| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gai-Gai Zhang, Xu Teng, Yue Liu, Yan Cai, Ye-Bo Zhou, Xiao-Hui Duan, Jun-Qiu Song, Yi Shi, Chao-Shu Tang, Xin-Hua Yin, Yong-Fen Q. Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart. Peptides. vol 30. issue 6. 2009-09-01. PMID:19406177. |
however, preadministration of ghrelin in vivo (10(-8)mol/kg, intraperitoneal injection, every 12h, twice in all) greatly ameliorated the damaged heart function, attenuated myocardial injury and apoptosis, and decreased the expression of ers markers: it decreased the mrna and protein levels of glucose-regulated protein78 (grp78) and c/ebp homologous protein (chop), with reduced caspase-12 protein expression. |
2009-09-01 |
2023-08-12 |
rat |
| Ravshan Burikhanov, Yanming Zhao, Anindya Goswami, Shirley Qiu, Steven R Schwarze, Vivek M Rangneka. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell. vol 138. issue 2. 2009-08-17. PMID:19632185. |
interestingly, extracellular par-4 induced apoptosis by binding to the stress response protein, glucose-regulated protein-78 (grp78), expressed at the surface of cancer cells. |
2009-08-17 |
2023-08-12 |
mouse |
| Ravshan Burikhanov, Yanming Zhao, Anindya Goswami, Shirley Qiu, Steven R Schwarze, Vivek M Rangneka. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell. vol 138. issue 2. 2009-08-17. PMID:19632185. |
the interaction of extracellular par-4 and cell surface grp78 led to apoptosis via er stress and activation of the fadd/caspase-8/caspase-3 pathway. |
2009-08-17 |
2023-08-12 |
mouse |
| Ravshan Burikhanov, Yanming Zhao, Anindya Goswami, Shirley Qiu, Steven R Schwarze, Vivek M Rangneka. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell. vol 138. issue 2. 2009-08-17. PMID:19632185. |
moreover, apoptosis inducible by trail, which also exerts cancer cell-specific effects, is dependent on extracellular par-4 signaling via cell surface grp78. |
2009-08-17 |
2023-08-12 |
mouse |
| Ravshan Burikhanov, Yanming Zhao, Anindya Goswami, Shirley Qiu, Steven R Schwarze, Vivek M Rangneka. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell. vol 138. issue 2. 2009-08-17. PMID:19632185. |
thus, par-4 activates an extrinsic pathway involving cell surface grp78 receptor for induction of apoptosis. |
2009-08-17 |
2023-08-12 |
mouse |
| Guo-Qiang Xu, Wen-Fang Huang, Hua Liu, Yong-Chang Yang, Wen Li. [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 43. issue 4. 2009-08-10. PMID:18664198. |
apoptosis rate of cells was determined with annexinv-fitc/pi double staining by flow cytometry; intracellular calcium concentration ([ca2+]i) was measured by laser scanning confocal microscope (lscm); the expression levels of glucose regulated protein 78 (grp78) and calpain gene mrna were determined by rt-pcr; the expression levels of caspase-3, -6, -7, -9, -12, calpain and grp78 proteins were evaluated by western blotting. |
2009-08-10 |
2023-08-12 |
Not clear |
| Braden C McFarland, Jerry Stewart, Amal Hamza, Robert Nordal, Donald J Davidson, Jack Henkin, Candece L Gladso. Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1. Cancer research. vol 69. issue 13. 2009-07-29. PMID:19549899. |
plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for grp78 and lrp1. |
2009-07-29 |
2023-08-12 |
Not clear |
| Braden C McFarland, Jerry Stewart, Amal Hamza, Robert Nordal, Donald J Davidson, Jack Henkin, Candece L Gladso. Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1. Cancer research. vol 69. issue 13. 2009-07-29. PMID:19549899. |
recombinant plasminogen kringle 5 (rk5) has been shown to induce apoptosis of dermal microvessel endothelial cells (mvec) in a manner that requires glucose-regulated protein 78 (grp78). |
2009-07-29 |
2023-08-12 |
Not clear |
| Braden C McFarland, Jerry Stewart, Amal Hamza, Robert Nordal, Donald J Davidson, Jack Henkin, Candece L Gladso. Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1. Cancer research. vol 69. issue 13. 2009-07-29. PMID:19549899. |
the rk5-induced apoptosis of both unirradiated and irradiated mvec required expression of grp78 and the low-density lipoprotein receptor-related protein 1 (lrp1), a scavenger receptor, based on down-regulation studies with small interfering rna, and blocking studies with either a grp78 antibody or a competitive inhibitor of ligand binding to lrp1. |
2009-07-29 |
2023-08-12 |
Not clear |
| Braden C McFarland, Jerry Stewart, Amal Hamza, Robert Nordal, Donald J Davidson, Jack Henkin, Candece L Gladso. Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1. Cancer research. vol 69. issue 13. 2009-07-29. PMID:19549899. |
these data suggest that irradiation sensitizes brain mvec to the rk5-induced apoptosis and that this signal requires lrp1 internalization of grp78 and the activation of p38 mitogen-activated protein kinase. |
2009-07-29 |
2023-08-12 |
Not clear |
| Wang Siyan, Yue Feng, Zhang Lichuan, Wang Jiarui, Wang Yingyan, Jiang Li, Lin Bingcheng, Wang Q. Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance. Journal of pharmaceutical and biomedical analysis. vol 49. issue 3. 2009-07-20. PMID:19162424. |
the expression of grp78 was detected by immunofluorescence, the apoptosis for the cells treated by vp-16 was assessed morphologically by 4',6-diamidino-2-phenylindole (dapi) staining. |
2009-07-20 |
2023-08-12 |
human |
| Min Wang, Ping Wang, Ji-Lin Peng, Sha Wu, Xiao-Ping Zhao, Li Li, Guan-Xin She. The altered expression of glucose-regulated proteins 78 in different phase of streptozotocin-affected pancreatic beta-cells. Cell stress & chaperones. vol 14. issue 1. 2009-06-25. PMID:18597185. |
grp78 expression significantly increased in the early phase but decreased in the later phase of affected beta-cells, while chop was induced and apoptosis occurred along with the decrease of grp78. |
2009-06-25 |
2023-08-12 |
mouse |
| Te-Chun Hsia, Jai-Sing Yang, Guang-Wei Chen, Tsan-Hung Chiu, Hsu-Feng Lu, Mei-Due Yang, Fu-Shun Yu, Kuo-Ching Liu, Kuang-Chi Lai, Chin-Chung Lin, Jing-Gung Chun. The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells. Anticancer research. vol 29. issue 1. 2009-04-16. PMID:19331167. |
flow cytometric analysis demonstrated that rhein increased the levels of gadd153 and grp78, both hallmarks of endoplasmic reticulum stress, promoted ros and ca2+ production, induced the loss of mitochondrial membrane potential (delta psi(m)), promoted cytochrome c release from mitochondria, promoted capase-3 activation and led to apoptosis. |
2009-04-16 |
2023-08-12 |
human |
| Shuw-Yuan Lin, Wan-Wen Lai, Chin-Chin Ho, Fu-Shun Yu, Guang-Wei Chen, Jai-Sing Yang, Kuo-Ching Liu, Meng-Liang Lin, Ping-Ping Wu, Ming-Jen Fan, Jing-Gung Chun. Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. Anticancer research. vol 29. issue 1. 2009-04-16. PMID:19331169. |
taken together, these findings suggest that emodin mediated oxidative injury (dna damage) based on ros production and er stress based on the levels of gadd153 and grp78 that acts as an early and upstream change in the cell death cascade to caspase- and mitochondria-dependent signaling pathways, triggers mitochondrial dysfunction from bcl-2 and bax modulation, mitochondrial cytochrome c release and caspase activation, consequently leading to apoptosis in scc-4 cells. |
2009-04-16 |
2023-08-12 |
human |
| Chen Chen Jiang, Zhi Gang Mao, Kelly A Avery-Kiejda, Margaret Wade, Peter Hersey, Xu Dong Zhan. Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells. Carcinogenesis. vol 30. issue 2. 2009-03-26. PMID:18842681. |
inhibition of grp78 by small-interference rna (sirna)-sensitized melanoma cells to cddp- and adriamycin-induced apoptosis. |
2009-03-26 |
2023-08-12 |
human |
| Chen Chen Jiang, Zhi Gang Mao, Kelly A Avery-Kiejda, Margaret Wade, Peter Hersey, Xu Dong Zhan. Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells. Carcinogenesis. vol 30. issue 2. 2009-03-26. PMID:18842681. |
in contrast, overexpression of grp78 attenuated activation of caspase-4 and -7 and induction of apoptosis by the drugs. |
2009-03-26 |
2023-08-12 |
human |
| Christine Radanyi, Gaëlle Le Bras, Céline Bouclier, Samir Messaoudi, Jean-François Peyrat, Jean-Daniel Brion, Mouâd Alami, Jack-Michel Renoi. Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23. Biochemical and biophysical research communications. vol 379. issue 2. 2009-02-13. PMID:19118525. |
in ht29 colon cancer cells, 4tcna and 7tcna up-regulated grp78 and grp94 supporting involvement of er stress in apoptosis. |
2009-02-13 |
2023-08-12 |
Not clear |
| Gisele Faria, Cristina R B Cardoso, Roy E Larson, João S Silva, Marcos A Ross. Chlorhexidine-induced apoptosis or necrosis in L929 fibroblasts: A role for endoplasmic reticulum stress. Toxicology and applied pharmacology. vol 234. issue 2. 2009-02-06. PMID:19027770. |
this hypothesis was further tested by means of light and electron microscopy, quantification of apoptosis and necrosis by flow cytometry, fluorescence visualization of the cytoskeleton and endoplasmic reticulum, and evaluation of the expression of 78-kda glucose-regulated protein 78 (grp78), a marker of activation of the unfolded protein response (upr) in cultured l929 fibroblasts. |
2009-02-06 |
2023-08-12 |
Not clear |
| Yingying Sun, Guanghui Liu, Tao Song, Fang Liu, Weiqiang Kang, Yun Zhang, Zhiming G. Upregulation of GRP78 and caspase-12 in diastolic failing heart. Acta biochimica Polonica. vol 55. issue 3. 2009-02-04. PMID:18787714. |
glucose regulated protein 78 (grp78) has been widely used as a marker for ers and caspase-12 mediated apoptosis was a specific apoptotic pathway of er. |
2009-02-04 |
2023-08-12 |
Not clear |
| Jing Chen, Jiong Qin, Xiaoyan Liu, Ying Han, Zhixian Yang, Xingzhi Chang, Xinna J. Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway. Neuroscience letters. vol 443. issue 3. 2009-02-03. PMID:18675883. |
we utilized a recurrent febrile seizures (fs) rat model and found that plasma no was increased, neuronal apoptosis was evident, the expression of glucose-regulated protein78 (grp78, a well-established marker of er stress) was elevated, and caspase-12 (an er stress-specific proapoptosis molecule) was activated in the hippocampus in a time-dependent manner after recurrent fs. |
2009-02-03 |
2023-08-12 |
rat |