| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Su. Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease. European journal of histochemistry : EJH. vol 69. issue 2. 2025-04-07. PMID:40191929. |
independent and interactive roles of hirudin and hmgb1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease. |
2025-04-07 |
2025-04-09 |
rat |
| Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Su. Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease. European journal of histochemistry : EJH. vol 69. issue 2. 2025-04-07. PMID:40191929. |
hmgb1 interference suppressed autophagy and apoptosis, as indicated by decreased lc3-ii/lc3-i, atg12, atg5, caspase-3, and caspase-9 levels, increased p62 expression (p<0.001), and reduced apoptosis. |
2025-04-07 |
2025-04-09 |
rat |
| Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Su. Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease. European journal of histochemistry : EJH. vol 69. issue 2. 2025-04-07. PMID:40191929. |
however, simultaneous hmgb1 interference in hirudin-treated cells weakened the therapeutic effects of hirudin, leading to increased autophagy and apoptosis markers, decreased p62 levels, and a higher renal coefficient. |
2025-04-07 |
2025-04-09 |
rat |
| Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Su. Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease. European journal of histochemistry : EJH. vol 69. issue 2. 2025-04-07. PMID:40191929. |
these findings indicate that hirudin exerts protective effects in ckd by modulating autophagy and apoptosis, potentially through hmgb1 regulation. |
2025-04-07 |
2025-04-09 |
rat |
| Li Zhang, Jian Zhang, Suqing Liu, Zhengzhou Shi, Yijian Zhu, Min Jiang, Leihong Xian. Effectiveness and Safety of Oral Compound Glycyrrhizin Followed by Phototherapy for the Treatment of Progressive Vitiligo in Children. Pigment cell & melanoma research. vol 38. issue 2. 2025-02-17. PMID:39960158. |
glycyrrhizin inhibits the release of high-mobility group box 1 (hmgb1) protein from keratinocytes, preventing melanocyte apoptosis and autophagy. |
2025-02-17 |
2025-02-23 |
Not clear |
| Guian Xu, Qingman Li, Lijie Zhu, Tingjie Yang, Yapan Yang, Honghui Yan. Exosomal ALKBH5 Alleviates Vascular Calcification by Suppressing Cell Apoptosis via m6A-Modified GSDME. Drug development research. vol 86. issue 1. 2025-02-14. PMID:39950329. |
exosomes containing alkbh5 overexpression inhibited high mobility group box 1 (hmgb1) and cell apoptosis, thereby promoting vascular calcification, whereas alkbh5 knockdown in exosomes exerted the opposite effect on calcification development. |
2025-02-14 |
2025-02-16 |
human |
| Guian Xu, Qingman Li, Lijie Zhu, Tingjie Yang, Yapan Yang, Honghui Yan. Exosomal ALKBH5 Alleviates Vascular Calcification by Suppressing Cell Apoptosis via m6A-Modified GSDME. Drug development research. vol 86. issue 1. 2025-02-14. PMID:39950329. |
overexpression of gsdme reversed the effects of alkbh5 in exosomes on hmgb1 expression and cell apoptosis. |
2025-02-14 |
2025-02-16 |
human |
| Xiaojuan Hu, Jiayao Feng, Chengjie Pan, Zhenzhen Sun, Jiechen Liu, Shuang Xie, Decheng Xiao, Xiaoyin Ma, Qinxiang Zheng, Wei Che. HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis. Investigative ophthalmology & visual science. vol 66. issue 2. 2025-02-04. PMID:39903181. |
hypertonic stress can induce apoptosis, inflammation, and dry eye disease (ded) through the upregulation of hmgb1 expression. |
2025-02-04 |
2025-02-07 |
Not clear |
| Ruisong Ma, Xiaochun Hu, Wenwen Fu, Xiaorong H. IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway. PloS one. vol 20. issue 1. 2025-01-30. PMID:39883639. |
we found that il-34 pretreatment increased the expression of inflammatory cytokines, including high mobility group box 1 (hmgb1), il-17a, and il-6; the expression of the apoptosis protein cleaved caspase-3; and the bcl-2/bax ratio within the ischemic myocardium. |
2025-01-30 |
2025-02-02 |
rat |
| Juhua Ji, Fei Hong, Yi Liu, Xiaobin Chu, Lei Song, Meijun Zhu, Yan Lu, Chuangli Ha. Long Noncoding RNA GAS5 Contributes to Mycoplasma pneumoniae Pneumonia by Regulating NF-κB via miR-29c/HMGB1 Axis. The Tohoku journal of experimental medicine. vol 264. issue 4. 2025-01-22. PMID:39019594. |
mir-29c mimic and knockdown of hmgb1 both significantly impeded lamps-induced apoptosis, il-6 and tnf- |
2025-01-22 |
2025-01-25 |
mouse |
| Meihua Lin, Xi Wu, Shuang Zhan. Sufentanil attenuates renal ischemia-reperfusion injury via the lncRNA KCNQ1OT1/miR-211-5p/HMGB1 axis. Pathology, research and practice. vol 266. 2025-01-12. PMID:39799887. |
furthermore, mir-211-5p targets the 3'utr of high mobility group box1 (hmgb1), and hmgb1 reversed the inhibitory effects of mir-211-5p mimic or sufentanil on cell proliferation, apoptosis, oxidative stress, and inflammation. |
2025-01-12 |
2025-01-16 |
rat |
| Ye Peng, Long Hu, Huilei Xu, Jian Fang, Hongliang Zhon. Resveratrol alleviates reactive oxygen species and inflammation in diabetic retinopathy via SIRT1/HMGB1 pathway-mediated ferroptosis. Toxicology and applied pharmacology. 2024-12-24. PMID:39719253. |
then, cell viability, apoptosis, reactive oxygen species (ros) levels, pro-inflammatory factors, and expression of the related proteins sirt1, hmgb1, vegf, and cd31 were assayed by a series of cell biology methods. |
2024-12-24 |
2024-12-27 |
mouse |
| Sayantap Datta, Mohammad Atiqur Rahman, Saisudha Koka, Krishna M Boin. High Mobility Group Box 1 (HMGB1): Molecular Signaling and Potential Therapeutic Strategies. Cells. vol 13. issue 23. 2024-12-17. PMID:39682695. |
high mobility group box 1 (hmgb1) is a highly conserved non-histone chromatin-associated protein across species, primarily recognized for its regulatory impact on vital cellular processes, like autophagy, cell survival, and apoptosis. |
2024-12-17 |
2024-12-21 |
Not clear |
| Yuanyuan Wu, Yanan Wang, Fei Chen, Cheng Han, Lili Huang, Wenli Sai, Yaping Fan, Nigel J Brunskill, Bin Yan. Co-treatment with erythropoietin derived HBSP and caspase-3 siRNA: A promising approach to prevent fibrosis after acute kidney injury. Journal of cellular and molecular medicine. vol 28. issue 23. 2024-12-04. PMID:39628378. |
serum creatinine, apoptosis, active caspase-3 and high mobility group protein b1 (hmgb1) in kidneys were decreased by hbsp, casp3sirna or both, with increased pcna. |
2024-12-04 |
2024-12-06 |
mouse |
| Xiaohong Chen, Junyi Wu, Meng Liu, Zheng Han, Jie Tan, Qingxi Zhu, Xiaodong Huang, Xia Tia. HMGB1 impacts the intestinal epithelial barrier by initiating NETs to regulate macrophage polarization. General physiology and biophysics. vol 43. issue 6. 2024-11-25. PMID:39584299. |
additionally, we observed that macrophages induced by nets containing hmgb1 can prompt caco-2 cell apoptosis and exacerbate the inflammatory response. |
2024-11-25 |
2024-11-27 |
Not clear |
| Fengqin Luo, Juan Zhang, Yunfei Miao, Danhong Wu, Hongxia Shen, Man L. Paeoniflorin regulates microglia-astrocyte crosstalk, inhibits inflammatory response, and alleviates neuropathic pain through HSP90AA1/HMGB1 signaling pathway. The international journal of biochemistry & cell biology. 2024-10-12. PMID:39395636. |
paeoniflorin alleviated mechanical abnormal pain, decreased levels of ionized calcium binding adapter molecule-1 (iba-1), glial fibrillary acidic protein, heat shock protein 90 alpha family class a member 1 (hsp90aa1, inflammatory factor) and high mobility group box 1 (hmgb1, inflammation-related protein), and inhibited neuronal apoptosis in chronic constrictive injury rats or lipopolysaccharide-induced bv-2 cells. |
2024-10-12 |
2024-10-15 |
mouse |
| Rufaida Wasim, Aditya Singh, Anas Islam, Saad Mohammed, Aamir Anwar, Tarique Mahmoo. High Mobility Group Box 1 and Cardiovascular Diseases: Study of Act and Connect. Cardiovascular toxicology. 2024-09-06. PMID:39242448. |
maintaining normal nuclear hmgb1 levels, interestingly, protects cardiomyocytes from apoptosis by limiting dna oxidative stress, and mice with hmgb1cardiomyocyte-specific overexpression are partially protected from cardiac injury. |
2024-09-06 |
2024-09-10 |
mouse |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. Corrigendum to "DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA" [Brain Behav. Immun. 73 (2018) 482-492]. Brain, behavior, and immunity. 2024-08-24. PMID:39181822. |
corrigendum to "dna binding protein hmgb1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with osa" [brain behav. |
2024-08-24 |
2024-08-28 |
Not clear |
| Maaly A Abd Elmaaboud, Ahmed M Kabel, Hany M Borg, Amr A Magdy, Shaimaa M Kabel, El-Shaimaa A Arafa, Shuruq E Alsufyani, Hany H Ara. Omarigliptin/rosinidin combination ameliorates cyclophosphamide-induced lung toxicity in rats: The interaction between glucagon-like peptide-1, TXNIP/NLRP3 inflammasome signaling, and PI3K/Akt/FoxO1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-27. PMID:38936197. |
both omarigliptin and rosinidin exhibited a synergistic ability to augment the tissue antioxidant defenses, mitigate the inflammatory pathways, restore glucagon-like peptide-1 levels, modulate high mobility group box 1 (hmgb1)/receptors of advanced glycation end products (rage)/nuclear factor kappa b (nf-κb) axis, downregulate the fibrogenic mediators, and create a balance between the pathways involved in apoptosis and the autophagy signals in the pulmonary tissues. |
2024-06-27 |
2024-06-30 |
rat |
| Kei Goto, Rina Fujiwara-Tani, Shota Nukaga, Yoshihiro Miyagawa, Isao Kawahara, Ryoichi Nishida, Ayaka Ikemoto, Rika Sasaki, Ruiko Ogata, Shingo Kishi, Yi Luo, Kiyomu Fujii, Hitoshi Ohmori, Hiroki Kuniyas. Berberine Improves Cancer-Derived Myocardial Impairment in Experimental Cachexia Models by Targeting High-Mobility Group Box-1. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38731953. |
our mechanistic investigations revealed that hmgb1 activated both nuclear factor κb and phosphoinositide 3-kinases-akt signals through hmgb1 receptors, namely the receptor for advanced glycation end products and toll-like receptor-4, thereby promoting apoptosis and autophagy. |
2024-05-11 |
2024-05-27 |
rat |