| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing-Ying Zhao, Yu-Bin W. Huaier Extract Attenuates Acute Kidney Injury to Chronic Kidney Disease Transition by Inhibiting Endoplasmic Reticulum Stress and Apoptosis via miR-1271 Upregulation. BioMed research international. vol 2020. 2021-09-13. PMID:33457422. |
this in vivo effect was supported by in vitro results in which he inhibited apoptosis and decreased the expression of chop and grp78 induced by ers. |
2021-09-13 |
2023-08-13 |
mouse |
| Jing-Ying Zhao, Yu-Bin W. Huaier Extract Attenuates Acute Kidney Injury to Chronic Kidney Disease Transition by Inhibiting Endoplasmic Reticulum Stress and Apoptosis via miR-1271 Upregulation. BioMed research international. vol 2020. 2021-09-13. PMID:33457422. |
in conclusion, he reduces kidney injury, probably by inhibiting apoptosis and decreasing the expression of grp78 and chop via mir-1271 upregulation. |
2021-09-13 |
2023-08-13 |
mouse |
| Heyu Ji, Feng Xiao, Suobei Li, Ruan Wei, Fei Yu, Junmei X. GRP78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the Nrf2/HO-1 signaling pathway. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32657424. |
grp78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the nrf2/ho-1 signaling pathway. |
2021-09-07 |
2023-08-13 |
Not clear |
| Heyu Ji, Feng Xiao, Suobei Li, Ruan Wei, Fei Yu, Junmei X. GRP78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the Nrf2/HO-1 signaling pathway. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32657424. |
recent findings revealed that grp78 could protect myocardial cells against ischemia reperfusion injury-induced apoptosis, but the exact function and molecular mechanism remains unclear. |
2021-09-07 |
2023-08-13 |
Not clear |
| Heyu Ji, Feng Xiao, Suobei Li, Ruan Wei, Fei Yu, Junmei X. GRP78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the Nrf2/HO-1 signaling pathway. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32657424. |
intriguingly, we first observed that grp78 overexpression significantly protected myocytes from h/r-induced apoptosis. |
2021-09-07 |
2023-08-13 |
Not clear |
| Heyu Ji, Feng Xiao, Suobei Li, Ruan Wei, Fei Yu, Junmei X. GRP78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the Nrf2/HO-1 signaling pathway. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32657424. |
on mechanism, our work revealed that grp78 protected myocardial cells from hypoxia/reperfusion-induced apoptosis via the activation of the nrf2/ho-1 signaling pathway. |
2021-09-07 |
2023-08-13 |
Not clear |
| Heyu Ji, Feng Xiao, Suobei Li, Ruan Wei, Fei Yu, Junmei X. GRP78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the Nrf2/HO-1 signaling pathway. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32657424. |
furthermore, we found that blocked the nrf2/ho-1 signaling by the ho-1 inhibitor zinc protoporphyrin ix (znpp) significantly retrieved h9c2 cells apoptosis that inhibited by grp78 overexpression. |
2021-09-07 |
2023-08-13 |
Not clear |
| Heyu Ji, Feng Xiao, Suobei Li, Ruan Wei, Fei Yu, Junmei X. GRP78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the Nrf2/HO-1 signaling pathway. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32657424. |
taken together, our findings revealed a new mechanism by which grp78 alleviated h/r-induced cardiomyocyte apoptosis in h9c2 cells via the promotion of the nrf2/ho-1 signaling pathway. |
2021-09-07 |
2023-08-13 |
Not clear |
| Man-Lin Guo, Xiang-Yu Ma, Yu-Qing Gong, Meng-Lin Feng, Yu-Wan Zhao, Leng-Xin Dua. [Protective effect of ethyl acetate extract from Bidens bipinnata on hepatocyte damage induced by endoplasmic reticulum stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472265. |
methyl thiazolyl tetrazolium(mtt) colorimetric assay was used to investigate the survival rate of ethyl acetate extract from b. bipinnata in l02 cells injury induced by endoplasmic reticulum stress; the protein expressions of endoplasmic reticulum stress-related molecule glucose regulated protein 78(grp78), pkr-like er kinase(perk), eukaryotic initiation factor-2(eif2α), activating transcription factor 4(atf4), c/ebp homologous protein(chop), b-cell cll/lymphoma 2(bcl-2), bal-2 associated x apoptosis regulator(bax) were examined by wes-tern blot. |
2021-09-03 |
2023-08-13 |
Not clear |
| Hong Ye, Ying Men. Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbilical vein endothelial cells. Endocrine journal. vol 68. issue 8. 2021-08-30. PMID:33952780. |
finally, the viability, apoptosis, and the contents of ros, mda, and sod, as well as the expressions of chop, grp78, p-perk, p-ire1α, cleaved caspase-3, akt, p-akt, and sirt1 in the cells transfected with small interfering rna sirt1 (sisirt1) were detected by the previously mentioned methods. |
2021-08-30 |
2023-08-13 |
human |
| Hong Ye, Ying Men. Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbilical vein endothelial cells. Endocrine journal. vol 68. issue 8. 2021-08-30. PMID:33952780. |
honokiol reversed the effect of hg/hf on promoting cell apoptosis, ros and mda contents, and the expressions of chop, grp78, p-perk, p-ire1α and cleaved caspase-3, and also reversed the inhibitory effect of hg/hf on cell viability, sod content and sirt1 expression. |
2021-08-30 |
2023-08-13 |
human |
| Shuxian Zhang, Jiale Duan, Yanping Yang, Hanjuan Gong, Yi Tang, Ming Xiao, Ming Li, Qingshu Li, Yalan Wan. Identification of the role of mono-ADP-ribosylation in colorectal cancer by integrated transcriptome analysis. Medical oncology (Northwood, London, England). vol 38. issue 9. 2021-08-24. PMID:34357465. |
the overall attenuation of the endoplasmic reticulum unfolded protein response (upr) signaling pathway caused by the inhibition of mono-adp-ribosylation of grp78 could disrupt upr signaling, leading to the occurrence of apoptosis to impede tumorigenesis. |
2021-08-24 |
2023-08-13 |
Not clear |
| Julia Saravia, Kurt Paschke, Ricardo Oyarzún-Salazar, C-H Christina Cheng, Jorge M Navarro, Luis Vargas-Chacof. Effects of warming rates on physiological and molecular components of response to CTMax heat stress in the Antarctic fish Harpagifer antarcticus. Journal of thermal biology. vol 99. 2021-08-23. PMID:34420652. |
we compared ctmax values, the relative transcript expression of genes relvant to heat shock response (hsc70, hsp70, grp78), hypoxia (hif1-α, ldha, gr), ubiquitination (ube2), and apoptosis (smac/diablo), and five plasma parameters - glucose, lactate, total protein, osmolality and cortisol. |
2021-08-23 |
2023-08-13 |
Not clear |
| Fan Lin, Fu Zhen, Xiong Yan, Ye Shaojun, Peng Guizhu, Wang Yanfeng, Ye Qif. Hypothermic oxygenated perfusion with defatting cocktail further improves steatotic liver grafts in a transplantation rat model. Artificial organs. vol 45. issue 9. 2021-08-16. PMID:33908066. |
graft function after orthotopic liver transplantation was assessed in terms of mitochondrial function (adenosine triphosphate [atp], glycogen), endoplasmic reticulum stress (ppy, grp78, chop, and atf-6), cell apoptosis (tunel assay, caspase-3), inflammatory level (hmgb1, tlr4, il-1β, il-6. |
2021-08-16 |
2023-08-13 |
rat |
| Soma Samanta, Suhui Yang, Bikash Debnath, Ding Xue, Yuting Kuang, Kavya Ramkumar, Amy S Lee, Mats Ljungman, Nouri Neamat. The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress-Mediated Apoptosis in Pancreatic Cancer. Cancer research. vol 81. issue 7. 2021-08-11. PMID:33531374. |
the hydroxyquinoline analogue yum70 inhibits grp78 to induce er stress-mediated apoptosis in pancreatic cancer. |
2021-08-11 |
2023-08-13 |
Not clear |
| Hao Wu, Zhichao Meng, Yang Jiao, Yali Ren, Xin Yang, Heng Liu, Rui Wang, Yunpeng Cui, Liping Pan, Yongping Ca. The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes. Journal of clinical laboratory analysis. vol 34. issue 10. 2021-08-03. PMID:32592208. |
our study revealed that the tunicamycin-induced persistent upr expression led to apoptosis of chondrocytes and activation of autophagy incorporation with grp78. |
2021-08-03 |
2023-08-13 |
Not clear |
| Danixa Martínez, Catalina Moncada-Kopp, Kurt Paschke, Jorge M Navarro, Luis Vargas-Chacof. Warming and freshening activate the transcription of genes involved in the cellular stress response in Harpagifer antarcticus. Fish physiology and biochemistry. vol 47. issue 2. 2021-07-26. PMID:33523350. |
we used qpcr analysis to evaluate the transcription of genes involved in the thermal shock response (hsp70, hsc70, hsp90, and grp78), ubiquitination (e2, e3, ubiquitin, and chip), 26s proteasome complex (psma2, psmb7, and psmc1), and apoptosis (smac/diablo and bax) in the liver and gill. |
2021-07-26 |
2023-08-13 |
Not clear |
| Wenjuan Song, Le Sheng, Fanghui Chen, Yu Tian, Lian Li, Genlin Wang, Honglin Li, Yafei Ca. C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium. Cell stress & chaperones. vol 25. issue 2. 2021-07-07. PMID:31925678. |
the results showed that c. sakazakii-induced inflammation caused damage of tissue, significantly increased the production of pro-inflammatory cytokines (including tnf-α, il-1β, and il-6), activated the aim2 inflammasome pathway (increased the expression of aim2 and cleaved il-1β), and induced endoplasmic reticulum stress (increased the expression of erdj4, chop, grp78) and apoptosis (increased the ratio of bax/bcl-2, a marker of apoptosis). |
2021-07-07 |
2023-08-13 |
human |
| Yibo Ying, Yifan Zhang, Yurong Tu, Min Chen, Zhiyang Huang, Weiyang Ying, Qiuji Wu, Jiahui Ye, Ziyue Xiang, Xiangyang Wang, Zhouguang Wang, Sipin Zh. Hypoxia Response Element-Directed Expression of aFGF in Neural Stem Cells Promotes the Recovery of Spinal Cord Injury and Attenuates SCI-Induced Apoptosis. Frontiers in cell and developmental biology. vol 9. 2021-07-02. PMID:34195203. |
this was accomplished by inhibiting the expression of caspase 12/caspase 3 pathway, eif2α-chop pathway, and grp78 protein to inhibit apoptosis. |
2021-07-02 |
2023-08-13 |
rat |
| Xuhong Chang, Minmin Tian, Qiong Zhang, Fangfang Liu, Jinxia Gao, Sheng Li, Han Liu, Xiangbo Hou, Lei Li, Chengyun Li, Yingbiao Su. Grape seed proanthocyanidin extract ameliorates cisplatin-induced testicular apoptosis via PI3K/Akt/mTOR and endoplasmic reticulum stress pathways in rats. Journal of food biochemistry. 2021-06-21. PMID:34152018. |
the results showed that gspe ameliorated cis-induced the apoptosis of testicular cells and inhibited the protein levels of bad, cyt c, caspase-9, caspase-3, caspase-12, grp78, chop, ire1α, p-ire1α, xbp-1s, perk, p-perk, eif2α, and p-eif2α. |
2021-06-21 |
2023-08-13 |
rat |