| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zi-Wei Han, Li-Cang Zhu, Yue-Chen Chang, Ying Zhou, Jia-An Zong, Ke-Tao Ma, Jun-Qiang Si, Li L. [G protein-coupled estrogen receptor alleviates cerebral ischemia-reperfusion injury through inhibiting endoplasmic reticulum stress]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 4. 2019-09-26. PMID:31440749. |
the results showed that the neurobehavioral score, cerebral infarct volume, cellular apoptosis index, as well as grp78, caspase-12 and chop protein and mrna expression levels in the mcao group were significantly higher than those of control group. |
2019-09-26 |
2023-08-13 |
rat |
| Miao Liu, Yilu Wang, Qian Zhu, Junyu Zhao, Yao Wang, Man Shang, Minglin Liu, Yanna Wu, Junqiu Song, Yanxia Li. Protective effects of circulating microvesicles derived from ischemic preconditioning on myocardial ischemia/reperfusion injury in rats by inhibiting endoplasmic reticulum stress. Apoptosis : an international journal on programmed cell death. vol 23. issue 7-8. 2019-09-17. PMID:29980896. |
moreover, ipc-mvs decreased the activity of caspase 3, and the expression of endoplasmic reticulum stress (ers) markers, grp78, chop and caspase 12 indicating the involvement of ers-specific apoptosis in i/r injury, and cardioprotective effects of ipc-mvs. |
2019-09-17 |
2023-08-13 |
rat |
| Manzhao Ouyang, Zhentao Luo, Weijie Zhang, Dajian Zhu, Yan Lu, Jinhao Wu, Xueqing Ya. Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress. International journal of oncology. vol 54. issue 4. 2019-08-26. PMID:30968152. |
furthermore, curcumin abolished nf‑κb signal transduction and protected the cells from cpt‑11‑induced apoptosis by upregulating the expression of molecular chaperones, such as grp78, p4hb and prdx4, and suppressing the levels of the apoptosis‑related proteins, chop and cleaved caspase‑3. |
2019-08-26 |
2023-08-13 |
mouse |
| Wei Liu, Tianyao Yang, Zhaofa Xu, Bin Xu, Yu Den. Methyl-mercury induces apoptosis through ROS-mediated endoplasmic reticulum stress and mitochondrial apoptosis pathways activation in rat cortical neurons. Free radical research. vol 53. issue 1. 2019-07-26. PMID:30513015. |
results showed that mehg induced neuronal oxidative stress, apoptosis, up-regulating glucose-regulated protein (grp78, grp94), spliced xbp1, activating transcription factor 4 (atf4) mrna, with activation of upr including pkr-like er kinase-eif2α, inositol-requiring enzyme 1, and atf6 pathways, as well as c/ebp homologous transcription factor protein and cleaved caspase-12 up-regulation. |
2019-07-26 |
2023-08-13 |
rat |
| Zhi-Li Jia, Juan Cen, Jia-Bo Wang, Feng Zhang, Qing Xia, Xue Wang, Xi-Qiang Chen, Rong-Chun Wang, Chung-der Hsiao, Ke-Chun Liu, Yun Zhan. Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. vol 227. 2019-07-10. PMID:31004821. |
furthermore, mrna levels of factors related to endoplasmic reticulum stress (ers) (grp78, atf6, perk, ire1, xbp1s and chop), apoptosis (bax, cyt, caspase-3, caspase-8 and caspase-9) and the nrf2 signalling pathway (nrf2, ho-1, nqo1, gclm and gclc) were significantly upregulated. |
2019-07-10 |
2023-08-13 |
cat |
| Hyeonji Kim, Jeong Yong Moon, Supawadee Burapan, Jaehong Han, Somi Kim Ch. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-Trimethoxyflavone Isolated from Kaempferia parviflora Tea Infusion. Nutrition and cancer. vol 70. issue 6. 2019-06-27. PMID:30273054. |
furthermore, it was found that tmf induced apoptosis via er stress, verified by an increase in the level of c/ebp homologous protein (chop), glucose regulated protein 78 (grp78), inositol-requiring enzyme 1 α (ire1α), activating transcription factor-4 (atf-4), and the splice isoform of x-box-binding protein-1 (xbp-1) mrna. |
2019-06-27 |
2023-08-13 |
human |
| Ying-Yan Fang, Peng Zeng, Na Qu, Lin-Na Ning, Jiang Chu, Teng Zhang, Xin-Wen Zhou, Qing Tia. Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy. Journal of neurochemistry. vol 146. issue 6. 2019-06-26. PMID:29939407. |
a link between neuronal loss and apoptosis was suggested, as evidenced by increases in adenylate kinase 2 (ak2), b-cell lymphoma 2 associated x (bax), cleaved caspase 3, and phosphorylated p53 and decreases in huntingtin-interacting protein k, hexokinase, and phosphorylated b-cell lymphoma 2 (bcl-2), and apoptosis might be triggered by endoplasmic reticulum stress (probed by increased glucose-regulated protein 78 (grp78), cleaved caspase 12, phosphorylated protein kinase r (pkr)-like endoplasmic reticulum kinase, inositol-requiring enzyme-1 and activating transcription factor 6), and mitochondrial dysfunction (probed by increased cytochrome c and cleaved caspase 3 and decreased sideroflexin-1 (sfxn1) and nadh dehydrogenase (ubiquinone) 1 α subcomplex 11 (ndufa11)). |
2019-06-26 |
2023-08-13 |
rat |
| Na Zhao, Lan Mi, Xunjun Zhang, Minyao Xu, Haiyi Yu, Zhongwei Liu, Xiaojun Liu, Gongchang Guan, Wei Gao, Junkui Wan. Enhanced MiR-711 transcription by PPARγ induces endoplasmic reticulum stress-mediated apoptosis targeting calnexin in rat cardiomyocytes after myocardial infarction. Journal of molecular and cellular cardiology. vol 118. 2019-06-25. PMID:29522763. |
additionally, the transfection of a mir-711 mimic into cardiomyocytes induced the endoplasmic reticulum (er) stress-induced apoptosis response by upregulating glucose-regulated protein 78 (grp78), activating transcription factor (atf6), spliced x-box binding protein 1 (xbp1), apoptotic signal-regulating kinase 1 (ask1), ccaat-enhancer binding protein homologous protein (chop), caspase-12, and endoplasmic reticulum oxidoreductase 1 alpha (ero1a). |
2019-06-25 |
2023-08-13 |
rat |
| Na Zhao, Lan Mi, Xunjun Zhang, Minyao Xu, Haiyi Yu, Zhongwei Liu, Xiaojun Liu, Gongchang Guan, Wei Gao, Junkui Wan. Enhanced MiR-711 transcription by PPARγ induces endoplasmic reticulum stress-mediated apoptosis targeting calnexin in rat cardiomyocytes after myocardial infarction. Journal of molecular and cellular cardiology. vol 118. 2019-06-25. PMID:29522763. |
similarly, on day 2 after mi, increased mir-711 levels in the heart were accompanied by increased cardiomyocyte apoptosis, decreased calnexin levels, and increased levels of grp78, atf6, spliced xbp1, ask1, chop, and caspase-12, as well as cardiomyocytes apoptosis. |
2019-06-25 |
2023-08-13 |
rat |
| Huijuan Wang, Liyan Chen, Xiangying Zhang, Lin Xu, Bangxiang Xie, Hongbo Shi, Zhongping Duan, Huanhu Zhang, Feng Re. Kaempferol protects mice from d-GalN/LPS-induced acute liver failure by regulating the ER stress-Grp78-CHOP signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-17. PMID:30594786. |
moreover, pretreatment of kaempferol increased the expression of glucose-regulated/binding immunoglobulin protein 78 (grp78), decreased the expression of c/ebp-homologous protein (chop), and protected hepatocytes from er stress-induced apoptosis in vitro. |
2019-06-17 |
2023-08-13 |
mouse |
| Sae-Bom Yoon, Hae-Ryong Par. Arctigenin Inhibits Etoposide Resistance in HT-29 Colon Cancer Cells during Microenvironmental Stress. Journal of microbiology and biotechnology. vol 29. issue 4. 2019-06-17. PMID:30955254. |
in addition, microenvironmental stress can induce the overexpression of 78kda glucose regulated protein (grp78), which can subsequently block the activation of apoptosis induced by treatment with anticancer agents. |
2019-06-17 |
2023-08-13 |
Not clear |
| Feng Li, Bei Bei Liu, Ming Cai, Jing Jing Li, Shu-Jie Lo. Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise. Brain research bulletin. vol 140. 2019-06-04. PMID:29630996. |
results showed that high fat diet induced obesity caused hyperlipidemia, and significantly promoted fatp1 expression in the prefrontal cortex, meanwhile, we found up-regulation of grp78, p-perk, p-eif2α, caspase-12, chop, and bax/bcl-2, reflecting the activation of ers and ers-mediated apoptosis. |
2019-06-04 |
2023-08-13 |
rat |
| Haixia Zhao, Na Ma, Zhaoqi Liu, Ting Wang, Chengfu Yuan, Yumin He, Yaoyan Dun, Zhiyong Zhou, Ding Yuan, Changcheng Zhan. Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress. Andrologia. vol 51. issue 2. 2019-05-29. PMID:30393883. |
in addition, wz significantly activated the onset of ers and prevented germ cell apoptosis by upregulating the expression levels of ers-responsive proteins grp78, phospho-perk, phospho-eif2α, atf4, phospho-ire-1α, xbp1 and atf6α, and downregulating the expression levels of pro-apoptotic proteins p-jnk, caspase12 and chop in testicular germ cell of ageing rats. |
2019-05-29 |
2023-08-13 |
rat |
| Yuan Gao, Xiaochun Wu, Shuqin Zhao, Yujun Zhang, Hailong Ma, Zhen Yang, Wanghao Yang, Chen Zhao, Li Wang, Quanwei Zhan. Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells. Cellular & molecular biology letters. vol 24. 2019-05-17. PMID:30915128. |
to further investigate the potential roles of melatonin receptors in hcg-induced regulation of er stress and apoptosis, we examined expression of some crucial er stress markers, including grp78, chop, atf4, xbp1, and ire1. |
2019-05-17 |
2023-08-13 |
mouse |
| Qing Shu, Hua Fan, Shi-Jun Li, Dan Zhou, Wei Ma, Xiao-Yan Zhao, Jun-Qiang Yan, Gang W. Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-κB activation in reactive astrocytes. Journal of cellular biochemistry. vol 119. issue 8. 2019-05-16. PMID:29665049. |
ttc staining was applied in order to detect the cerebral infarction volume, a tunel assay to detect the apoptosis rate of neurons, an elisa to measure mda, sod, inos, ldh, tnf-α, il-1β, il-6, and il-10 levels, and both rt-qpcr and western blotting methods in order to detect pgrn, gfap, grp78, chop, and nf-κb p65 expressions. |
2019-05-16 |
2023-08-13 |
rat |
| Qing Shu, Hua Fan, Shi-Jun Li, Dan Zhou, Wei Ma, Xiao-Yan Zhao, Jun-Qiang Yan, Gang W. Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-κB activation in reactive astrocytes. Journal of cellular biochemistry. vol 119. issue 8. 2019-05-16. PMID:29665049. |
both the in vivo and in vitro results, in comparison with the i/r and the nc groups, the pgrn-high dose and pgrn-low dose groups both presented a decrease in cerebral infarction volume, apoptosis rate of neurons, mda, ldh, inos, tnf-α, il-1β, il-6 levels, and gfap, grp78, chop, nf-κb p65 expressions, and an increase in sod, il-10, and pgrn levels as well as cell proliferation depending on dosage. |
2019-05-16 |
2023-08-13 |
rat |
| Chao Ma, Ke Du, Ying Zhao, Linkui Zhang, Baichun Hu, Maosheng Chen. Pyrrolo[2,1-c][1,4] benzodiazepine-3,11-diones protect SHSY-5Y cells from Cd-induced apoptosis involving suppression of endoplasmic reticulum stress. Bioorganic & medicinal chemistry. vol 26. issue 18. 2019-04-22. PMID:30243792. |
furthermore, we found that the compound 13c could inhibit cadmium-induced cell apoptosis with the downregulation of the er stress markers grp78, chop, cleaved-caspase12 and cleaved-caspase3 through western blotting. |
2019-04-22 |
2023-08-13 |
Not clear |
| Meng-Huang Wu, Ching-Yu Lee, Tsung-Jen Huang, Kuo-Yuan Huang, Chih-Hsin Tang, Shing-Hwa Liu, Kuan-Lin Kuo, Feng-Che Kuan, Wei-Chou Lin, Chung-Sheng Sh. MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis. International journal of molecular sciences. vol 20. issue 1. 2019-04-03. PMID:30586948. |
in addition, mln4924 activated er stress⁻related apoptosis by upregulating the phosphorylation of c-jun n-terminal kinase (jnk), enhancing the expression of grp78 and ccaat-enhancer-binding protein homologous protein (chop, an inducer of endoplasmic er stress⁻related apoptosis) and activating the cleavage of caspase-4. |
2019-04-03 |
2023-08-13 |
mouse |
| Elisa Landucci, Irene L Llorente, Berta Anuncibay-Soto, Domenico E Pellegrini-Giampietro, Arsenio Fernández-Lópe. Bicuculline Reverts the Neuroprotective Effects of Meloxicam in an Oxygen and Glucose Deprivation (OGD) Model of Organotypic Hippocampal Slice Cultures. Neuroscience. vol 386. 2019-03-11. PMID:29949743. |
western blot assays were performed to measure levels of cleaved and non-cleaved caspase-3 to quantify apoptosis, while levels of grp78, grp94 and phosphorylated eif2α were used to detect unfolded protein response (upr). |
2019-03-11 |
2023-08-13 |
rat |
| Wei Cui, Bin Leng, Wei Liu, GaoPin Wan. Suppression of Apoptosis in Human Umbilical Vein Endothelial Cells (HUVECs) by Klotho Protein is Associated with Reduced Endoplasmic Reticulum Oxidative Stress and Activation of the PI3K/AKT Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-02-25. PMID:30471224. |
klotho protein reduced the rate of apoptosis of h₂o₂-treated huvecs and downregulated the expression of proteins associated with endoplasmic reticulum oxidative stress, grp78 and chop, and the expression of the apoptotic proteins, caspase-3, caspase-9, and caspase-12, and activated the phosphorylation of akt. |
2019-02-25 |
2023-08-13 |
human |