| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junya Ning, Zhaomin Lin, Xuan Zhao, Baoxiang Zhao, Junying Mia. Inhibiting lysine 353 oxidation of GRP78 by a hypochlorous probe targeting endoplasmic reticulum promotes autophagy in cancer cells. Cell death & disease. vol 10. issue 11. 2020-08-26. PMID:31719525. |
in brief, we found that an endoplasmic reticulum-targeted hocl probe named zbm-h, acting through attenuating hocl-induced grp78 oxidation, inhibited tumor cell survival by promoting autophagy and apoptosis. |
2020-08-26 |
2023-08-13 |
Not clear |
| Yi-Jye Chern, John C T Wong, Grace S W Cheng, Angel Yu, Yaling Yin, David F Schaeffer, Hagen F Kennecke, Gregg Morin, Isabella T Ta. The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer. Cell death & disease. vol 10. issue 7. 2020-07-13. PMID:31243264. |
the interaction between sparc and grp78 interferes with er stress signaling and potentiates apoptosis via perk/eif2α and ire1α/xbp-1 in colorectal cancer. |
2020-07-13 |
2023-08-13 |
Not clear |
| Yi-Jye Chern, John C T Wong, Grace S W Cheng, Angel Yu, Yaling Yin, David F Schaeffer, Hagen F Kennecke, Gregg Morin, Isabella T Ta. The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer. Cell death & disease. vol 10. issue 7. 2020-07-13. PMID:31243264. |
we found that the interaction between grp78 and sparc increased during exposure to 5-fu, cpt-11, and tunicamycin, resulting in an attenuation of grp78's inhibition of apoptosis. |
2020-07-13 |
2023-08-13 |
Not clear |
| Hong Pan, Haipeng Huang, Liying Zhang, Shiqi Ma, Hongmei Yang, Hongfeng Wan. "Adjusting internal organs and dredging channel" electroacupuncture treatment prevents the development of diabetic peripheral neuropathy by downregulating glucose-related protein 78 (GRP78) and caspase-12 in streptozotocin-diabetic rats. Journal of diabetes. vol 11. issue 12. 2020-04-21. PMID:30884162. |
considering that glucose-regulated protein 78 (grp78) and caspase-12 are major proteins participating in cell apoptosis, we investigated the effects of "adjusting internal organs and dredging channel" electroacupuncture therapy on grp78 and caspase-12 levels in streptozotocin (stz)-diabetic rats to elucidate the mechanism of action. |
2020-04-21 |
2023-08-13 |
rat |
| Fenglei Chen, Jiaqi Jin, Jiahui Hu, Yujing Wang, Zhiyu Ma, Jinlong Zhan. Endoplasmic Reticulum Stress Cooperates in Silica Nanoparticles-Induced Macrophage Apoptosis via Activation of CHOP-Mediated Apoptotic Signaling Pathway. International journal of molecular sciences. vol 20. issue 23. 2020-04-20. PMID:31766455. |
moreover, 4-phenylbutyrate (4-pba), an er stress inhibitor, significantly decreased grp78, chop, and ero1α expression, and inhibited cell apoptosis in raw 264.7 macrophage cells. |
2020-04-20 |
2023-08-13 |
human |
| Zi-Jian Yang, Jun-Yao Huang, Ye-Fei Gao, Jun-Yao Huang, Wen-Ji Huang, Jun-Yao Huang, Shi-Lei Xu, Jun-Yao Huang, Jing-Jing Jin, Jun-Yao Huang, Ye-Dong Wan, Jun-Yao Huang, Ming Yan, Jun-Yao Huang, Hong-Jiao Mao, Jun-Yao Huang, Yun Zhang, Jun-Yao Huan. [Effects of bergapten on damages of osteocytes MLO-Y4 induced by TCP wear particles and its mechanism]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 35. issue 6. 2020-04-14. PMID:32239867. |
mtt assay and calcein-am staining were used to determine the viability of mlo-y4 cells; hoechst 33342 staining and the flow cytometry were applied to detect the apoptosis of mlo-y4; real-time pcr was performed to examine the mrna levels of dentin matrix protein1 (dmp-1), sclerostin (sost) and fibroblast growth factor23 (fgf23); western blot was performed to examine protein expressions of glucose-regulated protein 78 (grp78), protein kinase r-like er kinase (perk) phospho-perk (p-perk), eukaryotic initiation factor 2α (eif2α), phospho-eif2α (p-eif2α), activating transcription factor 4 (aft4), c/ebp homologous protein (chop) and caspase-3 in mlo-y4 cells. |
2020-04-14 |
2023-08-13 |
Not clear |
| Zi-Jian Yang, Jun-Yao Huang, Ye-Fei Gao, Jun-Yao Huang, Wen-Ji Huang, Jun-Yao Huang, Shi-Lei Xu, Jun-Yao Huang, Jing-Jing Jin, Jun-Yao Huang, Ye-Dong Wan, Jun-Yao Huang, Ming Yan, Jun-Yao Huang, Hong-Jiao Mao, Jun-Yao Huang, Yun Zhang, Jun-Yao Huan. [Effects of bergapten on damages of osteocytes MLO-Y4 induced by TCP wear particles and its mechanism]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 35. issue 6. 2020-04-14. PMID:32239867. |
;results: compared with control group, the mlo-y4 viability and dmp-1 mrna level in tcp group were decreased significantly (p＜0.05), while the percentage of apoptosis and mrna levels of sost and fgf23 were obviously increased (p＜0.05), and protein expressions of grp78, aft4, chop, p-perk/perk and p-eif2α/eif2α were up-regulated significantly in mlo-y4 cells (p＜0.05). |
2020-04-14 |
2023-08-13 |
Not clear |
| Zi-Jian Yang, Jun-Yao Huang, Ye-Fei Gao, Jun-Yao Huang, Wen-Ji Huang, Jun-Yao Huang, Shi-Lei Xu, Jun-Yao Huang, Jing-Jing Jin, Jun-Yao Huang, Ye-Dong Wan, Jun-Yao Huang, Ming Yan, Jun-Yao Huang, Hong-Jiao Mao, Jun-Yao Huang, Yun Zhang, Jun-Yao Huan. [Effects of bergapten on damages of osteocytes MLO-Y4 induced by TCP wear particles and its mechanism]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 35. issue 6. 2020-04-14. PMID:32239867. |
compared with tcp group, the damages of mlo-y4 and cell apoptosis in bergapten treated groups were decrease obviously (p＜0.05), the expressions of grp78, aft4, chop, p-perk/perk and p-eif2α/eif2α were down-regulated remarkably (p＜0.05). |
2020-04-14 |
2023-08-13 |
Not clear |
| Lumei Chi, Dan Jiao, Guangxian Nan, Honghua Yuan, Jing Shen, Yu Ga. miR-9-5p attenuates ischemic stroke through targeting ERMP1-mediated endoplasmic reticulum stress. Acta histochemica. vol 121. issue 8. 2020-04-07. PMID:31500865. |
mcao significantly increased the brain infract volume, reduced nissl bodies and cell apoptosis, and increased er stress-related proteins (ermp1, grp78, p-perk, p-eif2α and chop). |
2020-04-07 |
2023-08-13 |
rat |
| Patrycja Kurowska, Ewa Mlyczyńska, Monika Dawid, Małgorzata Opydo-Chanek, Joelle Dupont, Agnieszka Ra. In Vitro Effects of Vaspin on Porcine Granulosa Cell Proliferation, Cell Cycle Progression, and Apoptosis by Activation of GRP78 Receptor and Several Kinase Signaling Pathways Including MAP3/1, AKT, and STAT3. International journal of molecular sciences. vol 20. issue 22. 2020-04-07. PMID:31752432. |
in vitro effects of vaspin on porcine granulosa cell proliferation, cell cycle progression, and apoptosis by activation of grp78 receptor and several kinase signaling pathways including map3/1, akt, and stat3. |
2020-04-07 |
2023-08-13 |
Not clear |
| Jie Fu, Lilei Peng, Weijun Wang, Haiping He, Shan Zeng, Thomas C Chen, Yangmei Che. Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress. Neurochemical research. vol 44. issue 11. 2020-04-06. PMID:31512113. |
our results showed that vpa treatment could inhibit the increased expressions of er stress proteins (grp78 and chop), and significantly reduce neuronal apoptosis in the ptz-induced experimental seizure model. |
2020-04-06 |
2023-08-13 |
Not clear |
| Huan Xiao, Xia Yang, Li-Hui Luo, Zong Nin. Graphene oxide regulates endoplasmic reticulum stress: autophagic pathways in nasopharyngeal carcinoma cells. International journal of clinical and experimental pathology. vol 11. issue 12. 2020-03-25. PMID:31949666. |
go inhibits the proliferation of hone1 cells, promotes their apoptosis in a concentration-dependent manner and enhances the expression of the er stress chaperone grp78 in hone1 cells. |
2020-03-25 |
2023-08-13 |
Not clear |
| Marko Ljubkovic, Melanie Gressette, Cristijan Bulat, Marija Cavar, Darija Bakovic, Damir Fabijanic, Ivica Grkovic, Christophe Lemaire, Jasna Marinovi. Disturbed Fatty Acid Oxidation, Endoplasmic Reticulum Stress, and Apoptosis in Left Ventricle of Patients With Type 2 Diabetes. Diabetes. vol 68. issue 10. 2020-03-18. PMID:31391173. |
also, markers of er stress response (grp78 and chop) and apoptosis (cleaved caspase-3) were elevated in diabetic myocardium. |
2020-03-18 |
2023-08-13 |
Not clear |
| Zhongsheng Zhang, Shuangfeng Liu, Sichun Huan. Effects of thymosin β4 on neuronal apoptosis in a rat model of cerebral ischemia‑reperfusion injury. Molecular medicine reports. vol 20. issue 5. 2020-03-03. PMID:31545437. |
the zea‑longa score, neuronal apoptosis, and expression of grp78, chop, and casp12 in the i/r and tβ4 groups were significantly higher than those reported in the sham group. |
2020-03-03 |
2023-08-13 |
rat |
| Zhongsheng Zhang, Shuangfeng Liu, Sichun Huan. Effects of thymosin β4 on neuronal apoptosis in a rat model of cerebral ischemia‑reperfusion injury. Molecular medicine reports. vol 20. issue 5. 2020-03-03. PMID:31545437. |
the present data revealed that tβ4 can inhibit neuronal apoptosis by upregulating grp78 and downregulating chop and casp12, thereby reducing cerebral i/r injury. |
2020-03-03 |
2023-08-13 |
rat |
| Yongxiang Wang, Chunyan Wan. microRNA-211-3p has a Role in the Effects of Lipopolysaccharide on Endoplasmic Reticulum Stress in Cultured Human Skin Fibroblasts. Medical science monitor basic research. vol 25. 2020-01-24. PMID:31221950. |
protein expression levels of the transcription factors grp78, chop, p-jnk, and the endoplasmic reticulum stress apoptosis proteins, caspase-12 and bcl-2, were determined by western blot. |
2020-01-24 |
2023-08-13 |
human |
| Jing Zhang, Ying Han, Yang Zhao, Qin-Rui Li, Hong-Fang Jin, Jun-Bao Du, Jiong Qi. Role of endoplasmic reticulum stress-associated gene TRIB3 in rats following kainic acid-induced seizures. International journal of clinical and experimental pathology. vol 12. issue 2. 2020-01-17. PMID:31933865. |
in a rat model of kainic acid-induced seizures, neuronal excitotoxic injury and apoptosis, and increases in the expression of trib3 and er stress markers glucose-regulated protein 78 (grp78) and c/ebp homologous binding protein (chop) were observed in the hippocampus by 24 h to 30 d after ka administration. |
2020-01-17 |
2023-08-13 |
rat |
| Chun-Qing Song, Da-Zhuang Sun, Yong-Min Xu, Chen Yang, Quan Cai, Xue-Song Don. Effect of endoplasmic reticulum calcium on paraquat‑induced apoptosis of human lung type II alveolar epithelial A549 cells. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322172. |
treatment with the ca2+‑atpase inhibitor thapsigargin significantly increased pq‑induced cytotoxicity, elevated the intracellular level of ca2+, and increased the apoptosis rate, the protein expression of glucose‑regulated protein 78 (grp78) and c/ebp homologous protein (chop), and the activities of caspase‑7 and caspase‑12 in pq‑treated cells. |
2020-01-13 |
2023-08-13 |
human |
| Chun-Qing Song, Da-Zhuang Sun, Yong-Min Xu, Chen Yang, Quan Cai, Xue-Song Don. Effect of endoplasmic reticulum calcium on paraquat‑induced apoptosis of human lung type II alveolar epithelial A549 cells. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322172. |
by contrast, treatment with heparin, an inositol 1,4,5‑triphosphate receptor inhibitor, remarkably attenuated cytotoxicity and decreased the intracellular level of ca2+, the apoptosis rate and the expression levels of grp78, chop and caspases. |
2020-01-13 |
2023-08-13 |
human |
| Henrike Tscheschner, Eric Meinhardt, Philipp Schlegel, Andreas Jungmann, Lorenz H Lehmann, Oliver J Müller, Patrick Most, Hugo A Katus, Philip W Raak. CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression. PloS one. vol 14. issue 4. 2020-01-08. PMID:31034488. |
our aim was to investigate the effect of cardiac grp78 gene transfer on ca2+ dependent signaling, cell death, cardiac function and survival in clinically relevant in vitro and in vivo models for dox cardiotoxicity.by using neonatal cardiomyocytes we could demonstrate that dox induced ca2+ dependent ca2+ /calmodulin-dependent protein kinase ii (camkii) activation is one of the factors involved in dox cardiotoxicity by promoting apoptosis. |
2020-01-08 |
2023-08-13 |
mouse |