| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eleonora Foglio, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Liman. HMGB1-mediated apoptosis and autophagy in ischemic heart diseases. Vascular biology (Bristol, England). vol 1. issue 1. 2020-09-28. PMID:32923959. |
indeed, a detailed understanding of the crosstalk between apoptosis and autophagy in these pathologies and how hmgb1 regulates them would be of tremendous help in developing novel therapeutic approaches aimed to promote cardiomyocyte survival and to diminish tissue injury following mi. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hannah M Davis, Sinai Valdez, Leland Gomez, Peter Malicky, Fletcher A White, Mark A Subler, Jolene J Windle, Joseph P Bidwell, Angela Bruzzaniti, Lilian I Plotki. High mobility group box 1 protein regulates osteoclastogenesis through direct actions on osteocytes and osteoclasts in vitro. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31106449. |
further, prevention of osteocyte apoptosis blocks osteoclast differentiation and attenuates the extracellular release of hmgb1 and rankl. |
2020-09-14 |
2023-08-13 |
Not clear |
| Jianlei Cao, Yurong Da, Hang Li, Yuanyuan Peng, Xiaorong H. Upregulation of microRNA-451 attenuates myocardial I/R injury by suppressing HMGB1. PloS one. vol 15. issue 7. 2020-09-14. PMID:32678819. |
after 24 hours of reperfusion injury, the serum content of ck and ldh, the content of mda in tissue and activity of sod were detected; the infarcted areas were defined by ttc staining and evans blue; tunel staining and cleaved-caspase 3 were used to test apoptosis; hmgb1 was detected by real-time fluorescence quantitative pcr and western blotting. |
2020-09-14 |
2023-08-13 |
rat |
| Jianlei Cao, Yurong Da, Hang Li, Yuanyuan Peng, Xiaorong H. Upregulation of microRNA-451 attenuates myocardial I/R injury by suppressing HMGB1. PloS one. vol 15. issue 7. 2020-09-14. PMID:32678819. |
compared with the i/r and i/r+ad-gfp group, upregulation of mir-451 could reduce the infarcted areas, cardiomyocytes apoptosis index, expression of cleaved-caspase 3 and content of ck and ldh significantly(p<0.05); meanwhile, upregulation of mir-451 could also obviously inhibit hmgb1, the increase of mda and the decrease of sod (p<0.05). |
2020-09-14 |
2023-08-13 |
rat |
| Li Wenzhao, Ni Jiangdong, Song Deye, Ding Muliang, Wang Junjie, Huang Xianzhe, Yan Mingming, Huang Ju. Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice. Cell cycle (Georgetown, Tex.). vol 18. issue 18. 2020-09-01. PMID:31313630. |
in the current study, we used quantitative real-time pcr(q-pcr) to detect them rna levels of collagen type ii alpha 1(col2a1), aggrecan, mmp3(matrix metallopeptidase 3), mmp13, adamts4 and adamts5; enzyme-linked immunosorbent assay(elisa) was used to detect the content of il-1β and calpain protein; cell apoptosis was evaluated by terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling(tunel) assay and flow cytometryanalysis; western blot and immunofluorescence assays were applied to assess the expression of hmgb1; lastly autophagic activity was mainly verified by monodansylcadaverine (mdc) staining. |
2020-09-01 |
2023-08-13 |
mouse |
| Li Wenzhao, Ni Jiangdong, Song Deye, Ding Muliang, Wang Junjie, Huang Xianzhe, Yan Mingming, Huang Ju. Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice. Cell cycle (Georgetown, Tex.). vol 18. issue 18. 2020-09-01. PMID:31313630. |
our data revealed that in the early stage of chondrocyte inflammation(3 and 6 h of lps stimulation), cytosolic hmgb1 attenuated inflammation response by facilitating cell autophagy and preventing cell apoptosis. |
2020-09-01 |
2023-08-13 |
mouse |
| Kayo Harada-Shirado, Xintao Wang, Hirotaka Mori, Masahiko Fukatsu, Hiroshi Takahashi, Akiko Shichishima-Nakamura, Satoshi Kimura, Hiroshi Ohkawara, Shingo Yamada, Takashi Ito, Takayuki Ikezo. Circulating intranuclear proteins may play a role in development of disseminated intravascular coagulation in individuals with acute leukemia. International journal of hematology. vol 111. issue 3. 2020-09-01. PMID:31848990. |
these observations prompted us to hypothesize that hmgb1 and histone h3 liberated from leukemia cells undergoing apoptosis after chemotherapy might play a role in development of dic. |
2020-09-01 |
2023-08-13 |
Not clear |
| Yung-Yang Liu, Ning-Hung Chen, Chih-Hao Chang, Shih-Wei Lin, Kuo-Chin Kao, Han-Chung Hu, Gwo-Jyh Chang, Li-Fu L. Ethyl pyruvate attenuates ventilation-induced diaphragm dysfunction through high-mobility group box-1 in a murine endotoxaemia model. Journal of cellular and molecular medicine. vol 23. issue 8. 2020-08-25. PMID:31339670. |
additionally, disarrayed myofibrils and disrupted mitochondrial ultrastructures, as well as increased hmgb1 mrna and protein expression, and plasminogen activator inhibitor-1 protein, oxidative stress, autophagosomes and myonuclear apoptosis were also observed. |
2020-08-25 |
2023-08-13 |
mouse |
| Min Yu, He Huang, Shiyang Dong, Huanhuan Sha, Wei Wei, Cunming Li. High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31430517. |
inhibiting hmgb1 by glycyrrhizin or hmgb1 mab suppressed the hippocampal inflammatory, alleviated the apoptosis and ameliorated the cognitive impairment in hfhfd-fed rats. |
2020-08-25 |
2023-08-13 |
rat |
| Hoda Gol Fakhrabadi, Azra Rabbani-Chadegani, Parinaz Ghadam, Somayeh Amir. Protective effect of bleomycin on 5-azacitidine induced cytotoxicity and apoptosis in mice hematopoietic stem cells via Bcl-2/Bax and HMGB1 signaling pathway. Toxicology and applied pharmacology. vol 396. 2020-08-20. PMID:32278510. |
protective effect of bleomycin on 5-azacitidine induced cytotoxicity and apoptosis in mice hematopoietic stem cells via bcl-2/bax and hmgb1 signaling pathway. |
2020-08-20 |
2023-08-13 |
mouse |
| Weijie Xie, Ting Zhu, Xi Dong, Fengwei Nan, Xiangbao Meng, Ping Zhou, Guibo Sun, Xiaobo Su. HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-κB signaling pathways. Biomolecules. vol 9. issue 10. 2020-08-12. PMID:31547018. |
in vivo results suggested that in mcao/r model rats, pngl pretreatment (73.0, 146, 292 mg/kg) remarkably decreased infarct volume, reduced brain water content, and improved neurological functions; moreover, pngl (73.0, 146, 292 mg/kg) significantly alleviated blood-brain barrier (bbb) disruption and inhibited neuronal apoptosis and neuronal loss caused by cerebral i/r injury, while pngl with a different concertation (146, 292 mg/kg) significantly reduced the concentrations of il-6, tnf-α, il-1 β, and hmgb1 in serums in a dose-dependent way, which indicated that inflammation inhibition could be involved in the neuroprotective effects of pngl. |
2020-08-12 |
2023-08-13 |
rat |
| Jiyang Xue, Hanwei Ge, Zhiyong Lin, Hanlei Wang, Wei Lin, Yong Liu, Guowei Wu, Jie Xia, Qifeng Zha. The role of dendritic cells regulated by HMGB1/TLR4 signalling pathway in myocardial ischaemia reperfusion injury. Journal of cellular and molecular medicine. vol 23. issue 4. 2020-07-22. PMID:30784177. |
cellular experiments confirmed that hmgb1 promoted the release of inflammatory cytokines through tlr4/myd88/nf-κb, upregulated cd80 and cd86 expression, mediated the damage of cardiomyocytes and accelerated the apoptosis. |
2020-07-22 |
2023-08-13 |
Not clear |
| Yibin Ma, Yunhong Du, Qian Xu, Huijing Bao, Zhonglian Liu, Yingchao Li, Wenjing Li. Inhibiting MiR-34α reduces retinal cell apoptosis and downstream NF-κB pathway in diabetic retinopathy rats through regulating HMGB1 expression. Minerva medica. 2020-07-20. PMID:32683849. |
inhibiting mir-34α reduces retinal cell apoptosis and downstream nf-κb pathway in diabetic retinopathy rats through regulating hmgb1 expression. |
2020-07-20 |
2023-08-13 |
rat |
| Jingjing Zhao, Tianle Sun, Shengdi Wu, Yufeng Li. High Mobility Group Box 1: An Immune-regulatory Protein. Current gene therapy. vol 19. issue 2. 2020-07-06. PMID:31223085. |
recent studies indicate that extracellular hmgb1, coming from necrotic cells or activated immune cells, triggers inflammatory response whereas intracellular hmgb1 controls the balance between autophagy and apoptosis. |
2020-07-06 |
2023-08-13 |
Not clear |
| Qing Liu, Wanli Xie, Yanting Wang, Shiqiang Chen, Jingjing Han, Lei Wang, Ping Gui, Qingping W. JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 12. 2020-06-29. PMID:31467427. |
in addition, when mouse macrophage-like raw 264.7 cells were exposed to lps and cyclic stretch (cs), azd1480 prevented cell autophagy, reduced apoptosis, and suppressed lactate dehydrogenase release by downregulating jak2/stat1 phosphorylation levels and inducing hmgb1 translocation from the nucleus to the cytoplasm. |
2020-06-29 |
2023-08-13 |
mouse |
| Qing Liu, Wanli Xie, Yanting Wang, Shiqiang Chen, Jingjing Han, Lei Wang, Ping Gui, Qingping W. JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 12. 2020-06-29. PMID:31467427. |
furthermore, hmgb1 and stat1 knockdown attenuated lps+cs-induced autophagy and apoptosis in raw 264.7 cells. |
2020-06-29 |
2023-08-13 |
mouse |
| Yu-Mei Li, Jin-Guo Sun, Li-Hua Hu, Xian-Chun Ma, Gang Zhou, Xi-Zhao Huan. Propofol-mediated cardioprotection dependent of microRNA-451/HMGB1 against myocardial ischemia-reperfusion injury. Journal of cellular physiology. vol 234. issue 12. 2020-06-12. PMID:31188485. |
propofol pretreatment significantly increased mirna-451 expression, decreased hmgb1 expression, reduced infarct size, and i/r-induced cardiomyocyte apoptosis in rat hearts undergoing i/r injuries. |
2020-06-12 |
2023-08-13 |
rat |
| Yu-Mei Li, Jin-Guo Sun, Li-Hua Hu, Xian-Chun Ma, Gang Zhou, Xi-Zhao Huan. Propofol-mediated cardioprotection dependent of microRNA-451/HMGB1 against myocardial ischemia-reperfusion injury. Journal of cellular physiology. vol 234. issue 12. 2020-06-12. PMID:31188485. |
knockdown of mirna-451 48 hr before i/r injury was found to increase hmgb1 expression, infarct size, and i/r-induced cardiomyocyte apoptosis in rat hearts in the presence of propofol pretreatment. |
2020-06-12 |
2023-08-13 |
rat |
| Yu-Mei Li, Jin-Guo Sun, Li-Hua Hu, Xian-Chun Ma, Gang Zhou, Xi-Zhao Huan. Propofol-mediated cardioprotection dependent of microRNA-451/HMGB1 against myocardial ischemia-reperfusion injury. Journal of cellular physiology. vol 234. issue 12. 2020-06-12. PMID:31188485. |
these in vivo findings were reproduced in vivo that knockdown of mirna-451 48 hr before h/r injuries increased hmgb1 expression and h/r-induced apoptosis in cultured h9c2 supplemented with propofol. |
2020-06-12 |
2023-08-13 |
rat |
| João Pedro Maia de Oliveira da Silva, Ana Flávia Brugnerotto, Karen S Romanello, Karina K L Teixeira, Carolina Lanaro, Adriana S Duarte, Gustavo G L Costa, Aderson da Silva Araújo, Marcos André C Bezerra, Igor de Farias Domingos, Diego A Pereira Martins, Iran Malavazi, Fernando F Costa, Anderson F da Cunh. Global gene expression reveals an increase of HMGB1 and APEX1 proteins and their involvement in oxidative stress, apoptosis and inflammation pathways among beta-thalassaemia intermedia and major phenotypes. British journal of haematology. vol 186. issue 4. 2020-06-03. PMID:31218684. |
global gene expression reveals an increase of hmgb1 and apex1 proteins and their involvement in oxidative stress, apoptosis and inflammation pathways among beta-thalassaemia intermedia and major phenotypes. |
2020-06-03 |
2023-08-13 |
human |