| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Ying Zhang, Jia-Ying Yu, Yan-Long Leng, Ran-Ran Zhu, Hong-Xian Liu, Xin-Yu Wang, Ting-Ting Yang, Yi-Ning Guo, Jing-Ling Tang, Xin-Chen Zhan. MiR-181c sensitizes ovarian cancer cells to paclitaxel by targeting GRP78 through the PI3K/Akt pathway. Cancer gene therapy. 2021-06-19. PMID:34145425. |
mir-181c downregulated grp78 expression and induced apoptosis by directly targeting its 3'-untranslated region (utr). |
2021-06-19 |
2023-08-13 |
Not clear |
| Yongjie Xiong, Erhui Jin, Qirun Yin, Chuanyan Che, Shaojun H. Boron Attenuates Heat Stress-Induced Apoptosis by Inhibiting Endoplasmic Reticulum Stress in Mouse Granulosa Cells. Biological trace element research. vol 199. issue 2. 2021-06-18. PMID:32385716. |
however, boric acid treatment effectively alleviated the effects of both hs-induced and thapsigargin (an er stress agonist)-induced apoptosis, such as the enhanced activity of caspase-3 and increase in grp78 and chop expression. |
2021-06-18 |
2023-08-13 |
mouse |
| Qiaozhi Wang, Xiaoshu Ma, Cheng Zhan. Effects of thyroid hormone on ovarian cell apoptosis in the rat. Reproduction, fertility, and development. vol 32. issue 12. 2021-06-17. PMID:32758353. |
glucose-related protein 78 (grp78) is a well-characterised endoplasmic reticulum stress protein related to ovarian cell apoptosis. |
2021-06-17 |
2023-08-13 |
rat |
| Gargi Thakur, Gajanan Sathe, Indra Kundu, Barnali Biswas, Poonam Gautam, Saad Alkahtani, Susan Idicula-Thomas, Ravi Sirdeshmukh, Uday Kishore, Taruna Mada. Membrane Interactome of a Recombinant Fragment of Human Surfactant Protein D Reveals GRP78 as a Novel Binding Partner in PC3, a Metastatic Prostate Cancer Cell Line. Frontiers in immunology. vol 11. 2021-06-16. PMID:33542717. |
computational analysis of ppi network of this interactome in the context of prostate cancer metastasis and apoptosis revealed glucose regulated protein of 78 kda (grp78) as an important binding partner of rfhsp-d. docking studies suggested that rfhsp-d (crd) bound to the substrate-binding domain of glycosylated grp78. |
2021-06-16 |
2023-08-13 |
human |
| D Martínez, C Vargas-Lagos, J Saravia, R Oyarzún, C Loncoman, J P Pontigo, L Vargas-Chacof. Cellular stress responses of Eleginops maclovinus fish injected with Piscirickettsia salmonis and submitted to thermal stress. Cell stress & chaperones. vol 25. issue 1. 2021-06-15. PMID:31834618. |
the genes implied in the heat shock response (hsp70, hsc70, hsp90, and grp78), apoptosis pathway (bax and smac/diablo), ubiquitination (e2, e3, ubiquitin, and chip), and 26 proteasome complex (psmb7, psmc1, and psma2) showed expression profiles dependent on time and type of injection applied. |
2021-06-15 |
2023-08-13 |
Not clear |
| Yu Guo, Chenghong Zhang, Chunyang Wang, Yufei Huang, Jingyun Liu, Haiying Chu, Xiang Ren, Li Kong, Haiying M. Thioredoxin-1 Is a Target to Attenuate Alzheimer-Like Pathology in Diabetic Encephalopathy by Alleviating Endoplasmic Reticulum Stress and Oxidative Stress. Frontiers in physiology. vol 12. 2021-06-05. PMID:34079471. |
some key factors associated with ers, such as protein disulfide isomerase (pdi), glucose-regulated protein 78 (grp78), inositol-requiring enzyme 1α (ire1α), tumor necrosis factor receptor-associated factor 2 (traf2), apoptosis signal-regulating kinase-1 (ask1), c-jun n-terminal kinase (jnk), protein kinase rna (pkr)-like er kinase (perk), and c/ebp homologous protein (chop), were upregulated, and other factors related to anti-oxidant stress, such as nuclear factor erythroid 2-related factor (nrf2), were downregulated in the dm group. |
2021-06-05 |
2023-08-13 |
mouse |
| Slavisa Ninkovic, Simon J Harrison, Hang Quac. Glucose-regulated protein 78 (GRP78) as a potential novel biomarker and therapeutic target in multiple myeloma. Expert review of hematology. vol 13. issue 11. 2021-06-04. PMID:32990063. |
studies suggest cell-surface grp78 (csgrp78) to be of prognostic significance with emerging evidence that it interacts with a myriad of co-ligands to activate signaling pathways promoting cell proliferation and survival or apoptosis. |
2021-06-04 |
2023-08-13 |
Not clear |
| Mariam Markouli, Dimitrios Strepkos, Athanasios G Papavassiliou, Christina Piper. Targeting of endoplasmic reticulum (ER) stress in gliomas. Pharmacological research. vol 157. 2021-05-31. PMID:32305494. |
general upr activators or selective grp78, atf6 and perk inducers have been detected to modulate cell proliferation and induce apoptosis of glioma cells. |
2021-05-31 |
2023-08-13 |
Not clear |
| Shuo Zhang, Xiaona Zhao, Jiajia Hao, Yiran Zhu, Yue Wang, Lumei Wang, Shuhua Guo, Hui Yi, Yongxia Liu, Jianzhu Li. The role of ATF6 in Cr(VI)-induced apoptosis in DF-1 cells. Journal of hazardous materials. vol 410. 2021-05-31. PMID:33243643. |
meanwhile, atf-6 silencing lowered the apoptosis rate and er stress level, showing with the decrease of xbp-1, perk, grp78, caspase-12, cleaved caspase-3 and the increase of bcl-2. |
2021-05-31 |
2023-08-13 |
chicken |
| Meihua Wang, Zhilin Chen, Lei Yang, Lei Din. Sappanone A Protects Against Inflammation, Oxidative Stress and Apoptosis in Cerebral Ischemia-Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33411101. |
importantly, endoplasmic reticulum stressors, including the chop, the 78 kda glucose-regulated protein 78 (grp78), and phosphorylated eukaryotic initiation factors 2α (eif-2α), were significantly downregulated by sa, while chop overexpression attenuated the beneficial effects of sa on inflammation, oxidative stress, and apoptosis in ogd/r-induced pc12 cells. |
2021-05-24 |
2023-08-13 |
rat |
| Shuangshuang Zhang, Mengke Cao, Fang Fan. The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseases. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952149. |
ers-induced apoptosis of egcg influences cell survival and death in various diseases via regulating ire1, atf6, and perk signaling pathways, and activating grp78 and caspase proteins. |
2021-05-20 |
2023-08-13 |
human |
| Libo Chuan, Xin Huang, Chuming Fan, Shiyuan Wen, Xiaohua Yang, Jingrong Wang, Jingyu Ren, Jin Ru, Li Din. Metformin ameliorates brain damage caused by cardiopulmonary resuscitation via targeting endoplasmic reticulum stress-related proteins GRP78 and XBP1. European journal of pharmacology. vol 891. 2021-05-19. PMID:33197442. |
we confirmed that ca/cpr can induce ers-related apoptosis and oxidative stress in the brain; moreover, inhibiting ers-related proteins grp78 and xbp1 with metformin might attenuate cerebral injury post ca/cpr. |
2021-05-19 |
2023-08-13 |
rat |
| Ming Cai, Jing Yun Hu, Bei Bei Liu, Jing Jing Li, Feng Li, Shujie Lo. The Molecular Mechanisms of Excessive Hippocampal Endoplasmic Reticulum Stress Depressing Cognition-related Proteins Expression and the Regulatory Effects of Nrf2. Neuroscience. vol 431. 2021-05-14. PMID:32062019. |
results showed that the expression levels of glucose transporter 3 (glut3), fatty acid transport protein 1 (fatp1), er stress biomarkers (grp78, p-perk, p-ire1α and p-eif2α), er stress-mediated apoptosis biomarkers (caspase-12, chop and bax/bcl-2), and the activity of nlrp3-il-1β inflammatory pathway were significantly increased under high glucose and pa conditions, accompanied with depressed p38/erk-creb pathway and decreased levels of brain derived neurotrophic factor (bdnf) and synaptophysin (syn). |
2021-05-14 |
2023-08-13 |
Not clear |
| Emi Ikebe, Sahoko Matsuoka, Kenta Tezuka, Madoka Kuramitsu, Kazu Okuma, Makoto Nakashima, Seiichiro Kobayashi, Junya Makiyama, Makoto Yamagishi, Seiichi Oyadomari, Kaoru Uchimaru, Isao Hamaguch. Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells. Blood advances. vol 4. issue 9. 2021-05-14. PMID:32369565. |
we also identified a significant downregulation in glucose regulated protein 78 (grp78), a master regulator of the upr in the cd4+cadm1+ htlv-1-infected cell population of primary htlv-1 carrier peripheral blood mononuclear cells (pbmcs) (n = 9), suggesting that htlv-1-infected cells are hypersensitive to endoplasmic reticulum (er) stress-mediated apoptosis. |
2021-05-14 |
2023-08-13 |
human |
| Guoqin Wang, Qiuwen Ye, Shujuan Ning, Zhuangqing Yang, Yunlan Chen, Lijuan Zhang, Youguang Huang, Fujia Xie, Xi Cheng, Junlin Chi, Yi Lei, Rong Guo, Jiangqiong Ha. LncRNA MEG3 promotes endoplasmic reticulum stress and suppresses proliferation and invasion of colorectal carcinoma cells through the MEG3/miR-103a-3p/PDHB ceRNA pathway. Neoplasma. vol 68. issue 2. 2021-05-14. PMID:33118833. |
restoring meg3 suppressed cell viability, colony formation ability, and invasion, arrested cell cycle, and induced apoptosis rate in sw620 and hct116 cells, as well as promoted expression of er stress-related proteins (grp78, atf6, chop, caspase-3, and caspase-9). |
2021-05-14 |
2023-08-13 |
human |
| Qipeng Zhang, Wenying Chen, Boyang Zhang, Chen Li, Xunyao Zhang, Qian Wang, Yan Wang, Qian Zhou, Xiaohong Li, Xiao Li She. Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A. Toxicology. vol 450. 2021-05-12. PMID:33465424. |
results indicated that a 24 h-treatment of 1-5 μm ota could notably induce mitochondrial-mediated and er stress (ers)-excitated apoptosis via inhibiting trap1, thereby activating cypd, bax, cyt-c, cleaved caspase-9, cleaved caspase-3, grp78, p-perk, p-eif2α, atf4, and chop and inhibiting bcl-2 (p < 0.05). |
2021-05-12 |
2023-08-13 |
human |
| Jiong Li, Jing Xie, Yan-Zhen Wang, Yi-Rong Gan, Ling Wei, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xi. Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324. Molecular medicine reports. vol 23. issue 2. 2021-05-04. PMID:33300079. |
tm induced apoptosis, ers and autophagy, as indicated by an increased ratio of apoptotic cells, increased expression levels of bax, cleaved (c)-caspase-3/9, glucose-regulated protein 78 kda (grp78), phosphorylated (p)-inositol-requiring enzyme-1α (ire1α), spliced x-box-binding protein 1 (xbp1s), ire1α, activating transcription factor (atf)6, atf4, beclin 1 and microtubule associated protein 1 light chain 3α (lc3)ii/i, and decreased expression levels of bcl-2, unspliced xbp1 (xbp1u) and p62 in the tm group compared with the control group. |
2021-05-04 |
2023-08-13 |
rat |
| Wenwen Sun, Hong Li, Jin G. Up-regulation of microRNA-574 attenuates lipopolysaccharide- or cecal ligation and puncture-induced sepsis associated with acute lung injury. Cell biochemistry and function. vol 38. issue 7. 2021-05-03. PMID:32090367. |
sic3 enhanced cell viability and inhibited apoptosis, however, it suppressed the mrna levels of grp78, chop and caspase-12. |
2021-05-03 |
2023-08-13 |
mouse |
| Xiaoqiao Shi, Zhiwen Liu, Junwei L. Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway. Molecular medicine reports. vol 22. issue 4. 2021-04-30. PMID:32945482. |
chop was overexpressed or knocked down to detect the cell viability, apoptosis, ldh level and the expression levels of inflammatory factors and grp78. |
2021-04-30 |
2023-08-13 |
Not clear |
| Xiaoqiao Shi, Zhiwen Liu, Junwei L. Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway. Molecular medicine reports. vol 22. issue 4. 2021-04-30. PMID:32945482. |
silencing of chop significantly reversed the h/r‑reduced cell viability, high apoptotic rate and ldh levels, as well as the elevated expression levels of inflammatory factors and grp78 caused by h/r injury, whereas the overexpression of chop inhibited cell viability and promoted apoptosis, elevated ldh level and expression of inflammatory factors and grp78 compared with the negative control. |
2021-04-30 |
2023-08-13 |
Not clear |