| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Fei Qi, Juan Zhang, Lei Wang, Vinayak Shenoy, Eric Krause, S Paul Oh, Carl J Pepine, Michael J Katovich, Mohan K Raizad. Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia. Journal of molecular medicine (Berlin, Germany). vol 94. issue 1. 2016-10-19. PMID:26498282. |
notably, ace2 overexpression significantly reduced the mi-induced increase in apoptosis, macrophage infiltration, and hmgb1 and proinflammatory cytokine expression (tnf-α and il-6). |
2016-10-19 |
2023-08-13 |
mouse |
| Tao Peng, Min Hu, Tingting Wu, Zhe Chen, Cen Zhang, Shou Huang, Xuhong Zho. Effects of high‑mobility group box 1 knockdown on proliferation, migration and invasion of the HONE‑1 human nasopharyngeal carcinoma cell line. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26459833. |
the results of the present study demonstrated that hmgb1 knockdown suppressed the proliferation, migration and invasion of hone‑1 cells, the mechanisms of which may be associated with the induction of mitochondria‑mediated apoptosis and inhibition of hmgb1/rage pathways. |
2016-08-29 |
2023-08-13 |
human |
| J Hanus, C Anderson, D Sarraf, J Ma, S Wan. Retinal pigment epithelial cell necroptosis in response to sodium iodate. Cell death discovery. vol 2. 2016-08-23. PMID:27551542. |
by using tunel assays, active caspase-3 and hmgb1 immunostaining, we confirmed that photoreceptor cells die mainly from apoptosis and rpe cells die mainly from necroptosis in response to naio3 in vivo. |
2016-08-23 |
2023-08-13 |
mouse |
| Zhichao Huang, Zhaohui Zhong, Lei Zhang, Xinjun Wang, Ran Xu, Liang Zhu, Zijian Wang, Shanbiao Hu, Xiaokun Zha. Down-regulation of HMGB1 expression by shRNA constructs inhibits the bioactivity of urothelial carcinoma cell lines via the NF-κB pathway. Scientific reports. vol 5. 2016-08-02. PMID:26239046. |
the expression of hmgb1, the bioactivity of buc cells, including proliferation, apoptosis, cell cycle distribution, migration and invasion, and the effects of hmgb1 knockdown on downstream signalling pathways were investigated. |
2016-08-02 |
2023-08-13 |
Not clear |
| Zong-sheng Wu, Yong-ming Yao, Guang-liang Hong, Xiu-ping Xu, Yao Liu, Ning Dong, Jia-yi Zheng, Zhong-qiu Lu, Guang-ju Zhao, Xiao-mei Zhu, Qing-hong Zhang, Zhi-yong Shen. Role of mitofusin-2 in high mobility group box-1 protein-mediated apoptosis of T cells in vitro. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 33. issue 3. 2016-08-01. PMID:24662494. |
previous studies have shown that hmgb1 also plays a role in t cell-mediated immunity, but the effect of hmgb1 on apoptosis of t cells and its precise mechanism remain to be determined. |
2016-08-01 |
2023-08-12 |
Not clear |
| Haiqiu Liao, Yang Xiao, Yingbin Hu, Yangming Xiao, Zhaofa Yin, Liang Li. Suppression of Cellular Proliferation and Invasion by HMGB1 Knockdown in Bladder Urothelial Carcinoma Cells. Oncology research. vol 22. issue 5-6. 2016-07-28. PMID:26629935. |
the decrease in cell viability caused by hmgb1 knockdown/out was due to an increase in apoptosis via bax/bcl-2, both of which were important molecules involved in the apoptotic pathway. |
2016-07-28 |
2023-08-13 |
human |
| L Y Zhou, L Y Shi, Y Xia. Changes of HMGB1 expression on angiogenesis of ovarian cancer and its mechanism. Journal of biological regulators and homeostatic agents. vol 30. issue 1. 2016-07-07. PMID:27049097. |
western blot was adopted to investigate the changes of hmgb1, cxcl12 and vascular endothelial growth factor (vegf) before and after the transfection and flow cytometry (fcm) was applied to detect skov3 apoptosis. |
2016-07-07 |
2023-08-13 |
Not clear |
| L Y Zhou, L Y Shi, Y Xia. Changes of HMGB1 expression on angiogenesis of ovarian cancer and its mechanism. Journal of biological regulators and homeostatic agents. vol 30. issue 1. 2016-07-07. PMID:27049097. |
thus, it can be concluded that hmgb1 interference can reduce vegf and cxcl12 expression in ovarian cancer cells, but increase the apoptosis of ovarian cancer cells. |
2016-07-07 |
2023-08-13 |
Not clear |
| Lin Qi, Xue Sun, Feng-E Li, Bao-Song Zhu, Frank K Braun, Zhi-Qiang Liu, Jin-Le Tang, Chao Wu, Fei Xu, Hui-Han Wang, Luis A Velasquez, Kui Zhao, Feng-Rui Lei, Ji-Gang Zhang, Yun-Tian Shen, Jian-Xuan Zou, Hui-Min Meng, Gang-Li An, Lin Yang, Xing-Ding Zhan. HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation. PloS one. vol 10. issue 11. 2016-06-29. PMID:26565401. |
hmgb1 promotes mitochondrial dysfunction-triggered striatal neurodegeneration via autophagy and apoptosis activation. |
2016-06-29 |
2023-08-13 |
rat |
| Lin Qi, Xue Sun, Feng-E Li, Bao-Song Zhu, Frank K Braun, Zhi-Qiang Liu, Jin-Le Tang, Chao Wu, Fei Xu, Hui-Han Wang, Luis A Velasquez, Kui Zhao, Feng-Rui Lei, Ji-Gang Zhang, Yun-Tian Shen, Jian-Xuan Zou, Hui-Min Meng, Gang-Li An, Lin Yang, Xing-Ding Zhan. HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation. PloS one. vol 10. issue 11. 2016-06-29. PMID:26565401. |
in this study, we focused on the high-mobility group box 1 (hmgb1) protein, which is important in oxidative stress signaling as well as in autophagy and apoptosis, to explore whether the mechanisms of autophagy and apoptosis in neurodegenerative diseases are associated with metabolic impairment. |
2016-06-29 |
2023-08-13 |
rat |
| Lin Qi, Xue Sun, Feng-E Li, Bao-Song Zhu, Frank K Braun, Zhi-Qiang Liu, Jin-Le Tang, Chao Wu, Fei Xu, Hui-Han Wang, Luis A Velasquez, Kui Zhao, Feng-Rui Lei, Ji-Gang Zhang, Yun-Tian Shen, Jian-Xuan Zou, Hui-Min Meng, Gang-Li An, Lin Yang, Xing-Ding Zhan. HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation. PloS one. vol 10. issue 11. 2016-06-29. PMID:26565401. |
these results suggest that hmgb1 plays important roles in signaling for both autophagy and apoptosis in neurodegeneration induced by mitochondrial dysfunction. |
2016-06-29 |
2023-08-13 |
rat |
| Ahmed M Abu El-Asrar, Ghulam Mohammad, Mohammad Imtiaz Nawaz, Mohammad Mairaj Siddique. High-Mobility Group Box-1 Modulates the Expression of Inflammatory and Angiogenic Signaling Pathways in Diabetic Retina. Current eye research. vol 40. issue 11. 2016-06-22. PMID:25495026. |
hmgb1 mediates inflammation, breakdown of the blood-retinal barrier and apoptosis in the diabetic retina. |
2016-06-22 |
2023-08-13 |
Not clear |
| Ma Ruisong, Hu Xiaorong, Hu Gangying, Yi Chunfeng, Zhang Changjiang, Li Xuefei, Li Yuanhong, Jiang Hon. The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38 MAPK Signaling Pathway. PloS one. vol 10. issue 11. 2016-06-17. PMID:26571038. |
compared with the i/r group, the il-33 group had significantly lower cardiac injury (lower serum creatine kinase (ck), lactate dehydrogenase (ldh), and ctni levels and myocardial infarct size), a suppressed inflammatory response in myocardial tissue (lower expression of hmgb1, il-6, tnf-α and inf-γ) and less myocardial apoptosis (much higher bcl-2/bax ratio and lower cleaved caspase-3 expression). |
2016-06-17 |
2023-08-13 |
Not clear |
| Ma Ruisong, Hu Xiaorong, Hu Gangying, Yi Chunfeng, Zhang Changjiang, Li Xuefei, Li Yuanhong, Jiang Hon. The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38 MAPK Signaling Pathway. PloS one. vol 10. issue 11. 2016-06-17. PMID:26571038. |
these findings indicated that il-33 protects against myocardial i/r injury by inhibiting inflammatory responses and myocardial apoptosis, which may be associated with the hmgb1 and p38 mapk signaling pathways. |
2016-06-17 |
2023-08-13 |
Not clear |
| Xi Chen, Ying Wang, Juan Liu, Ping Xu, Xiao-Min Zhang, Yao-Yao Tian, Yan-Ming Xue, Xin-Yu Gao, Yao Liu, Jing-Hua Wan. Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26081986. |
the aim of the present study was to investigate the impact of hmgb1 knockdown and cordycepin treatment on proliferation, apoptosis, reactive oxygen species (ros) levels and adhesion of k562 human chronic myeloid leukemia cells. |
2016-05-17 |
2023-08-13 |
human |
| Xi Chen, Ying Wang, Juan Liu, Ping Xu, Xiao-Min Zhang, Yao-Yao Tian, Yan-Ming Xue, Xin-Yu Gao, Yao Liu, Jing-Hua Wan. Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26081986. |
it was also identified that hmgb1 knockdown had synergistic effects with cordycepin, which aided in accelerating apoptosis, and inhibiting proliferation and adhesion in chronic myeloid leukemia cells. |
2016-05-17 |
2023-08-13 |
human |
| Yao Yu, Lu Yang, Jinlei Lv, Xu Huang, Jinglin Yi, Chonggang Pei, Yi Sha. The role of high mobility group box 1 (HMGB-1) in the diabetic retinopathy inflammation and apoptosis. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261566. |
hmgb1 may involve in the pathogenesis of diabetic retinopathy by binding with rage receptor to accelerate rat retinal cells apoptosis. |
2016-05-16 |
2023-08-13 |
rat |
| Yu Zhou, Yan Li, Tong M. HMGB1 Neutralizing Antibody Attenuates Cardiac Injury and Apoptosis Induced by Hemorrhagic Shock/Resuscitation in Rats. Biological & pharmaceutical bulletin. vol 38. issue 8. 2016-05-09. PMID:26040987. |
hmgb1 neutralizing antibody attenuates cardiac injury and apoptosis induced by hemorrhagic shock/resuscitation in rats. |
2016-05-09 |
2023-08-13 |
rat |
| Lei Zhao, Rui An, Yang Yang, Xiangmin Yang, Haixiao Liu, Liang Yue, Xia Li, Yan Lin, Russel J Reiter, Yan Q. Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. Journal of pineal research. vol 59. issue 2. 2016-05-06. PMID:26094939. |
the blood-brain barrier (bbb) integrity, brain water content, levels of inflammatory cytokines (tnf-α, il-1β, and hmgb1), and the level of oxidative stress (superoxide dismutase (sod), catalase (cat), and malondialdehyde (mda)) and apoptosis were assessed. |
2016-05-06 |
2023-08-13 |
mouse |
| M Zhang, Y Guo, H Fu, S Hu, J Pan, Y Wang, J Cheng, J Song, Q Yu, S Zhang, J-F Xu, G Pei, X Xiang, P Yang, C-Y Wan. Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling. Cell death & disease. vol 6. 2016-04-12. PMID:26247732. |
mechanistic studies revealed that loss of chop protected tubular cells from uuo-induced apoptosis and secondary necrosis along with attenuated hmgb1 passive release and active secretion. |
2016-04-12 |
2023-08-13 |
mouse |