| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hua-Sheng Ding, Jun Yang, Jian Yang, Xin Guo, Yan-Hong Tang, Yan Huang, Zhen Chen, Zhi-Xing Fan, Cong-Xin Huan. Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway. Molecular biology reports. vol 48. issue 5. 2021-07-12. PMID:34032975. |
after reperfusion, the hemodynamic parameters, myocardial infarct size, structural alteration of myocardium, apoptosis index, pro-inflammatory cytokine production, beclin-1, light chain 3 (lc3), hmgb1, tlr4 and nuclear factor kappa b (nf-κb) protein levels were measured and recorded. |
2021-07-12 |
2023-08-13 |
rat |
| Hanqing Liu, Wei Liu, Huiliang Qiu, Dezhi Zou, Huayang Cai, Qiuxiong Chen, Chaoyang Zheng, Danping X. Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 8. 2021-07-06. PMID:31853618. |
cardiac function, infarct size, myocardial injury marker levels, inflammatory response and cardiomyocyte apoptosis as well as bcl-2, bax, p-akt, hmgb1 and tlr4 expression were measured. |
2021-07-06 |
2023-08-13 |
rat |
| Hanqing Liu, Wei Liu, Huiliang Qiu, Dezhi Zou, Huayang Cai, Qiuxiong Chen, Chaoyang Zheng, Danping X. Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 8. 2021-07-06. PMID:31853618. |
in the current study, sal b significantly ameliorated myocardial i/r injury in a dose-dependent manner, ameliorated cardiac function, reduced myocardial infarction size, decreased myocardial injury marker expression, decreased inflammatory responses, reduced apoptosis, activated pi3k/akt expression and inhibited hmgb1 expression. |
2021-07-06 |
2023-08-13 |
rat |
| Jiong Zhang, Qing Li, Yu-Rong Zou, Shu-Kun Wu, Xiang-Heng Lu, Gui-Sen Li, Jia Wan. HMGB1-TLR4-IL-23-IL-17A axis accelerates renal ischemia-reperfusion injury via the recruitment and migration of neutrophils. International immunopharmacology. vol 94. 2021-06-22. PMID:33592404. |
in vivo, anti-hmgb1 antibody decreased the acetylation, translocation, and secretion of hmgb1, reduced the expression of tlr-4, il-23, il-17a, kc, lix, and mip-2, alleviated the activation of macrophages and neutrophils, improved the survival rate and renal dysfunction, and decreased inflammation, apoptosis, oxidative stress, and pathological injury of the kidney. |
2021-06-22 |
2023-08-13 |
Not clear |
| Haiyan Sun, Huahui Zhao, Zhipeng Yan, Xiaokun Liu, Pengfei Yin, Jun Zhan. Protective role and molecular mechanism of action of Nesfatin-1 against high glucose-induced inflammation, oxidative stress and apoptosis in retinal epithelial cells. Experimental and therapeutic medicine. vol 22. issue 2. 2021-06-22. PMID:34149879. |
taken together, these findings demonstrated that nesfatin-1 inhibited the activation of the nf-κb/nlrp3 inflammasome signaling via modulating hmgb1 and exerted a protective effect on arpe-19 cells against high glucose-induced inflammation, oxidative stress and apoptosis. |
2021-06-22 |
2023-08-13 |
human |
| Jingwen Xu, Yi Wang, Zhe Wang, Yihai Wang, Xiangjiu H. T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells. Steroids. vol 170. 2021-06-21. PMID:33781788. |
besides, t-17 induces apoptosis and autophagy in gastric cancer cells by decreasing the expression of hmgb1, also in a p53-independent manner. |
2021-06-21 |
2023-08-13 |
Not clear |
| Mingming Li, Hao Jiang, Kuo Gu, Xuechao Sun, Jing Gu, Chunming Li, Guonian Wan. Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1α/CCR1 Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 16. issue 2. 2021-06-18. PMID:32301050. |
cell apoptosis in the spinal dorsal horn and the generation of inflammatory cytokines were enhanced in sni rats, and the expression levels of hmgb1, mip-1α, ccr1 and ccr5 were upregulated. |
2021-06-18 |
2023-08-13 |
rat |
| Yuan Xu, Yulin Niu, Haiyang Li, Guanghui Pa. Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation. vol 43. issue 4. 2021-06-10. PMID:32206944. |
downregulation of lncrna tug1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging mir-449b-5p via targeting hmgb1 and mmp2. |
2021-06-10 |
2023-08-13 |
Not clear |
| Yuan Xu, Yulin Niu, Haiyang Li, Guanghui Pa. Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation. vol 43. issue 4. 2021-06-10. PMID:32206944. |
the levels of inflammation, apoptosis, and the expression of hmgb1 and mmp2 were detected. |
2021-06-10 |
2023-08-13 |
Not clear |
| Yuan Xu, Yulin Niu, Haiyang Li, Guanghui Pa. Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation. vol 43. issue 4. 2021-06-10. PMID:32206944. |
these findings demonstrated that tug1 silencing attenuates i/r-induced inflammation and apoptosis via targeting mir-449b-5p and regulating hmgb1 and mmp2 expression. |
2021-06-10 |
2023-08-13 |
Not clear |
| Lulu Liu, Jingjing Zhang, Xianning Zhang, Panpan Cheng, Lei Liu, Qian Huang, Haihui Liu, Saisai Ren, Peng Wei, Cuiling Wang, Cuiyun Dou, Lulu Chen, Xin Liu, Hao Zhang, Mingtai Che. HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target. Journal of molecular medicine (Berlin, Germany). vol 99. issue 1. 2021-06-09. PMID:33128580. |
here in this study, we further demonstrated that hmgb1 presents higher expression in the bone marrow mononuclear cells of acute myeloid leukemia (aml) patients compared with the normal controls and contributes to the aml pathogenesis and progression by inhibiting apoptosis, facilitating proliferation, and inducing myeloid differentiation blockade of aml cells. |
2021-06-09 |
2023-08-13 |
Not clear |
| Lulu Liu, Jingjing Zhang, Xianning Zhang, Panpan Cheng, Lei Liu, Qian Huang, Haihui Liu, Saisai Ren, Peng Wei, Cuiling Wang, Cuiyun Dou, Lulu Chen, Xin Liu, Hao Zhang, Mingtai Che. HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target. Journal of molecular medicine (Berlin, Germany). vol 99. issue 1. 2021-06-09. PMID:33128580. |
on the other hand, chidamide, an orally histone deacetylase inhibitor, decreases hmgb1 expression significantly in aml cells with concomitant upregulation of tgfbi expression, and confers therapeutic effect on aml by inducing cell differentiation, apoptosis and inhibiting cell proliferation. |
2021-06-09 |
2023-08-13 |
Not clear |
| Lulu Liu, Jingjing Zhang, Xianning Zhang, Panpan Cheng, Lei Liu, Qian Huang, Haihui Liu, Saisai Ren, Peng Wei, Cuiling Wang, Cuiyun Dou, Lulu Chen, Xin Liu, Hao Zhang, Mingtai Che. HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target. Journal of molecular medicine (Berlin, Germany). vol 99. issue 1. 2021-06-09. PMID:33128580. |
key messages: hmgb1 induces cell proliferation and myeloid differentiation blockade and inhibits apoptosis of aml cells. |
2021-06-09 |
2023-08-13 |
Not clear |
| Sevket Evran, Fatih Calis, Enes Akkaya, Oguz Baran, Serdar Cevik, Salim Katar, Ebru Gurel Gurevin, Hakan Hanimoglu, Mustafa Aziz Hatiboglu, Elif Ilkay Armutak, Ersin Karatas, Abdurrahim Kocyigit, Mehmet Yasar Kayna. The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model. Brain research bulletin. vol 154. 2021-06-07. PMID:31715313. |
the aim of this study is to investigate the effects of hmgb1 on its receptors tlr4 and rage, cerebral edema, blood-brain barrier, oxidative stress and apoptosis causing secondary damage in an experimental traumatic brain injury model. |
2021-06-07 |
2023-08-13 |
rat |
| Lujia Feng, Liang Liang, Shaochong Zhang, Jinglu Yang, Yanan Yue, Xuedong Zhan. HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway. Autophagy. 2021-06-01. PMID:34024230. |
knockdown of hmgb1 expression rescued lmp, restored the degradative capacity of autophagy, decreased the expression of inflammatory factors and vegf (vascular endothelial growth factor), and protected against apoptosis in rpe cells in the early stages of dr. |
2021-06-01 |
2023-08-13 |
Not clear |
| Xin Huang, Xiangping Hou, Libo Chuan, Shutao Wei, Jingrong Wang, Xiaohua Yang, Jin R. miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway. International immunopharmacology. vol 89. issue Pt A. 2021-05-25. PMID:33039954. |
the present study aimed to investigate whether mir-129-5p can regulate high-mobility group box protein 1 (hmgb1)-modulated tlrs/nf-kappab inflammatory pathway that contributed to lipopolysaccharide (lps)-induced podocyte apoptosis and acutekidneyinjury (aki). |
2021-05-25 |
2023-08-13 |
Not clear |
| Kai Le, Shanshan Wu, Enkhmurun Chibaatar, Abdoulaye Idriss Ali, Yijing Gu. Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin. ACS chemical neuroscience. vol 11. issue 6. 2021-05-24. PMID:32073822. |
subsequent analysis found that this neuroprotective effect was achieved through the inhibition of hmgb1 expression and nucleocytoplasmic translocation, a reduction in the abnormal expression of proteins associated with the downstream signaling pathway of hmgb1, a decrease in the inflammatory response, the suppression of increases in microglia/astrocytes, and the inhibition of hippocampal cell apoptosis. |
2021-05-24 |
2023-08-13 |
mouse |
| Mengying Zhu, Yilong Wang, Chufan Qu, Rongxian Liu, Chudi Zhang, Jinhu Wang, Dongming Zhou, Weizhong Gu, Peichun Chen, Benqing Wu, Zhengyan Zha. Recombinant Chinese Hu191 measles virus exhibits a significant antitumor activity against nephroblastoma mediated by immunogenic form of apoptosis. American journal of translational research. vol 13. issue 4. 2021-05-23. PMID:34017376. |
caspase-induced apoptosis exerted a significant impact on mv-induced cell death, which was accompanied by emission of cellular atp and high-mobility group protein 1 (hmgb1) and by translocation of calreticulin (crt). |
2021-05-23 |
2023-08-13 |
Not clear |
| Guohu Han, Rui Ling, Changchun Sun, Xuefeng Wang, Yuepeng Zhou, Lijiang Yu, Shenzha Li. HMGB1 knockdown increases the radiosensitivity of esophageal squamous cell carcinoma by regulating the expression of molecules involved in DNA repair. Oncology letters. vol 22. issue 1. 2021-05-16. PMID:33986864. |
the results revealed that hmgb1 knockdown significantly decreased cell viability, and the apoptosis rate of te-1 cells transfected with sihmgb1 combined with radiation treatment was increased compared with that in cells with either sihmgb1 transfection or radiation treatment alone. |
2021-05-16 |
2023-08-13 |
Not clear |
| Guohu Han, Rui Ling, Changchun Sun, Xuefeng Wang, Yuepeng Zhou, Lijiang Yu, Shenzha Li. HMGB1 knockdown increases the radiosensitivity of esophageal squamous cell carcinoma by regulating the expression of molecules involved in DNA repair. Oncology letters. vol 22. issue 1. 2021-05-16. PMID:33986864. |
hmgb1 knockdown increased nicotinamide adenine nucleotide phosphate oxidase-mediated ros production and induced dna damage via the mapk signaling pathway, which may promote apoptosis and radiosensitivity after radiation in te-1 cells. |
2021-05-16 |
2023-08-13 |
Not clear |