| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristen M Livesey, Rui Kang, Herbert J Zeh, Michael T Lotze, Daolin Tan. Direct molecular interactions between HMGB1 and TP53 in colorectal cancer. Autophagy. vol 8. issue 5. 2012-11-13. PMID:22647615. |
we have demonstrated that tp53-hmgb1 complexes regulate the balance between apoptosis and autophagy through regulation of the cytosolic localization of the reciprocal binding partner, whereby increased cytosolic hmgb1 enhances autophagy and increased cytosolic tp53 enhances apoptosis in colon cancer cells. |
2012-11-13 |
2023-08-12 |
Not clear |
| Kristen M Livesey, Rui Kang, Herbert J Zeh, Michael T Lotze, Daolin Tan. Direct molecular interactions between HMGB1 and TP53 in colorectal cancer. Autophagy. vol 8. issue 5. 2012-11-13. PMID:22647615. |
thus, hmgb1 and tp53 are critical in the cross-regulation of apoptosis and autophagy and central to colon cancer biology. |
2012-11-13 |
2023-08-12 |
Not clear |
| Zhongjun Fan, Xuming Hu, Yongpan Zhang, Chuan Yu, Kun Qian, Aijian Qi. Proteomics of DF-1 cells infected with avian leukosis virus subgroup J. Virus research. vol 167. issue 2. 2012-11-08. PMID:22664373. |
other proteins, such as dj-1, uchl1, vdac1 and hmgb1, have some relationship to apoptosis or oncogenesis. |
2012-11-08 |
2023-08-12 |
Not clear |
| Daniel J Antoine, Rosalind E Jenkins, James W Dear, Dominic P Williams, Mitchell R McGill, Matthew R Sharpe, Darren G Craig, Kenneth J Simpson, Hartmut Jaeschke, B Kevin Par. RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. Journal of hepatology. vol 56. issue 5. 2012-10-23. PMID:22266604. |
in addition, the caspase-cleaved fragment of k18 (ck18) and hyper-acetylated hmgb1 represent serum indicators of apoptosis and immune cell activation, respectively. |
2012-10-23 |
2023-08-12 |
Not clear |
| Jie Chen, Xiaoyan Liu, Jie Zhang, Yueran Zha. Targeting HMGB1 inhibits ovarian cancer growth and metastasis by lentivirus-mediated RNA interference. Journal of cellular physiology. vol 227. issue 11. 2012-10-03. PMID:22331597. |
furthermore, knockdown of hmgb1 induced ovarian cancer cell apoptosis, which was mediated by increased expression of bax and decreased expression of bcl-2. |
2012-10-03 |
2023-08-12 |
Not clear |
| Yi Liu, Peng Zhang, Zhihao Wu, Jun Chen, Qinghua Zho. [Screening of Highly-expressed-HMGB1-Gene Human Lung Cancer Cell Lines.]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 12. issue 9. 2012-10-02. PMID:20719193. |
hmgb1 overexpression can result in cell apoptosis, differentiation, migration and proliferation. |
2012-10-02 |
2023-08-12 |
human |
| Yan Yu, Min Xie, Rui Kang, Kristen M Livesey, Lizhi Cao, Daolin Tan. HMGB1 is a therapeutic target for leukemia. American journal of blood research. vol 2. issue 1. 2012-08-23. PMID:22432086. |
moreover, hmgb1 is a negative regulator of apoptosis in leukemia cells through regulation of bcl-2 expression and caspase-3 activity. |
2012-08-23 |
2023-08-12 |
Not clear |
| Yu Mi Ha, Min Young Kim, Min Kyu Park, Young Soo Lee, Young Min Kim, Hye Jung Kim, Jae Heun Lee, Ki Churl Chan. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis : an international journal on programmed cell death. vol 17. issue 5. 2012-07-26. PMID:22183510. |
growing lines of evidence suggests that high mobility group box-1 (hmgb1) plays an important role for promoting inflammation and apoptosis in brain ischemia. |
2012-07-26 |
2023-08-12 |
rat |
| Yu Mi Ha, Min Young Kim, Min Kyu Park, Young Soo Lee, Young Min Kim, Hye Jung Kim, Jae Heun Lee, Ki Churl Chan. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis : an international journal on programmed cell death. vol 17. issue 5. 2012-07-26. PMID:22183510. |
thus, we tested our hypothesis that higenamine protects brain injury by inhibition of middle cerebral artery occlusion (mcao)-mediated hmgb1 release in vivo, and glucose/glucose oxidase (gox)-induced apoptosis in c6 cells in vitro due to ho-1 induction. |
2012-07-26 |
2023-08-12 |
rat |
| Jing Zhang, Jin-Shui Zhu, Zhou Zhou, Wei-Xiong Chen, Ni-Wei Che. Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo. Oncology reports. vol 27. issue 5. 2012-07-23. PMID:22246223. |
after sgc-7901 gastric cancer cells were treated with ep, the expression of hmgb1, rage, akt, phosphorylated akt (p-akt) and some transcription factors was identified and the effects of ep on cell proliferation, invasion, cell cycle distribution and apoptosis were assessed. |
2012-07-23 |
2023-08-12 |
human |
| Yongwei Yao, Xuemei Xu, Guohui Zhang, Yingyu Zhang, Wei Qian, Tao Ru. Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. Basic research in cardiology. vol 107. issue 3. 2012-07-09. PMID:22527657. |
role of hmgb1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. |
2012-07-09 |
2023-08-12 |
mouse |
| Yongwei Yao, Xuemei Xu, Guohui Zhang, Yingyu Zhang, Wei Qian, Tao Ru. Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. Basic research in cardiology. vol 107. issue 3. 2012-07-09. PMID:22527657. |
we found treatment of isolated cardiomyocytes and naive mice with the dox resulted in an increased hmgb1 expression which was associated with increased myocardial cell apoptosis. |
2012-07-09 |
2023-08-12 |
mouse |
| Yongwei Yao, Xuemei Xu, Guohui Zhang, Yingyu Zhang, Wei Qian, Tao Ru. Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. Basic research in cardiology. vol 107. issue 3. 2012-07-09. PMID:22527657. |
pharmacological (a-box) or genetic blockade (tlr4 deficiency, tlr4(-/-)) of hmgb1 attenuated the dox-induced myocardial apoptosis and cardiac dysfunction. |
2012-07-09 |
2023-08-12 |
mouse |
| Yongwei Yao, Xuemei Xu, Guohui Zhang, Yingyu Zhang, Wei Qian, Tao Ru. Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. Basic research in cardiology. vol 107. issue 3. 2012-07-09. PMID:22527657. |
pretreatment of myocytes with fetpps, a peroxynitrite decomposition catalyst, prevented dox-induced jnk phosphorylation, hmgb1 expression, myocardial apoptosis and cardiac dysfunction. |
2012-07-09 |
2023-08-12 |
mouse |
| Yongwei Yao, Xuemei Xu, Guohui Zhang, Yingyu Zhang, Wei Qian, Tao Ru. Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. Basic research in cardiology. vol 107. issue 3. 2012-07-09. PMID:22527657. |
genetic (jnk(-/-)) or pharmacological (sp600125) inhibition of jnk ameliorated the dox-induced hmgb1 expression and diminished myocardial apoptosis and cardiac dysfunction. |
2012-07-09 |
2023-08-12 |
mouse |
| Asada Leelahavanichkul, Yuning Huang, Xuzhen Hu, Hua Zhou, Takayuki Tsuji, Richard Chen, Jeffrey B Kopp, Jürgen Schnermann, Peter S T Yuen, Robert A Sta. Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1. Kidney international. vol 80. issue 11. 2012-06-11. PMID:21832986. |
ckd-induced splenic apoptosis and hmgb1 release could be important common mediators for both ckd and sepsis. |
2012-06-11 |
2023-08-12 |
mouse |
| ZhenZhen Zhan, Qun Li, Ping Wu, Yan Ye, Hsin-Yi Tseng, Linjie Zhang, Xu Dong Zhan. Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1. Autophagy. vol 8. issue 1. 2012-06-06. PMID:22108005. |
autophagy-mediated hmgb1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of mcl-1. |
2012-06-06 |
2023-08-12 |
Not clear |
| ZhenZhen Zhan, Qun Li, Ping Wu, Yan Ye, Hsin-Yi Tseng, Linjie Zhang, Xu Dong Zhan. Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1. Autophagy. vol 8. issue 1. 2012-06-06. PMID:22108005. |
we show in this study that hmgb1 released into the extracellular space protects gastric cancer cells from apoptosis induced by the microtubule-targeting drug vincristine through transcriptional upregulation of mcl-1. |
2012-06-06 |
2023-08-12 |
Not clear |
| ZhenZhen Zhan, Qun Li, Ping Wu, Yan Ye, Hsin-Yi Tseng, Linjie Zhang, Xu Dong Zhan. Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1. Autophagy. vol 8. issue 1. 2012-06-06. PMID:22108005. |
extracellular hmgb1 appeared essential for autophagy-mediated inhibition of apoptosis, in that sirna knockdown of hmgb1 or inhibition of its release abolished the protective effect of autophagy. |
2012-06-06 |
2023-08-12 |
Not clear |
| Kristen M Livesey, Rui Kang, Philip Vernon, William Buchser, Patricia Loughran, Simon C Watkins, Lin Zhang, James J Manfredi, Herbert J Zeh, Luyuan Li, Michael T Lotze, Daolin Tan. p53/HMGB1 complexes regulate autophagy and apoptosis. Cancer research. vol 72. issue 8. 2012-06-01. PMID:22345153. |
these insights provide a novel link between hmgb1 and p53 in the cross-regulation of apoptosis and autophagy in the setting of cell stress, providing insights into their reciprocal roles in carcinogenesis. |
2012-06-01 |
2023-08-12 |
mouse |