| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wang-Lin Jiang, Yong Xu, Shu-Ping Zhang, Hai-Bo Zhu, Jian Ho. Tricin 7-glucoside protects against experimental cerebral ischemia by reduction of NF-κB and HMGB1 expression. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 45. issue 1-2. 2012-05-04. PMID:22085682. |
for in vivo experiment, rats were subjected to middle cerebral artery occlusion (maco) for 1h, then followed by reperfusion for 23 h. treatment of sh-sy5y cells with tricin 7-glucoside reduced the ogd-induced apoptosis and cytotoxicity, blocked tnf-α-induced nf-κb and iκb-α phosphorylation, and decreased hmgb1 expression. |
2012-05-04 |
2023-08-12 |
rat |
| Geum-Youn Gwak, Tae Gun Moon, Dong Ho Lee, Byung Chul Yo. Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway. World journal of gastroenterology. vol 18. issue 7. 2012-04-11. PMID:22363140. |
to examine how high-mobility group box 1 (hmgb1) regulates hepatocyte apoptosis and, furthermore, to determine whether glycyrrhizin (gl), a known hmgb1 inhibitor, prevents hmgb1-induced hepatocyte apoptosis. |
2012-04-11 |
2023-08-12 |
Not clear |
| Jürgen Rödel, Christina Grosse, Hangxing Yu, Katharina Wolf, Gordon P Otto, Elisabeth Liebler-Tenorio, Vera Forsbach-Birk, Eberhard Straub. Persistent Chlamydia trachomatis infection of HeLa cells mediates apoptosis resistance through a Chlamydia protease-like activity factor-independent mechanism and induces high mobility group box 1 release. Infection and immunity. vol 80. issue 1. 2012-02-16. PMID:22025513. |
the data of this study suggest that cells infected with persistent c. trachomatis are protected from apoptosis independently of cpaf but may promote chronic inflammation through hmgb1 release. |
2012-02-16 |
2023-08-12 |
Not clear |
| Darren G N Craig, Patricia Lee, Elizabeth A Pryde, Gail S Masterton, Peter C Hayes, Kenneth J Simpso. Circulating apoptotic and necrotic cell death markers in patients with acute liver injury. Liver international : official journal of the International Association for the Study of the Liver. vol 31. issue 8. 2012-02-13. PMID:21745283. |
nucleosomes, formed during apoptosis, can complex with high-mobility group box 1 (hmgb1) protein and may play a pathogenic role in liver injury. |
2012-02-13 |
2023-08-12 |
Not clear |
| Su Yeon Lee, Hyun Min Jeon, Cho Hee Kim, Min Kyung Ju, Hye Sun Bae, Hye Gyeong Park, Sung-Chul Lim, Song Iy Han, Ho Sung Kan. Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis. Molecular cancer. vol 10. 2012-02-03. PMID:21917150. |
in contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (hmgb1), and its presence in tumor patients is associated with poor prognosis. |
2012-02-03 |
2023-08-12 |
Not clear |
| W Jiang, F Fu, J Tian, H Zhu, J Ho. Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo. Neuroscience. vol 192. 2012-01-18. PMID:21756977. |
for in vivo experiment, rats were subjected to middle cerebral artery occlusion (mcao) for 1 h, then followed by reperfusion for 23 h. treatment of sh-sy5y cells with curculigoside a reduced the oxygen-glucose deprivation-induced cytotoxicity and apoptosis, blocked tnf-α-induced nf-κb and iκb-α phosphorylation, and decreased hmgb1 expression. |
2012-01-18 |
2023-08-12 |
rat |
| Seung-Woo Kim, Chae-Moon Lim, Jung-Bin Kim, Joo-Hyun Shin, Sanghyun Lee, Minhyung Lee, Ja-Kyeong Le. Extracellular HMGB1 released by NMDA treatment confers neuronal apoptosis via RAGE-p38 MAPK/ERK signaling pathway. Neurotoxicity research. vol 20. issue 2. 2011-09-30. PMID:21116767. |
extracellular hmgb1 released by nmda treatment confers neuronal apoptosis via rage-p38 mapk/erk signaling pathway. |
2011-09-30 |
2023-08-12 |
Not clear |
| Seung-Woo Kim, Chae-Moon Lim, Jung-Bin Kim, Joo-Hyun Shin, Sanghyun Lee, Minhyung Lee, Ja-Kyeong Le. Extracellular HMGB1 released by NMDA treatment confers neuronal apoptosis via RAGE-p38 MAPK/ERK signaling pathway. Neurotoxicity research. vol 20. issue 2. 2011-09-30. PMID:21116767. |
a series of rage and hmgb1 co-immunoprecipitation experiments in the presence of sb203580 and pd98059 (p38 mapk and erk inhibitors, respectively) demonstrated that rage-p38 mapk and rage-erk pathway might underlie extracellular hmgb1-mediated neuronal apoptosis. |
2011-09-30 |
2023-08-12 |
Not clear |
| Daolin Tang, Rui Kang, Herbert J Zeh, Michael T Lotz. High-mobility group box 1, oxidative stress, and disease. Antioxidants & redox signaling. vol 14. issue 7. 2011-06-17. PMID:20969478. |
high-mobility group box 1 (hmgb1) protein, a chromatin-binding nuclear protein and damage-associated molecular pattern molecule, is integral to oxidative stress and downstream apoptosis or survival. |
2011-06-17 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
endogenous hmgb1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of tnf-α/jnk. |
2011-05-26 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
the purpose of the present study was to assess the role of hmgb1 in myocardial apoptosis induced by i/r. |
2011-05-26 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
in vivo, myocardial i/r induced an increase in myocardial hmgb1 expression and apoptosis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
inhibition of hmgb1 (a-box) ameliorated the i/r-induced myocardial apoptosis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
a/r-challenged myocytes also generated hmgb1 and underwent apoptosis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
inhibition of hmgb1 attenuated the a/r-induced myocyte apoptosis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
exogenous hmgb1 had no effect on myocyte apoptosis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
finally, a/r increased hmgb1 production in both wild-type and toll-like receptor 4-deficient myocytes; however, deficiency in toll-like receptor 4 diminished a/r-induced myocyte apoptosis, tnf-α, and jnk activation. |
2011-05-26 |
2023-08-12 |
Not clear |
| Hu Xu, Yongwei Yao, Zhaoliang Su, Yunbo Yang, Raymond Kao, Claudio M Martin, Tao Ru. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21186276. |
our results indicate that myocyte-derived hmgb1 and tnf-α work in concert to promote i/r-induced myocardial apoptosis through jnk activation. |
2011-05-26 |
2023-08-12 |
Not clear |
| Yoichiro Yamada, Taku Fujii, Rei Ishijima, Haruki Tachibana, Natsuki Yokoue, Ryoko Takasawa, Sei-Ichi Tanum. DR396, an apoptotic DNase γ inhibitor, attenuates high mobility group box 1 release from apoptotic cells. Bioorganic & medicinal chemistry. vol 19. issue 1. 2011-05-05. PMID:21167721. |
recently, hmgb1 has been shown to be secreted into extracellular milieu in necrosis and apoptosis, and involved in inflammatory responses. |
2011-05-05 |
2023-08-12 |
Not clear |
| Yoichiro Yamada, Taku Fujii, Rei Ishijima, Haruki Tachibana, Natsuki Yokoue, Ryoko Takasawa, Sei-Ichi Tanum. DR396, an apoptotic DNase γ inhibitor, attenuates high mobility group box 1 release from apoptotic cells. Bioorganic & medicinal chemistry. vol 19. issue 1. 2011-05-05. PMID:21167721. |
therefore, we examined whether apoptotic nucleosomal dna fragmentation is involved in the release of hmgb1 during apoptosis. |
2011-05-05 |
2023-08-12 |
Not clear |