| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ssu-Ming Huang, Chi-Wai Cheung, Chih-Shiang Chang, Chih-Hsin Tang, Ju-Fang Liu, Yu-Hsin Lin, Jia-Hong Chen, Shihi-Hsun Ko, Kar-Lok Wong, Dah-Yuu L. Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer. Journal of cellular biochemistry. vol 112. issue 2. 2011-05-03. PMID:21268086. |
transfection of cells with grp78 or chop sirna, or treatment of gsk3 inhibitor sb216163 reduced mcpp-mediated cell apoptosis. |
2011-05-03 |
2023-08-12 |
human |
| Ssu-Ming Huang, Chi-Wai Cheung, Chih-Shiang Chang, Chih-Hsin Tang, Ju-Fang Liu, Yu-Hsin Lin, Jia-Hong Chen, Shihi-Hsun Ko, Kar-Lok Wong, Dah-Yuu L. Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer. Journal of cellular biochemistry. vol 112. issue 2. 2011-05-03. PMID:21268086. |
taken together, the present study provides evidences to support that grp78 and chop expression, and gsk3α/β activation in mediating the mcpp-induced human colon cancer cell apoptosis. |
2011-05-03 |
2023-08-12 |
human |
| Koji Shimoke, Harue Sasaya, Toshihiko Ikeuch. Analysis of the role of nerve growth factor in promoting cell survival during endoplasmic reticulum stress in PC12 cells. Methods in enzymology. vol 490. 2011-04-18. PMID:21266243. |
in the process of er stress-mediated apoptosis, the cleavage of pro-caspase-12 residing on the er and the expression of glucose-regulated protein 78 (grp78) can be observed. |
2011-04-18 |
2023-08-12 |
Not clear |
| Yajing Yuan, Qulian Guo, Zhi Ye, Xia Pingping, Na Wang, Zongbin Son. Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. Brain research. vol 1367. 2011-04-15. PMID:20940001. |
our results showed that postcond significantly attenuated brain i/r injury, as shown by reduction in infarct size, cell apoptosis, chop expression, caspase-12 activation and increase in grp78 expression. |
2011-04-15 |
2023-08-12 |
rat |
| Zhu-Ying Zhou, Guang-Qian L. [Effects of W-7 on the expression of GRP78 and neuronal apoptosis in immature rat hippocampus after status convulsion]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 13. issue 1. 2011-04-13. PMID:21251387. |
[effects of w-7 on the expression of grp78 and neuronal apoptosis in immature rat hippocampus after status convulsion]. |
2011-04-13 |
2023-08-12 |
rat |
| Zhu-Ying Zhou, Guang-Qian L. [Effects of W-7 on the expression of GRP78 and neuronal apoptosis in immature rat hippocampus after status convulsion]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 13. issue 1. 2011-04-13. PMID:21251387. |
to investigate the effects of the calmodulin inhibitor w-7 on the expression of the key marker of ers grp78 and neuronal apoptosis in the immature rat hippocampus after status convulsion (sc). |
2011-04-13 |
2023-08-12 |
rat |
| Britta Hardy, Annat Raite. Peptide-binding heat shock protein GRP78 protects cardiomyocytes from hypoxia-induced apoptosis. Journal of molecular medicine (Berlin, Germany). vol 88. issue 11. 2011-02-23. PMID:20664993. |
peptide-binding heat shock protein grp78 protects cardiomyocytes from hypoxia-induced apoptosis. |
2011-02-23 |
2023-08-12 |
mouse |
| Britta Hardy, Annat Raite. Peptide-binding heat shock protein GRP78 protects cardiomyocytes from hypoxia-induced apoptosis. Journal of molecular medicine (Berlin, Germany). vol 88. issue 11. 2011-02-23. PMID:20664993. |
apoptosis that was significantly increased in cardiomyocytes under hypoxic conditions was inhibited by the presence of the peptide-binding grp78 during hypoxia. |
2011-02-23 |
2023-08-12 |
mouse |
| Britta Hardy, Annat Raite. Peptide-binding heat shock protein GRP78 protects cardiomyocytes from hypoxia-induced apoptosis. Journal of molecular medicine (Berlin, Germany). vol 88. issue 11. 2011-02-23. PMID:20664993. |
inhibition of apoptosis was mediated by the binding of the peptide to cardiomyocytes cell surface grp78 resulting in blocking caspase-3/7 activation. |
2011-02-23 |
2023-08-12 |
mouse |
| Tsung-Teng Huang, Hung-Chi Lin, Chang-Chieh Chen, Chia-Chen Lu, Chia-Fong Wei, Ting-Shu Wu, Fu-Guo Liu, Hsin-Chih La. Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple apoptotic pathways. Journal of cellular physiology. vol 226. issue 3. 2011-01-27. PMID:20717957. |
molecular mechanistic studies of apoptosis unraveled resveratrol treatment resulted in a significant loss of mitochondrial transmembrane potential, release of cytochrome c, enhanced expression of fas ligand (fasl), and suppression of glucose-regulated protein 78 kda (grp78). |
2011-01-27 |
2023-08-12 |
human |
| Shaun Martin, David S Hill, James C Paton, Adrienne W Paton, Mark A Birch-Machin, Penny E Lovat, Chris P F Redfer. Targeting GRP78 to enhance melanoma cell death. Pigment cell & melanoma research. vol 23. issue 5. 2011-01-24. PMID:20546536. |
down-regulation of grp78 by small-interfering rna increased fenretinide- or bortezomib-induced apoptosis. |
2011-01-24 |
2023-08-12 |
Not clear |
| Takushi Namba, Tatsuya Hoshino, Shintaro Suemasu, Mika Takarada-Iemata, Osamu Hori, Naomi Nakagata, Akinori Yanaka, Tohru Mizushim. Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20861013. |
we recently found that in cultured gastric cells, expression of endoplasmic reticulum (er) chaperones (such as 150-kda oxygen-regulated protein (orp150) and glucose-regulated protein 78 (grp78)) is induced by nsaids and confers protection against nsaid-induced apoptosis, which is important in the development of nsaid-induced gastric lesions. |
2010-12-30 |
2023-08-12 |
mouse |
| R Y Dai, S K Chen, D M Yan, R Chen, Y P Lui, C Y Duan, J Li, T He, H L. PI3K/Akt promotes GRP78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in HEK293 cells. Folia biologica. vol 56. issue 2. 2010-11-12. PMID:20492754. |
pi3k/akt promotes grp78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in hek293 cells. |
2010-11-12 |
2023-08-12 |
Not clear |
| R Y Dai, S K Chen, D M Yan, R Chen, Y P Lui, C Y Duan, J Li, T He, H L. PI3K/Akt promotes GRP78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in HEK293 cells. Folia biologica. vol 56. issue 2. 2010-11-12. PMID:20492754. |
here, we showed that pi3k/akt inhibition promoted endoplasmic reticulum stress-induced apoptosis in a glucose-regulated protein 78 (grp78)-dependent manner. |
2010-11-12 |
2023-08-12 |
Not clear |
| R Y Dai, S K Chen, D M Yan, R Chen, Y P Lui, C Y Duan, J Li, T He, H L. PI3K/Akt promotes GRP78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in HEK293 cells. Folia biologica. vol 56. issue 2. 2010-11-12. PMID:20492754. |
these results suggest that pi3k/akt inhibits endoplasmic reticulum stress-induced apoptosis in hek293 cells, at least in part, by promoting grp78 protein stability. |
2010-11-12 |
2023-08-12 |
Not clear |
| Fang Chai, Rongjiang Luo, Yiqing Li, Yujing Bai, Yuan He, Yantao Wei, Zhichao Yan, Jian Ge, Yehong Zhu. Down-regulation of GRP78 in human glaucomatous trabecular meshwork cells. Molecular vision. vol 16. 2010-11-12. PMID:20664690. |
since the 78 kda glucose-regulated protein (grp78) is a key marker of endoplasmic reticulum (er) stress, we investigated and analyzed grp78 expression levels in the trabecular meshwork (tm) by eyes with primary open angle glaucoma (poag) and normal eyes to understand the role of grp78 in human tm cells apoptosis. |
2010-11-12 |
2023-08-12 |
human |
| Masanori Sato, Virginia J Yao, Wadih Arap, Renata Pasqualin. GRP78 signaling hub a receptor for targeted tumor therapy. Advances in genetics. vol 69. 2010-11-05. PMID:20807604. |
in contrast, association of grp78 with the plasminogen kringle 5 domain or extracellular par-4 promotes apoptosis. |
2010-11-05 |
2023-08-12 |
Not clear |
| Uma K Misra, Salvatore V Pizz. Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. Cancer biology & therapy. vol 9. issue 2. 2010-08-25. PMID:20368692. |
we have previously shown that treatment of prostate cancer and melanoma cells expressing grp78 on their cell surface with antibody directed against the cooh-terminal domain of grp78 upregulates and activates p53 causing decreased cell proliferation and upregulated apoptosis. |
2010-08-25 |
2023-08-12 |
human |
| Shin-Hwar Wu, Liang-Wen Hang, Jai-Sing Yang, Hung-Yi Chen, Hui-Yi Lin, Jo-Hua Chiang, Chi-Cheng Lu, Jiun-Long Yang, Tung-Yuan Lai, Yang-Ching Ko, Jing-Gung Chun. Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways. Anticancer research. vol 30. issue 6. 2010-08-24. PMID:20651361. |
curcumin-induced apoptosis was also stimulated through the fas/caspase-8 (extrinsic) pathway and er stress proteins, growth arrest- and dna damage-inducible gene 153 (gadd153) and glucose-regulated protein 78 (grp78) were activated in the nci-h460 cells. |
2010-08-24 |
2023-08-12 |
human |
| Chang-Qing Zhao, Yue-Hui Zhang, Sheng-Dan Jiang, Lei-Sheng Jiang, Li-Yang Da. Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. Age (Dordrecht, Netherlands). vol 32. issue 2. 2010-08-09. PMID:19960285. |
ivdd was characterized by x-ray and histomorphology examination, disc cell apoptosis was detected by tunel staining, and the co-involvement of er and mitochondria in apoptosis was determined by immunohistochemical staining for grp78, gadd153, caspase-12, and cytochrome c. additional eight rats were used for annular cell isolation and culture. |
2010-08-09 |
2023-08-12 |
rat |