| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayse Albayrak, Muhammet H Uyanik, Serkan Cerrah, Sare Altas, Hakan Dursun, Mehmet Demir, Hakan Usl. Is HMGB1 a new indirect marker for revealing fibrosis in chronic hepatitis and a new therapeutic target in treatment? Viral immunology. vol 23. issue 6. 2011-03-03. PMID:21142449. |
we believe that the inhibition of hmgb1 may reduce inflammation, apoptosis, and fibrosis, and may stop the progression of chronic liver disease. |
2011-03-03 |
2023-08-12 |
Not clear |
| Daolin Tang, Michael T Loze, Herbert J Zeh, Rui Kan. The redox protein HMGB1 regulates cell death and survival in cancer treatment. Autophagy. vol 6. issue 8. 2011-03-02. PMID:20861675. |
the prototypical damp, high-mobility group box 1 protein (hmgb1) is released with sustained autophagy, late apoptosis and necrosis. |
2011-03-02 |
2023-08-12 |
Not clear |
| Daolin Tang, Michael T Loze, Herbert J Zeh, Rui Kan. The redox protein HMGB1 regulates cell death and survival in cancer treatment. Autophagy. vol 6. issue 8. 2011-03-02. PMID:20861675. |
our recent findings reveal that the hmgb1 protein triggers autophagy or apoptosis in cancer cells, depending on its redox status. |
2011-03-02 |
2023-08-12 |
Not clear |
| Daolin Tang, Michael T Loze, Herbert J Zeh, Rui Kan. The redox protein HMGB1 regulates cell death and survival in cancer treatment. Autophagy. vol 6. issue 8. 2011-03-02. PMID:20861675. |
in contrast, oxidized hmgb1 increases the cytotoxicity of these agents and induces apoptosis via the mitochondrial pathway. |
2011-03-02 |
2023-08-12 |
Not clear |
| Daolin Tang, Michael T Loze, Herbert J Zeh, Rui Kan. The redox protein HMGB1 regulates cell death and survival in cancer treatment. Autophagy. vol 6. issue 8. 2011-03-02. PMID:20861675. |
this suggests a new function for hmgb1 within the tumor microenvironment, regulating cell death and survival and suggests that it plays an important functional role in cross-regulating apoptosis and autophagy. |
2011-03-02 |
2023-08-12 |
Not clear |
| Yoichiro Yamada, Taku Fujii, Rei Ishijima, Haruki Tachibana, Natsuki Yokoue, Ryoko Takasawa, Sei-ichi Tanum. The release of high mobility group box 1 in apoptosis is triggered by nucleosomal DNA fragmentation. Archives of biochemistry and biophysics. vol 506. issue 2. 2011-03-01. PMID:21093407. |
high mobility group box 1 (hmgb1) initially identified as a non-histone chromosomal protein, which mainly functions as chromatin structure and transcriptional regulation, has been recently reported to be secreted into extracellular milieu in necrosis and apoptosis, and act as a proinflammatory mediator. |
2011-03-01 |
2023-08-12 |
Not clear |
| Daniel James Antoine, Dominic P Williams, Anja Kipar, Hugh Laverty, B Kevin Par. Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity. Molecular medicine (Cambridge, Mass.). vol 16. issue 11-12. 2011-02-17. PMID:20811657. |
diet restriction inhibits apoptosis and hmgb1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity. |
2011-02-17 |
2023-08-12 |
mouse |
| Daniel James Antoine, Dominic P Williams, Anja Kipar, Hugh Laverty, B Kevin Par. Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity. Molecular medicine (Cambridge, Mass.). vol 16. issue 11-12. 2011-02-17. PMID:20811657. |
thus, the inhibition of caspase-driven apoptosis and hmgb1 oxidation by atp depletion from fasting promotes an inflammatory response during drug-induced hepatotoxicity/liver pathology. |
2011-02-17 |
2023-08-12 |
mouse |
| D A Abdulahad, J Westra, P C Limburg, C G M Kallenberg, M Bij. HMGB1 in systemic lupus Erythematosus: Its role in cutaneous lesions development. Autoimmunity reviews. vol 9. issue 10. 2011-02-14. PMID:20546955. |
cells die by apoptosis and eventually necrosis which both are thought to lead to release of hmgb1 into the microenvironment. |
2011-02-14 |
2023-08-12 |
Not clear |
| D Tang, R Kang, C-W Cheh, K M Livesey, X Liang, N E Schapiro, R Benschop, L J Sparvero, A A Amoscato, K J Tracey, H J Zeh, M T Lotz. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. vol 29. issue 38. 2010-10-05. PMID:20622903. |
hmgb1 release and redox regulates autophagy and apoptosis in cancer cells. |
2010-10-05 |
2023-08-12 |
Not clear |
| D Tang, R Kang, C-W Cheh, K M Livesey, X Liang, N E Schapiro, R Benschop, L J Sparvero, A A Amoscato, K J Tracey, H J Zeh, M T Lotz. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. vol 29. issue 38. 2010-10-05. PMID:20622903. |
in this study we show that the high-mobility group box 1 protein (hmgb1) is a redox-sensitive regulator of the balance between autophagy and apoptosis. |
2010-10-05 |
2023-08-12 |
Not clear |
| D Tang, R Kang, C-W Cheh, K M Livesey, X Liang, N E Schapiro, R Benschop, L J Sparvero, A A Amoscato, K J Tracey, H J Zeh, M T Lotz. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. vol 29. issue 38. 2010-10-05. PMID:20622903. |
in cancer cells, anticancer agents enhanced autophagy and apoptosis, as well as hmgb1 release. |
2010-10-05 |
2023-08-12 |
Not clear |
| D Tang, R Kang, C-W Cheh, K M Livesey, X Liang, N E Schapiro, R Benschop, L J Sparvero, A A Amoscato, K J Tracey, H J Zeh, M T Lotz. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. vol 29. issue 38. 2010-10-05. PMID:20622903. |
diminished hmgb1 by short hairpin rna transfection or inhibition of hmgb1 release by ethyl pyruvate or other small molecules led predominantly to apoptosis and decreased autophagy in stressed cancer cells. |
2010-10-05 |
2023-08-12 |
Not clear |
| D Tang, R Kang, C-W Cheh, K M Livesey, X Liang, N E Schapiro, R Benschop, L J Sparvero, A A Amoscato, K J Tracey, H J Zeh, M T Lotz. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. vol 29. issue 38. 2010-10-05. PMID:20622903. |
on the contrary, oxidized hmgb1 increases the cytotoxicity of these agents and induces apoptosis mediated by the caspase-9/-3 intrinsic pathway. |
2010-10-05 |
2023-08-12 |
Not clear |
| D Tang, R Kang, C-W Cheh, K M Livesey, X Liang, N E Schapiro, R Benschop, L J Sparvero, A A Amoscato, K J Tracey, H J Zeh, M T Lotz. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. vol 29. issue 38. 2010-10-05. PMID:20622903. |
hmgb1 release, as well as its redox state, thus links autophagy and apoptosis, representing a suitable target when coupled with conventional tumor treatments. |
2010-10-05 |
2023-08-12 |
Not clear |
| Xiaorong Hu, Xiaoya Zhou, Bo He, Changwu Xu, Liu Wu, Bo Cui, Huazhi Wen, Zhibing Lu, Hong Jian. Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. European journal of pharmacology. vol 638. issue 1-3. 2010-09-27. PMID:20406632. |
in vitro, hmgb1 could significantly decrease the cell viability and promote the apoptosis of neonatal myocytes in a dose-dependent manner. |
2010-09-27 |
2023-08-12 |
rat |
| Cho Hee Kim, Hyun Min Jeon, Su Yeon Lee, Eui Kyong Jeong, Min Kyung Ju, Bum Joon Park, Hye Gyeong Park, Sung-Chul Lim, Song Iy Han, Ho Sung Kan. Role of reactive oxygen species-dependent protein aggregation in metabolic stress-induced necrosis. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514401. |
unlike in apoptosis, where the cellular contents remain packed in the apoptotic bodies that are removed by macrophages, necrosis is characterized by cell membrane rupture, and the release of many cellular proteins including tumour promoting cytokine high mobility group box 1 (hmgb1) into the extra-cellular space. |
2010-09-27 |
2023-08-12 |
Not clear |
| Laura Ramos, Geber Peña, Bolin Cai, E A Deitch, Luis Ullo. Mast cell stabilization improves survival by preventing apoptosis in sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 1. 2010-09-01. PMID:20519642. |
mc stabilizers fail to inhibit hmgb1 secretion from macrophages, but they prevent apoptosis and caspase-3 activation in sepsis. |
2010-09-01 |
2023-08-12 |
mouse |
| Yan Yu, Min Xie, Yu-Lei He, Wang-Qiong Xu, Shan Zhu, Li-Zhi Ca. [Role of high mobility group box 1 in adriamycin-induced apoptosis in leukemia K562 cells]. Ai zheng = Aizheng = Chinese journal of cancer. vol 27. issue 9. 2010-08-31. PMID:18799030. |
this study was to explore the role of hmgb1 in adriamycin (adm)-induced apoptosis in leukemia k562 cells. |
2010-08-31 |
2023-08-12 |
Not clear |
| Hideyuki Kawabata, Takao Setoguchi, Kazunori Yone, Masakazu Souda, Hiroki Yoshida, Ko-ichi Kawahara, Ikuro Maruyama, Setsuro Komiy. High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis. Spine. vol 35. issue 11. 2010-08-13. PMID:20195207. |
in addition, relationship between upregulation of hmgb1 and neural cells apoptosis was evaluated after sci. |
2010-08-13 |
2023-08-12 |
rat |