| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noriyuki Kuroda, Kouji Inoue, Tadayuki Ikeda, Yaiko Hara, Kenjiro Wake, Tetsuji Sat. Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition. PloS one. vol 9. issue 4. 2015-12-15. PMID:24690901. |
the current findings claim that a single injection of lps/galn might stimulate apoptosis of hepatocytes through the binding of hmgb1 protein to gsto1 promoter region and that gl-treatment might prevent the apoptosis and inflammatory infiltrates caused with lps/galn-injection by disturbing the binding of hmgb1 protein to gsto1 promoter sequence. |
2015-12-15 |
2023-08-13 |
mouse |
| Mehboob Ali, Kathryn M Heyob, Markus Velten, Trent E Tipple, Lynette K Roger. DHA suppresses chronic apoptosis in the lung caused by perinatal inflammation. American journal of physiology. Lung cellular and molecular physiology. vol 309. issue 5. 2015-12-15. PMID:26138643. |
we detected substantial increases in markers of apoptosis including parp-1, apaf-1, caspase-9, bcl2, and hmgb1, and these increases were attenuated in mice that were nursed by dha-supplemented dams during the perinatal period. |
2015-12-15 |
2023-08-13 |
mouse |
| Min Yang, Daniel J Antoine, James L Weemhoff, Rosalind E Jenkins, Anwar Farhood, B Kevin Park, Hartmut Jaeschk. Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 20. issue 11. 2015-12-08. PMID:25046819. |
to address this important issue with a standard murine model of hepatic irp injury, plasma biomarkers of necrotic cell death such as micro-rna 122, full-length cytokeratin 18 (fk18), and high-mobility group box 1 (hmgb1) protein and plasma biomarkers of apoptosis such as plasma caspase-3 activity and caspase-cleaved fragment of cytokeratin 18 (ck18) coupled with markers of inflammation (hyperacetylated hmgb1) were compared by histological features in hematoxylin and eosin-stained and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (tunel)-stained liver sections. |
2015-12-08 |
2023-08-13 |
mouse |
| W P Zhao, Q X Che. Effects of HMGB1 on proliferation and apoptosis of human brain glioma CD133 cells. Bratislavske lekarske listy. vol 116. issue 8. 2015-11-24. PMID:26350087. |
effects of hmgb1 on proliferation and apoptosis of human brain glioma cd133 cells. |
2015-11-24 |
2023-08-13 |
human |
| W P Zhao, Q X Che. Effects of HMGB1 on proliferation and apoptosis of human brain glioma CD133 cells. Bratislavske lekarske listy. vol 116. issue 8. 2015-11-24. PMID:26350087. |
to understand the effects of hmgb1 recombinant lentivirus vector on proliferation and apoptosis on cd133 cells after transfecting a human glioma cell strain cd133. |
2015-11-24 |
2023-08-13 |
human |
| Yunhua Wang, Tao Tao, Yinv Dong, Jing Zhang, Zaisheng Qi. Effect of ulinastatin on the expression and distribution of high mobility group box 1 in human colon carcinoma cells in vitro. Molecular medicine reports. vol 11. issue 3. 2015-10-12. PMID:25385285. |
the aim of the present study was to investigate the in vitro effects of ulinastatin (uti) on the proliferation, invasion, apoptosis, expression and distribution of high mobility group box 1 (hmgb1) and the expression of nuclear factor κb (nf‑κb) in human colon carcinoma lovo cells. |
2015-10-12 |
2023-08-13 |
human |
| Yunhua Wang, Tao Tao, Yinv Dong, Jing Zhang, Zaisheng Qi. Effect of ulinastatin on the expression and distribution of high mobility group box 1 in human colon carcinoma cells in vitro. Molecular medicine reports. vol 11. issue 3. 2015-10-12. PMID:25385285. |
the cell proliferation, invasion, apoptosis and the gene and protein expression of hmgb1 and nf‑κb were detected using a tetrazolium assay, transwell cell invasion assays, a caspase‑3 activity assay, western blot analysis and reverse transcription quantitative polymerase chain reaction, respectively. |
2015-10-12 |
2023-08-13 |
human |
| Yunhua Wang, Tao Tao, Yinv Dong, Jing Zhang, Zaisheng Qi. Effect of ulinastatin on the expression and distribution of high mobility group box 1 in human colon carcinoma cells in vitro. Molecular medicine reports. vol 11. issue 3. 2015-10-12. PMID:25385285. |
thus, uti inhibited lovo cell proliferation and induced lovo cell apoptosis, the mechanism of which may be associated with a decreased in the expression of hmgb1 and nf‑κb, and the cytoplasmic distribution of hmgb1. |
2015-10-12 |
2023-08-13 |
human |
| Xiao-Rong Ni, Zhou-Jun Sun, Guo-Hua Hu, Rong-Hui Wan. High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 3. 2015-09-30. PMID:25228632. |
high concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular hmgb1. |
2015-09-30 |
2023-08-13 |
rat |
| Xiao-Rong Ni, Zhou-Jun Sun, Guo-Hua Hu, Rong-Hui Wan. High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 3. 2015-09-30. PMID:25228632. |
furthermore, we discovered that high concentration of insulin, which mimics insulin resistance model, promoted apoptosis in primary cultured rat ovarian granulosa cells (gcs) via its effect on the increase in extracellular hmgb1. |
2015-09-30 |
2023-08-13 |
rat |
| Xiao-Rong Ni, Zhou-Jun Sun, Guo-Hua Hu, Rong-Hui Wan. High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 3. 2015-09-30. PMID:25228632. |
our data presented the first evidence that increased hmgb1 induced by insulin resistance/hyperinsulinemia promoted apoptosis of ovarian gcs, which provided new molecular basis for the pcos pathogenesis. |
2015-09-30 |
2023-08-13 |
rat |
| Shaobo Ke, Fuxiang Zhou, Hui Yang, Yuehua Wei, Jun Gong, Zijie Mei, Lin Wu, Haijun Yu, Yunfeng Zho. Downregulation of high mobility group box 1 modulates telomere homeostasis and increases the radiosensitivity of human breast cancer cells. International journal of oncology. vol 46. issue 3. 2015-09-22. PMID:25501936. |
moreover, knockdown of hmgb1 in mcf-7 cells inhibited telomerase activity and cell proliferation, while increasing the extent of apoptosis. |
2015-09-22 |
2023-08-13 |
human |
| Ranran Wu, Jiajie W. [Inhibition on the proliferation of human endometrial cancer cells by RNAi inhibiting HMGB1 gene expression and its possible molecular mechanism]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 39. issue 7. 2015-09-08. PMID:25080914. |
to investigate the effect of hmgb1 small interfering rna (sirna) on the proliferation, cell cycle and apoptosis of human endometrial cancer cell line hec-1a, and its possible molecular mechanism. |
2015-09-08 |
2023-08-13 |
human |
| Liu-Cheng Li, Jian Gao, Jun L. Emerging role of HMGB1 in fibrotic diseases. Journal of cellular and molecular medicine. vol 18. issue 12. 2015-08-28. PMID:25284457. |
extracellular hmgb1 is a multifunctional cytokine that contributes to the process of infection, injury, inflammation, apoptosis, and immune responses by binding to specific cell-surface receptors. |
2015-08-28 |
2023-08-13 |
Not clear |
| Bao Song, Wei-guo Song, Zeng-jun Li, Zhong-fa Xu, Xing-wu Wang, Chuan-xi Wang, Jie Li. Effect of HMGB1 silencing on cell proliferation, invasion and apoptosis of MGC-803 gastric cancer cells. Cell biochemistry and function. vol 30. issue 1. 2015-08-24. PMID:21953494. |
effect of hmgb1 silencing on cell proliferation, invasion and apoptosis of mgc-803 gastric cancer cells. |
2015-08-24 |
2023-08-12 |
Not clear |
| Bao Song, Wei-guo Song, Zeng-jun Li, Zhong-fa Xu, Xing-wu Wang, Chuan-xi Wang, Jie Li. Effect of HMGB1 silencing on cell proliferation, invasion and apoptosis of MGC-803 gastric cancer cells. Cell biochemistry and function. vol 30. issue 1. 2015-08-24. PMID:21953494. |
furthermore, hmgb1 silencing sensitized cells to apoptosis that was induced by oxaliplatin and mediated by the caspase-3 pathway. |
2015-08-24 |
2023-08-12 |
Not clear |
| Chengcheng Christine Zhang, Georg Gdynia, Volker Ehemann, Wilfried Rot. The HMGB1 protein sensitizes colon carcinoma cells to cell death triggered by pro-apoptotic agents. International journal of oncology. vol 46. issue 2. 2015-08-21. PMID:25434832. |
treatment of crc cells with low concentrations of recombinant hmgb1 results in dose-dependent cytotoxicity which is morphologically characterized by the formation of giant mitochondria and does not share features of apoptosis. |
2015-08-21 |
2023-08-13 |
human |
| Chhinder P Sodhi, Hongpeng Jia, Yukihiro Yamaguchi, Peng Lu, Misty Good, Charlotte Egan, John Ozolek, Xiaorong Zhu, Timothy R Billiar, David J Hacka. Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. Journal of immunology (Baltimore, Md. : 1950). vol 194. issue 10. 2015-07-21. PMID:25862813. |
activation of intestinal tlr4 after trauma led to increased endoplasmic reticulum (er) stress, enterocyte apoptosis, and the release of circulating hmgb1, whereas inhibition of er stress attenuated apoptosis, reduced circulating hmgb1, and decreased lung injury severity. |
2015-07-21 |
2023-08-13 |
mouse |
| P Duewell, A Steger, H Lohr, H Bourhis, H Hoelz, S V Kirchleitner, M R Stieg, S Grassmann, S Kobold, J T Siveke, S Endres, M Schnur. RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells. Cell death and differentiation. vol 21. issue 12. 2015-07-14. PMID:25012502. |
in addition, tumor cells died via intrinsic apoptosis and displayed features of immunogenic cell death, such as release of hmgb1 and translocation of calreticulin to the outer cell membrane. |
2015-07-14 |
2023-08-13 |
mouse |
| Zhe Liu, Yuanhong Xu, Jin Long, Kejian Guo, Chunlin Ge, Ruixia D. microRNA-218 suppresses the proliferation, invasion and promotes apoptosis of pancreatic cancer cells by targeting HMGB1. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu. vol 27. issue 3. 2015-07-09. PMID:26157321. |
microrna-218 suppresses the proliferation, invasion and promotes apoptosis of pancreatic cancer cells by targeting hmgb1. |
2015-07-09 |
2023-08-13 |
human |