| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akiko Kusume, Tomonori Sasahira, Yi Luo, Mamoru Isobe, Naoya Nakagawa, Naokuni Tatsumoto, Kiyomu Fujii, Hitoshi Ohmori, Hiroki Kuniyas. Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human colon cancer. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 76. issue 4. 2009-09-14. PMID:19571604. |
high mobility groupbox-1 (hmgb1) is a multifunctional cytokine secreted by cancer cells, which accelerates cell growth, invasion and angiogenesis in cancer, and induces apoptosis in macrophages. |
2009-09-14 |
2023-08-12 |
mouse |
| Kristina Mayer, Anna Vreemann, Hong Qu, Klaudia Bri. Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation. Biological chemistry. vol 390. issue 5-6. 2009-07-16. PMID:19284293. |
manipulation of iec6 cells induced necrosis rather than apoptosis, and resulted in release of hmgb1, which is known to function as a trigger of inflammatory responses in vivo. |
2009-07-16 |
2023-08-12 |
Not clear |
| Feng Liu, Yong-Ming Yao, Ning Dong, Shan Xu, Zhi-Yong Shen. [The receptor mechanism of high mobility group box-1 protein induced apoptosis in peritoneal macrophages in mice]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 23. issue 6. 2009-07-07. PMID:18457255. |
to investigate the influence of high mobility group box-1 protein (hmgb1) on apoptosis of peritoneal macrophages in mice and its receptor mechanism. |
2009-07-07 |
2023-08-12 |
mouse |
| Oliver Kepp, Antoine Tesniere, Frederic Schlemmer, Mickael Michaud, Laura Senovilla, Laurence Zitvogel, Guido Kroeme. Immunogenic cell death modalities and their impact on cancer treatment. Apoptosis : an international journal on programmed cell death. vol 14. issue 4. 2009-04-29. PMID:19145485. |
moreover, the release of high-mobility group box 1 (hmgb1) during late apoptosis and secondary necrosis contributes to efficient antigen presentation and cytotoxic t-cell activation because hmgb1 can bind to toll like receptor 4 on dendritic cells, thereby stimulating optimal antigen processing. |
2009-04-29 |
2023-08-12 |
Not clear |
| Munirathinam Gnanasekar, Sivasakthivel Thirugnanam, Kalyanasundaram Ramaswam. Short hairpin RNA (shRNA) constructs targeting high mobility group box-1 (HMGB1) expression leads to inhibition of prostate cancer cell survival and apoptosis. International journal of oncology. vol 34. issue 2. 2009-04-27. PMID:19148477. |
short hairpin rna (shrna) constructs targeting high mobility group box-1 (hmgb1) expression leads to inhibition of prostate cancer cell survival and apoptosis. |
2009-04-27 |
2023-08-12 |
Not clear |
| Munirathinam Gnanasekar, Sivasakthivel Thirugnanam, Kalyanasundaram Ramaswam. Short hairpin RNA (shRNA) constructs targeting high mobility group box-1 (HMGB1) expression leads to inhibition of prostate cancer cell survival and apoptosis. International journal of oncology. vol 34. issue 2. 2009-04-27. PMID:19148477. |
down-regulation of hmgb1 expression resulted in the inhibition of cell growth in lncap prostate cancer cells and the decreased cell number was due to transfected cells undergoing apoptosis via caspase-3-dependent pathways. |
2009-04-27 |
2023-08-12 |
Not clear |
| Yingkai Feng, Qinghua Yang, Jiancheng Xu, Guisheng Qian, Yousheng Li. Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury. Experimental and molecular pathology. vol 85. issue 3. 2008-12-17. PMID:18952078. |
effects of hmgb1 on pmn apoptosis during lps-induced acute lung injury. |
2008-12-17 |
2023-08-12 |
human |
| Yingkai Feng, Qinghua Yang, Jiancheng Xu, Guisheng Qian, Yousheng Li. Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury. Experimental and molecular pathology. vol 85. issue 3. 2008-12-17. PMID:18952078. |
to observe the effects of intravenous injection of hmgb1 inhibitor sodium butyrate on changes in apoptosis of pmn during lps-induced acute lung injury in rats and hmgb1 in vitro on human circulating pmn apoptosis, in order to clarify the role of hmgb1 in the pathogenesis of acute lung injury. |
2008-12-17 |
2023-08-12 |
human |
| Naoki Hamada, Takashige Maeyama, Tomonobu Kawaguchi, Michihiro Yoshimi, Jyutaro Fukumoto, Mizuho Yamada, Singo Yamada, Kazuyoshi Kuwano, Yoichi Nakanish. The role of high mobility group box1 in pulmonary fibrosis. American journal of respiratory cell and molecular biology. vol 39. issue 4. 2008-11-24. PMID:18441281. |
in addition, we examined the effect of hmgb1 on fibroblast proliferation, apoptosis, and collagen synthesis in vitro. |
2008-11-24 |
2023-08-12 |
mouse |
| Naoki Hamada, Takashige Maeyama, Tomonobu Kawaguchi, Michihiro Yoshimi, Jyutaro Fukumoto, Mizuho Yamada, Singo Yamada, Kazuyoshi Kuwano, Yoichi Nakanish. The role of high mobility group box1 in pulmonary fibrosis. American journal of respiratory cell and molecular biology. vol 39. issue 4. 2008-11-24. PMID:18441281. |
hmgb1 significantly induced proliferation, but not apoptosis or collagen synthesis on cultured fibroblasts. |
2008-11-24 |
2023-08-12 |
mouse |
| Jared M Huston, Haichao Wang, Mahendar Ochani, Kanta Ochani, Mauricio Rosas-Ballina, Margot Gallowitsch-Puerta, Mala Ashok, Lihong Yang, Kevin J Tracey, Huan Yan. Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 5. 2008-09-15. PMID:18714026. |
currently, it is unclear whether this accelerated lymphoid organ apoptosis contributes to systemic release of hmgb1 in sepsis. |
2008-09-15 |
2023-08-12 |
mouse |
| Jared M Huston, Haichao Wang, Mahendar Ochani, Kanta Ochani, Mauricio Rosas-Ballina, Margot Gallowitsch-Puerta, Mala Ashok, Lihong Yang, Kevin J Tracey, Huan Yan. Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 5. 2008-09-15. PMID:18714026. |
treatment with a broad-spectrum caspase inhibitor reduces systemic lymphocyte apoptosis, suppresses circulating hmgb1 concentrations, and improves survival during polymicrobial sepsis, but fails to protect septic mice following splenectomy. |
2008-09-15 |
2023-08-12 |
mouse |
| Xiang-Shun Cui, Xing-Hui Shen, Nam-Hyung Ki. High mobility group box 1 (HMGB1) is implicated in preimplantation embryo development in the mouse. Molecular reproduction and development. vol 75. issue 8. 2008-08-05. PMID:17290427. |
high mobility group box 1 (hmgb1) regulates multiple cell functions, including transcription, dna repair, differentiation, and apoptosis. |
2008-08-05 |
2023-08-12 |
mouse |
| Christian Bopp, Angelika Bierhaus, Stefan Hofer, Axel Bouchon, Peter P Nawroth, Eike Martin, Markus A Weigan. Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis. Critical care (London, England). vol 12. issue 1. 2008-06-23. PMID:18226173. |
according to experimental data, inhibiting macrophage migration inhibitory factor, high-mobility group box protein 1 (hmgb1), and complement factor c5a and inhibiting the trem-1 (triggering receptor expressed on myeloid cells 1) signaling pathway and apoptosis represent promising new therapeutic options. |
2008-06-23 |
2023-08-12 |
mouse |
| Marco E Bianchi, Angelo A Manfred. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunological reviews. vol 220. 2008-01-17. PMID:17979838. |
dcs secrete hmgb1 several hours after contact with the first maturation stimulus; hmgb1 secretion is critical for their ability to reach the lymph nodes, to sustain the proliferation of antigen-specific t cells, to prevent their activation-dependent apoptosis, and to promote their polarization towards a t-helper 1 phenotype. |
2008-01-17 |
2023-08-12 |
Not clear |
| Sung-Chul Lim, Jeong Eun Choi, Cho Hee Kim, Hong-Quan Duong, Gui-Ae Jeong, Ho Sung Kang, Song Iy Ha. Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. International journal of molecular medicine. vol 20. issue 2. 2007-10-23. PMID:17611636. |
here we show that ep prevented gd-induced necrosis and hmgb1 release and switched the cell death mode to apoptosis through inhibiting gd-induced cuzn superoxide dismutase release and ros production. |
2007-10-23 |
2023-08-12 |
Not clear |
| Dara Ditsworth, Wei-Xing Zong, Craig B Thompso. Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus. The Journal of biological chemistry. vol 282. issue 24. 2007-09-25. PMID:17430886. |
hmgb1 is normally a chromatin-associated protein and is sequestered at condensed chromatin during apoptosis. |
2007-09-25 |
2023-08-12 |
human |
| Xiang Da Eric Dong, Norimasa Ito, Michael T Lotze, Richard A Demarco, Petar Popovic, Stuart H Shand, Simon Watkins, Stephen Winikoff, Charles K Brown, David L Bartlett, Herbert J Ze. High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapy. Journal of immunotherapy (Hagerstown, Md. : 1997). vol 30. issue 6. 2007-09-24. PMID:17667523. |
we measured the release of hmgb1 after chemotherapy or immune cytolysis and demonstrated that this did not correlate with conventional markers of apoptosis and necrosis in several human colorectal, pancreatic, and melanoma tumor cell lines. |
2007-09-24 |
2023-08-12 |
human |
| Xing-Hui Shen, Yong-Xun Jin, Yeoung-Gye Ko, Hak-Jae Chung, Xiang-Shun Cui, Nam-Hyung Ki. High mobility group box 1 (HMGB1) enhances porcine parthenotes developing in vitro in the absence of BSA. Theriogenology. vol 66. issue 9. 2007-07-12. PMID:16860383. |
when cultured in ncsu23 medium supplemented with 10 or 100ng/ml hmgb1 and without bsa, apoptosis in parthenotes at the blastocyst stage was decreased (p<0.05). |
2007-07-12 |
2023-08-12 |
Not clear |
| Xing-Hui Shen, Yong-Xun Jin, Yeoung-Gye Ko, Hak-Jae Chung, Xiang-Shun Cui, Nam-Hyung Ki. High mobility group box 1 (HMGB1) enhances porcine parthenotes developing in vitro in the absence of BSA. Theriogenology. vol 66. issue 9. 2007-07-12. PMID:16860383. |
in conclusion, we inferred that recombinant hmgb1 in the culture medium in the absence of bsa prevented apoptosis of porcine parthenotes and enhanced porcine embryo viability. |
2007-07-12 |
2023-08-12 |
Not clear |