| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sucharita Patra, Pritam Kumar Roy, Ankita Dey, Mahitosh Manda. Impact of HMGB1 on cancer development and therapeutic insights focused on CNS malignancy. Biochimica et biophysica acta. Reviews on cancer. 2024-05-03. PMID:38701938. |
notably, hmgb1 exhibits tumor-suppressive roles by inducing apoptosis, limiting cellular proliferation, and enhancing the sensitivity of gbm to therapeutic interventions. |
2024-05-03 |
2024-05-06 |
Not clear |
| Jinlian Liu, Ke Song, Bingqi Lin, Zhenfeng Chen, Zirui Zuo, Yixing Fang, Qi He, Xiaodan Yao, Zhifeng Liu, Qiaobing Huang, Xiaohua Gu. HMGB1 promotes neutrophil PD-L1 expression through TLR2 and mediates T cell apoptosis leading to immunosuppression in sepsis. International immunopharmacology. vol 133. 2024-04-22. PMID:38648712. |
hmgb1 promotes neutrophil pd-l1 expression through tlr2 and mediates t cell apoptosis leading to immunosuppression in sepsis. |
2024-04-22 |
2024-04-26 |
mouse |
| Xin Qi, Xin Chen, Wen-Bo An, Zhi-Ming Xu, Duo-Xian Wang, Peng-Fei Luo, Yi-Xin Chen, Jiao-Jiao Ma, Zi-Yang Hu, Wei Qi, Jian-Jun Liu, Jun-Xi Li. [Ligusticum cycloprolactam inhibits IL-1β-induced apoptosis and inflammation of rat chondrocytes via HMGB1/TLR4/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621908. |
the modeled chondrocytes showed increased apoptosis rate, promoted expression of cox-2, pge2, and tnf-α, up-regulated protein levels of bax, caspase-3, hmgb1, tlr4, and nf-κb p65 and mrna levels of hmgb1, tlr4, nf-κb p65, and myd88, and down-regulated protein level of bcl-2. |
2024-04-15 |
2024-04-18 |
rat |
| Yu Meng, Shuqi Meng, Yu Zhang, Yu Song, Enquan Wang, Guolin Wang, Keliang Xie, Yan Cu. THE PROTECTIVE EFFECT OF DEXMEDETOMIDINE ON THE LIVER INJURY IN SEPSIS THROUGH INHIBITION OF NECROPTOSIS. Shock (Augusta, Ga.). vol 61. issue 3. 2024-03-29. PMID:38320216. |
liver pathological changes and apoptosis, the contents of il-6 and tnf-α in liver tissue homogenates, the ros content in liver tissue, and the expression levels of rip1, rip3, mlkl, and hmgb1 were detected. |
2024-03-29 |
2024-04-01 |
rat |
| Yu Meng, Shuqi Meng, Yu Zhang, Yu Song, Enquan Wang, Guolin Wang, Keliang Xie, Yan Cu. THE PROTECTIVE EFFECT OF DEXMEDETOMIDINE ON THE LIVER INJURY IN SEPSIS THROUGH INHIBITION OF NECROPTOSIS. Shock (Augusta, Ga.). vol 61. issue 3. 2024-03-29. PMID:38320216. |
the morphological impairment of liver tissues, increased apoptosis, elevated inflammatory factors (il-6 and tnf-α), increased ros level, and necroptosis components (rip1, rip3, mlkl, and hmgb1) were all observed in sepsis rats. |
2024-03-29 |
2024-04-01 |
rat |
| Shuang Chen, Jingrui Pan, Zhe Gong, Meiling Wu, Xiaoni Zhang, Hansen Chen, Dan Yang, Suhua Qi, Ying Peng, Jiangang She. Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia-reperfusion injury. Journal of neuroinflammation. vol 21. issue 1. 2024-03-22. PMID:38515139. |
the hocl promoted disulfide hmgb1 translocation and secretion and aggravated ogd/r-induced apoptosis. |
2024-03-22 |
2024-03-24 |
rat |
| Pengfei Jiao, Yingrui Wang, Gaofei Ren, Dan Chu, Yameng Li, Yingwu Yang, Tianqing San. Urolithin A exerts a protective effect on lipopolysaccharide-induced acute lung injury by regulating HMGB1-mediated MAPK and NF-κB signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. 2024-02-06. PMID:38319388. |
hmgb1 overexpression greatly abrogated the inhibition of ua on inflammation, ros, and cell apoptosis in lps-administrated beas-2b. |
2024-02-06 |
2024-02-09 |
mouse |
| Pengfei Jiao, Yingrui Wang, Gaofei Ren, Dan Chu, Yameng Li, Yingwu Yang, Tianqing San. Urolithin A exerts a protective effect on lipopolysaccharide-induced acute lung injury by regulating HMGB1-mediated MAPK and NF-κB signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. 2024-02-06. PMID:38319388. |
ua alleviated lung inflammation, oxidative stress, and apoptosis in ali by targeting hmgb1 to inactivate the mapk/nf-κb signaling, suggesting the potential of ua to treat ali. |
2024-02-06 |
2024-02-09 |
mouse |
| Ruiye Qiu, Yajuan Zhang, Jun Li, Jun Wu, Ruifeng H. Influences of microRNA-451 on the expression of HMGB1 in myocardial cells and its mechanism in ischemia-reperfusion injury. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279466. |
mir-451 up-regulation can inhibit hmgb1 expression, relieve iri, and protect myocardial cells, which may be achieved by improving oxidative stress injury and inhibiting cell apoptosis. |
2024-01-27 |
2024-01-29 |
rat |
| Hong-Mei You, Ling Wang, Hong-Wu Meng, Cheng Huang, Guo-Ying Fang, Jun L. Pyroptosis: shedding light on the mechanisms and links with cancers. Frontiers in immunology. vol 14. 2023-11-28. PMID:38016064. |
pyroptosis, a novel form of programmed cell death (pcd) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin dna fragmentation, and the release of intracellular proinflammatory contents, such as interleukin (il) 8, il-1β, atp, il-1α, and high mobility group box 1 (hmgb1). |
2023-11-28 |
2023-12-07 |
human |
| Ruochan Chen, Ju Zou, Xiao Zhong, Jie Li, Rui Kang, Daolin Tan. HMGB1 in the interplay between autophagy and apoptosis in cancer. Cancer letters. 2023-11-25. PMID:38007142. |
hmgb1 in the interplay between autophagy and apoptosis in cancer. |
2023-11-25 |
2023-11-28 |
human |
| Ruochan Chen, Ju Zou, Xiao Zhong, Jie Li, Rui Kang, Daolin Tan. HMGB1 in the interplay between autophagy and apoptosis in cancer. Cancer letters. 2023-11-25. PMID:38007142. |
high-mobility group box 1 (hmgb1), a nonhistone chromosomal protein, plays a pivotal role in coordinating autophagy and apoptosis levels during tumor initiation, progression, and therapy. |
2023-11-25 |
2023-11-28 |
human |
| Ruochan Chen, Ju Zou, Xiao Zhong, Jie Li, Rui Kang, Daolin Tan. HMGB1 in the interplay between autophagy and apoptosis in cancer. Cancer letters. 2023-11-25. PMID:38007142. |
the regulation of autophagy machinery and the apoptosis pathway by hmgb1 is influenced by various factors, including the protein's subcellular localization, oxidative state, and interactions with binding partners. |
2023-11-25 |
2023-11-28 |
human |
| Fangyu An, Bai Sun, Ying Liu, Chunmei Wang, Xiaxia Wang, Jiayu Wang, Yongqi Liu, Chunlu Ya. Advances in understanding effects of miRNAs on apoptosis, autophagy, and pyroptosis in knee osteoarthritis. Molecular genetics and genomics : MGG. 2023-11-02. PMID:37914978. |
furthermore, we note that p2x7r and hmgb1 may be crucial regulatory molecules involved in the interconnected regulation of apoptosis, autophagy, and pyroptosis in koa. |
2023-11-02 |
2023-11-08 |
Not clear |
| Qianwen Zhang, Yiyu He, Hao Xu, Yuqiao Zeng, Li Wang, Zengxi Xue, Qingyun Sun, Likun Wan. MicroRNA-181a-5p alleviates acute liver failure in mice by inhibiting HMGB1. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 9. 2023-10-09. PMID:37807324. |
microrna-181a-5p could directly target hmgb1 mrna and repress its expressions, in further hmgb1 is involved in microrna-181a-5p effect on cell apoptosis of alf. |
2023-10-09 |
2023-10-15 |
mouse |
| Qianwen Zhang, Yiyu He, Hao Xu, Yuqiao Zeng, Li Wang, Zengxi Xue, Qingyun Sun, Likun Wan. MicroRNA-181a-5p alleviates acute liver failure in mice by inhibiting HMGB1. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 9. 2023-10-09. PMID:37807324. |
in conclusion, these findings demonstrate that microrna-181a-5p regulates hepatocyte apoptosis via hmgb1 in the development of alf, which may provide potential therapeutic targets for alf. |
2023-10-09 |
2023-10-15 |
mouse |
| Kevin P Gillespie, Ross Pirnie, Clementina Mesaros, Ian A Blai. Cisplatin Dependent Secretion of Immunomodulatory High Mobility Group Box 1 (HMGB1) Protein from Lung Cancer Cells. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759736. |
in contrast, mainly oxidized forms of hmgb1 were secreted by dimethyl sulfoxide (dmso)-mediated apoptosis. |
2023-09-28 |
2023-10-07 |
human |
| De-Wei He, De-Zhao Liu, Xiao-Zhi Luo, Chuan-Bin Chen, Chuang-Hong Lu, Na Na, Feng Huan. HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice. Biological chemistry. 2023-09-28. PMID:37768929. |
collectively, this study indicates that the hmgb1-rage axis aggravated diabetic mi/ri via apoptosis and pink1/parkin mediated autophagy pathways, and inhibition of hmgb1 or rage contributes to alleviating those adverse situations. |
2023-09-28 |
2023-10-07 |
mouse |
| Sourour Idoudi, Takwa Bedhiafi, Shona Pedersen, Mohamed Elahtem, Izzaldin Alremawi, Sabah Akhtar, Said Dermime, Maysaloun Merhi, Shahab Uddi. Role of HMGB1 and its associated signaling pathways in human malignancies. Cellular signalling. 2023-09-27. PMID:37757902. |
hmgb1 has been reported to regulate several signaling pathways engaged in inflammation, genome stability, immune function, cell proliferation, cell autophagy, metabolism, and apoptosis. |
2023-09-27 |
2023-10-07 |
human |
| Ahsas Goyal, Anant Agrawal, Nandini Dubey, Aanchal Verm. High Mobility Group Box 1 Protein: A Plausible Therapeutic Molecular Target in Parkinson's disease. Current pharmaceutical biotechnology. 2023-09-06. PMID:37670710. |
given that hmgb1 regulates mitochondrial dysfunction, participates in neuroinflammation, and modulates autophagy and apoptosis, it is hypothesised that hmgb1 has significance in the onset of pd. |
2023-09-06 |
2023-10-07 |
Not clear |