| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yifan Jia, Zeyu Li, Yang Feng, Ruixia Cui, Yanyan Dong, Xing Zhang, Xiaohong Xiang, Kai Qu, Chang Liu, Jingyao Zhan. Methane-Rich Saline Ameliorates Sepsis-Induced Acute Kidney Injury through Anti-Inflammation, Antioxidative, and Antiapoptosis Effects by Regulating Endoplasmic Reticulum Stress. Oxidative medicine and cellular longevity. vol 2018. 2019-01-22. PMID:30581532. |
in addition, the endoplasmic reticulum (er) stress-related glucose-regulated protein 78 (grp78)/activating transcription factor 4 (atf4)/c/ebp homologous protein (chop)/caspase-12 apoptosis signaling pathway was significantly suppressed in the clp + mrs group. |
2019-01-22 |
2023-08-13 |
mouse |
| Haibo Ni, Qin Rui, Yitian Xu, Jun Zhu, Fan Gao, Baoqi Dang, Di Li, Rong Gao, Gang Che. RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in rats. Experimental neurology. vol 304. 2019-01-07. PMID:29518365. |
rack1 overexpression significantly ameliorated neuronal apoptosis, blood-brain barrier disruption, brain edema and neurological deficits at 48 h after tbi, which was concomitant with upregulation of p-ire1, xbp1 and grp78 expression, while its knockdown induced the opposite effects. |
2019-01-07 |
2023-08-13 |
rat |
| Ruey-Ho Kao, Gi-Ming Lai, Jyh-Ming Chow, Chien-Huang Liao, Yu-Mei Zheng, Wei-Lun Tsai, Simon Hsia, I-Chun Lai, Hsin-Lun Lee, Shuang-En Chuang, Jacqueline Whang-Peng, Chih-Jung Ya. Opposite Regulation of CHOP and GRP78 and Synergistic Apoptosis Induction by Selenium Yeast and Fish Oil via AMPK Activation in Lung Adenocarcinoma Cells. Nutrients. vol 10. issue 10. 2019-01-02. PMID:30297634. |
opposite regulation of chop and grp78 and synergistic apoptosis induction by selenium yeast and fish oil via ampk activation in lung adenocarcinoma cells. |
2019-01-02 |
2023-08-13 |
Not clear |
| Guodong Liang, Xuedong Fang, Yubo Yang, Yan Son. Knockdown of CEMIP suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of GRP78 and attenuation of unfolded protein response. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 96. issue 3. 2018-12-11. PMID:29024602. |
knockdown of cemip suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of grp78 and attenuation of unfolded protein response. |
2018-12-11 |
2023-08-13 |
Not clear |
| Guodong Liang, Xuedong Fang, Yubo Yang, Yan Son. Knockdown of CEMIP suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of GRP78 and attenuation of unfolded protein response. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 96. issue 3. 2018-12-11. PMID:29024602. |
cemip shrna induced apoptosis and inhibited grp78 expression in sw480 and colo205 cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Yun Hou, Xi Feng Wang, Zhi Qiang Lang, Yin Chuan Jin, Jia Rong Fu, Xiao Min Xv, Shi Tian Sun, Xin Xin, Lian Shuang Zhan. Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 12. 2018-12-11. PMID:30462773. |
the levels of reactive oxygen species (ros), ultrastructure, rate of apoptosis, the expression of inositol-requiring enzyme 1α (ire1α) protein, and its downstream molecules (78 kda glucose-regulated protein (grp78), c/ebp homologous protein (chop), and caspase-12) were detected. |
2018-12-11 |
2023-08-13 |
human |
| Anna Kawiak, Anna Domachowska, Anna Jaworska, Ewa Lojkowsk. Plumbagin sensitizes breast cancer cells to tamoxifen-induced cell death through GRP78 inhibition and Bik upregulation. Scientific reports. vol 7. 2018-11-26. PMID:28287102. |
collectively, the results of this research suggest that plumbagin inhibits the antiapoptotic activity of grp78 leading to bik upregulation and apoptosis induction, which contributes to the sensitization of breast cancer cells to tamoxifen. |
2018-11-26 |
2023-08-13 |
Not clear |
| Kyung-Won Park, Gyoung Eun Kim, Rodrigo Morales, Fabio Moda, Ines Moreno-Gonzalez, Luis Concha-Marambio, Amy S Lee, Claudio Hetz, Claudio Sot. The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo. Scientific reports. vol 7. 2018-11-09. PMID:28333162. |
grp78, also called bip, is a master regulator of the upr, reducing er stress levels and apoptosis due to an enhancement of the cellular folding capacity. |
2018-11-09 |
2023-08-13 |
Not clear |
| Chieh Kao, Ritu Chandna, Abhijeet Ghode, Charlotte Dsouza, Mo Chen, Andreas Larsson, Siau Hoi Lim, Minjun Wang, Zhonglian Cao, Yizhun Zhu, Ganesh S Anand, Ruowen G. Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice. EBioMedicine. vol 33. 2018-11-07. PMID:29907328. |
we show that bc71 triggers apoptosis via cell-surface grp78 and activates caspase-8 and p53 signaling pathways in huvecs. |
2018-11-07 |
2023-08-13 |
mouse |
| Yun-Long Bao, Yu Wang, Zhe Wu, Xiao-Xue Cui, Jian-Jun Du, Yi-Lin Wang, Ming Zha. [Effects of caspase inhibitor z-VAD-fmk on the expressions of calumenin, caspase-3, GRP78 and GRP94 in adriamycin-injured cardiomyocytes]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 33. issue 3. 2018-11-06. PMID:29931936. |
to study the effects of caspase broad spectrum inhibitor z-vad-fmk on the expressions of calumenin,caspase-3, grp78 and grp94 in adriamycin-injured cardiomyocytes and to discuss whether there is a regulation relationship between calumenin and endo-plasmic reticulum stress and myocardial apoptosis. |
2018-11-06 |
2023-08-13 |
Not clear |
| Yunlu Jiang, Haiqing Liu, Bingyuan Ji, Zhengwen Wang, Chunmei Wang, Chunqing Yang, Yanyou Pan, Jing Chen, Baohua Cheng, Bo Ba. Apelin‑13 attenuates ER stress‑associated apoptosis induced by MPP+ in SH‑SY5Y cells. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29901077. |
taken together, the present results support a model in which apelin‑13 inhibits mpp+‑induced apoptosis of sh‑sy5y cells by decreasing the expression of grp78, chop, and cleaved caspase‑12, and by increasing the expression of phospho‑erk1/2. |
2018-10-29 |
2023-08-13 |
human |
| Qian Liu, Yun Li, Lin Zhou, Yunzi Li, Pengfei Xu, Xiaoyun Liu, Qiushi Lv, Juanji Li, Hongquan Guo, Haodi Cai, Rui Sun, Xinfeng Li. GRP78 Promotes Neural Stem Cell Antiapoptosis and Survival in Response to Oxygen-Glucose Deprivation (OGD)/Reoxygenation through PI3K/Akt, ERK1/2, and NF- Oxidative medicine and cellular longevity. vol 2018. 2018-10-16. PMID:29849883. |
grp78 promotes neural stem cell antiapoptosis and survival in response to oxygen-glucose deprivation (ogd)/reoxygenation through pi3k/akt, erk1/2, and nf- when brain injury happens, endogenous neural stem cells (nscs) located in the adult subventricular zone (svz) and subgranular zone (sgz) are attacked by ischemia/reperfusion to undergo cellular apoptosis and death before being induced to migrate to the lesion point and differentiate into mature neural cells for damaged cell replacement. |
2018-10-16 |
2023-08-13 |
Not clear |
| Xiaokun Sun, Linzhi Dai, Hang Zhang, Xuejun He, Fandi Hou, Wengao He, Shijun Tang, Dong Zha. Neuritin Attenuates Neuronal Apoptosis Mediated by Endoplasmic Reticulum Stress In Vitro. Neurochemical research. vol 43. issue 7. 2018-10-15. PMID:29790068. |
grp78, caspase-12 and chop expression as well as apoptosis rate of primary cultured neurons and the ultrastructural changes of endoplasmic reticulum in the ogd/r + neuritin group significantly improved compared with the ogd/r group. |
2018-10-15 |
2023-08-13 |
Not clear |
| Jian Chen, Yanli Bi, Lei Chen, Qi Zhang, Linhao X. Tanshinone IIA exerts neuroprotective effects on hippocampus-dependent cognitive impairments in diabetic rats by attenuating ER stress-induced apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 104. 2018-10-11. PMID:29800917. |
superoxide dismutase (sod) activity was reduced, and reactive oxygen species (ros) production, malondialdehyde (mda) content, and 78-kda glucose-regulated protein (grp78), growth arrest and dna damage-inducible gene 153 (chop/gad153) and cleaved caspase-3 levels were increased in the hippocampus of diabetic rats compared with that of control rats, changes that were accompanied by an increase in neuronal apoptosis in diabetic rats compared with control rats (p < 0.01). |
2018-10-11 |
2023-08-13 |
rat |
| Yang-Hua Tang, Zhen-Shuang Yue, Wen-Jie Zheng, Hong-Fei Shen, Lin-Ru Zeng, Zhong-Qing Hu, Zhen-Fei Xion. 4-Phenylbutyric acid presents therapeutic effect on osteoarthritis via inhibiting cell apoptosis and inflammatory response induced by endoplasmic reticulum stress. Biotechnology and applied biochemistry. vol 65. issue 4. 2018-10-02. PMID:29327364. |
downregulation of bax/bcl-2, chop, grp78, inflammatory factors, and reactive oxygen species generation, and the increase of mmp level detected after 4-pba treatment indicated an inhibitory effect of 4-pba on cell apoptosis, inflammatory response, and er stress in oa. |
2018-10-02 |
2023-08-13 |
Not clear |
| Haiyue Zhang, Wenbin Zhang, Fangzhou Jiao, Xun Li, Hong Zhang, Luwen Wang, Zuojiong Gon. The Nephroprotective Effect of MS-275 on Lipopolysaccharide (LPS)-Induced Acute Kidney Injury by Inhibiting Reactive Oxygen Species (ROS)-Oxidative Stress and Endoplasmic Reticulum Stress. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-28. PMID:29704392. |
in the in vitro studies, ms-275 reduced the lps-induced apoptosis of hk-2 cells, inhibited ros and mda production, increased the production gsh and sod activity, decreased the expressions of chop, grp78, caspase3, and capase12, which was related to endoplasmic reticulum stress in lps stimulated hk-2 cells. |
2018-09-28 |
2023-08-13 |
mouse |
| Oxana Ryabaya, Anastasia Prokofieva, Dmitry Khochenkov, Ivan Abramov, Alexander Zasedatelev, Evgenia Stepanov. Inhibition of endoplasmic reticulum stress-induced autophagy sensitizes melanoma cells to temozolomide treatment. Oncology reports. vol 40. issue 1. 2018-09-27. PMID:29749510. |
we found that downregulation of grp78 led to inhibition of autophagy, cell cycle arrest in the g0/g1 phase, and activation of caspase-7-induced apoptosis, and this was affected by the initial autophagy level. |
2018-09-27 |
2023-08-13 |
Not clear |
| Chengyan Luo, Wen Fan, Yi Jiang, Shulin Zhou, Wenjun Chen. Glucose-Related Protein 78 Expression and Its Effects on Cisplatin-Resistance in Cervical Cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-12. PMID:29650944. |
data suggested that grp78 silencing increased chemo-sensitivity and improved the effects of cisplatin-induced apoptosis in siha cells. |
2018-09-12 |
2023-08-13 |
Not clear |
| Jian Xu, Jingjing Wang, Yusheng Cheng, Xiang Li, Mengyu He, Jiali Zhu, Honghao Han, Guihong Wei, Hui Kong, Weiping Xie, Hong Wang, Xiangrong Zu. Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats. BioMed research international. vol 2018. 2018-09-05. PMID:29607314. |
in addition, sitagliptin, as well as liraglutide, alleviated the mct-induced apoptosis of renal cells by increasing the expression of survival factor glucose-regulated protein 78 (grp78), which was abolished by the glp-1r antagonist ex-3. |
2018-09-05 |
2023-08-13 |
rat |
| Ling Liu, Yan Zhang, Yankui Wang, Wei Peng, Ning Zhang, Yuanhua Y. Progesterone inhibited endoplasmic reticulum stress associated apoptosis induced by interleukin-1β via the GRP78/PERK/CHOP pathway in BeWo cells. The journal of obstetrics and gynaecology research. vol 44. issue 3. 2018-09-04. PMID:29239061. |
this study investigated the relationship between progesterone and endoplasmic reticulum stress (ers) associated apoptosis induced by interleukin (il)-1β via the glucose regulated protein 78 (grp78)/protein kinase rna-like endoplasmic reticulum kinase (perk)/c/ebp-homologous protein (chop) pathway in bewo cells. |
2018-09-04 |
2023-08-13 |
Not clear |