| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yonglin Zhu, Luping Zhang, Rongzhan Fu, Limin Gao, Guoying Feng, Chao Du, Zhaojie Wang, Xinfeng Ya. The change tendency of endoplasmic reticulum stress associated proteins in rats with spinal cord injury. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105809. |
these results suggest that some er stress-induced apoptosis proteins, such as chop, grp78, xbp1, eif-2α and bad, were activated after spinal cord injury, but the precise regulatory mechanisms remain unclear. |
2020-10-01 |
2023-08-13 |
mouse |
| Lei Yu, Rujia Xie, Tian Tian, Lu Zheng, Lei Tang, Shuang Cai, Zihua Ma, Ting Yang, Bing Han, Qin Yan. Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells. Oncology letters. vol 18. issue 4. 2020-10-01. PMID:31516571. |
saha induced dose-dependent apoptosis and increased both protein and mrna expression levels of grp78, atf4 and chop in hepg2 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lei Yu, Rujia Xie, Tian Tian, Lu Zheng, Lei Tang, Shuang Cai, Zihua Ma, Ting Yang, Bing Han, Qin Yan. Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells. Oncology letters. vol 18. issue 4. 2020-10-01. PMID:31516571. |
furthermore, the acetylation levels of h4 in the promoter regions of grp78, atf4 and chop were significantly increased in hepg2 cells exposed to 6 µm saha for 36 h. thus, saha induces apoptosis in hepg2 cells by activating the er stress-mediated apoptotic signaling pathway, at least partially by enhancing the acetylation of histone h4 on the promoter regions of er-stress associated genes, including grp78, atf4 and chop. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xinchen Zhang, Liying Zhang, Shu Wang, Dequan Wu, Weiliang Yan. Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line Oncology letters. vol 9. issue 3. 2020-09-30. PMID:25663878. |
decreased functional expression of grp78 and grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line the aim of the present study was to determine the effect of downregulating the expression of glucose-regulated protein 78 (grp78) and grp94 upon the rate of proliferation and apoptosis in the human gastric cancer sgc-7901 cell line. |
2020-09-30 |
2023-08-13 |
human |
| Xinchen Zhang, Liying Zhang, Shu Wang, Dequan Wu, Weiliang Yan. Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line Oncology letters. vol 9. issue 3. 2020-09-30. PMID:25663878. |
furthermore, the reduction in the expression of grp78 and grp94 inhibited cellular proliferation and significantly downregulated the rate of apoptosis in the sgc-7901 cells |
2020-09-30 |
2023-08-13 |
human |
| Bomi Kim, Jayoung Kim, Yeong Seok Ki. Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress. Anatomy & cell biology. vol 50. issue 4. 2020-09-30. PMID:29354301. |
instead, celecoxib-induced apoptosis might be deeply associated with er stress depending on grp78 because sirna for grp78 enhanced apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bomi Kim, Jayoung Kim, Yeong Seok Ki. Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress. Anatomy & cell biology. vol 50. issue 4. 2020-09-30. PMID:29354301. |
taken together, celecoxib triggered er stress on lung cancer cells and celecoxib-induced apoptosis might be involved in both non-classical caspase-4 and grp78. |
2020-09-30 |
2023-08-13 |
Not clear |
| Weijie Yao, Xinwei Yang, Jiayue Zhu, Biane Gao, Renhui Liu, Liping X. Tang-Luo-Ning, a Traditional Chinese Medicine, Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis of Schwann Cells under High Glucose Environment. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:29362588. |
our previous researches have demonstrated that tln could increase the expression of er stress marker protein grp78 and inhibited the expression of apoptosis marker protein chop in er stress. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zhongli Wang, Rongsheng Cui, Kai Wan. Effects of sevoflurane pretreatment on the apoptosis of rat H9c2 cardiomyocytes and the expression of GRP78. Experimental and therapeutic medicine. vol 15. issue 3. 2020-09-30. PMID:29599827. |
effects of sevoflurane pretreatment on the apoptosis of rat h9c2 cardiomyocytes and the expression of grp78. |
2020-09-30 |
2023-08-13 |
rat |
| Xiaolong Xu, Qingquan Liu, Shasha He, Jingxia Zhao, Ning Wang, Xuyang Han, Yuhong Gu. Qiang-Xin 1 Formula Prevents Sepsis-Induced Apoptosis in Murine Cardiomyocytes by Suppressing Endoplasmic Reticulum- and Mitochondria-Associated Pathways. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30104976. |
moreover, the abnormal expression of key regulators of endoplasmic reticulum (er) and mitochondria-associated apoptosis in cardiomyocytes of septic mice, including chop, grp78, cyt-c, bcl-2, bcl-x |
2020-09-30 |
2023-08-13 |
mouse |
| Hao-Hsiang Chang, Shih-Ping Hsu, Chiang-Ting Chie. Intrarenal Transplantation of Hypoxic Preconditioned Mesenchymal Stem Cells Improves Glomerulonephritis through Anti-Oxidation, Anti-ER Stress, Anti-Inflammation, Anti-Apoptosis, and Anti-Autophagy. Antioxidants (Basel, Switzerland). vol 9. issue 1. 2020-09-28. PMID:31861336. |
hypoxic preconditioning significantly upregulated hypoxic inducible factor-1α/vegf (hif-1α/vegf) in the mscs and was more efficient than normoxic mscs in reducing the degree of urinary protein, glomerulosclerosis, fibrosis, macrophage/monocyte infiltration, grp78 mediated endoplasmic reticulum stress, beclin-1/lc3-ii mediated autophagy, and bax/bcl-2/caspase 3 mediated apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Zhihui Jiao, Xiaoning Liu, Yajun Ma, Yansong Ge, Qianzhen Zhang, Boyang Liu, Hongbin Wan. Adipose-Derived Stem Cells Protect Ischemia-Reperfusion and Partial Hepatectomy by Attenuating Endoplasmic Reticulum Stress. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32266259. |
mechanistically, the adscs significantly downregulated ers-related proteins, including grp78, p-eif2α, atf6 and xbp1s, as well as the proteins involved in ers-induced apoptosis like p-jnk, atf4 and chop. |
2020-09-28 |
2023-08-13 |
Not clear |
| Guanhua Lu, Hui Luo, Xiao Zh. Targeting the GRP78 Pathway for Cancer Therapy. Frontiers in medicine. vol 7. 2020-09-28. PMID:32850882. |
the 78-kda glucose-regulated protein (grp78) plays an important part in maintaining protein stability, regulating protein folding, and inducing apoptosis autophagy, which is considered as a powerful protein. |
2020-09-28 |
2023-08-13 |
Not clear |
| Guanhua Lu, Hui Luo, Xiao Zh. Targeting the GRP78 Pathway for Cancer Therapy. Frontiers in medicine. vol 7. 2020-09-28. PMID:32850882. |
the ability of grp78 to respond to endoplasmic reticulum stress (ers) determines whether tumor cells survive and whether the changes in expression level of grp78 regulated by endoplasmic reticulum (er) caused by various factors will directly or indirectly affect cell proliferation, apoptosis, and injury, or reduce the body's defense ability, or have protective effects on various organs. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
we found that rfp increased apoptosis of l02 cells, decreased cell survival, and increased the gene and protein expression levels of grp78, perk, atf4, chop, atf6, armet, p-ire1 and xbp-1, suggesting that rfp could induce hepatocyte injury, and the degree of injury was positively correlated with the dose and time of rfp. |
2020-09-23 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
we found that schizandrin b increased cell survival rate in dose-dependent and time-dependent manner, decreased cell apoptosis rate, and reduced protein and gene expression levels of grp78, perk, atf4, chop, atf6, armet and xbp-1. |
2020-09-23 |
2023-08-13 |
Not clear |
| Lina Zhao, Meili Zhai, Xu Yang, Hongjie Guo, Ying Cao, Donghui Wang, Ping Li, Chong Li. Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia-reperfusion injury by targeting the CNPY2-endoplasmic reticulum stress signalling. Journal of cellular and molecular medicine. vol 23. issue 12. 2020-09-22. PMID:31625681. |
to determine whether the endoplasmic reticulum apoptosis pathway cnpy2-perk was involved in the neuroprotective mechanism of dex, the expression levels of related proteins (cnpy2, grp78, perk, chop, caspase-12, caspase-9 and caspase-3) were detected by western blot analysis and rt-pcr. |
2020-09-22 |
2023-08-13 |
rat |
| Lingjuan Cui, Xiaoyan Jiang, Chengjun Zhang, Danxia Li, Shengqiang Yu, Fengchun Wan, Yue Ma, Wei Guo, Zhengfei Sha. Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3/TXNIP aix. Bioscience reports. vol 39. issue 10. 2020-09-15. PMID:31652453. |
we found that ketamine effectively damaged bladder tissues of rats and promoted apoptosis through regulating the expression levels of grp78, chop, bcl-2, bax and cleaved caspase-3 proteins in vivo and in vitro. |
2020-09-15 |
2023-08-13 |
human |
| Youbo Zuo, Xingping Hu, Qiuyan Yang, Lei Zhao, Xueli Chen, Jiangtao Lin, Tiande Yan. Preoperative vitamin-rich carbohydrate loading alleviates postoperative cognitive dysfunction in aged rats. Behavioural brain research. vol 373. 2020-09-14. PMID:31340174. |
furthermore, preoperative cho loading reduced er stress and neuronal apoptosis in the hippocampus of aged rats, as indicated by the protein biomarkers of grp78, eif2a, beclin1, bax, and bcl-2. |
2020-09-14 |
2023-08-13 |
rat |
| Andrew J Ambrose, Christopher J Zerio, Jared Sivinski, Cody J Schmidlin, Taoda Shi, Alison B Ross, Kimberly J Widrick, Steven M Johnson, Donna D Zhang, Eli Chapma. A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorganic & medicinal chemistry letters. vol 29. issue 14. 2020-09-09. PMID:31129054. |
biological investigations showed that this molecule induces the unfolded protein response, induces autophagy, and leads to apoptosis in a colon carcinoma cell model, which is known to be sensitive to grp78 inhibition. |
2020-09-09 |
2023-08-13 |
Not clear |