| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramachandra K Reddy, Changhui Mao, Peter Baumeister, Richard C Austin, Randal J Kaufman, Amy S Le. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. The Journal of biological chemistry. vol 278. issue 23. 2003-07-18. PMID:12665508. |
we report here that without the use of endoplasmic reticulum (er) stress inducers, specific overexpression of grp78 results in reduced apoptosis and higher colony survival when challenged with topoisomerase ii inhibitors, etoposide and doxorubicin, and topoisomerase i inhibitor, camptothecin. |
2003-07-18 |
2023-08-12 |
Not clear |
| Ramachandra K Reddy, Changhui Mao, Peter Baumeister, Richard C Austin, Randal J Kaufman, Amy S Le. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. The Journal of biological chemistry. vol 278. issue 23. 2003-07-18. PMID:12665508. |
however, the mechanism of how grp78, a presumably er lumen protein, can regulate cytosolic effectors of apoptosis is not known. |
2003-07-18 |
2023-08-12 |
Not clear |
| Ramachandra K Reddy, Changhui Mao, Peter Baumeister, Richard C Austin, Randal J Kaufman, Amy S Le. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. The Journal of biological chemistry. vol 278. issue 23. 2003-07-18. PMID:12665508. |
lastly, a grp78 mutant deleted of its atp binding domain fails to bind procaspase-7 and loses its protective effect against etoposide-induced apoptosis. |
2003-07-18 |
2023-08-12 |
Not clear |
| Cara L Crowley-Weber, Katerina Dvorakova, Cheray Crowley, Harris Bernstein, Carol Bernstein, Harinder Garewal, Claire M Payn. Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. Chemico-biological interactions. vol 145. issue 1. 2003-05-09. PMID:12606154. |
nicotine increases oxidative stress, activates nf-kappab and grp78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. |
2003-05-09 |
2023-08-12 |
Not clear |
| Cara L Crowley-Weber, Claire M Payne, Mary Gleason-Guzman, George S Watts, Bernard Futscher, Caroline N Waltmire, Cheray Crowley, Katerina Dvorakova, Carol Bernstein, Mary Craven, Harinder Garewal, Harris Bernstei. Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. Carcinogenesis. vol 23. issue 12. 2003-02-10. PMID:12507930. |
genes that may play a role in apoptosis and early stage carcinogenesis have been identified as upregulated in these cell lines, including grp78, bcl-2, nf-kappab(p50), nf-kappab(p65), thioredoxin peroxidase (peroxiredoxin) 2, peroxiredoxin 4, maspin, guanylate cyclase activating protein-1, pkczeta, egfr, ras family members, pka, pi(4,5)k, traf2 and birc1 (iap protein). |
2003-02-10 |
2023-08-12 |
human |
| H Miyake, I Hara, S Arakawa, S Kamidon. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. Journal of cellular biochemistry. vol 77. issue 3. 2000-06-21. PMID:10760948. |
stress protein grp78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. |
2000-06-21 |
2023-08-12 |
human |
| H Miyake, I Hara, S Arakawa, S Kamidon. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. Journal of cellular biochemistry. vol 77. issue 3. 2000-06-21. PMID:10760948. |
this article characterizes the different biological features associated with grp78 induction by two kinds of stress agents, calcium ionophore, ionomycin (im), and glycosylation inhibitor, tunicamycin (tm), focusing on the association with apoptosis in human prostate cancer cells. |
2000-06-21 |
2023-08-12 |
human |
| H Miyake, I Hara, S Arakawa, S Kamidon. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. Journal of cellular biochemistry. vol 77. issue 3. 2000-06-21. PMID:10760948. |
under both experimental conditions described, dna fragmentation assays showed a direct correlation between the onset of apoptosis in lncap cells after im treatment and the initiation of grp78 transcript induction, while induction of grp78 expression preceded tm-induced apoptosis. |
2000-06-21 |
2023-08-12 |
human |
| H Miyake, I Hara, S Arakawa, S Kamidon. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. Journal of cellular biochemistry. vol 77. issue 3. 2000-06-21. PMID:10760948. |
antisense grp78 odn treatment substantially enhanced apoptosis of lncap cells induced by im compared with mismatch control odn treatment, whereas no marked differences were observed in apoptotic features induced by tm with antisense grp78 and mismatch control odn treatment. |
2000-06-21 |
2023-08-12 |
human |
| H Miyake, I Hara, S Arakawa, S Kamidon. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. Journal of cellular biochemistry. vol 77. issue 3. 2000-06-21. PMID:10760948. |
studies of additional androgen-independent prostate cancer pc3 cells also demonstrated a correlation between grp78 induction and resistance to apoptosis after im treatment, but not after tm treatment. |
2000-06-21 |
2023-08-12 |
human |
| H Miyake, I Hara, S Arakawa, S Kamidon. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. Journal of cellular biochemistry. vol 77. issue 3. 2000-06-21. PMID:10760948. |
these findings suggest that there are at least two grp78 signaling pathways, which play different roles in resistance against stress-induced apoptosis. |
2000-06-21 |
2023-08-12 |
human |
| G H Yang, S Li, J J Pestk. Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol). Toxicology and applied pharmacology. vol 162. issue 3. 2000-03-10. PMID:10652249. |
grp78 and p58(ipk) are critical for maintenance of cell homeostasis and prevention of apoptosis. |
2000-03-10 |
2023-08-12 |
Not clear |
| B van De Water, Y Wang, S Asmellash, H Liu, Y Zhan, E Miller, J L Steven. Distinct endoplasmic reticulum signaling pathways regulate apoptotic and necrotic cell death following iodoacetamide treatment. Chemical research in toxicology. vol 12. issue 10. 2000-01-04. PMID:10525270. |
thus, the expression of grp78 antisense perturbs er functions and activates expression of other er stress genes accounting for the resistance to apoptosis. |
2000-01-04 |
2023-08-12 |
Not clear |
| Z Yu, H Luo, W Fu, M P Mattso. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072306. |
the endoplasmic reticulum stress-responsive protein grp78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. |
1999-04-07 |
2023-08-12 |
rat |
| Z Yu, H Luo, W Fu, M P Mattso. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072306. |
grp78 antisense treatment enhanced apoptosis of differentiated pc12 cells following ngf withdrawal or exposure to staurosporine. |
1999-04-07 |
2023-08-12 |
rat |
| M R Jacquier-Sarlin, D Dreher, B S Poll. Selective induction of the glucose-regulated protein grp78 in human monocytes by bacterial extracts (OM-85): a role for calcium as second messenger. Biochemical and biophysical research communications. vol 226. issue 1. 1996-10-22. PMID:8806608. |
recent studies are in favor of a protective role of grp78 against cytokine-mediated cytotoxicity and apoptosis. |
1996-10-22 |
2023-08-12 |
human |
| S Sugawara, K Takeda, A Lee, G Denner. Suppression of stress protein GRP78 induction in tumor B/C10ME eliminates resistance to cell mediated cytotoxicity. Cancer research. vol 53. issue 24. 1994-01-24. PMID:8261413. |
the possibility that grp78 plays a role in defense against ctl mediated apoptosis is supported by the finding that ctl but not cd4+ cells express a high level of unphosphorylated grp78. |
1994-01-24 |
2023-08-12 |
Not clear |