| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| João Pedro Maia de Oliveira da Silva, Ana Flávia Brugnerotto, Karen S Romanello, Karina K L Teixeira, Carolina Lanaro, Adriana S Duarte, Gustavo G L Costa, Aderson da Silva Araújo, Marcos André C Bezerra, Igor de Farias Domingos, Diego A Pereira Martins, Iran Malavazi, Fernando F Costa, Anderson F da Cunh. Global gene expression reveals an increase of HMGB1 and APEX1 proteins and their involvement in oxidative stress, apoptosis and inflammation pathways among beta-thalassaemia intermedia and major phenotypes. British journal of haematology. vol 186. issue 4. 2020-06-03. PMID:31218684. |
considering the role of reactive oxygen species (ros) in the pathophysiology of thalassaemia, we focused on differentially expressed genes involved in metabolic pathways triggered by ros, such as inflammation and apoptosis, and, from these, we selected the apurinic/apyrimidinic endodeoxyribonuclease 1 (apex1) and high mobility group box1 (hmgb1) genes, whose role in bt is not well established. |
2020-06-03 |
2023-08-13 |
human |
| Je-Jung Lee, In Ho Park, Woo Joong Rhee, Hee Sue Kim, Jeon-Soo Shi. HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 10. 2020-06-01. PMID:31284735. |
hmgb1 modulates the balance between senescence and apoptosis in response to genotoxic stress. |
2020-06-01 |
2023-08-13 |
mouse |
| Quan-Fang Chen, Wei Wang, Zhou Huang, Dong-Ling Huang, Fan Wang, Jun Li, Xue-Feng Liu, Zhong-Yi Sun, Xiang-Tao Zen. Role of high-mobility group B1 in myocardial injury induced by coronary microembolization in rats. Journal of cellular biochemistry. vol 120. issue 3. 2020-04-06. PMID:30269353. |
this study aimed to explore the effects of high-mobility group b1 (hmgb1) on coronary microembolization (cme)-induced myocardial inflammation, myocardial apoptosis, and cardiac function injury in rats. |
2020-04-06 |
2023-08-13 |
rat |
| Miao Wang, Lu Zhao, Dongdong Tong, Linrui Yang, Hongjie Zhu, Qing Li, Fenghe Zhan. BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma. International immunopharmacology. vol 76. 2020-03-17. PMID:31600692. |
a key discovery in the past decade is that chemotherapeutics can alter tumor cell immunogenicity via inducing release of damage-associated molecular patterns (damps), including ecto-calreticulin (ecto-calr), high mobility group box 1 (hmgb1) and atp, causing tumor cells to die in a manner known as bona fide immunogenic apoptosis or immunogenic cell death (icd). |
2020-03-17 |
2023-08-13 |
mouse |
| Juan Jin, Jianguang Gong, Li Zhao, Hongjuan Zhang, Qiang He, Xinxin Jian. Inhibition of high mobility group box 1 (HMGB1) attenuates podocyte apoptosis and epithelial-mesenchymal transition by regulating autophagy flux. Journal of diabetes. vol 11. issue 10. 2020-03-12. PMID:30864227. |
inhibition of high mobility group box 1 (hmgb1) attenuates podocyte apoptosis and epithelial-mesenchymal transition by regulating autophagy flux. |
2020-03-12 |
2023-08-13 |
Not clear |
| Wenwen Wang, Liwei Wu, Jingjing Li, Jie Ji, Kan Chen, Qiang Yu, Sainan Li, Jiao Feng, Tong Liu, Jie Zhang, Jiaojiao Chen, Yuting Zhou, Yuqing Mao, Fan Wang, Weiqi Dai, Xiaoming Fan, Chuanyong Guo, Jianye W. Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy. Mediators of inflammation. vol 2019. 2020-02-24. PMID:31316298. |
alleviation of hepatic ischemia reperfusion injury by oleanolic acid pretreating via reducing hmgb1 release and inhibiting apoptosis and autophagy. |
2020-02-24 |
2023-08-13 |
mouse |
| Suzanne Ostrand-Rosenberg, Daniel W Beury, Katherine H Parker, Lucas A Hor. Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment. Cancer immunology, immunotherapy : CII. vol 69. issue 2. 2020-02-11. PMID:31501954. |
the survival of tumor cells within the tme is partially governed by two mechanisms: (1) activation of the transcription factor nuclear factor erythroid-derived 2-like 2 (nrf2) which turns on genes that attenuate oxidative stress; and (2) the presence of high mobility group box protein-1 (hmgb1), a damage-associated molecular pattern molecule (damp) that induces autophagy and protects against apoptosis. |
2020-02-11 |
2023-08-13 |
Not clear |
| Ning Jiang, Xiaolong Che. Protective effect of high mobility group box-1 silence on diabetic retinopathy: an International journal of clinical and experimental pathology. vol 10. issue 8. 2020-01-26. PMID:31966667. |
protective effect of high mobility group box-1 silence on diabetic retinopathy: an to explore the effects of hmgb1 silence on cell apoptosis, inflammatory response and endothelial permeability barrier. |
2020-01-26 |
2023-08-13 |
Not clear |
| Yeo Reum Jeon, Hyun Roh, Ji Hyuk Jung, Hyo Min Ahn, Ju Hee Lee, Chae-Ok Yun, Won Jai Le. Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis. International journal of molecular sciences. vol 20. issue 17. 2020-01-24. PMID:31450620. |
suppression of hmgb1 inhibits autophagy while increasing apoptosis. |
2020-01-24 |
2023-08-13 |
Not clear |
| Xiangyu Guo, Yu Shi, Ping Du, Jiahui Wang, Yelei Han, Bei Sun, Jing Fen. HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA. Life sciences. vol 239. 2019-12-23. PMID:31678553. |
we previously reported that cognitive impairment is exacerbated in kkay mice exposed to intermittent hypoxia (ih), during which the dna binding protein hmgb1 mediates hippocampal neuronal apoptosis by maintaining microglia-associated neuroinflammation, but the underlying mechanism remains largely unknown. |
2019-12-23 |
2023-08-13 |
mouse |
| Hui Luo, Ling Wang, Ding Bao, Li Wang, Hongjun Zhao, Yun Lian, Mei Yan, Chandra Mohan, Quan-Zhen L. Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus. Genomics, proteomics & bioinformatics. vol 17. issue 3. 2019-12-20. PMID:31494269. |
a group of autoabs associated with cell apoptosis and dna repair function, including those targeting apex1, aurka, polb, ago1, hmgb1, ifit5, mapkapk3, padi4, rgs3, srp19, ube2s, and vrk1, were further validated by elisa and western blot in a larger cohort. |
2019-12-20 |
2023-08-13 |
Not clear |
| Jianqiang Zhang, Jing Wang, Xinan Wu, Yuhui We. Ginsenoside Rb1 inhibits proliferation and promotes apoptosis by regulating HMGB1 in uterine fibroid cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-16. PMID:31313594. |
ginsenoside rb1 inhibits proliferation and promotes apoptosis by regulating hmgb1 in uterine fibroid cells. |
2019-12-16 |
2023-08-13 |
human |
| Jianqiang Zhang, Jing Wang, Xinan Wu, Yuhui We. Ginsenoside Rb1 inhibits proliferation and promotes apoptosis by regulating HMGB1 in uterine fibroid cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-16. PMID:31313594. |
to study the effects of ginsenoside rb1 and the molecular mechanisms on proliferation and apoptosis of uterine fibroid cells, rb1 + pc dna3.1, rb1 + pc dna3.1-hmgb1, si-nc or si-hmgb1 was transfected into uterine fibroid cells by liposome method; the inhibitory rate and proliferation of human uterine fibroid cells were detected by mtt assay; apoptosis of uterine fibroid cells was detected by flow cytometry assay; hmgb1 protein expression in uterine fibroid cells was detected by western blot assay. |
2019-12-16 |
2023-08-13 |
human |
| Jianqiang Zhang, Jing Wang, Xinan Wu, Yuhui We. Ginsenoside Rb1 inhibits proliferation and promotes apoptosis by regulating HMGB1 in uterine fibroid cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-16. PMID:31313594. |
compared with untreated uterine fibroid cells, the inhibitory and apoptosis rate of uterine fibroid cells treated with rb1 were significantly up-regulated, while the expression level of hmgb1 was significantly down-regulated ( |
2019-12-16 |
2023-08-13 |
human |
| Ying Shi, Weihua Gong, Lu Lu, Yunfeng Wang, Jingjing Re. Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 11. 2019-11-25. PMID:31664305. |
we found that interference of hmgb1 enhanced the chemosensitivity of taxol by inhibiting autophagy and inducing apoptosis in mcf-7 cells. |
2019-11-25 |
2023-08-13 |
Not clear |
| Ying Shi, Weihua Gong, Lu Lu, Yunfeng Wang, Jingjing Re. Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 11. 2019-11-25. PMID:31664305. |
taken together, our findings suggested that mir-129-5p increased the chemosensitivity of mcf-7 cells to taxol through suppressing autophagy and enhancing apoptosis by inhibiting hmgb1. |
2019-11-25 |
2023-08-13 |
Not clear |
| Hubin Yin, Xiaoyu Yang, Wen Gu, Yan Liu, Xinyuan Li, Xiaolong Huang, Xin Zhu, Yong Tao, Xin Gou, Weiyang H. HMGB1-mediated autophagy attenuates gemcitabine-induced apoptosis in bladder cancer cells involving JNK and ERK activation. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069735. |
suppressing hmgb1 expression with sirna strongly potentiated gemcitabine-induced apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chao Ren, Ya-Lin Tong, Jun-Cong Li, Ning Dong, Ji-Wei Hao, Qing-Hong Zhang, Yong-Ming Ya. Early antagonism of cerebral high mobility group box-1 protein is benefit for sepsis induced brain injury. Oncotarget. vol 8. issue 54. 2019-11-20. PMID:29190939. |
the expression of hmgb1, morphological changes of brain tissues, apoptosis of brain cells, and alteration of behavior were determined. |
2019-11-20 |
2023-08-13 |
mouse |
| Chao Ren, Ya-Lin Tong, Jun-Cong Li, Ning Dong, Ji-Wei Hao, Qing-Hong Zhang, Yong-Ming Ya. Early antagonism of cerebral high mobility group box-1 protein is benefit for sepsis induced brain injury. Oncotarget. vol 8. issue 54. 2019-11-20. PMID:29190939. |
neutralizing brain hmgb1 significantly improved brain injury and apoptosis of brain cells, and further ameliorated disturbed locomotor activities and damaged memory and learning. |
2019-11-20 |
2023-08-13 |
mouse |
| Ying-Yi Luan, Min Jia, Hui Zhang, Fu-Jun Zhu, Ning Dong, Yong-Wen Feng, Ming Wu, Ya-Lin Tong, Yong-Ming Ya. The potential mechanism of extracellular high mobility group box-1 protein mediated p53 expression in immune dysfunction of T lymphocytes. Oncotarget. vol 8. issue 68. 2019-11-20. PMID:29348880. |
taken together, our data strongly indicated that hmgb1 might enhance p53 expression, which was associated with both the proliferative activity as well as apoptosis of t cells. |
2019-11-20 |
2023-08-13 |
Not clear |