| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxue Gong, Xiao Hu, Yingling Xu, Jinhuan Yang, Lei Zong, Cui Wang, Ji Zhu, Zhuoyu Li, Dezhao L. Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78. Anti-cancer drugs. vol 31. issue 2. 2021-02-01. PMID:31743135. |
in addition, we found that the effects of bbr on cell proliferation, migration, and apoptosis in sw480 cells were reversed by the overexpression of grp78. |
2021-02-01 |
2023-08-13 |
human |
| Chenxue Gong, Xiao Hu, Yingling Xu, Jinhuan Yang, Lei Zong, Cui Wang, Ji Zhu, Zhuoyu Li, Dezhao L. Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78. Anti-cancer drugs. vol 31. issue 2. 2021-02-01. PMID:31743135. |
our findings demonstrated that bbr inhibited the proliferation and migration and induced the apoptosis of sw480 cells by downregulating the expression of grp78, and targeting grp78 might be a potential way to develop the effective anticancer therapy. |
2021-02-01 |
2023-08-13 |
human |
| Chao Rong, Wu Wei, Tian Yu-Hon. Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106370. |
asperuloside exhibits a novel anti-leukemic activity by triggering er stress-regulated apoptosis via targeting grp78. |
2021-01-19 |
2023-08-13 |
mouse |
| Chao Rong, Wu Wei, Tian Yu-Hon. Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106370. |
in addition, grp78 knockdown significantly diminished er stress and apoptosis triggered by asp. |
2021-01-19 |
2023-08-13 |
mouse |
| Ke Chen, Hu Hua, Ziyang Zhu, Tong Wu, Zhanjun Jia, Qianqi Li. Artemisinin and dihydroartemisinin promote β-cell apoptosis induced by palmitate via enhancing ER stress. Apoptosis : an international journal on programmed cell death. vol 25. issue 3-4. 2021-01-08. PMID:31894447. |
cell apoptosis was investigated by using flow cytometry, and the expression of er stress markers, including chop, grp78 and pdi, was detected by western blotting and/or qrt-pcr. |
2021-01-08 |
2023-08-13 |
mouse |
| Mukund P Srinivasan, Kamlesh K Bhopale, Anna A Caracheo, Samir M Amer, Shamis Khan, Lata Kaphalia, Gopalakrishnan Loganathan, Appakalai N Balamurugan, Bhupendra S Kaphali. Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells. Biochemical pharmacology. vol 180. 2020-12-31. PMID:32717227. |
these cells also showed significant er stress as evidenced by the increased expression for grp78, ire1α, and perk/chop arm of unfolded protein response promoting apoptosis and activating p-jnk1/2 and p-erk1/2 with increased secretion of cytokines. |
2020-12-31 |
2023-08-13 |
human |
| Hanna A Zielinska, Carl S Daly, Ahmad Alghamdi, Amit Bahl, Muhammed Sohail, Paul White, Sarah R Dean, Jeff M P Holly, Claire M Perk. Interaction between GRP78 and IGFBP-3 Affects Tumourigenesis and Prognosis in Breast Cancer Patients. Cancers. vol 12. issue 12. 2020-12-31. PMID:33352865. |
with breast cancer cells, in vitro igfbp-3 enhanced induced apoptosis, however when grp78 expression was silenced the actions of igfbp-3 were switched from increasing to inhibiting ceramide (c2)-induced cell death and promoted cell invasion. |
2020-12-31 |
2023-08-13 |
Not clear |
| Junjian Wang, Rui Hu, Chunyan Yin, Yanfeng Xia. Tanshinone IIA reduces palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 liver cells. Fundamental & clinical pharmacology. vol 34. issue 2. 2020-11-25. PMID:31520549. |
palmitate led to cytotoxicity, tg accumulation, and apoptosis in hepg2 cells and also strongly induced er stress indicated by increased grp78, phosphorylation of eif2α, atf6, and chop. |
2020-11-25 |
2023-08-13 |
Not clear |
| Yongjie Xiong, Qirun Yin, Erhui Jin, Huatao Chen, Shaojun H. Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells. Molecules (Basel, Switzerland). vol 25. issue 3. 2020-11-09. PMID:32012916. |
the heat treatment for 6-48 h induced apoptosis, potentiated caspase 3 activity, increased the expression levels of apoptosis-related gene bax and er stress markers, glucose-regulated protein 78 (grp78), and ccaat/enhancer binding protein homologous protein (chop) in mouse granulosa cells. |
2020-11-09 |
2023-08-13 |
mouse |
| Yongjie Xiong, Qirun Yin, Erhui Jin, Huatao Chen, Shaojun H. Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells. Molecules (Basel, Switzerland). vol 25. issue 3. 2020-11-09. PMID:32012916. |
selenium treatment significantly attenuated the chs- or thapsigargin (tg, an er stress activator)-induced apoptosis, potentiation of caspase 3 activity, and the increased protein expression levels of bax, grp78, and chop. |
2020-11-09 |
2023-08-13 |
mouse |
| Hyun Jung Lee, Jae Hyeon Kim, Sujeong Hong, Inhwa Hwang, Soo Jung Park, Tae Il Kim, Won Ho Kim, Je-Wook Yu, Seung Won Kim, Jae Hee Cheo. Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet's disease. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31406212. |
expression of grp78 and xbp1s and apoptosis rates were all higher in shlgals3-transfected cells upon the induction of endoplasmic reticulum stress. |
2020-10-26 |
2023-08-13 |
mouse |
| Qian Xu, Shasha Yang, Fangzhen Wu, Yao Lin, Jianan Zhong, Lanfang Tang, Xuefeng Hu, Jing Ca. Congrong Shujing Granule-Induced GRP78 Expression Reduced Endoplasmic Reticulum Stress and Neuronal Apoptosis in the Midbrain in a Parkinson's Disease Rat Model. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-10-22. PMID:33062012. |
congrong shujing granule-induced grp78 expression reduced endoplasmic reticulum stress and neuronal apoptosis in the midbrain in a parkinson's disease rat model. |
2020-10-22 |
2023-08-13 |
rat |
| Yue Wang, Zhu Zhang, Kathy Ka-Wai Auyeung, Chi-Hin Cho, Ken Kin-Lam Yung, Joshua Ka-Shun K. Cryptotanshinone-Induced p53-Dependent Sensitization of Colon Cancer Cells to Apoptotic Drive by Regulation of Calpain and Calcium Homeostasis. The American journal of Chinese medicine. vol 48. issue 5. 2020-10-20. PMID:32668972. |
grp78 knockdown increased the sensitivity of cancer cells to cryptotanshinone-evoked apoptosis and reduction of cancer cell colony formation. |
2020-10-20 |
2023-08-13 |
Not clear |
| Guohong Zhao, Jianqin Kang, Guanghui Xu, Jing Wei, Xiaoguang Wang, Xiaorui Jing, Lan Zhang, Aili Yang, Kai Wang, Jue Wang, Li Wang, Junfeng Hou, Qingquan Liu, Kai Jiao, Bin Ga. Tunicamycin promotes metastasis through upregulating endoplasmic reticulum stress induced GRP78 expression in thyroid carcinoma. Cell & bioscience. vol 10. 2020-10-06. PMID:33014334. |
glucose-regulated protein (grp78) is the key molecule of tumor growth, apoptosis and metastasis. |
2020-10-06 |
2023-08-13 |
Not clear |
| Xiangyu Zhang, Jia Chen, Cheng Cheng, Ping Li, Fangfang Cai, Huangru Xu, Yanyan Lu, Nini Cao, Jia Liu, Jigang Wang, Zi-Chun Hua, Hongqin Zhuan. Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity. Therapeutic advances in medical oncology. vol 12. 2020-10-02. PMID:32994805. |
aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting grp78 activity. |
2020-10-02 |
2023-08-13 |
human |
| Yanhong Ma, Yahui Li, Hongzhi Zhang, Ying Wang, Caie Wu, Wuyang Huan. Malvidin induces hepatic stellate cell apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway. Food science & nutrition. vol 8. issue 9. 2020-10-02. PMID:32994970. |
moreover, malvidin upregulated the protein levels of some endoplasmic reticulum stress (ers)-typical markers, including caspase-12, glucose-regulated protein 78 (grp78), and ccaat/enhancer-binding protein (c/ebp) homologous protein (chop), suggesting that malvidin induced hsc apoptosis by the ers apoptosis pathway as well as the mitochondrial-dependent pathway. |
2020-10-02 |
2023-08-13 |
rat |
| Dalia O Saleh, Dina F Mansour, Rasha E Mostaf. Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways. Toxicology reports. vol 7. 2020-10-02. PMID:32995293. |
in addition, cp exposure resulted in grp78 induction; an er stress and elevation marker at calpain-1 content as well as activation of activated caspase-3 (acasp3) and caspase-12 were reflected on cp-triggered apoptosis evidenced by elevation in the bax/bcl-2 ratio. |
2020-10-02 |
2023-08-13 |
rat |
| Yang Ye, Shuhan Miao, Yan Wang, Jianwei Zhou, Rongzhu L. 3,3'-diindolylmethane potentiates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of gastric cancer cells. Oncology letters. vol 9. issue 5. 2020-10-01. PMID:26137077. |
to the best of our knowledge, the present study is the first to provide evidence that dim sensitizes trail-induced inhibition of proliferation and apoptosis in gastric cancer cells, accompanied by the upregulated expression of dr5, chop and grp78 proteins, which may be involved in endoplasmic reticulum stress mechanisms. |
2020-10-01 |
2023-08-13 |
Not clear |
| H N Banerjee, G Hyman, S Evans, V Manglik, E Gwebu, A Banerjee, D Vaughan, J Medley, C Krauss, J Wilkins, V Smith, A Banerji, J Rousc. Identification of the Transmembrane Glucose Regulated Protein 78 as a Biomarker for the Brain Cancer Glioblastoma Multiforme by Gene Expression and Proteomic Studies. Journal of membrane science & technology. vol 4. issue 1. 2020-10-01. PMID:26207187. |
grp78 is implicated in tumor cell proliferation, apoptosis resistance, immune escape, metastasis and angiogenesis, and its elevated expression usually correlates with a variety of tumor micro environmental stresses, including hypoxia, glucose deprivation, lactic acidosis and inflammatory response. |
2020-10-01 |
2023-08-13 |
human |
| Chengbin Qu, Jun Ma, Xiaobai Liu, Yixue Xue, Jian Zheng, Libo Liu, Jing Liu, Zhen Li, Lei Zhang, Yunhui Li. Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:29033794. |
enhanced expression of grp78, chop and eif2α and activation of caspase 12 were additionally confirmed that endoplasmic reticulum (er) stress pathway of apoptosis was involved in the cytotoxicity of dha. |
2020-10-01 |
2023-08-13 |
human |