirt6 restoration led to apoptosis with alterative expression of bax, bcl-2, cleaved caspase-8, and inhibition of janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway in glioma. |
2018-07-23 |
2023-08-13 |
human |
| Chunyang Du, Fang Yao, Yunzhuo Ren, Yunxia Du, Jinying Wei, Haijiang Wu, Huijun Duan, Yonghong Sh. SOCS-1 is involved in TNF-α-induced mitochondrial dysfunction and apoptosis in renal tubular epithelial cells. Tissue & cell. vol 49. issue 5. 2018-06-20. PMID:28732559. |
in addition, a specific jak2 inhibitor, ag490, that both attenuated tnf-α-induced oxidative stress, also reduced apoptosis. |
2018-06-20 |
2023-08-13 |
human |
| Jun Lei, Ju-Hua Xiao, Shou-Hua Zhang, Zhi-Qiang Liu, Kai Huang, Zhi-Peng Luo, Xin-Lan Xiao, Zheng-Dong Hon. Non-coding RNA 886 promotes renal cell carcinoma growth and metastasis through the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. Molecular medicine reports. vol 16. issue 4. 2018-05-14. PMID:28765891. |
ag490, an inhibitor of jak2, could attenuate the effects of nc886 on cell proliferation, apoptosis and invasion. |
2018-05-14 |
2023-08-13 |
human |
| Yoshihiro Umezawa, Tetsuya Kurosu, Hiroki Akiyama, Nang Wu, Ayako Nogami, Toshikage Nagao, Osamu Miur. Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells. Oncotarget. vol 7. issue 28. 2018-02-27. PMID:27286446. |
down regulation of chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for jak2 or bcr/abl in hematopoietic cells. |
2018-02-27 |
2023-08-13 |
Not clear |
| Maria Gabriela Berzoti-Coelho, Aline Fernanda Ferreira, Natalia de Souza Nunes, Mariana Tomazini Pinto, Maurício Cristiano Rocha Júnior, Belinda Pinto Simões, Carlos Martínez-A, Elizabeth Xisto Souto, Rodrigo Alexandre Panepucci, Dimas Tadeu Covas, Simone Kashima, Fabíola Attié Castr. The expression of Death Inducer-Obliterator (DIDO) variants in Myeloproliferative Neoplasms. Blood cells, molecules & diseases. vol 59. 2018-01-12. PMID:27282563. |
considerable effort is being made to understand the role of jak2(v617f) at the mpn initiation and to clarify the pathogenesis and apoptosis resistance in cml, pv, et and pmf patients. |
2018-01-12 |
2023-08-13 |
Not clear |
| Ji Hyun Cheon, Ji Yeong Kim, Byung-Mu Lee, Hyung Sik Kim, Sungpil Yoo. P-gp Inhibition by XL019, a JAK2 Inhibitor, Increases Apoptosis of Vincristine-treated Resistant KBV20C Cells with Increased p21 and pH2AX Expression. Anticancer research. vol 37. issue 12. 2017-12-19. PMID:29187454. |
p-gp inhibition by xl019, a jak2 inhibitor, increases apoptosis of vincristine-treated resistant kbv20c cells with increased p21 and ph2ax expression. |
2017-12-19 |
2023-08-13 |
Not clear |
| A M Savino, J Sarno, L Trentin, M Vieri, G Fazio, M Bardini, C Bugarin, G Fossati, K L Davis, G Gaipa, S Izraeli, L H Meyer, G P Nolan, A Biondi, G Te Kronnie, C Palmi, G Cazzanig. The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL. Leukemia. vol 31. issue 11. 2017-12-05. PMID:28331226. |
here, we found that givinostat inhibited proliferation and induced apoptosis of bcp-all crlf2-rearranged cell lines, positive for exon 16 jak2 mutations. |
2017-12-05 |
2023-08-13 |
human |
| Chao-Feng Mu, Yang Xiong, Xue Bai, Yun-Jie Sheng, Jiajun Cu. Codelivery of Ponatinib and SAR302503 by Active Bone-Targeted Polymeric Micelles for the Treatment of Therapy-Resistant Chronic Myeloid Leukemia. Molecular pharmaceutics. vol 14. issue 1. 2017-10-25. PMID:27957861. |
in this study, combined tki ponatinib and jak2 inhibitor sar302503 short-term treatment effectively suppressed growth and promoted apoptosis of baf3/t315i cells in cytokine-containing medium in vitro. |
2017-10-25 |
2023-08-13 |
mouse |
| Mariana B de Oliveira, Veruska L Fook-Alves, Angela I P Eugenio, Rodrigo C Fernando, Luiz Felipe G Sanson, Mariana F de Carvalho, Walter M T Braga, Faith E Davies, Gisele W B Colleon. Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients. Cancer letters. vol 403. 2017-09-26. PMID:28645562. |
we evaluated jak1 and jak2 expression in mm patients and the effects of jak/stat pathway inhibition on apoptosis, cell cycle, gene and protein expression in rpmi-8226 and u266 mm cell lines. |
2017-09-26 |
2023-08-13 |
Not clear |
| Azar Sheikholeslami, Mohammad Nabiuni, Ehsan Arefia. Suppressing the molecular signaling pathways involved in inflammation and cancer in breast cancer cell lines MDA-MB-231 and MCF-7 by miR-590. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 4. 2017-06-13. PMID:28443471. |
following the mir-590 treatment, jak2, pi3k, mapk1, and creb were down-regulated and the apoptosis level was increased in breast cancer cell lines. |
2017-06-13 |
2023-08-13 |
Not clear |
| L X Fu, Q W Lian, J D Pan, Z L Xu, T M Zhou, B Y. JAK2 tyrosine kinase inhibitor AG490 suppresses cell growth and invasion of gallbladder cancer cells via inhibition of JAK2/STAT3 signaling. Journal of biological regulators and homeostatic agents. vol 31. issue 1. 2017-06-01. PMID:28337870. |
as a consequence, we found that jak2 inhibitor ag490 inhibited cell growth and invasion, and induced cell apoptosis and cycle arrest in gbc-sd and sgc-996 cells. |
2017-06-01 |
2023-08-13 |
Not clear |
| Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Lou. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-05-09. PMID:28146135. |
aspalathin was able to modulate key regulators associated with lipid metabolism (adipoq, apob, cd36, cpt1, pparγ, srebf1/2, scd1 and vldlr), insulin resistance (igf1, akt1, pde3 and map2k1), inflammation (il3, il6, jak2, lepr, socs3, and tnf13) and apoptosis (bcl2 and chuk). |
2017-05-09 |
2023-08-13 |
Not clear |
| Yongsheng Yang, Qiumei Dong, Rongheng L. Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway. International journal of molecular medicine. vol 39. issue 2. 2017-03-16. PMID:28035365. |
after treatment of fls with varying conc-entrations of matrine, the jak2 inhibitor ag490, or a combination of both drugs, cell proliferation, apoptosis rate, expression of apoptotic markers and the activation of the jak/stat pathway were assessed. |
2017-03-16 |
2023-08-13 |
rat |
| Yuqing Wang, Dongfei Wang, Lizhi Zhang, Fangyu Ye, Mengmeng Li, Ke We. Role of JAK-STAT pathway in reducing cardiomyocytes hypoxia/reoxygenation injury induced by S1P postconditioning. European journal of pharmacology. vol 784. 2017-03-02. PMID:27215146. |
the data showed that s1p could significantly increase cell viability, lower the rate of apoptosis, decrease the content of lactate dehydrogenase (ldh) and caspase3 activity in the culture medium, increase the activity of total superoxide dismutase (t-sod) and manganese superoxide dismutase (mn-sod), reduce the loss of mitochondrial membrane potential and the fluorescence intensity of intracellular calcium, as well as increase the phosphorylation of jak2 and stat3 in comparison with the h/r group. |
2017-03-02 |
2023-08-13 |
rat |
| Elham Farhadi, Farhad Zaker, Majid Safa, Mohammad Reza Rezvan. miR-101 sensitizes K562 cell line to imatinib through Jak2 downregulation and inhibition of NF-κB target genes. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-28. PMID:27517565. |
according to new findings, the inhibition of janus kinase 2 (jak2) in bcr-abl+ cells can promote apoptosis in im-resistant cells. |
2017-02-28 |
2023-08-13 |
Not clear |
| Elham Farhadi, Farhad Zaker, Majid Safa, Mohammad Reza Rezvan. miR-101 sensitizes K562 cell line to imatinib through Jak2 downregulation and inhibition of NF-κB target genes. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-28. PMID:27517565. |
in this report, we proposed that mirna-101 targets jak2 mrna and regulates its expression and induces k562 leukemia cell apoptosis. |
2017-02-28 |
2023-08-13 |
Not clear |
| Ying Xu, Sheng-Xiang L. The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-13. PMID:27788478. |
the effect of jak2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via stats and pi3k/akt signaling pathways. |
2017-02-13 |
2023-08-13 |
Not clear |
| Ying Xu, Sheng-Xiang L. The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-13. PMID:27788478. |
janus kinase 2 (jak2) has been reported to play an essential role in the progression of apoptosis, autophagy and proliferation for cells. |
2017-02-13 |
2023-08-13 |
Not clear |