| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aida Barreiro-Alonso, Mónica Lamas-Maceiras, Rosa García-Díaz, Esther Rodríguez-Belmonte, Lu Yu, Mercedes Pardo, Jyoti S Choudhary, María Esperanza Cerdá. Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer. Oncotarget. vol 9. issue 27. 2019-11-20. PMID:29721183. |
hmgb1 interacts with many nuclear proteins that control gene expression, but also with proteins that form part of the cytoskeleton, cell-adhesion structures and others involved in intracellular protein translocation, cellular migration, secretion, apoptosis and cell survival. |
2019-11-20 |
2023-08-13 |
Not clear |
| Liang Tian, Zheng-Yu Wang, Jun Hao, Xiao-Yu Zhan. miR-505 acts as a tumor suppressor in gastric cancer progression through targeting HMGB1. Journal of cellular biochemistry. 2019-11-20. PMID:30525214. |
subsequently, knockdown of hmgb1 can inhibit gc cell proliferation, colony formation, and induce cell apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| Dong-Mei Wu, Shan Wang, Min Shen, Yong-Jian Wang, Bo Zhang, Zi-Qi Wu, Jun Lu, Yuan-Lin Zhen. S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. Journal of cellular and molecular medicine. vol 22. issue 4. 2019-10-28. PMID:29441717. |
mtt assay, flow cytometry, rt-qpcr and western blotting were used to evaluate cell proliferation, cell cycle and apoptosis, and expressions of s100a9, tlr4, rage, il-17, hmgb1 and s100a12 in tissues and cells. |
2019-10-28 |
2023-08-13 |
mouse |
| Dong-Mei Wu, Shan Wang, Min Shen, Yong-Jian Wang, Bo Zhang, Zi-Qi Wu, Jun Lu, Yuan-Lin Zhen. S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. Journal of cellular and molecular medicine. vol 22. issue 4. 2019-10-28. PMID:29441717. |
the in vivo results: compare with the control group, the blank, nc, shrna1 and shrna2 groups demonstrated increased expressions of s100a9, tlr4, rage, il-17, hmgb1 and s100a12, as well as cell apoptosis and cells at the g1 phase, with reduced proliferation. |
2019-10-28 |
2023-08-13 |
mouse |
| Dong-Mei Wu, Shan Wang, Min Shen, Yong-Jian Wang, Bo Zhang, Zi-Qi Wu, Jun Lu, Yuan-Lin Zhen. S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. Journal of cellular and molecular medicine. vol 22. issue 4. 2019-10-28. PMID:29441717. |
compared with the blank and nc groups, the shrna1 and shrna2 groups had declined expressions of s100a9, tlr4, rage, il-17, hmgb1 and s100a12, as well as cell apoptosis and cells at the g1 phase, with elevated proliferation. |
2019-10-28 |
2023-08-13 |
mouse |
| Lili Wang, Ying Zhang, Haofeng Wang, Hui Li, Ziying Zhao, Ning Wang, Bin He, Cuige Shi, Shucheng Zhang, Jiedong Wan. Repeated abortion in adulthood induces cognition impairment in aged mice. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30061639. |
finally, we identified that mpp-induced cell apoptosis and increased hmgb1 expression as well as il-1β, il-6, and tnf-α expression as following aβ elevation. |
2019-10-18 |
2023-08-13 |
mouse |
| Jun-Xiu Zhang, Shao-Dan Li, Yi Liu, Ming-Hui Yan. Preventive effect of Tongxinluo on endothelial survival and vascular integrity, together with inhibition of inflammatory reaction in rats model of intestine ischemia/reperfusion injury. Pakistan journal of pharmaceutical sciences. vol 31. issue 6. 2019-10-15. PMID:30473511. |
i/r induced massively endothelial cell apoptosis, accompanied with reduced expression of adherens junction protein ve-cadherin and up regulation of inflammatory mediator hmgb1 and nf-κb. |
2019-10-15 |
2023-08-13 |
rat |
| Fei Lin, Likai Pei, Qingbin Zhang, Weizhong Han, Shiliang Jiang, Yanliang Lin, Bo Dong, Lianqun Cui, Min L. Ox-LDL induces endothelial cell apoptosis and macrophage migration by regulating caveolin-1 phosphorylation. Journal of cellular physiology. vol 233. issue 10. 2019-10-03. PMID:29323707. |
intracellular accumulation of ox-ldl induced nf-κb p65 phosphorylation, promoted hmgb1 translocation from nucleus to cytoplasm and cytochrome c release from mitochondria to cytoplasm, and activated caspase 3, resulting in cell apoptosis. |
2019-10-03 |
2023-08-13 |
human |
| Aifen Liu, Jing Wu, Cheng Yang, Yuanyuan Wu, Yufang Zhang, Fengbo Zhao, Hui Wang, Li Yuan, Lirui Song, Tongyu Zhu, Yaping Fan, Bin Yan. TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury. Scientific reports. vol 8. issue 1. 2019-10-02. PMID:29615639. |
trpm7 was also positively associated with ldh, hmgb1, caspase-3, bax/bcl-2, inflammation, apoptosis, tubulointerstitial damage and renal function respectively. |
2019-10-02 |
2023-08-13 |
mouse |
| Aifen Liu, Bin Yan. Roles of TRPM7 in Renal Ischemia-Reperfusion Injury. Current protein & peptide science. vol 20. issue 8. 2019-09-30. PMID:31060485. |
the association between trpm7, inflammatory response and apoptosis, as well as related caspase-3, hmgb1 and bax/bcl-2 ratio, was also discussed. |
2019-09-30 |
2023-08-13 |
Not clear |
| Jia Li, Yijun Zhang, Jun Li, Wen Che. [Knockdown of HMGB1 inhibits proliferation and promotes apoptosis of rat mesangial cells induced by high glucose]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292055. |
[knockdown of hmgb1 inhibits proliferation and promotes apoptosis of rat mesangial cells induced by high glucose]. |
2019-09-10 |
2023-08-13 |
rat |
| Jia Li, Yijun Zhang, Jun Li, Wen Che. [Knockdown of HMGB1 inhibits proliferation and promotes apoptosis of rat mesangial cells induced by high glucose]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292055. |
results compared with the sirna-nc-hg group or hg treatment group, hmgb1 mrna level decreased in gmcs in the sirna-hmgb1-hg group, and after 24-, 48-, 72- and 96-hour treatment, the proliferation activity and apoptosis rate of gmcs decreased. |
2019-09-10 |
2023-08-13 |
rat |
| Jia Li, Yijun Zhang, Jun Li, Wen Che. [Knockdown of HMGB1 inhibits proliferation and promotes apoptosis of rat mesangial cells induced by high glucose]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292055. |
conclusion knockdown of hmgb1 inhibits proliferation and promotes apoptosis of gmcs induced by hg, which may be related to the inhibition of nf-κb/iκb-α pathway. |
2019-09-10 |
2023-08-13 |
rat |
| Shingo Hirao, Kenji Minakata, Hidetoshi Masumoto, Kazuhiro Yamazaki, Tadashi Ikeda, Kenji Minatoya, Ryuzo Sakat. Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model. The Journal of thoracic and cardiovascular surgery. vol 154. issue 6. 2019-08-13. PMID:28645823. |
recombinant human soluble thrombomodulin (rtm) is reported to attenuate the secretion of inflammatory cytokines and the high-mobility group box 1 (hmgb1) protein, which is critical in controlling systemic inflammation and apoptosis. |
2019-08-13 |
2023-08-13 |
human |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29920330. |
dna binding protein hmgb1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with osa. |
2019-08-06 |
2023-08-13 |
mouse |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29920330. |
we aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (hmgb1), after high glucose (hg) and intermittent hypoxia (ih) exposure. |
2019-08-06 |
2023-08-13 |
mouse |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29920330. |
in a cellular monoculture or co-culture system, hmgb1 sirna was able to alleviate the activation of bv2 cells and the apoptosis of ht22 cells induced by hg combined with ih. |
2019-08-06 |
2023-08-13 |
mouse |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29920330. |
our object is to show that inhibition of hmgb1 may break the vicious cycle to prevent or treat neuroinflammation and hippocampal neuronal apoptosis caused by t2dm complicated with osa. |
2019-08-06 |
2023-08-13 |
mouse |
| Efthalia Angelopoulou, Christina Piperi, Athanasios G Papavassilio. High-mobility group box 1 in Parkinson's disease: from pathogenesis to therapeutic approaches. Journal of neurochemistry. vol 146. issue 3. 2019-06-26. PMID:29676481. |
hmgb1 has been shown to participate in neuroinflammation, modulate autophagy and apoptosis as well as regulate gene transcription. |
2019-06-26 |
2023-08-13 |
Not clear |
| b' Murielle Gr\\xc3\\xa9goire, Fabrice Uhel, Mathieu Lesouhaitier, Arnaud Gacouin, Marion Guirriec, Frederic Mourcin, Erwan Dumontet, Arnaud Chalin, Michel Samson, Laure-Line Berthelot, Adrien Tissot, Mallorie Kerjouan, St\\xc3\\xa9phane Jouneau, Yves Le Tulzo, Karin Tarte, Jaroslaw W Zmijewski, Jean-Marc Tadi\\xc3\\xa. Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDS. The European respiratory journal. vol 52. issue 2. 2019-06-20. PMID:29946009.' |
metformin (an ampk activator) and neutralising antibody against hmgb1 were applied to improve efferocytosis and net clearance.neutrophils from ards patients showed significantly reduced apoptosis. |
2019-06-20 |
2023-08-13 |
Not clear |