| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiying Liu, Luguang Wang, Linyu Dai, Fumin Feng, Yonghong Xia. CaMK II/Ca2+ dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1. International journal of biological macromolecules. vol 172. 2021-04-29. PMID:33454324. |
in the experiment, we demonstrate that kn-62 and utp can inhibit the proliferation and promote the apoptosis in hscs, increase the level of intracellular ca2+ and the expression of ers protein grp78, and increase the apoptosis protein caspase-12 and bax expression, while decrease the expression of bcl-2 protein. |
2021-04-29 |
2023-08-13 |
rat |
| Qingli Kong, Zhisheng Zhang, Zhipeng Lian. Upregulating miR-637 aggravates endoplasmic reticulum stress-induced apoptosis in gastric cancer cells by suppressing Calreticulin. Animal cells and systems. vol 24. issue 5. 2021-04-22. PMID:33209200. |
overexpression of mir-637 promoted tm-induced apoptosis and expression of er stress associated proteins (grp78 and chop), but inhibited expression of calreticulin. |
2021-04-22 |
2023-08-13 |
Not clear |
| Lihua Yang, Ningning Guo, Wei Fan, Chunmin Ni, Mengbing Huang, Liping Bai, Le Zhang, Xianwen Zhang, Yunbo Wen, Ye Li, Xiaoshuang Zhou, Jie Ba. Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice. Neurotoxicology. vol 78. 2021-04-21. PMID:32203791. |
we further examined er stress-related proteins and mitochondrial apoptosis pathway in the vta and nac, and found that meth increased the expressions of glucose regulated protein 78 (grp78), c/ebp homologous protein (chop), and bax, as same time decreased the expressions of procaspase12, bcl-2, and procaspase3, while trx-1 overexpression blocked these changes. |
2021-04-21 |
2023-08-13 |
mouse |
| Tong Lu, Yue Wang, Kang Xu, Zhijun Zhou, Juan Gong, Yingang Zhang, Hua Gong, Qiang Dai, Jun Yang, Biao Xiong, Ze Song, Gang Yan. Co-downregulation of GRP78 and GRP94 Induces Apoptosis and Inhibits Migration in Prostate Cancer Cells. Open life sciences. vol 14. 2021-04-06. PMID:33817173. |
co-downregulation of grp78 and grp94 induces apoptosis and inhibits migration in prostate cancer cells. |
2021-04-06 |
2023-08-13 |
Not clear |
| Xu Chen, Jun Yin, Yuyin Xu, Zhi Qiu, Jing Liu, Xiaolan Che. Effect of selective inhibition or activation of PGE2 EP1 receptor on glomerulosclerosis. Molecular medicine reports. vol 22. issue 4. 2021-04-05. PMID:32700746. |
the present in vitro experiments demonstrated that, compared with the control group, the ep1 receptor antagonist suppressed the expression of grp78, trpc1 and perk (p<0.05), reduced the production of pge2 (p<0.05) and decreased the mc apoptosis rate (p<0.05), thus alleviating tgf‑β1‑stimulated mc injury. |
2021-04-05 |
2023-08-13 |
mouse |
| Kyoung-Jin Min, Sk Abrar Shahriyar, Taeg Kyu Kwo. Arylquin 1, a potent Par-4 secretagogue, induces lysosomal membrane permeabilization-mediated non-apoptotic cell death in cancer cells. Toxicological research. vol 36. issue 2. 2021-04-02. PMID:32257929. |
secreted par-4 binds to its receptor, 78-kda glucose-regulated protein (grp78), on the cancer cell surface and induces apoptosis. |
2021-04-02 |
2023-08-13 |
Not clear |
| Tsun-Jui Liu, Yueh-Chiao Yeh, Wen-Lieng Lee, Li-Chuan Wang, Hsiao-Wei Lee, Miau-Tsz Shiu, Chieh-Shou Su, Hui-Chin La. Insulin ameliorates hypoxia-induced autophagy, endoplasmic reticular stress and apoptosis of myocardial cells: In vitro and ex vivo models. European journal of pharmacology. vol 880. 2021-03-24. PMID:32360347. |
coronary ligation-induced acute ischemia upregulated glucose-related protein 78 (grp78) and triggered cellular apoptosis in the jeopardized myocardium. |
2021-03-24 |
2023-08-13 |
rat |
| Yongjie Xiong, Jing Li, Shaojun H. Zinc Protects against Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells. Biological trace element research. 2021-03-19. PMID:33738683. |
hs treatment inhibited cell viability and induced apoptosis, which was accompanied by the induction of the activity of caspase 3, an executioner of apoptosis, involved in the expression of pro-apoptotic protein b cell lymphoma 2-associated x protein (bax), and in the reduction of the expression of anti-apoptotic protein b cell lymphoma 2 (bcl-2), thereby activating er stress marker protein expression (glucose-regulated protein 78 (grp78) and ccaat/enhancer-binding protein homologous protein (chop)). |
2021-03-19 |
2023-08-13 |
Not clear |
| Yongjie Xiong, Jing Li, Shaojun H. Zinc Protects against Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells. Biological trace element research. 2021-03-19. PMID:33738683. |
however, zinc sulfate led to the attenuation of deleterious effects, including increases in apoptosis, caspase-3 activity, bax, grp78, and chop expression, and decreases in cell viability and bcl-2 protein expression in cells treated with hs or thapsigargin (an er stress activator). |
2021-03-19 |
2023-08-13 |
Not clear |
| Patrycja Kurowska, Ewa Mlyczyńska, Joelle Dupont, Agnieszka Ra. Novel Insights on the Corpus Luteum Function: Role of Vaspin on Porcine Luteal Cell Angiogenesis, Proliferation and Apoptosis by Activation of GRP78 Receptor and MAP3/1 Kinase Pathways. International journal of molecular sciences. vol 21. issue 18. 2021-03-15. PMID:32957618. |
novel insights on the corpus luteum function: role of vaspin on porcine luteal cell angiogenesis, proliferation and apoptosis by activation of grp78 receptor and map3/1 kinase pathways. |
2021-03-15 |
2023-08-13 |
Not clear |
| Patrycja Kurowska, Ewa Mlyczyńska, Joelle Dupont, Agnieszka Ra. Novel Insights on the Corpus Luteum Function: Role of Vaspin on Porcine Luteal Cell Angiogenesis, Proliferation and Apoptosis by Activation of GRP78 Receptor and MAP3/1 Kinase Pathways. International journal of molecular sciences. vol 21. issue 18. 2021-03-15. PMID:32957618. |
the aim of this study was to examine the effect of vaspin on angiogenesis, apoptosis and proliferation as well as the involvement of 78-kda glucose-regulated protein receptor (grp78) and mitogen-activated kinase (map3/1) in these processes. |
2021-03-15 |
2023-08-13 |
Not clear |
| Jia-Yi Zhou, Deng-Gui Huang, Min Zhu, Chun-Qi Gao, Hui-Chao Yan, Xiang-Guang Li, Xiu-Qi Wan. Wnt/β-catenin-mediated heat exposure inhibits intestinal epithelial cell proliferation and stem cell expansion through endoplasmic reticulum stress. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31960439. |
thereby, in vitro a confluent monolayer of ipec-j2 cells was exposed to the high temperatures (39, 40, and 41°c), the ipec-j2 cell proliferation, apoptosis, differentiation, and barrier were determined, as well as the expression of grp78, which is a marker protein of endoplasmic reticulum stress (ers). |
2021-03-10 |
2023-08-13 |
Not clear |
| Jia-Yi Zhou, Deng-Gui Huang, Min Zhu, Chun-Qi Gao, Hui-Chao Yan, Xiang-Guang Li, Xiu-Qi Wan. Wnt/β-catenin-mediated heat exposure inhibits intestinal epithelial cell proliferation and stem cell expansion through endoplasmic reticulum stress. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31960439. |
furthermore, exposure to 41°c for 24 hr reduced isc activity, stimulated crypt-cell apoptosis, upregulated the expression of grp78 and caspase-3, and downregulated the expression of β-catenin, lgr5, bmi1, ki67, krt20, zo-1, occludin, and claudin-1. |
2021-03-10 |
2023-08-13 |
Not clear |
| Hongguang Jia, Zhan Yu, Xiaohui Ge, Zhiting Chen, Xiaobing Huang, Yongxiang We. Glucocorticoid-induced leucine zipper protects noise-induced apoptosis in cochlear cells by inhibiting endoplasmic reticulum stress in rats. Medical molecular morphology. vol 53. issue 2. 2021-03-08. PMID:31485805. |
noise exposure increased abr threshold shifts and cochlear apoptosis in parallel with downregulation of bcl-xl and upregulation of grp78, chop, bax and cleaved caspase-3. |
2021-03-08 |
2023-08-13 |
rat |
| Xinyue Wang, Xuewen Wu, Qingqing Wang, Yue Zhang, Chunmei Wang, Jinlian Che. NLRP6 suppresses gastric cancer growth via GRP78 ubiquitination. Experimental cell research. vol 395. issue 1. 2021-03-05. PMID:32682010. |
overexpression of grp78 abolished the effects of nlrp6 overexpression in gastric cancer cell proliferation, cell cycle progression, cell apoptosis, migration and cyclin d1 expression. |
2021-03-05 |
2023-08-13 |
human |
| Shuang Liu, Wen-Chang Sun, Yun-Long Zhang, Qiu-Yue Lin, Jia-Wei Liao, Gui-Rong Song, Xiao-Lei Ma, Hui-Hua Li, Bo Zhan. SOCS3 Negatively Regulates Cardiac Hypertrophy via Targeting GRP78-Mediated ER Stress During Pressure Overload. Frontiers in cell and developmental biology. vol 9. 2021-03-05. PMID:33585485. |
we found that glucose regulatory protein 78 (grp78) was a direct target of socs3, and that overexpression of socs3 inhibited cardiomyocyte hypertrophy and apoptosis through promoting proteasomal degradation of grp78, thereby inhibiting activation of endoplasmic reticulum (er) stress and mitophagy in the heart. |
2021-03-05 |
2023-08-13 |
mouse |
| Yingying He, John Bosco Ruganzu, Chengheng Lin, Bo Ding, Quzhao Zheng, Xiangyuan Wu, Ruiyang Ma, Qian Liu, Yang Wang, Hui Jin, Yihua Qian, Xiaoqian Peng, Shengfeng Ji, Liangliang Zhang, Weina Yang, Xiaomei Le. Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice. Neurochemistry international. vol 133. 2021-02-23. PMID:31778727. |
furthermore, tan iia significantly reduced the deposition of aβ plaques and neuronal apoptosis, and markedly prevented abnormal expression of glucose regulated protein 78 (grp78), initiation factor 2α (eif2α), inositol-requiring enzyme 1α (ire1α), activating transcription factor 6 (atf6), as well as suppressed the activation of c/ebp homologous protein (chop) and c-jun n-terminal kinase (jnk) pathways in the parietal cortex and hippocampus. |
2021-02-23 |
2023-08-13 |
mouse |
| Junli Liu, Limin Wei, Zhizhou Wang, Shiyu Song, Zhongyi Lin, Jiaxu Zhu, Xiang Ren, Li Kon. Protective effect of Liraglutide on diabetic retinal neurodegeneration via inhibiting oxidative stress and endoplasmic reticulum stress. Neurochemistry international. vol 133. 2021-02-23. PMID:31794832. |
in vitro, the apoptosis percentage, ros production and the expression of ers related protein grp78, ask1, p-ire1α was increased and the expression of nrf2, p-erk1/2, trx was decreased after hg treatment, however, the apoptosis percentage, generation of ros and the expression of grp78, ask1, p-ire1 were decreased. |
2021-02-23 |
2023-08-13 |
Not clear |
| Yong Chen, Weijian Jiang, Xin Liu, Yuechao Du, Liang Liu, Jose M Ordovas, Chao-Qiang Lai, Lirong She. Curcumin supplementation improves heat-stress-induced cardiac injury of mice: physiological and molecular mechanisms. The Journal of nutritional biochemistry. vol 78. 2021-02-23. PMID:31978712. |
moreover, the levels of grp78 and chop proteins in the ht group were significantly higher than those of cur groups, indicating that cur supplementation reversed the endoplasmic reticulum hs-mediated apoptosis. |
2021-02-23 |
2023-08-13 |
mouse |
| Cui Cui, Tao Lin, Zunlei Gong, Yue Zh. Relationship between autophagy, apoptosis and endoplasmic reticulum stress induced by melatonin in osteoblasts by septin7 expression. Molecular medicine reports. vol 21. issue 6. 2021-02-12. PMID:32323792. |
western blotting results showed that there was an upregulation in the expression of apoptosis marker proteins [poly (adp‑ribose) polymerase 1 (parp‑1)], endoplasmic reticulum stress [ers; c/ebp homologous protein (chop) and glucose‑regulated protein, 78 kda (grp78)] and autophagy [microtubule‑associated protein 1 light chain 3β (lc3)‑i/lc3ii]. |
2021-02-12 |
2023-08-13 |
Not clear |