| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji-Eun Kim, Tae-Cheon Kan. Differential Roles of Mitochondrial Translocation of Active Caspase-3 and HMGB1 in Neuronal Death Induced by Status Epilepticus. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30233331. |
these findings suggest that se-induced aberrant mitochondrial dynamics may be involved in translocation of active caspase-3 and hmgb1 into mitochondria, which regulate neuronal apoptosis and necrosis, respectively. |
2020-10-01 |
2023-08-13 |
rat |
| Shu-Wen Mu, Yuan Dang, Shou-Sen Wang, Jian-Jun G. The role of high mobility group box 1 protein in acute cerebrovascular diseases. Biomedical reports. vol 9. issue 3. 2020-10-01. PMID:30271593. |
in the initial stage of disease, hmgb1 is released into the outside of the cell to participate in the cascade amplification reaction of inflammation, causing vasospasm, destruction of the blood-brain barrier and apoptosis of nerve cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Joanna I Clarke, Nathalie Brillanf, Daniel J Antoin. Novel circulating- and imaging-based biomarkers to enhance the mechanistic understanding of human drug-induced liver injury. Journal of clinical and translational research. vol 3. issue 1. 2020-10-01. PMID:30873474. |
several putative liver safety biomarkers are under investigation as discussed throughout this review, informing on a multitude of hepatocellular mechanisms including: early cell death (mir-122), necrosis (hmgb1, k18), apoptosis, (k18), inflammation (hmgb1), mitochondrial damage (gldh, mtdna), liver dysfunction (mri, msot) and regeneration (csf1). |
2020-10-01 |
2023-08-13 |
human |
| Xiao Liu, Jian Zhuang, Deguo Wang, Lanxin Lv, Fenghui Zhu, Aiming Yao, Tie X. Glycyrrhizin suppresses inflammation and cell apoptosis by inhibition of HMGB1 via p38/p-JUK signaling pathway in attenuating intervertebral disc degeneration. American journal of translational research. vol 11. issue 8. 2020-10-01. PMID:31497226. |
glycyrrhizin suppresses inflammation and cell apoptosis by inhibition of hmgb1 via p38/p-juk signaling pathway in attenuating intervertebral disc degeneration. |
2020-10-01 |
2023-08-13 |
human |
| Xiao Liu, Jian Zhuang, Deguo Wang, Lanxin Lv, Fenghui Zhu, Aiming Yao, Tie X. Glycyrrhizin suppresses inflammation and cell apoptosis by inhibition of HMGB1 via p38/p-JUK signaling pathway in attenuating intervertebral disc degeneration. American journal of translational research. vol 11. issue 8. 2020-10-01. PMID:31497226. |
these results suggested that gl prevented np degradation via restraining inflammation and cell apoptosis by inhibition of hmgb1 via p38/p-jnk signaling pathway. |
2020-10-01 |
2023-08-13 |
human |
| Jianjun Gu, Rong Xu, Yaxing Li, Jianhe Zhang, Shousen Wan. MicroRNA-218 modulates activities of glioma cells by targeting HMGB1. American journal of translational research. vol 8. issue 9. 2020-09-30. PMID:27725858. |
co-transfection with pchmgb1 and mir-218 significantly decreased the growth inhibition and increased the apoptosis of glioma cells while these effects were abolished in glioma cells co-transfected with hmgb1 sirna and mir-218 inhibitor. |
2020-09-30 |
2023-08-13 |
Not clear |
| Junsu Lee, Jaesung Choi, Seokang Chung, JooYong Park, Ji-Eun Kim, Hyuna Sung, Wonshik Han, Jong Won Lee, Sue K Park, Mi Kyung Kim, Sei-Hyun Ahn, Dong-Young Noh, Keun-Young Yoo, Daehee Kang, Ji-Yeob Cho. Genetic Predisposition of Polymorphisms in Journal of breast cancer. vol 20. issue 1. 2020-09-30. PMID:28382092. |
genetic predisposition of polymorphisms in the high mobility group box 1 (hmgb1) protein has roles in apoptosis and immune responses by acting as a ligand for receptor for advanced glycation end products (rage), toll-like receptors (tlrs), and triggering receptor expressed on myeloid cells 1. |
2020-09-30 |
2023-08-13 |
Not clear |
| Richard A Seidu, Min Wu, Zhaoliang Su, Huaxi X. Paradoxical Role of High Mobility Group Box 1 in Glioma: A Suppressor or a Promoter? Oncology reviews. vol 11. issue 1. 2020-09-30. PMID:28382190. |
it is known that excessive release of hmgb1 in cancer leads to unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Richard A Seidu, Min Wu, Zhaoliang Su, Huaxi X. Paradoxical Role of High Mobility Group Box 1 in Glioma: A Suppressor or a Promoter? Oncology reviews. vol 11. issue 1. 2020-09-30. PMID:28382190. |
in this review we explore the mechanisms by which hmgb1 regulates apoptosis and autophagy in glioma. |
2020-09-30 |
2023-08-13 |
Not clear |
| Wen Sh. Downregulation of high mobility group protein box-1 resensitizes ovarian cancer cells to carboplatin. Oncology letters. vol 16. issue 4. 2020-09-30. PMID:30214593. |
cell proliferation and apoptosis analyses were performed to evaluate the effect of hmgb1 silencing on resistant ovarian cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Wen Sh. Downregulation of high mobility group protein box-1 resensitizes ovarian cancer cells to carboplatin. Oncology letters. vol 16. issue 4. 2020-09-30. PMID:30214593. |
annexin v-fluorescein isothiocyanate/propidium iodide staining demonstrated that hmgb1 silencing enhanced the effects of carboplatin in inducing the apoptosis of skov3-carb cells relative to hmgb1 non-silenced control cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Zhang, Yan Wang, Junjie Ma, Xingqiang Lai, Jiali Fang, Guanghui Li, Lu Xu, Guanghui Pan, Zheng Che. Exogenous MSCs ameliorate hypoxia/reoxygenation injury in renal tubular epithelial cells through JAK/STAT signaling pathway-mediated regulation of HMGB1. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559991. |
when the cells were transfected with sirna stat3, the expression of stat3 at protein and mrna levels and jak2 and hmgb1 at mrna level was down-regulated; the cell viability was reduced and apoptosis increased. |
2020-09-29 |
2023-08-13 |
Not clear |
| Gerwyn Morris, Chiara C Bortolasci, Basant K Puri, Lisa Olive, Wolfgang Marx, Adrienne O'Neil, Eugene Athan, Andre F Carvalho, Michael Maes, Ken Walder, Michael Ber. The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach. Life sciences. vol 258. 2020-09-29. PMID:32739471. |
the contribution to ards of increased extracellular histone levels, circulating mitochondrial dna, the chromatin protein hmgb1, decreased neutrophil apoptosis, impaired macrophage efferocytosis, the cytokine storm, the toll-like receptor radical cycle, pyroptosis, necroinflammation, lymphopenia and a high th17 to regulatory t lymphocyte ratio are detailed. |
2020-09-29 |
2023-08-13 |
human |
| Peng Fang, Jiajun Liang, Xuejiao Jiang, Xian Fang, Mengli Wu, Xiaoyi Wei, Wenlong Yang, Weixin Hou, Qiuyun Zhan. Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32431618. |
quercetin attenuates d-galn-induced l02 cell damage by suppressing oxidative stress and mitochondrial apoptosis high mobility group box-1 (hmgb1) plays an important role in various liver injuries. |
2020-09-28 |
2023-08-13 |
Not clear |
| Peng Fang, Jiajun Liang, Xuejiao Jiang, Xian Fang, Mengli Wu, Xiaoyi Wei, Wenlong Yang, Weixin Hou, Qiuyun Zhan. Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32431618. |
further research showed that after transfection with hmgb1 short hairpin rna (shrna), cell viability was improved, and intracellular ros production and apoptosis were suppressed. |
2020-09-28 |
2023-08-13 |
Not clear |
| Peng Fang, Jiajun Liang, Xuejiao Jiang, Xian Fang, Mengli Wu, Xiaoyi Wei, Wenlong Yang, Weixin Hou, Qiuyun Zhan. Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32431618. |
when co-treated with que, the expression of hmgb1 was decreased significantly, the expression of proteins in the corresponding signal pathway were further reduced, and the production of ros and apoptosis were further suppressed. |
2020-09-28 |
2023-08-13 |
Not clear |
| Pan Li, Kai Ren, Yin Yin Liang, Ji Kai Liu, Zhuo Wen Liang, Yong Feng Zhan. Aloin promotes cell apoptosis by targeting HMGB1-TLR4-ERK axis in human melanoma cells. EXCLI journal. vol 19. 2020-09-28. PMID:32536835. |
in this study, we explored the effect of alo on cell survival and apoptosis by targeting hmgb1 signal pathway. |
2020-09-28 |
2023-08-13 |
human |
| Lu Liang, Jijun Fu, Siran Wang, Huiyu Cen, Lingmin Zhang, Safur Rehman Mandukhail, Lingran Du, Qianni Wu, Peiquan Zhang, Xiyong Y. MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1. Acta pharmaceutica Sinica. B. vol 10. issue 6. 2020-09-28. PMID:32642410. |
moreover, overexpression of hmgb1 dramatically reversed the promotion of apoptosis and inhibition of autophagy mediated by mir-142-3p up-regulation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Wresti L Anggayasti, Chikahiro Imashiro, Taiki Kuribara, Kiichiro Totani, Kenjiro Takemur. Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells. Engineering in life sciences. vol 20. issue 7. 2020-09-28. PMID:32647502. |
in this study, we examined the effects of brief (1 h) low-frequency (20 hz) mechanical vibration on glucose consumption and survival (apoptosis, necrosis, hmgb1 release) of the human epidermoid carcinoma cell line a431. |
2020-09-28 |
2023-08-13 |
human |
| Ming Cheng, Yue Wan. Downregulation of HMGB1 by miR-103a-3p Promotes Cell Proliferation, Alleviates Apoptosis and in Flammation in a Cell Model of Osteoarthritis. Iranian journal of biotechnology. vol 18. issue 1. 2020-09-28. PMID:32884953. |
downregulation of hmgb1 by mir-103a-3p promotes cell proliferation, alleviates apoptosis and in flammation in a cell model of osteoarthritis. |
2020-09-28 |
2023-08-13 |
human |