| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Ma, L Rao, H L Wang, Z W Mao, R H Lei, Z Y Yang, H Qing, Y L Den. Transcriptome analysis of glioma cells for the dynamic response to γ-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas. Cell death & disease. vol 4. 2014-06-12. PMID:24176853. |
moreover, hmgb1, hmgb2 and top2a involved in the positive regulation of dna fragmentation during apoptosis showed early continual downregulation due to irradiation. |
2014-06-12 |
2023-08-12 |
human |
| Rui Kang, Qiuhong Zhang, Herbert J Zeh, Michael T Lotze, Daolin Tan. HMGB1 in cancer: good, bad, or both? Clinical cancer research : an official journal of the American Association for Cancer Research. vol 19. issue 15. 2014-03-17. PMID:23723299. |
during tumor development and in cancer therapy, hmgb1 has been reported to play paradoxical roles in promoting both cell survival and death by regulating multiple signaling pathways, including inflammation, immunity, genome stability, proliferation, metastasis, metabolism, apoptosis, and autophagy. |
2014-03-17 |
2023-08-12 |
Not clear |
| Liang Feng, Maomao Zhu, Minghua Zhang, Junfei Gu, Xiaobin Jia, Xiaobin Tan, Chenglin Gao, Quan Zh. The protection of 4,4'-diphenylmethane-bis(methyl) carbamate from Cortex Mori on advanced glycation end product-induced endothelial dysfunction: via inhibiting AGE formation or blocking AGEs-RAGE axis? Fitoterapia. vol 89. 2014-02-27. PMID:23769884. |
however, the pretreatment with cm1 could significantly decrease age or high-mobility group box-1 (hmgb1, a ligand of rage)-induced cytotoxicity, apoptosis and reactive oxygen species (ros) in human umbilical vein endothelial cells (huvecs). |
2014-02-27 |
2023-08-12 |
human |
| Daniel J Antoine, James W Dear, Philip Starkey Lewis, Vivien Platt, Judy Coyle, Moyra Masson, Ruben H Thanacoody, Alasdair J Gray, David J Webb, Jonathan G Moggs, D Nicholas Bateman, Christopher E Goldring, B Kevin Par. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology (Baltimore, Md.). vol 58. issue 2. 2014-01-16. PMID:23390034. |
in the first hospital presentation plasma sample from patients (n = 129), we measured microrna-122 (mir-122; high liver specificity), high mobility group box-1 (hmgb1; marker of necrosis), full-length and caspase-cleaved keratin-18 (k18; markers of necrosis and apoptosis), and glutamate dehydrogenase (gldh; marker of mitochondrial dysfunction). |
2014-01-16 |
2023-08-12 |
Not clear |
| Ya-Dong Dong, Long Cui, Cheng-Hong Peng, Dong-Feng Cheng, Bao-San Han, Fang Huan. Expression and clinical significance of HMGB1 in human liver cancer: Knockdown inhibits tumor growth and metastasis in vitro and in vivo. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23042506. |
knockdown of hmgb1 downregulated the expression of p-akt, ki-67 and mmp-2, inhibited the proliferative activities and metastatic potential of smmc-7721 cells, induced cell cycle arrest and apoptosis, and slowed the growth of xenograft tumors. |
2014-01-09 |
2023-08-12 |
human |
| Isabelle Martins, Oliver Kepp, Laurie Menger, Mickäel Michaud, Sandy Adjemian, Abdul Qader Sukkurwala, Erika Vacchelli, Lorenzo Galluzzi, Guido Kroeme. Fluorescent biosensors for the detection of HMGB1 release. Methods in molecular biology (Clifton, N.J.). vol 1004. 2013-12-18. PMID:23733568. |
during necrosis and following some instances of apoptosis (in particular in the absence of a proficient phagocytic system), the nonhistone chromatin component high-mobility group box 1 (hmgb1) is released in the extracellular space. |
2013-12-18 |
2023-08-12 |
human |
| Martin Schiller, Petra Heyder, Saskia Ziegler, Anna Niessen, Laura Claßen, Anna Lauffer, Hanns-Martin Loren. During apoptosis HMGB1 is translocated into apoptotic cell-derived membranous vesicles. Autoimmunity. vol 46. issue 5. 2013-12-09. PMID:23194089. |
during apoptosis hmgb1 is translocated into apoptotic cell-derived membranous vesicles. |
2013-12-09 |
2023-08-12 |
Not clear |
| Martin Schiller, Petra Heyder, Saskia Ziegler, Anna Niessen, Laura Claßen, Anna Lauffer, Hanns-Martin Loren. During apoptosis HMGB1 is translocated into apoptotic cell-derived membranous vesicles. Autoimmunity. vol 46. issue 5. 2013-12-09. PMID:23194089. |
employing immune blots we observed abundand amounts of hmgb1 in the fraction of the small membraneous particles isolated from cell culture supernatants and conclude that hmgb1 is translocated into vesicles generated during apoptosis. |
2013-12-09 |
2023-08-12 |
Not clear |
| Shr-Yun Chiou, Yu-Sheng Lee, Mei-Jy Jeng, Pei-Chen Tsao, Wen-Jue Soon. Moderate hypothermia attenuates oxidative stress injuries in alveolar epithelial A549 cells. Experimental lung research. vol 39. issue 6. 2013-11-14. PMID:23647088. |
significantly intracellular damage was found to affect the 24-hour h2o2-exposed cells in 37°c (p < .05), including an increase in apoptosis and necrosis, intracellular ros, caspase-3 activity, hmgb1 protein expression, and some alterations to the cell cycle. |
2013-11-14 |
2023-08-12 |
human |
| Yu Chen, Wei Sun, Rongfen Gao, Yuying Su, Hisanori Umehara, Lingli Dong, Feili Gon. The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis. Rheumatology (Oxford, England). vol 52. issue 10. 2013-11-13. PMID:23584368. |
only a small amount of hmgb1 release occurs during apoptosis, which undergoes oxidative modification on cys106 and delivers tolerogenic signals to suppress immune activity. |
2013-11-13 |
2023-08-12 |
Not clear |
| Hua-Sheng Ding, Jun Yang, Ping Chen, Jian Yang, Sun-Qing Bo, Jia-Wang Ding, Qin-Qin Y. The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene. vol 527. issue 1. 2013-10-22. PMID:23727604. |
the myocardial infarct size, hmgb1 levels, apoptosis index, bax, bcl-2 and tnf-α mrna levels were assessed. |
2013-10-22 |
2023-08-12 |
mouse |
| Hua-Sheng Ding, Jun Yang, Ping Chen, Jian Yang, Sun-Qing Bo, Jia-Wang Ding, Qin-Qin Y. The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene. vol 527. issue 1. 2013-10-22. PMID:23727604. |
the results showed that a lowered amount of cardiomyocyte apoptosis and infarct size in the myocardium of tlr4-mutant mice after myocardial i/r and that tlr4 deficiency notably inhibited the expression of hmgb1 and tnf-a, both of which were up-regulated by ischemia/reperfusion. |
2013-10-22 |
2023-08-12 |
mouse |
| Ryszard Smolarczyk, Tomasz Cichoń, Magdalena Jarosz, Stanisław Szal. [HMGB1--its role in tumor progression and anticancer therapy]. Postepy higieny i medycyny doswiadczalnej (Online). vol 66. 2013-09-05. PMID:23175347. |
hmgb1 protects cells from apoptosis, as it affects telomere stability. |
2013-09-05 |
2023-08-12 |
Not clear |
| Huan Yang, Daniel J Antoine, Ulf Andersson, Kevin J Trace. The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis. Journal of leukocyte biology. vol 93. issue 6. 2013-07-22. PMID:23446148. |
the many faces of hmgb1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis. |
2013-07-22 |
2023-08-12 |
Not clear |
| Daolin Tang, Timothy R Billiar, Michael T Lotz. A Janus tale of two active high mobility group box 1 (HMGB1) redox states. Molecular medicine (Cambridge, Mass.). vol 18. 2013-05-09. PMID:23073660. |
reduced hmgb1 protein promotes autophagy, whereas oxidized hmgb1 promotes apoptosis. |
2013-05-09 |
2023-08-12 |
Not clear |
| Juan A Moreno, Cristina Sastre, Julio Madrigal-Matute, Begoña Muñoz-García, Luis Ortega, Linda C Burkly, Jesús Egido, Jose L Martín-Ventura, Luis M Blanco-Coli. HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes. Arteriosclerosis, thrombosis, and vascular biology. vol 33. issue 3. 2013-04-10. PMID:23288170. |
we have analyzed the effect of tumor necrosis factor-like weak inducer of apoptosis (tweak) on hmgb1 expression both in vivo and in vitro. |
2013-04-10 |
2023-08-12 |
Not clear |
| Chunting Ye, Jang-Gi Choi, Sojan Abraham, Haoquan Wu, Dolores Diaz, Daniel Terreros, Premlata Shankar, N Manjunat. Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 51. 2013-02-28. PMID:23213216. |
moreover, targeted delivery of hmgb1 sirna to human macrophages and dendritic cells using a short acetylcholine receptor (achr)-binding peptide [rabies virus glycoprotein (rvg)-9r] effectively suppressed secretion of hmgb1, reduced the human cytokine storm, human lymphocyte apoptosis, and rescued humanized mice from clp-induced mortality. |
2013-02-28 |
2023-08-12 |
mouse |
| Isabelle Martins, Mickaël Michaud, Abdul Qader Sukkurwala, Sandy Adjemian, Yuting Ma, Shensi Shen, Oliver Kepp, Laurie Menger, Erika Vacchelli, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroeme. Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death. Autophagy. vol 8. issue 3. 2013-01-03. PMID:22361584. |
cancer cell lines stably depleted of atg5 or atg7 normally generate tumors in vivo, and such autophagy-deficient neoplasms, upon systemic treatment with icd inducers, exhibit the same levels of apoptosis (as monitored by nuclear shrinkage and caspase-3 activation) and necrosis (as determined by following the kinetics of hmgb1 release) as their autophagy-proficient counterparts. |
2013-01-03 |
2023-08-12 |
human |
| Alicia K Au, Rajesh K Aneja, Michael J Bell, Hülya Bayir, Keri Feldman, P David Adelson, Ericka L Fink, Patrick M Kochanek, Robert S B Clar. Cerebrospinal fluid levels of high-mobility group box 1 and cytochrome C predict outcome after pediatric traumatic brain injury. Journal of neurotrauma. vol 29. issue 11. 2012-12-14. PMID:22540160. |
thus, hmgb1 and cytochrome c may in part reflect the degree of necrosis and apoptosis present after traumatic brain injury (tbi), where both are felt to contribute to cell death and neurological morbidity. |
2012-12-14 |
2023-08-12 |
Not clear |
| Il-Doo Kim, Joo-Hyun Shin, Hye-Kyung Lee, Yin-Chuan Jin, Ja-Kyeong Le. Intranasal delivery of HMGB1-binding heptamer peptide confers a robust neuroprotection in the postischemic brain. Neuroscience letters. vol 525. issue 2. 2012-12-10. PMID:22877697. |
in a previous report, we showed that hmgb1 is massively released during nmda-induced acute damaging process in the postischemic brain and triggers inflammatory processes and induces neuronal apoptosis. |
2012-12-10 |
2023-08-12 |
rat |