| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Xu, Sheng-Xiang L. The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-13. PMID:27788478. |
and apoptosis and autophagy were found in jak2 knockout liver cancer cells through activating caspase-3, cyclin-d1 and mtor regulated by stat3/5 and pi3k/akt signaling pathway. |
2017-02-13 |
2023-08-13 |
Not clear |
| Ying Xu, Sheng-Xiang L. The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-13. PMID:27788478. |
to our knowledge, it was the first time to evaluate the role of jak2 knockout in improving liver cancer from apoptosis, autophagy and proliferation, which could be a potential target for future therapeutic approach clinically. |
2017-02-13 |
2023-08-13 |
Not clear |
| Cheng-Lin Luo, Yu-Qiong Liu, Peng Wang, Chun-Hua Song, Kai-Juan Wang, Li-Ping Dai, Jian-Ying Zhang, Hua Y. The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 82. 2017-02-07. PMID:27470402. |
the effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via jak2 suppression. |
2017-02-07 |
2023-08-13 |
Not clear |
| Cheng-Lin Luo, Yu-Qiong Liu, Peng Wang, Chun-Hua Song, Kai-Juan Wang, Li-Ping Dai, Jian-Ying Zhang, Hua Y. The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 82. 2017-02-07. PMID:27470402. |
janus kinase 2 (jak2) has been reported to play an essential role in the progression of apoptosis, autophagy and proliferation for cells. |
2017-02-07 |
2023-08-13 |
Not clear |
| Wenbin Zhou, Xingjie Bi, Guojun Gao, Lijiang Su. miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-03. PMID:27710896. |
transient transfection of mir-133b and mir-135a reduced viability and induced apoptosis by inhibition of jak2 expression and its phosphorylation and activation of caspase 3 and 7 in all three ccrcc cell lines. |
2017-02-03 |
2023-08-13 |
human |
| Wenbin Zhou, Xingjie Bi, Guojun Gao, Lijiang Su. miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-03. PMID:27710896. |
our results demonstrate that mir-133b and mir-135a which are down-regulated in wildtype and mutated ccrccs, induce apoptosis in vitro by a signaling cascade involving jak2, stat3 and bcl-2. |
2017-02-03 |
2023-08-13 |
human |
| Zi Ming Zhang, Chao Shen, Hai Li, Qing Fan, Jing Ding, Fang Chun Jin, Lin Sh. Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2‑STAT3 signaling pathway. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26936086. |
it has been demonstrated that leptin is associated with the pathogenesis of oa via the janus kinase 2 (jak2)‑signal transducer and activator of transcription 3 (stat3) signaling pathway, and data gathered in the present study demonstrated that suppression of this signaling pathway using a jak2 inhibitor, ag490, significantly ameliorated leptin‑induced apoptosis in damaged chondrocytes in vitro, and reduced the generation of ros. |
2016-12-28 |
2023-08-13 |
Not clear |
| Ly Quoc Trung, J Luis Espinoza, Dao T An, Nguyen Hoang Viet, Kazuya Shimoda, Shinji Naka. Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway. Molecular nutrition & food research. vol 59. issue 11. 2016-12-13. PMID:26375873. |
resveratrol selectively induces apoptosis in malignant cells with the jak2v617f mutation by inhibiting the jak2 pathway. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yuqin He, Jinxia Yang, Hongzhu Li, Hongjiang Shao, Can Wei, Yuehong Wang, Meixiu Li, Changqing X. Exogenous spermine ameliorates high glucose-induced cardiomyocytic apoptosis via decreasing reactive oxygen species accumulation through inhibiting p38/JNK and JAK2 pathways. International journal of clinical and experimental pathology. vol 8. issue 12. 2016-11-07. PMID:26884823. |
exogenous spermine ameliorates high glucose-induced cardiomyocytic apoptosis via decreasing reactive oxygen species accumulation through inhibiting p38/jnk and jak2 pathways. |
2016-11-07 |
2023-08-13 |
rat |
| Yuqin He, Jinxia Yang, Hongzhu Li, Hongjiang Shao, Can Wei, Yuehong Wang, Meixiu Li, Changqing X. Exogenous spermine ameliorates high glucose-induced cardiomyocytic apoptosis via decreasing reactive oxygen species accumulation through inhibiting p38/JNK and JAK2 pathways. International journal of clinical and experimental pathology. vol 8. issue 12. 2016-11-07. PMID:26884823. |
taken together, the present data suggested that spermine could suppress ros accumulation to decrease cardiomyocytes apoptosis in hg condition, which may be attributed to the inhibition of p38/jnk and jak2 activation and its natural antioxidative property. |
2016-11-07 |
2023-08-13 |
rat |
| João Agostinho Machado-Neto, Paula de Melo Campos, Patricia Favaro, Mariana Lazarini, Adriana da Silva Santos Duarte, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Teresinha Olalla Saad, Fabiola Train. Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells. Oncotarget. vol 6. issue 30. 2016-08-02. PMID:26356819. |
induction of microtubule stability, through stathmin 1 silencing or paclitaxel treatment, combined with ruxolitinib could be an effective strategy for promoting apoptosis in jak2(v617f) cells. |
2016-08-02 |
2023-08-13 |
Not clear |
| Feng Li, Wei Li, Yang Liu, Yu-Xue Tong, Ping Zhou, Lin Wang, Chong Chen, Ling-Yu Zeng, Qing-Yun Wu, Xiao-Yun Wang, Kai-Lin X. Effects of the I682F mutation on JAK2's activity, structure and stability. International journal of biological macromolecules. vol 79. 2016-04-21. PMID:25940527. |
janus kinase 2 (jak2) plays important roles in the regulation of varieties cellular processes including cell migration, proliferation and apoptosis. |
2016-04-21 |
2023-08-13 |
Not clear |
| Xilong Wang, Wenxiu Qiu, Guoqiang Zhang, Shujian Xu, Qiang Gao, Zhenlin Yan. MicroRNA-204 targets JAK2 in breast cancer and induces cell apoptosis through the STAT3/BCl-2/survivin pathway. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-04-18. PMID:26191195. |
microrna-204 targets jak2 in breast cancer and induces cell apoptosis through the stat3/bcl-2/survivin pathway. |
2016-04-18 |
2023-08-13 |
human |
| Xilong Wang, Wenxiu Qiu, Guoqiang Zhang, Shujian Xu, Qiang Gao, Zhenlin Yan. MicroRNA-204 targets JAK2 in breast cancer and induces cell apoptosis through the STAT3/BCl-2/survivin pathway. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-04-18. PMID:26191195. |
knockdown of jak2 suppressed cell viability and induced apoptosis in breast cancer cells. |
2016-04-18 |
2023-08-13 |
human |
| Danny Hung-Chieh Chou, Amedeo Vetere, Amit Choudhary, Stephen S Scully, Monica Schenone, Alicia Tang, Rachel Gomez, Sean M Burns, Morten Lundh, Tamara Vital, Eamon Comer, Patrick W Faloon, Vlado Dančík, Christie Ciarlo, Joshiawa Paulk, Mingji Dai, Clark Reddy, Hanshi Sun, Matthew Young, Nicholas Donato, Jacob Jaffe, Paul A Clemons, Michelle Palmer, Steven A Carr, Stuart L Schreiber, Bridget K Wagne. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. Journal of the American Chemical Society. vol 137. issue 24. 2016-03-21. PMID:26042473. |
here, we show that the small-molecule brd0476, a novel suppressor of pancreatic β-cell apoptosis, inhibits interferon-gamma (ifn-γ)-induced janus kinase 2 (jak2) and signal transducer and activation of transcription 1 (stat1) signaling to promote β-cell survival. |
2016-03-21 |
2023-08-13 |
rat |
| Lata Chauhan, Gregory D Jenkins, Neha Bhise, Tanya Feldberg, Taraswi Mitra-Ghosh, Brooke L Fridley, Jatinder K Lamb. Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity. BMC genomics. vol 16. 2016-02-25. PMID:26121980. |
triptolide is a therapeutic diterpenoid derived from the chinese herb tripterygium wilfordii hook f. triptolide has been shown to induce apoptosis by activation of pro-apoptotic proteins, inhibiting nfkb and c-kit pathways, suppressing the jak2 transcription, activating mapk8/jnk signaling and modulating the heat shock responses. |
2016-02-25 |
2023-08-13 |
Not clear |
| Jun-Ru Liu, Wen-Juan Wu, Shu-Xia Liu, Lian-Fu Zuo, Yuan Wang, Jian-Zhu Yang, Yue-Min Na. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. Pathology, research and practice. vol 211. issue 6. 2016-02-22. PMID:25724470. |
nimesulide downregulated the phosphorylation levels of jak2 and stat3, and jak2 inhibition by ag490 significantly augmented both nimesulide-induced apoptosis and the downregulation of cox-2 and survivin (p<0.05). |
2016-02-22 |
2023-08-13 |
mouse |
| Sanguine Byun, Semi Lim, Ji Young Mun, Ki Hyun Kim, Timothy R Ramadhar, Lee Farrand, Seung Ho Shin, N R Thimmegowda, Hyong Joo Lee, David A Frank, Jon Clardy, Sam W Lee, Ki Won Le. Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. The Journal of biological chemistry. vol 290. issue 39. 2016-01-19. PMID:26242912. |
more importantly, the combined inhibition of jak2 and s6k1 by commercial inhibitors selectively induced apoptosis in cancer cells, whereas treatment with either agent alone did not. |
2016-01-19 |
2023-08-13 |
Not clear |
| Wanke Zhao, Kang Zou, Taleah Farasyn, Wanting Tina Ho, Zhizhuang Joe Zha. Generation and characterization of a JAK2V617F-containing erythroleukemia cell line. PloS one. vol 9. issue 7. 2015-11-30. PMID:25036984. |
j53z1 cells were responsive to stimulation with erythropoietin and stem cell factor and were selectively inhibited by jak2 inhibitors which induced apoptosis of the cells. |
2015-11-30 |
2023-08-13 |
mouse |
| Shu-Wei Wang, Jun Hu, Qin-Hao Guo, Yan Zhao, Jie-Jing Cheng, Dong-Sheng Zhang, Qiang Fei, Juan Li, Yue-Ming Su. AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway. Oncology reports. vol 32. issue 5. 2015-10-26. PMID:25216185. |
the results showed that, azd1480 effectively prevents constitutive and il-6-induced jak2 and stat-3 phosphorylation and exerted antitumor functional effects by a decrease in proliferation and an increase in apoptosis in crc cells. |
2015-10-26 |
2023-08-13 |
human |