| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shangping Zhao, Jinming Yang, Ting Liu, Juanxian Zeng, Liangliang Mi, Kaimin Xian. Dexamethasone inhibits NF‑кBp65 and HMGB1 expression in the pancreas of rats with severe acute pancreatitis. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30365121. |
in vitro, dxm was able to suppress the apoptosis and cell death induced by caerulein (cae), and dxm could suppress the expression of nf‑κbp65 and hmgb1 induced by cae, as demonstrated by western blotting and immunofluorescence analysis. |
2019-01-28 |
2023-08-13 |
rat |
| Wenjia Zhang, Fangmei An, Min Xia, Qiang Zhan, Wenying Tian, Yang Jia. Increased HMGB1 expression correlates with higher expression of c-IAP2 and pERK in colorectal cancer. Medicine. vol 98. issue 3. 2019-01-25. PMID:30653121. |
immunohistochemical analysis was performed to determine hmgb1, perk, and c-inhibitor of apoptosis protein 2 (c-iap2) protein expression levels in the cancer tissues.a total 144 patients with crc and 50 healthy subjects underwent serum hmgb1 testing. |
2019-01-25 |
2023-08-13 |
human |
| Yurong Qu, Yuan Zhan, Shen Yang, Shanhui Ren, Xusheng Qiu, Zaib Ur Rehamn, Lei Tan, Yingjie Sun, Chunchun Meng, Cuiping Song, Shengqing Yu, Chan Din. Newcastle disease virus infection triggers HMGB1 release to promote the inflammatory response. Virology. vol 525. 2019-01-07. PMID:30216776. |
newcastle disease virus (ndv) infection is proved to cause intense inflammatory responses that result in excessive cellular apoptosis and tissue damage, but the function of hmgb1 in ndv-induced cytokine storm has not been elucidated. |
2019-01-07 |
2023-08-13 |
chicken |
| Fatemeh Hashemi-Niasari, Azra Rabbani-Chadegani, Mahdieh Razmi, Soudabeh Falla. Synergy of theophylline reduces necrotic effect of berberine, induces cell cycle arrest and PARP, HMGB1, Bcl-2 family mediated apoptosis in MDA-MB-231 breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:30119256. |
synergy of theophylline reduces necrotic effect of berberine, induces cell cycle arrest and parp, hmgb1, bcl-2 family mediated apoptosis in mda-mb-231 breast cancer cells. |
2018-12-18 |
2023-08-13 |
Not clear |
| Xiaolong Xie, Tiebing Zhu, Lulu Chen, Shuang Ding, Han Chu, Jing Wang, Honghong Yao, Jie Cha. MCPIP1-induced autophagy mediates ischemia/reperfusion injury in endothelial cells via HMGB1 and CaSR. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29379093. |
i/r induced hmgb1 and casr expression, which subsequently upreguated the migration and apoptosis of huvecs and coincided with the increase of autophagy. |
2018-12-11 |
2023-08-13 |
Not clear |
| Xiaolong Xie, Tiebing Zhu, Lulu Chen, Shuang Ding, Han Chu, Jing Wang, Honghong Yao, Jie Cha. MCPIP1-induced autophagy mediates ischemia/reperfusion injury in endothelial cells via HMGB1 and CaSR. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29379093. |
hmgb1 was involved in cell migration, whereas casr specifically participated in i/r-induced huvec apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Xiaolong Xie, Tiebing Zhu, Lulu Chen, Shuang Ding, Han Chu, Jing Wang, Honghong Yao, Jie Cha. MCPIP1-induced autophagy mediates ischemia/reperfusion injury in endothelial cells via HMGB1 and CaSR. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29379093. |
based on these findings, i/r-induced mcpip1 expression regulates the migration and apoptosis of huvecs via hmgb1 and casr, respectively, suggesting a new therapeutic targetof i/r injury. |
2018-12-11 |
2023-08-13 |
Not clear |
| Yueqin Wang, Guangwei Luo, Jie Chen, Rui Jiang, Jianhua Zhu, Na Hu, Wei Huang, Guilian Cheng, Min Jia, Bingtao Su, Nian Zhang, Tianpen Cu. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions. Scientific reports. vol 7. 2018-11-05. PMID:28195210. |
in this study, apoptosis was increased and the level of mfg-e8 was decreased while hmgb1 expression was increased in lung tissues of cs-exposed mice. |
2018-11-05 |
2023-08-13 |
mouse |
| Lin Lu, Donghui Zhang, Yu Xu, Guang Bai, Yong Lv, Jian Lian. miR-505 enhances doxorubicin-induced cytotoxicity in hepatocellular carcinoma through repressing the Akt pathway by directly targeting HMGB1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 104. 2018-10-05. PMID:29803174. |
we found that hmgb1 knockdown and mir-505 overexpression exacerbated adm-induced cell viability inhibition, enhanced adm-induced apoptosis, and increased caspase-3 activity in adm-treated hcc cells. |
2018-10-05 |
2023-08-13 |
Not clear |
| Rui Liu, Qiancheng Luo, Wen You, Mingming Ji. MicroRNA-106 attenuates hyperglycemia-induced vascular endothelial cell dysfunction by targeting HMGB1. Gene. vol 677. 2018-10-01. PMID:30055307. |
increasing evidence shows that high mobility group box 1 (hmgb1) expression is related to inflammation and apoptosis. |
2018-10-01 |
2023-08-13 |
human |
| Rui Liu, Qiancheng Luo, Wen You, Mingming Ji. MicroRNA-106 attenuates hyperglycemia-induced vascular endothelial cell dysfunction by targeting HMGB1. Gene. vol 677. 2018-10-01. PMID:30055307. |
downregulation of hmgb1 attenuated the high glucose-induced antiangiogenesis of huvecs, and the decrease expression of hmgb1 inhibiting huvec apoptosis and inflammatory factor expression. |
2018-10-01 |
2023-08-13 |
human |
| Rui Liu, Qiancheng Luo, Wen You, Mingming Ji. MicroRNA-106 attenuates hyperglycemia-induced vascular endothelial cell dysfunction by targeting HMGB1. Gene. vol 677. 2018-10-01. PMID:30055307. |
taken together, these data collectively suggested that mir-106 was a potential molecular target for inhibiting high glucose-induced inflammation and apoptosis by targeting hmgb1. |
2018-10-01 |
2023-08-13 |
human |
| Li Fu, Keyue Liu, Hidenori Wake, Kiyoshi Teshigawara, Tadashi Yoshino, Hideo Takahashi, Shuji Mori, Masahiro Nishibor. Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice. Scientific reports. vol 7. issue 1. 2018-09-06. PMID:28446773. |
these results suggested that anti-hmgb1 mab prevented the bbb permeability, reduced hmgb1 translocation while inhibiting the expression of inflammation-related factors, protected against neural cell apoptosis and prolonged racine stage 5 seizure onset and latency. |
2018-09-06 |
2023-08-13 |
mouse |
| Jia-Ying Tan, Feng Zhao, Shui-Xiang Deng, He-Chen Zhu, Ye Gong, Wei Wan. Glycyrrhizin affects monocyte migration and apoptosis by blocking HMGB1 signaling. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436639. |
glycyrrhizin affects monocyte migration and apoptosis by blocking hmgb1 signaling. |
2018-08-30 |
2023-08-13 |
Not clear |
| Jia-Ying Tan, Feng Zhao, Shui-Xiang Deng, He-Chen Zhu, Ye Gong, Wei Wan. Glycyrrhizin affects monocyte migration and apoptosis by blocking HMGB1 signaling. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436639. |
high mobility group box‑1 protein (hmgb1) promotes recruitment and suppresses apoptosis in monocytes through the receptor for advanced glycation end products/ nuclear factor (nf)‑κb and toll‑like receptor 4/mitogen‑activated protein kinase (mapk)/extracellular signal‑regulated kinase (erk) signaling pathways. |
2018-08-30 |
2023-08-13 |
Not clear |
| Jia-Ying Tan, Feng Zhao, Shui-Xiang Deng, He-Chen Zhu, Ye Gong, Wei Wan. Glycyrrhizin affects monocyte migration and apoptosis by blocking HMGB1 signaling. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436639. |
the present study investigated the effect of gl on the migration and apoptosis of monocytes associated with hmgb1 signaling. |
2018-08-30 |
2023-08-13 |
Not clear |
| Wei Zhang, Jian Song, Yue Zhang, Yingxue Ma, Jing Yang, Guanghui He, Song Che. Intermittent high glucose-induced oxidative stress modulates retinal pigmented epithelial cell autophagy and promotes cell survival via increased HMGB1. BMC ophthalmology. vol 18. issue 1. 2018-08-22. PMID:30081847. |
in this study, we evaluated the effects of intermittent high glucose on oxidative stress production in retinal pigmented epithelial (rpe) cells and explored whether the mechanisms of autophagy and apoptosis in oxidative stress are associated with high-mobility group box 1 (hmgb1) protein. |
2018-08-22 |
2023-08-13 |
Not clear |
| Yinzong Xiao, Lunquan Sun, Yongming Fu, Yan Huang, Rongrong Zhou, Xingwang Hu, Pengcheng Zhou, Jun Quan, Ning Li, Xue-Gong Fa. High mobility group box 1 promotes sorafenib resistance in HepG2 cells and in vivo. BMC cancer. vol 17. issue 1. 2018-08-08. PMID:29246127. |
high mobility group box 1 (hmgb1) is a multifaceted protein that plays a key role in the proliferation, apoptosis, metastasis and angiogenesis of hcc cells. |
2018-08-08 |
2023-08-13 |
Not clear |
| Yong Chai, Juhua Xiao, Shouhua Zhang, Yunyan Du, Zhipeng Luo, Xin Zhou, Kai Huan. High-mobility group protein B1 silencing promotes susceptibility of retinoblastoma cells to chemotherapeutic drugs through downregulating nuclear factor-κB. International journal of molecular medicine. vol 41. issue 3. 2018-08-03. PMID:29328447. |
moreover, following sirna hmgb1, sirna nc and ammonium pdtc treatment, the apoptosis of rb cells with vcr incubation was evaluated by hoechst staining, and the expression of cleaved caspase-3, cleaved poly(adp-ribose) polymerase (parp), beclin 1 and p62 were determined with western blot analysis. |
2018-08-03 |
2023-08-13 |
Not clear |
| Yong Chai, Juhua Xiao, Shouhua Zhang, Yunyan Du, Zhipeng Luo, Xin Zhou, Kai Huan. High-mobility group protein B1 silencing promotes susceptibility of retinoblastoma cells to chemotherapeutic drugs through downregulating nuclear factor-κB. International journal of molecular medicine. vol 41. issue 3. 2018-08-03. PMID:29328447. |
similar to the nf-κb inhibitor pdtc, sirna hmgb1 significantly promoted apoptosis and suppressed autophagy of vcr‑treated rb cells through reversing the effects of vcr on these signaling molecules (p<0.01). |
2018-08-03 |
2023-08-13 |
Not clear |