| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshikazu Suzuki, Jun Lu, Muhammed Zahed, Kazuko Kita, Nobuo Suzuk. Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17936241. |
activation of upr-dependent transcription and induction of apoptosis were also observed in cells transfected with grp78 sirna. |
2007-12-18 |
2023-08-12 |
human |
| Toshikazu Suzuki, Jun Lu, Muhammed Zahed, Kazuko Kita, Nobuo Suzuk. Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17936241. |
induction of apoptosis by grp78 sirna was also observed in pc-3 cells, which expressed high basal levels of grp78 protein similar to that observed in hela cells. |
2007-12-18 |
2023-08-12 |
human |
| Toshikazu Suzuki, Jun Lu, Muhammed Zahed, Kazuko Kita, Nobuo Suzuk. Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17936241. |
by contrast, five other human cell lines with lower basal expression of grp78 protein did not undergo apoptosis when treated with grp78 sirna. |
2007-12-18 |
2023-08-12 |
human |
| Toshikazu Suzuki, Jun Lu, Muhammed Zahed, Kazuko Kita, Nobuo Suzuk. Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17936241. |
possible reasons for the strong activation of the upr and apoptosis induced by grp78 knockdown in hela cells, and the therapeutic utility of 2'-o-methyl-modified grp78 sirnas in anticancer treatment, are discussed. |
2007-12-18 |
2023-08-12 |
human |
| Satoshi Endo, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Ayumi Kasai, Yasuhiro Tagawa, Norifumi Sawada, Jian Yao, Masanori Kitamur. Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70. Molecular pharmacology. vol 72. issue 5. 2007-12-13. PMID:17702888. |
dominant-negative suppression of ire1 or xbp1 significantly attenuated apoptosis without affecting the levels of chop and grp78. |
2007-12-13 |
2023-08-12 |
Not clear |
| Satoshi Endo, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Ayumi Kasai, Yasuhiro Tagawa, Norifumi Sawada, Jian Yao, Masanori Kitamur. Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70. Molecular pharmacology. vol 72. issue 5. 2007-12-13. PMID:17702888. |
blockade of atf6 by 4-(2-aminoethyl) benzenesulfonyl fluoride enhanced apoptosis by gga, and it was correlated with attenuated induction of both grp78 and chop. |
2007-12-13 |
2023-08-12 |
Not clear |
| Satoshi Endo, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Ayumi Kasai, Yasuhiro Tagawa, Norifumi Sawada, Jian Yao, Masanori Kitamur. Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70. Molecular pharmacology. vol 72. issue 5. 2007-12-13. PMID:17702888. |
overexpression of grp78 or dominant-negative inhibition of chop significantly attenuated gga-induced apoptosis. |
2007-12-13 |
2023-08-12 |
Not clear |
| Chen Chen Jiang, Li Hua Chen, Susan Gillespie, Yu Fang Wang, Kelly A Kiejda, Xu Dong Zhang, Peter Herse. Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Cancer research. vol 67. issue 20. 2007-12-12. PMID:17942905. |
we report in this study that inhibition of the mek/erk pathway also sensitizes melanoma cells to endoplasmic reticulum (er) stress-induced apoptosis, and this is mediated, at least in part, by caspase-4 activation and is associated with inhibition of the er chaperon glucose-regulated protein 78 (grp78) expression. |
2007-12-12 |
2023-08-12 |
human |
| Chen Chen Jiang, Li Hua Chen, Susan Gillespie, Yu Fang Wang, Kelly A Kiejda, Xu Dong Zhang, Peter Herse. Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Cancer research. vol 67. issue 20. 2007-12-12. PMID:17942905. |
in addition, sirna knockdown of grp78 increased er stress-induced caspase-4 activation and apoptosis. |
2007-12-12 |
2023-08-12 |
human |
| Peter Pyrko, Axel H Schönthal, Florence M Hofman, Thomas C Chen, Amy S Le. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer research. vol 67. issue 20. 2007-12-12. PMID:17942911. |
as a ca2+-binding molecular chaperone in the endoplasmic reticulum (er), grp78 maintains er homeostasis, suppresses stress-induced apoptosis, and controls upr signaling. |
2007-12-12 |
2023-08-12 |
human |
| M Wang, X R Zhao, P Wang, L Li, Y Dai, H Huang, P Lei, H F Zhu, G X She. Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes. The international journal of biochemistry & cell biology. vol 39. issue 11. 2007-12-07. PMID:17689130. |
in this study, we investigated the effect of grp78 on the beta-cell apoptosis. |
2007-12-07 |
2023-08-12 |
Not clear |
| M Wang, X R Zhao, P Wang, L Li, Y Dai, H Huang, P Lei, H F Zhu, G X She. Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes. The international journal of biochemistry & cell biology. vol 39. issue 11. 2007-12-07. PMID:17689130. |
an insulinoma cell line, nit-1, transfected with grp78 was established, named nit-grp78, and used to study apoptosis, which was induced by streptozotocin or inflammatory cytokines. |
2007-12-07 |
2023-08-12 |
Not clear |
| M Wang, X R Zhao, P Wang, L Li, Y Dai, H Huang, P Lei, H F Zhu, G X She. Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes. The international journal of biochemistry & cell biology. vol 39. issue 11. 2007-12-07. PMID:17689130. |
in addition, the level of chop was also decreased in the nit-grp78 cells, which may mediate the resistance of the grp78 overexpressed nit-1 cells from apoptosis. |
2007-12-07 |
2023-08-12 |
Not clear |
| Tsuneo Takadera, Mineki Fujibayashi, Hisako Kaniyu, Naho Sakota, Takao Ohyashik. Caspase-dependent apoptosis induced by thapsigargin was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical neurons. Neurochemical research. vol 32. issue 8. 2007-12-03. PMID:17401651. |
blockade of n-methyl-d-aspartate (nmda) receptors with nmda antagonists induced apoptosis without grp78 protein expression. |
2007-12-03 |
2023-08-12 |
rat |
| Xiaoyong Lei, Sheng Zhang, Alan Bohrer, Shunzhong Bao, Haowei Song, Sasanka Ramanadha. The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Biochemistry. vol 46. issue 35. 2007-11-27. PMID:17685585. |
er stress induced expression of er stress factors grp78 and chop, cleavage of apoptotic factor parp, and apoptosis in v and oe ins-1 cells. |
2007-11-27 |
2023-08-12 |
Not clear |
| Xian-Qi Feng, Yong You, Juan Xiao, Ping Zo. [Thapsigargin-induced apoptosis of K562 cells and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 14. issue 1. 2007-10-19. PMID:16584585. |
after the treatment of leukemia cell line k562 by thapsigargin, morphological change of apoptotic cells was investigated by ao/eb fluorescent staining under fluorescent microscope; apoptosis rate was determined with annexin v-fitc/pi double staining by flow cytometry; intracellular calcium concentrations ([ca(2+)]i) were measured by fluorescence spectrophotometer with calcium sensitive fluorescence indicator fura-2/am; mitochondrial transmembrance potentials (delta psi m) was detected on flow cytometry through staining of rhodamine (rh123); the changes of caspase-3, -7, -9, -12, cytochrome c, grp78 proteins were detected by western blot. |
2007-10-19 |
2023-08-12 |
Not clear |
| Weike Mao, Shuji Fukuoka, Chikao Iwai, Jiahao Liu, Virendra K Sharma, Shey-Shing Sheu, Michael Fu, Chang-seng Lian. Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. American journal of physiology. Heart and circulatory physiology. vol 293. issue 3. 2007-10-19. PMID:17545481. |
myocyte apoptosis was determined by terminal deoxytransferase-mediated dutp nick-end labeling and caspase-3 activity, whereas camkii, mapk family (jnk, p38, erk), and er stress signals (atf6, grp78, chop, caspase-12) were measured by western blot, immunohistochemistry, and kinase activity assay. |
2007-10-19 |
2023-08-12 |
Not clear |
| Peter Pyrko, Adel Kardosh, Yen-Ting Liu, Nathaniel Soriano, Wenyong Xiong, Robert H Chow, Jasim Uddin, Nicos A Petasis, Austin K Mircheff, Robert A Farley, Stan G Louie, Thomas C Chen, Axel H Schöntha. Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Molecular cancer therapeutics. vol 6. issue 4. 2007-06-12. PMID:17431104. |
small interfering rna-mediated knockdown of the protective chaperone grp78 further sensitizes tumor cells to killing by dmc, whereas inhibition of caspase-4 prevents drug-induced apoptosis. |
2007-06-12 |
2023-08-12 |
Not clear |
| Yong Fu, Jianze Li, Amy S Le. GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Cancer research. vol 67. issue 8. 2007-05-23. PMID:17440086. |
grp78 overexpression decreases apoptosis of 293t cells induced by er-targeted bik. |
2007-05-23 |
2023-08-12 |
human |
| Yong Fu, Jianze Li, Amy S Le. GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Cancer research. vol 67. issue 8. 2007-05-23. PMID:17440086. |
for estrogen-dependent mcf-7/bus breast cancer cells, overexpression of grp78 inhibits estrogen starvation-induced bax activation, mitochondrial permeability transition, and consequent apoptosis. |
2007-05-23 |
2023-08-12 |
human |