| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teodora Oltean, Lien Lippens, Kelly Lemeire, Caroline De Tender, Marnik Vuylsteke, Hannelore Denys, Katrien Vandecasteele, Peter Vandenabeele, Sandy Adjemia. Association of Cell Death Markers With Tumor Immune Cell Infiltrates After Chemo-Radiation in Cervical Cancer. Frontiers in oncology. vol 12. 2022-07-29. PMID:35903697. |
pre-treatment tumor biopsy and post-treatment hysterectomy samples were stained for cell death markers and danger associated molecular patterns (damps): cleaved caspase-3 (apoptosis), phosphorylated mixed lineage kinase domain like pseudokinase (pmlkl; necroptosis), glutathione peroxidase 4 (gpx4; ferroptosis) and 4-hydroxy-2-noneal (4-hne; ferroptosis), high mobility group box 1 (hmgb1) and calreticulin. |
2022-07-29 |
2023-08-14 |
Not clear |
| Peng Fang, Bo Dou, Weixin Hou, Xiaoyi Wei, Jiajun Liang, Chongyang Ma, Qiuyun Zhan. Jieduan-Niwan Formula Ameliorates Oxidative Stress and Apoptosis in Acute-on-Chronic Liver Failure by Suppressing HMGB1/TLR-4/NF- Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-07-25. PMID:35873636. |
therefore, the present study investigated whether jdnw inhibits the overexpression and cytoplasmic translocation of hmgb1 in aclf liver tissue and alleviates its mediated oxidative stress and apoptosis. |
2022-07-25 |
2023-08-14 |
rat |
| Fei He, Lina Gu, Nan Cai, Jun Ni, Yong Liu, Quan Zhang, Chao W. The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2022-07-24. PMID:35871648. |
apoptosis plays a major role in the progression of acute respiratory distress syndrome (ards) that may involve the interaction of the high mobility group box 1 (hmgb1) protein with the receptor for advanced glycation end products (rage). |
2022-07-24 |
2023-08-14 |
Not clear |
| L Zhang, S Miao, Z Yang, Z Li, Y Fan, K Yu, K Huang, Q Huang, X Xi. [Suppression of HMGB1 inhibits neuronal autophagy and apoptosis to improve neurological deficits in rats following intracerebral hemorrhage]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 42. issue 7. 2022-07-23. PMID:35869769. |
[suppression of hmgb1 inhibits neuronal autophagy and apoptosis to improve neurological deficits in rats following intracerebral hemorrhage]. |
2022-07-23 |
2023-08-14 |
rat |
| L Zhang, S Miao, Z Yang, Z Li, Y Fan, K Yu, K Huang, Q Huang, X Xi. [Suppression of HMGB1 inhibits neuronal autophagy and apoptosis to improve neurological deficits in rats following intracerebral hemorrhage]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 42. issue 7. 2022-07-23. PMID:35869769. |
to investigate the effect of suppressing high-mobility group box 1 (hmgb1) on neuronal autophagy and apoptosis in rats after intracerebral hemorrhage (ich) in rats. |
2022-07-23 |
2023-08-14 |
rat |
| Zhiwu Wu, Meihua L. High-Mobility Group Box 1 in Spinal Cord Injury and Its Potential Role in Brain Functional Remodeling After Spinal Cord Injury. Cellular and molecular neurobiology. 2022-06-17. PMID:35715656. |
hmgb1 expression has been reported to be increased in the tissues of spinal cord injury (sci) patients and involved in the regulation of neuroinflammation, neuronal apoptosis, and ferroptosis. |
2022-06-17 |
2023-08-14 |
Not clear |
| Amir Raoofi, Ali Delbari, Davood Nasiry, Rahim Golmohammadi, Sara Sadat Javadinia, Reza Sadrzadeh, Mohammad-Shafi Mojadadi, Auob Rustamzadeh, Amin Mousavi Khaneghah, Vahid Ebrahimi, Mohammad Jafar Rezai. Caffeine modulates apoptosis, oxidative stress, and inflammation damage induced by tramadol in cerebellum of male rats. Journal of chemical neuroanatomy. 2022-06-06. PMID:35660069. |
at the end of study (day 21), after performing rotarod behavioral test, cerebellum tissue samples were removed and prepared for further evaluations including biochemical profile markers (mda, gpx, and sod), immunohistochemistry for caspase-3, as well as the expression of genes involved in cellular processes such as inflammation markers (il-1β, hmgb1, il-6, and tnf), apoptosis markers (caspase-3, caspase-8, bax, and p21), and autophagy markers (lamp2, atg5, becn1, and atg12). |
2022-06-06 |
2023-08-14 |
rat |
| Liyu Jiang, Yan Zeng, Leilei Ai, Hao Yan, Xiaochun Yang, Peihua Luo, Bo Yang, Zhifei Xu, Qiaojun H. Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib. Biochemical pharmacology. 2022-05-26. PMID:35617997. |
overexpression of hmgb1 inhibited keratinocyte apoptosis and inflammatory reactions. |
2022-05-26 |
2023-08-13 |
mouse |
| Liyu Jiang, Yan Zeng, Leilei Ai, Hao Yan, Xiaochun Yang, Peihua Luo, Bo Yang, Zhifei Xu, Qiaojun H. Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib. Biochemical pharmacology. 2022-05-26. PMID:35617997. |
finally, we found that saikosaponin a could significantly rescue the reduced hmgb1 transcription, which could alleviate lapatinib-induced dna damage, inhibit keratinocyte apoptosis and further prevent the toxicity of lapatinib in mice. |
2022-05-26 |
2023-08-13 |
mouse |
| Tianyao Lei, Jiali Huang, Fei Xie, Jingyao Gu, Zhixiang Cheng, Zhaoxia Wan. HMGB1-mediated autophagy promotes gefitinib resistance in human non-small cell lung cancer. Acta biochimica et biophysica Sinica. vol 54. issue 4. 2022-04-24. PMID:35462475. |
rna interference-mediated knockdown of hmgb1 reduces pc9gr cell viability, induces apoptosis, and partially restores gefitinib sensitivity. |
2022-04-24 |
2023-08-13 |
human |
| Hector Katifelis, Maria-Paraskevi Nikou, Iuliia Mukha, Nadiia Vityuk, Nefeli Lagopati, Christina Piperi, Ammad Ahmad Farooqi, Natassa Pippa, Efstathios P Efstathopoulos, Maria Gazoul. Ag/Au Bimetallic Nanoparticles Trigger Different Cell Death Pathways and Affect Damage Associated Molecular Pattern Release in Human Cell Lines. Cancers. vol 14. issue 6. 2022-03-25. PMID:35326698. |
we studied the cytotoxic effects of agau nps, ag nps and au nps with regard to the programmed cell death (apoptosis, necroptosis, pyroptosis) and the secretion/release of hsp70 and hmgb1. |
2022-03-25 |
2023-08-13 |
human |
| Rongmao Nong, Chunyan Qin, Qiqing Lin, Yi Lu, Jun L. Down-regulated HDAC1 and up-regulated microRNA-124-5p recover myocardial damage of septic mice. Bioengineered. vol 13. issue 3. 2022-03-14. PMID:35285407. |
septic mice were injected with hdac1 low expression-, mir-124-5p high expression- or hmgb1 low expression-related structures to observe cardiac function, inflammatory response, oxidative stress response, myocardial pathological changes and apoptosis in myocardial tissues of septic mice. |
2022-03-14 |
2023-08-13 |
mouse |
| Rongmao Nong, Chunyan Qin, Qiqing Lin, Yi Lu, Jun L. Down-regulated HDAC1 and up-regulated microRNA-124-5p recover myocardial damage of septic mice. Bioengineered. vol 13. issue 3. 2022-03-14. PMID:35285407. |
restored mir-124-5p/depleted hdac1 or hmgb1 recovered the cardiac function, improved cardiac function, inflammatory response, oxidative stress response, myocardial pathological changes and inhibit ed cardiomyocyte apoptosis in septic mice. |
2022-03-14 |
2023-08-13 |
mouse |
| Ruochan Chen, Rui Kang, Daolin Tan. The mechanism of HMGB1 secretion and release. Experimental & molecular medicine. 2022-02-26. PMID:35217834. |
the secretion and release of hmgb1 is fine-tuned by a variety of factors, including its posttranslational modification (e.g., acetylation, adp-ribosylation, phosphorylation, and methylation) and the molecular machinery of cell death (e.g., apoptosis, pyroptosis, necroptosis, alkaliptosis, and ferroptosis). |
2022-02-26 |
2023-08-13 |
Not clear |
| Wei Wang, Wen-Li Sai, Bin Yan. [The role of macrophage polarization and interaction with renal tubular epithelial cells in ischemia-reperfusion induced acute kidney injury]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 1. 2022-02-24. PMID:35199123. |
ir rapidly initiates innate immune responses, activates complement and innate immune cells, releasing a large number of injury-related molecules such as high mobility group box-1 (hmgb1), inflammatory mediators such as caspase-3, and then recruits immune inflammatory cells including m1 macrophages (mϕ) to the microenvironment of injury, causing apoptosis and necrosis of renal tubular epithelial cells (tecs). |
2022-02-24 |
2023-08-13 |
Not clear |
| Yazhou Gao, Liming Wang, Zequn Niu, Hui Feng, Jie Liu, Jiangli Sun, Yanxia Gao, Longfei Pa. miR-340-5p inhibits pancreatic acinar cell inflammation and apoptosis via targeted inhibition of HMGB1. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069821. |
mir-340-5p inhibits pancreatic acinar cell inflammation and apoptosis via targeted inhibition of hmgb1. |
2022-01-24 |
2023-08-13 |
Not clear |
| Yazhou Gao, Liming Wang, Zequn Niu, Hui Feng, Jie Liu, Jiangli Sun, Yanxia Gao, Longfei Pa. miR-340-5p inhibits pancreatic acinar cell inflammation and apoptosis via targeted inhibition of HMGB1. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069821. |
inflammation and apoptosis are considered to be important pathogenic mechanisms of ap, and high mobility group box 1 (hmgb1) has been shown to play a particularly important role in the etiology of this disease. |
2022-01-24 |
2023-08-13 |
Not clear |
| Yazhou Gao, Liming Wang, Zequn Niu, Hui Feng, Jie Liu, Jiangli Sun, Yanxia Gao, Longfei Pa. miR-340-5p inhibits pancreatic acinar cell inflammation and apoptosis via targeted inhibition of HMGB1. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069821. |
the results suggest that mir-340-5p attenuates the induction of hmgb1 by lps, thereby inhibiting inflammation and apoptosis via blunted activation of toll-like receptor 4 and enhanced akt signaling. |
2022-01-24 |
2023-08-13 |
Not clear |
| Yazhou Gao, Liming Wang, Zequn Niu, Hui Feng, Jie Liu, Jiangli Sun, Yanxia Gao, Longfei Pa. miR-340-5p inhibits pancreatic acinar cell inflammation and apoptosis via targeted inhibition of HMGB1. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069821. |
thus, the therapeutic application of mir-340-5p may be a useful strategy in ap via upregulation of hmgb1 and subsequent promotion of inflammation and apoptosis. |
2022-01-24 |
2023-08-13 |
Not clear |
| YaQing Zhan, YiHong Ling, Qiwen Deng, YuXin Qiu, JianTong Shen, HanJin Lai, ZhaoRong Chen, ChanYan Huang, LiQun Liang, Xiang Li, JianFeng Wu, WenQi Huang, ShiHong We. HMGB1-Mediated Neutrophil Extracellular Trap Formation Exacerbates Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury. Journal of immunology (Baltimore, Md. : 1950). 2022-01-22. PMID:35063996. |
high-mobility group protein b1 (hmgb1) blocking prevented net formation and protected against tissue inflammation, as well as reduced cell apoptosis and improved survival rate. |
2022-01-22 |
2023-08-13 |
mouse |