| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Vogel, V Börger, C Peters, M Förster, P Liebfried, K Metzger, R Meisel, W Däubener, T Trapp, J C Fischer, M Gawaz, R V Sor. Necrotic cell-derived high mobility group box 1 attracts antigen-presenting cells but inhibits hepatocyte growth factor-mediated tropism of mesenchymal stem cells for apoptotic cell death. Cell death and differentiation. vol 22. issue 7. 2016-04-08. PMID:25571972. |
moreover, necrotic cardiomyocytic and neuronal cells caused an hmgb1/toll-like receptor-4-dependent inhibition of msc migration towards apoptosis or hgf, while recruitment of monocytes and idc by necrosis or hmgb1 was not affected by apoptotic cells or hgf. |
2016-04-08 |
2023-08-13 |
Not clear |
| Ruiguang Zhang, Yan Li, Zhongliang Wang, Lingjuan Chen, Xiaorong Dong, Xiu Ni. Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 11. 2016-04-06. PMID:26040768. |
interference with hmgb1 increases the sensitivity to chemotherapy drugs by inhibiting hmgb1-mediated cell autophagy and inducing cell apoptosis. |
2016-04-06 |
2023-08-13 |
human |
| Ruiguang Zhang, Yan Li, Zhongliang Wang, Lingjuan Chen, Xiaorong Dong, Xiu Ni. Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 11. 2016-04-06. PMID:26040768. |
however, interference with endogenous hmgb1 obviously suppressed autophagy-related proteins and increased cell apoptosis rate and the expression of cleaved caspase-3 in a549/ddp cells. |
2016-04-06 |
2023-08-13 |
human |
| Ruiguang Zhang, Yan Li, Zhongliang Wang, Lingjuan Chen, Xiaorong Dong, Xiu Ni. Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 11. 2016-04-06. PMID:26040768. |
all of the data suggested that interference with the endogenous hmgb1 significantly inhibited cell autophagy and increased cell apoptosis of a549/ddp cells. |
2016-04-06 |
2023-08-13 |
human |
| Natalia Girola, Carlos R Figueiredo, Camyla F Farias, Ricardo A Azevedo, Adilson K Ferreira, Sarah F Teixeira, Tabata M Capello, Euder G A Martins, Alisson L Matsuo, Luiz R Travassos, João H G Lag. Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo. Biochemical and biophysical research communications. vol 467. issue 4. 2016-03-16. PMID:26471302. |
camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (er) stress, with release of ca(2+) together with hmgb1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity. |
2016-03-16 |
2023-08-13 |
human |
| Miroslaw J Szczepanski, Michal Luczak, Ewa Olszewska, Marta Molinska-Glura, Mariola Zagor, Antoni Krzeski, Henryk Skarzynski, Jan Misiak, Karolina Dzaman, Mikolaj Bilusiak, Tomasz Kopec, Malgorzata Leszczynska, Henryk Witmanowski, Theresa L Whitesid. Molecular signaling of the HMGB1/RAGE axis contributes to cholesteatoma pathogenesis. Journal of molecular medicine (Berlin, Germany). vol 93. issue 3. 2016-03-14. PMID:25385222. |
effects of hmgb1 signaling on proliferation, migration, cytokine production, and apoptosis of human immortalized keratinocytes (hacats) and normal keratinocytes were studied by quantitative reverse transcription (qrt)-pcr, ihc, western blots, and flow cytometry after cell co-incubation with hmgb1. |
2016-03-14 |
2023-08-13 |
human |
| Miroslaw J Szczepanski, Michal Luczak, Ewa Olszewska, Marta Molinska-Glura, Mariola Zagor, Antoni Krzeski, Henryk Skarzynski, Jan Misiak, Karolina Dzaman, Mikolaj Bilusiak, Tomasz Kopec, Malgorzata Leszczynska, Henryk Witmanowski, Theresa L Whitesid. Molecular signaling of the HMGB1/RAGE axis contributes to cholesteatoma pathogenesis. Journal of molecular medicine (Berlin, Germany). vol 93. issue 3. 2016-03-14. PMID:25385222. |
hmgb1 also prevented hacat cell apoptosis and induced activation of several molecular signaling pathways in keratinocytes. |
2016-03-14 |
2023-08-13 |
human |
| Howard C Masuoka, Raj Vuppalanchi, Ross Deppe, Phelan Bybee, Megan Comerford, Suthat Liangpunsakul, Marwan Ghabril, Naga Chalasan. Individuals with Primary Sclerosing Cholangitis Have Elevated Levels of Biomarkers for Apoptosis but Not Necrosis. Digestive diseases and sciences. vol 60. issue 12. 2016-02-17. PMID:26195313. |
the aim of the current study was to measure serum markers of hepatocyte apoptosis (cytokeratin-18 fragments--k18) and necrosis (high-mobility group protein b1--hmgb1) in adults with psc and examine the relationship with disease severity. |
2016-02-17 |
2023-08-13 |
Not clear |
| Suhashini S Dhumale, Bhargav N Waghela, Chandramani Patha. Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells. IUBMB life. vol 67. issue 5. 2016-02-16. PMID:25983116. |
quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of rage and its ligand hmgb1 in human breast adenocarcinoma cells. |
2016-02-16 |
2023-08-13 |
human |
| Suhashini S Dhumale, Bhargav N Waghela, Chandramani Patha. Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells. IUBMB life. vol 67. issue 5. 2016-02-16. PMID:25983116. |
the accumulation of rage and its ligand high-mobility group box proteins-1 (hmgb1) activates complex signaling network for cell survival and evades apoptosis. |
2016-02-16 |
2023-08-13 |
human |
| Christin Pilzweger, Stefan Holdenriede. Circulating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune Diseases. Diagnostics (Basel, Switzerland). vol 5. issue 2. 2016-02-08. PMID:26854151. |
high molecular group box 1 (hmgb1) is a highly conserved member of the hmg-box-family; abundantly expressed in almost all human cells and released in apoptosis; necrosis or by activated immune cells. |
2016-02-08 |
2023-08-13 |
human |
| Yuan Yang, Ling-Hao Zhao, Bo Huang, Ruo-Yu Wang, Sheng-Xian Yuan, Qi-Fei Tao, Yong Xu, Han-Yong Sun, Chuan Lin, Wei-Ping Zho. Pioglitazone, a PPARγ agonist, inhibits growth and invasion of human hepatocellular carcinoma via blockade of the rage signaling. Molecular carcinogenesis. vol 54. issue 12. 2016-01-22. PMID:25307746. |
moreover, pgz inhibited proliferative activity and invasive potential, and induced apoptosis and cell cycle arrest in hcc cells resulting in increased expression of pparγ and decreased expression of rage, nf-κb, hmgb1, p38mapk, ki-67, mmp-2, and cyclind1. |
2016-01-22 |
2023-08-13 |
human |
| Weijun Liu, Zhenyong Zhang, Yongxue Zhang, Xinju Chen, Shikui Guo, Yi Lei, Yu Xu, Chao Ji, Zhigang Bi, Kunhua Wan. HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway. Cancer biology & therapy. vol 16. issue 4. 2016-01-20. PMID:25778491. |
administration of oxaliplatin to human crc cells significantly enhanced the expression of hmgb1, which regulated the autophagy response and negatively regulate the cell apoptosis. |
2016-01-20 |
2023-08-13 |
human |
| Weijun Liu, Zhenyong Zhang, Yongxue Zhang, Xinju Chen, Shikui Guo, Yi Lei, Yu Xu, Chao Ji, Zhigang Bi, Kunhua Wan. HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway. Cancer biology & therapy. vol 16. issue 4. 2016-01-20. PMID:25778491. |
moreover, a decreased oxaliplatin -induced autophagy response and an increased apoptosis level were detected in stable crc cells harboring hmgb1 shrna. |
2016-01-20 |
2023-08-13 |
human |
| Zhaoliang Su, Ting Wang, Haitao Zhu, Pan Zhang, Rongxia Han, Yueqin Liu, Ping Ni, Huiling Shen, Wenlin Xu, Huaxi X. HMGB1 modulates Lewis cell autophagy and promotes cell survival via RAGE-HMGB1-Erk1/2 positive feedback during nutrient depletion. Immunobiology. vol 220. issue 5. 2016-01-19. PMID:25578401. |
prevention of hmgb1 binding to the receptor for advanced glycation end products (rage) or knock-down of hmgb1 expression led to inhibition of autophagy and increased apoptosis. |
2016-01-19 |
2023-08-13 |
Not clear |
| Qiao-Li Ma, Ai-Cui Liu, Xiao-Juan Ma, Yan-Bai Wang, Yu-Ting Hou, Zhen-Hai Wan. Brucella outer membrane protein Omp25 induces microglial cells in vitro to secrete inflammatory cytokines and inhibit apoptosis. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770344. |
mouse bv2 microglial cells were incubated with different concentrations of omp25 for 24 h, and an enzyme-linked immunosorbent assay (elisa) was used to detect the secretion of the inflammatory cytokines interleukin (il)-6, tumour necrosis factor (tnf)-α and hmgb1 (high mobility group box-1 protein); reverse transcription polymerase chain reaction (rt-pcr) was used to detect the expression of tlr4 (toll-like receptor 4) mrna; annexin v-fluorescein isothiocyanate (fitc) double staining was used to detect apoptosis in the bv2 cells. |
2016-01-15 |
2023-08-13 |
mouse |
| Desheng Fu, Xiaofeng Tia. Effect of high mobility group box 1 on the human retinal pigment epithelial cell in high-glucose condition. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770371. |
in the in-vitro study, it was found that up-regulation of hmgb1 inhibited the rpe cell viability and induce the apoptosis. |
2016-01-15 |
2023-08-13 |
human |
| Desheng Fu, Xiaofeng Tia. Effect of high mobility group box 1 on the human retinal pigment epithelial cell in high-glucose condition. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770371. |
in conclusion, we have demonstrated that hmgb1 and vegfa are key players in the ability to suppress cell viability and induce apoptosis. |
2016-01-15 |
2023-08-13 |
human |
| J Fučíková, J Bartůňková, R Špíše. [The Concept of Immunogenic Cell Death in Antitumor Immunity]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. vol 28 Suppl 4. 2016-01-11. PMID:26647889. |
other damage-associated molecular patterns are produced in late stage apoptosis as high mobility group box 1 protein (hmgb1) into the extracellular milieu. |
2016-01-11 |
2023-08-13 |
Not clear |
| Taro Narumi, Tetsuro Shishido, Yoichiro Otaki, Shinpei Kadowaki, Yuki Honda, Akira Funayama, Shintaro Honda, Hiromasa Hasegawa, Daisuke Kinoshita, Miyuki Yokoyama, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Tetsu Watanabe, Atsushi Tanaka, Chang-Hoon Woo, Jun-ichi Abe, Yasuchika Takeishi, Isao Kubot. High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis. Journal of molecular and cellular cardiology. vol 82. 2016-01-06. PMID:25736854. |
given that high-mobility group box 1 (hmgb1) is a nuclear dna-binding protein capable of inhibiting apoptosis, we aimed to clarify the role of hmgb1 in heat shock protein beta 1 (hspb1) expression during doxorubicin-induced cardiomyopathy. |
2016-01-06 |
2023-08-13 |
Not clear |