| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Guan, L Lei, Q Lv, Y Gong, L Yan. Curcumin attenuates palmitic acid-induced cell apoptosis by inhibiting endoplasmic reticulum stress in H9C2 cardiomyocytes. Human & experimental toxicology. vol 38. issue 6. 2020-01-02. PMID:30859861. |
treatment with pa reduced cell viability, induced apoptosis, enhanced apoptosis-related protein expression (caspase 3 and bcl-2 associated x protein (bax)), and activated er stress marker protein expression (glucose-regulated protein 78 (grp78) and ccaat/enhancer binding protein homologous protein (chop)). |
2020-01-02 |
2023-08-13 |
Not clear |
| G Guan, L Lei, Q Lv, Y Gong, L Yan. Curcumin attenuates palmitic acid-induced cell apoptosis by inhibiting endoplasmic reticulum stress in H9C2 cardiomyocytes. Human & experimental toxicology. vol 38. issue 6. 2020-01-02. PMID:30859861. |
curcumin attenuated pa-induced reduction in cell viability and activation of apoptosis, caspase 3 activity, bax, chop, and grp78 expression. |
2020-01-02 |
2023-08-13 |
Not clear |
| Baimei He, Qiong Chen, Dongbo Zhou, Lijing Wang, Zhaoqian Li. Role of reciprocal interaction between autophagy and endoplasmic reticulum stress in apoptosis of human bronchial epithelial cells induced by cigarette smoke extract. IUBMB life. vol 71. issue 1. 2019-12-13. PMID:30332528. |
moreover, the cse-induced autophagy was diminished by knockdown of grp78, perk, or eif2α but enhanced by knockdown of atf4 or chop; however, the cse-induced hbe apoptosis was enhanced by knockdown of grp78, perk, or eif2α but was attenuated by knockdown of atf4 or chop. |
2019-12-13 |
2023-08-13 |
human |
| Baimei He, Qiong Chen, Dongbo Zhou, Lijing Wang, Zhaoqian Li. Role of reciprocal interaction between autophagy and endoplasmic reticulum stress in apoptosis of human bronchial epithelial cells induced by cigarette smoke extract. IUBMB life. vol 71. issue 1. 2019-12-13. PMID:30332528. |
additionally, both sodium hydrosulfide (nahs) and melatonin attenuated the cse-induced apoptosis, enhanced the cse-induced autophagy, increased grp78, p-perk, and p-eif2α, and decreased chop, atf4, and caspase-4, via sirt1/orp150 pathway. |
2019-12-13 |
2023-08-13 |
human |
| Yiming Zhang, Na Wan, Tingru Pan, Xueyuan Hu, Qingqing Liu, Shu L. MicroRNA-33-3p Regulates Vein Endothelial Cell Apoptosis in Selenium-Deficient Broilers by Targeting E4F1. Oxidative medicine and cellular longevity. vol 2019. 2019-12-13. PMID:31249647. |
interestingly, the mir-33-3p inhibitor and ver-155008 (grp78 inhibitor) partly hindered the apoptosis caused by se deficiency. |
2019-12-13 |
2023-08-13 |
Not clear |
| Wang Chengji, Fan Xianji. Exercise protects against diabetic cardiomyopathy by the inhibition of the endoplasmic reticulum stress pathway in rats. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30076729. |
myocardial tissues were sampled for morphological analysis to detect myocardial cell apoptosis, and to analyze protein expression of glucose-regulated protein 78 (grp78), c/ebp homologous protein (chop), and caspase-12. |
2019-12-10 |
2023-08-13 |
rat |
| Youli Cai, Yifeng Zheng, Jiangyong Gu, Shengqi Wang, Neng Wang, Bowen Yang, Fengxue Zhang, Dongmei Wang, Wenjun Fu, Zhiyu Wan. Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78. Cell death & disease. vol 9. issue 6. 2019-11-29. PMID:29802332. |
betulinic acid chemosensitizes breast cancer by triggering er stress-mediated apoptosis by directly targeting grp78. |
2019-11-29 |
2023-08-13 |
Not clear |
| Youli Cai, Yifeng Zheng, Jiangyong Gu, Shengqi Wang, Neng Wang, Bowen Yang, Fengxue Zhang, Dongmei Wang, Wenjun Fu, Zhiyu Wan. Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78. Cell death & disease. vol 9. issue 6. 2019-11-29. PMID:29802332. |
molecular docking and coimmunoprecipitation assay further demonstrated that ba might competitively bind with atpase domain of grp78 to interrupt its interaction with er stress sensor perk, thereby initiating the downstream apoptosis cascade. |
2019-11-29 |
2023-08-13 |
Not clear |
| Youli Cai, Yifeng Zheng, Jiangyong Gu, Shengqi Wang, Neng Wang, Bowen Yang, Fengxue Zhang, Dongmei Wang, Wenjun Fu, Zhiyu Wan. Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78. Cell death & disease. vol 9. issue 6. 2019-11-29. PMID:29802332. |
in vivo breast cancer xenografts finally validated the chemosensitizing effects of ba and its biofunction in activating grp78 to trigger er stress-mediated apoptosis. |
2019-11-29 |
2023-08-13 |
Not clear |
| Qixing Zhou, Zongkai Yue, Qingzhao Li, Ruiren Zhou, Lu Li. Exposure to PbSe Nanoparticles and Male Reproductive Damage in a Rat Model. Environmental science & technology. vol 53. issue 22. 2019-11-28. PMID:31362495. |
endoplasmic reticulum and mitochondria-mediated cell apoptosis were triggered via oxidative stress, as shown by upregulation of cytoplasmic cyt-c, bax, cleaved caspase-3, grp78, and caspase-12. |
2019-11-28 |
2023-08-13 |
rat |
| Tian-Rui Yang, Tong Zhang, Ning-Hui Mu, Li-Bo Ruan, Jin-Lan Duan, Rong-Ping Zhang, Yun-Bo Mia. Resina draconis inhibits the endoplasmic-reticulum-induced apoptosis of myocardial cells via regulating miR-423-3p/ERK signaling pathway in a tree shrew myocardial ischemia- reperfusion model. Journal of biosciences. vol 44. issue 2. 2019-11-27. PMID:31180066. |
importantly, mir-423-3p mimics inhibited ir increased erk, chop and grp78 expressions, and enhanced ir decreased bcl-2 expression, and inhibited the ir-induced apoptosis of myocardial cells. |
2019-11-27 |
2023-08-13 |
Not clear |
| Zhaoyu Du, Shuanshuan Xu, Shuxian Hu, Hong Yang, Zhe Zhou, Kuldip Sidhu, Yiliang Miao, Zhonghua Liu, Wei Shen, Russel J Reiter, Jinlian Hua, Sha Pen. Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells. Cell death & disease. vol 9. issue 10. 2019-11-25. PMID:30237484. |
continuous high glycemic status of testes stimulated expression of caspase12, grp78, and chop, the three ers response factors; this might induce cell cycle arrest and apoptosis of leydig cells in response to ers. |
2019-11-25 |
2023-08-13 |
mouse |
| Rohit Gundamaraju, Ravichandra Vemuri, Wai Chin Chong, Stephen Myers, Shaghayegh Norouzi, Madhur D Shastri, Rajaraman Er. Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells. Cells. vol 7. issue 10. 2019-11-20. PMID:30326660. |
our results demonstrate that ers inhibition not only significantly reduced the upr genes (grp78, atf6, perkandxbp1) along with survivin but also downregulated the inflammatory markers such as il8, il4, and il6, which suggests a positive correlation between ers and the inhibition of apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Yang He, Lingyun Zhou, Zhiqiang Fan, Shikun Liu, Weijin Fan. Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29752433. |
these effects were concomitant with blocked ers and apoptosis, as evidenced by inactivation of phosphorylated inositol-requiring enzyme-1α (ire1α)/spliced x-box binding protein 1 (xbp1), phosphorylated protein kinase-like kinase (perk)/phosphorylated eukaryotic initiation factor 2α (eif2α) and glucose-regulated protein 78 (grp78)/activating transcription factor 6 (atf6α)/c/ebp homologous protein (chop) pathways, as well as suppressed bcl-2-associated x protein (bax)/b-cell lymphoma-2 (bcl-2) and cleaved caspase 3 expressions. |
2019-11-07 |
2023-08-13 |
rat |
| Chong Liu, Qiang Fu, Rong Mu, Fang Wang, Chunjing Zhou, Li Zhang, Baojin Yu, Yang Zhang, Tao Fang, Fengshi Tia. Dexmedetomidine alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress dependent apoptosis through the PERK-CHOP-Caspase-11 pathway. Brain research. vol 1701. 2019-11-04. PMID:30201260. |
after dex treatment, the expression levels of er stress-related apoptosis pathway proteins (grp78, p-perk, chop and cleaved-caspase-3) were significantly decreased and the apoptosis of brain cells was also significantly reduced. |
2019-11-04 |
2023-08-13 |
Not clear |
| Yanglei Yi, Fan Zhao, Nan Wang, Huan Liu, Lijun Yu, Aihua Wang, Yaping Ji. Endoplasmic reticulum stress is involved in the T-2 toxin-induced apoptosis in goat endometrium epithelial cells. Journal of applied toxicology : JAT. vol 38. issue 12. 2019-10-29. PMID:29893033. |
the altered expression of two er stress markers chop and grp78 proved that er stress is involved in the t-2 toxin-induced apoptosis. |
2019-10-29 |
2023-08-13 |
Not clear |
| Yanglei Yi, Fan Zhao, Nan Wang, Huan Liu, Lijun Yu, Aihua Wang, Yaping Ji. Endoplasmic reticulum stress is involved in the T-2 toxin-induced apoptosis in goat endometrium epithelial cells. Journal of applied toxicology : JAT. vol 38. issue 12. 2019-10-29. PMID:29893033. |
4-phenylbutyrate pretreatment was applied to relieve the er stress, pretreated endometrium epithelial cells showed a decreased apoptosis level and the expression pattern of chop and grp78 was reversed. |
2019-10-29 |
2023-08-13 |
Not clear |
| Wilson Max Almeida Monteiro De Moraes, Pamella Ramona Moraes de Souza, Nathalie Alves da Paixão, Luís Gustavo Oliveira de Sousa, Daniel Araki Ribeiro, Andrea G Marshall, Jonato Prestes, Maria Claudia Irigoyen, Patricia Chakur Brum, Alessandra Medeiro. Aerobic exercise training rescues protein quality control disruption on white skeletal muscle induced by chronic kidney disease in rats. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-10. PMID:29265674. |
5/6nxs presented a trend towards to atrophy, with a reduction in motor performance, down-regulation of protein synthesis and up-regulation of apoptosis signalling; increases in ups activity, misfolded proteins, grp78, derlin, hsp27 and hsp70 protein levels, atf4 and grp78 genes; and increase in oxidative damage compared to cs group. |
2019-10-10 |
2023-08-13 |
rat |
| Simona Martinotti, Elia Ranzato, Bruno Burland. (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress. Journal of cellular physiology. vol 233. issue 10. 2019-09-30. PMID:29744892. |
increased expression of grp78 and mild upr can be constitutive in cancer cells, hindering apoptosis, and promoting cell survival, for example, by grp78 relocation to the plasma membrane that activates mapk and pi3 k/akt pathways. |
2019-09-30 |
2023-08-13 |
Not clear |
| Jiabing Shen, Tingting Zhou, Haizhen Li, Wanyan Li, Shuyao Wang, Yan Song, Kaifu Ke, Maohong Ca. Cab45s inhibits neuronal apoptosis following intracerebral hemorrhage in adult rats. Brain research bulletin. vol 143. 2019-09-30. PMID:30266588. |
depletion of cab45s attenuated the expression of grp78, but increased the expressions of bax and caspase-3 in pc12 cells treated with hemin, which finally promoted apoptosis. |
2019-09-30 |
2023-08-13 |
rat |